JP2007535498A5 - - Google Patents

Info

Publication number

JP2007535498A5

JP2007535498A5 JP2007502006A JP2007502006A JP2007535498A5 JP 2007535498 A5 JP2007535498 A5 JP 2007535498A5 JP 2007502006 A JP2007502006 A JP 2007502006A JP 2007502006 A JP2007502006 A JP 2007502006A JP 2007535498 A5 JP2007535498 A5 JP 2007535498A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

symptoms

amount

reduce

amino

Prior art date

2005-03-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 28
• 208000024891 symptom Diseases 0.000 claims 18
• 108010072051 Glatiramer Acetate Proteins 0.000 claims 14
• FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims 13
• 229960003776 glatiramer acetate Drugs 0.000 claims 13
• 230000004112 neuroprotection Effects 0.000 claims 13
• 201000006417 multiple sclerosis Diseases 0.000 claims 9
• 210000003169 central nervous system Anatomy 0.000 claims 8
• 210000001428 peripheral nervous system Anatomy 0.000 claims 8
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 7
• FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 claims 4
• IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 201000010901 lateral sclerosis Diseases 0.000 claims 2
• 208000005264 motor neuron disease Diseases 0.000 claims 2
• 230000004224 protection Effects 0.000 claims 2
• YLOCGHYTXIINAI-XKUOMLDTSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 YLOCGHYTXIINAI-XKUOMLDTSA-N 0.000 claims 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
• 102000010909 Monoamine Oxidase Human genes 0.000 claims 1
• 108010062431 Monoamine oxidase Proteins 0.000 claims 1
• 206010028289 Muscle atrophy Diseases 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 229940042385 glatiramer Drugs 0.000 claims 1
• 229930195712 glutamate Natural products 0.000 claims 1
• 230000020763 muscle atrophy Effects 0.000 claims 1
• 201000000585 muscular atrophy Diseases 0.000 claims 1
• 210000000653 nervous system Anatomy 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 230000000737 periodic effect Effects 0.000 claims 1
• 230000002093 peripheral effect Effects 0.000 claims 1
• 231100000331 toxic Toxicity 0.000 claims 1
• 230000002588 toxic effect Effects 0.000 claims 1
• 231100000419 toxicity Toxicity 0.000 claims 1
• 230000001988 toxicity Effects 0.000 claims 1