WO2021070200A3 - Stable compositions of (7as,2's)-2-oxoclopidogrel and its pharmaceutical salts - Google Patents
Stable compositions of (7as,2's)-2-oxoclopidogrel and its pharmaceutical salts Download PDFInfo
- Publication number
- WO2021070200A3 WO2021070200A3 PCT/IN2020/050865 IN2020050865W WO2021070200A3 WO 2021070200 A3 WO2021070200 A3 WO 2021070200A3 IN 2020050865 W IN2020050865 W IN 2020050865W WO 2021070200 A3 WO2021070200 A3 WO 2021070200A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oxoclopidogrel
- stable
- stable compositions
- pharmaceutical salts
- salts
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses stable oral pharmaceutical composition containing therapeutically effective amount of (7aS,2'S)-2-oxoclopidogrel and/or its salts or derivatives, in combination with pharmaceutically acceptable adjuvants or carriers. More particularly, the present invention discloses highly pure (7aS,2'S)-2-oxoclopidogrel and/or its salts, processes for manufacturing pure and stable (7aS,2'S)-2-oxoclopidogrel and stable compositions having a shelf-life of at least one year or more.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201921022792 | 2019-10-08 | ||
IN201921022792 | 2019-10-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2021070200A2 WO2021070200A2 (en) | 2021-04-15 |
WO2021070200A3 true WO2021070200A3 (en) | 2021-07-01 |
Family
ID=75437322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2020/050865 WO2021070200A2 (en) | 2019-10-08 | 2020-10-08 | Stable compositions of (7as,2's)-2-oxoclopidogrel and its pharmaceutical salts |
Country Status (1)
Country | Link |
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WO (1) | WO2021070200A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115518066A (en) * | 2022-06-17 | 2022-12-27 | 成都施贝康生物医药科技有限公司 | Pharmaceutical composition for treating anticoagulation and application |
CN115327005B (en) * | 2022-08-12 | 2024-01-26 | 成都施贝康生物医药科技有限公司 | Method for detecting clopidogrel oxide related substances |
CN115327003B (en) * | 2022-08-12 | 2024-03-12 | 成都施贝康生物医药科技有限公司 | Method for detecting clopidogrel oxide related substances |
CN115327004B (en) * | 2022-08-12 | 2024-01-26 | 成都施贝康生物医药科技有限公司 | Method for detecting clopidogrel oxide crude product |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120329763A1 (en) * | 2011-06-27 | 2012-12-27 | Ashok Kumar | Anti-thrombotic compounds |
US20150011583A1 (en) * | 2010-02-02 | 2015-01-08 | Jiangsu Vcare Pharmatech Co., Ltd. | Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof |
US20170334853A1 (en) * | 2013-01-09 | 2017-11-23 | The Regents Of The University Of Michigan | Mixed disulfide conjugates of thienopyridine compounds and uses thereof |
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2020
- 2020-10-08 WO PCT/IN2020/050865 patent/WO2021070200A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150011583A1 (en) * | 2010-02-02 | 2015-01-08 | Jiangsu Vcare Pharmatech Co., Ltd. | Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof |
US20120329763A1 (en) * | 2011-06-27 | 2012-12-27 | Ashok Kumar | Anti-thrombotic compounds |
US20170334853A1 (en) * | 2013-01-09 | 2017-11-23 | The Regents Of The University Of Michigan | Mixed disulfide conjugates of thienopyridine compounds and uses thereof |
Non-Patent Citations (1)
Title |
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QIU ZHIXIA, LI NING, SONG LING, LU YANG, JING JING, PAREKHA HARENDRA S., GAO WENCHAO, TIAN FENGJIE, WANG XIN, REN SHUANGXIA, CHEN : "Contributions of Intestine and Plasma to the Presystemic Bioconversion of Vicagrel, an Acetate of Clopidogrel", PHARMACEUTICAL RESEARCH, vol. 31, no. 1, 1 January 2014 (2014-01-01), pages 238 - 251, XP055834803, ISSN: 0724-8741, DOI: 10.1007/s11095-013-1158-5 * |
Also Published As
Publication number | Publication date |
---|---|
WO2021070200A2 (en) | 2021-04-15 |
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