JP2007537244A - ２０位にてインテグリンアンタゴニストと接合したカンプトテシン誘導体 - Google Patents

２０位にてインテグリンアンタゴニストと接合したカンプトテシン誘導体 Download PDF

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Publication number
JP2007537244A
JP2007537244A JP2007512735A JP2007512735A JP2007537244A JP 2007537244 A JP2007537244 A JP 2007537244A JP 2007512735 A JP2007512735 A JP 2007512735A JP 2007512735 A JP2007512735 A JP 2007512735A JP 2007537244 A JP2007537244 A JP 2007537244A
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JP
Japan
Prior art keywords
group
alkyl
branched
linear
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007512735A
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English (en)
Japanese (ja)
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JP2007537244A5 (https=
Inventor
アルマ・ダル・ポッツォ
セルジョ・ペンコ
ルーチョ・メルリーニ
ジュゼッペ・ジャンニーニ
マリア・オルネッラ・ティンティ
クラウディオ・ピサーノ
フランコ・ツニーノ
ドメニコ・アッロアッティ
ロレダナ・ヴェシ
サブリナ・ダッラヴァッレ
ミン・ホン・ニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of JP2007537244A publication Critical patent/JP2007537244A/ja
Publication of JP2007537244A5 publication Critical patent/JP2007537244A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2007512735A 2004-05-13 2005-05-04 ２０位にてインテグリンアンタゴニストと接合したカンプトテシン誘導体 Withdrawn JP2007537244A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000241A ITRM20040241A1 (it) 2004-05-13 2004-05-13 Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
PCT/IT2005/000261 WO2005110487A2 (en) 2004-05-13 2005-05-04 Camptothecin derivatives conjugated in position 20 with integrin antagonists

Publications (2)

Publication Number Publication Date
JP2007537244A true JP2007537244A (ja) 2007-12-20
JP2007537244A5 JP2007537244A5 (https=) 2008-06-26

Family

ID=35124307

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007512735A Withdrawn JP2007537244A (ja) 2004-05-13 2005-05-04 ２０位にてインテグリンアンタゴニストと接合したカンプトテシン誘導体

Country Status (12)

Country Link
US (1) US20070232639A1 (https=)
EP (1) EP1747019A2 (https=)
JP (1) JP2007537244A (https=)
CN (1) CN101010103A (https=)
AR (1) AR049275A1 (https=)
AU (1) AU2005243834A1 (https=)
BR (1) BRPI0511037A (https=)
CA (1) CA2562572A1 (https=)
IT (1) ITRM20040241A1 (https=)
MX (1) MXPA06012886A (https=)
TW (1) TW200538125A (https=)
WO (1) WO2005110487A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2604284A1 (en) 2007-02-16 2013-06-19 KTB Tumorforschungsgesellschaft mbH Receptor And Antigen Targeted Prodrug
BR112014016736A8 (pt) * 2012-01-27 2017-07-04 Hoffmann La Roche composto, composição farmacêutica, método para tratamento, uso de um composto e invenção
CN105399757A (zh) * 2015-12-29 2016-03-16 遵义医学院 酸敏感型喜树碱-20位去甲斑蝥酸酯衍生物及其抗肿瘤应用
CN111068068A (zh) * 2019-12-04 2020-04-28 云南民族大学 一种rgd多肽-喜树碱多肽药物偶联物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
ATE216998T1 (de) * 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
DE60042700D1 (de) * 1999-09-08 2009-09-17 Markus Albers Integrin-vermittelte arzneimittel-zielrichtung

Also Published As

Publication number Publication date
BRPI0511037A (pt) 2007-11-27
EP1747019A2 (en) 2007-01-31
ITRM20040241A1 (it) 2004-08-13
AU2005243834A1 (en) 2005-11-24
MXPA06012886A (es) 2007-02-15
WO2005110487A3 (en) 2007-02-15
TW200538125A (en) 2005-12-01
US20070232639A1 (en) 2007-10-04
CA2562572A1 (en) 2005-11-24
WO2005110487A2 (en) 2005-11-24
AR049275A1 (es) 2006-07-12
CN101010103A (zh) 2007-08-01

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