JP2007534657A5 - - Google Patents
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- JP2007534657A5 JP2007534657A5 JP2006547443A JP2006547443A JP2007534657A5 JP 2007534657 A5 JP2007534657 A5 JP 2007534657A5 JP 2006547443 A JP2006547443 A JP 2006547443A JP 2006547443 A JP2006547443 A JP 2006547443A JP 2007534657 A5 JP2007534657 A5 JP 2007534657A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- serine
- brain
- daao
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004556 brain Anatomy 0.000 description 15
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 description 14
- 102100026908 D-amino-acid oxidase Human genes 0.000 description 10
- 108010003989 D-amino-acid oxidase Proteins 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 10
- 208000024827 Alzheimer disease Diseases 0.000 description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 229930195711 D-Serine Natural products 0.000 description 5
- 241000700159 Rattus Species 0.000 description 5
- 206010012289 Dementia Diseases 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 230000027455 binding Effects 0.000 description 3
- 230000003920 cognitive function Effects 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- PKYCWFICOKSIHZ-UHFFFAOYSA-N 1-(3,7-dihydroxyphenoxazin-10-yl)ethanone Chemical compound OC1=CC=C2N(C(=O)C)C3=CC=C(O)C=C3OC2=C1 PKYCWFICOKSIHZ-UHFFFAOYSA-N 0.000 description 2
- LPWVUDLZUVBQGP-FLIBITNWSA-N 3-[(z)-2-carboxy-2-phenylethenyl]-4,6-dichloro-1h-indole-2-carboxylic acid Chemical compound OC(=O)C=1NC2=CC(Cl)=CC(Cl)=C2C=1\C=C(C(=O)O)\C1=CC=CC=C1 LPWVUDLZUVBQGP-FLIBITNWSA-N 0.000 description 2
- 208000000044 Amnesia Diseases 0.000 description 2
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 208000026139 Memory disease Diseases 0.000 description 2
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 description 2
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 230000006984 memory degeneration Effects 0.000 description 2
- 208000023060 memory loss Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000007425 progressive decline Effects 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 1
- 208000006888 Agnosia Diseases 0.000 description 1
- 241001047040 Agnosia Species 0.000 description 1
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 1
- 206010003062 Apraxia Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 108010006152 Serine racemase Proteins 0.000 description 1
- 102100035717 Serine racemase Human genes 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960002274 atenolol Drugs 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000005392 carboxamide group Chemical group NC(=O)* 0.000 description 1
- 125000004181 carboxyalkyl group Chemical group 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 239000000544 cholinesterase inhibitor Substances 0.000 description 1
- 208000030251 communication disease Diseases 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 229960003530 donepezil Drugs 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000005553 heteroaryloxy group Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- ZUFVXZVXEJHHBN-UHFFFAOYSA-N hydron;1,2,3,4-tetrahydroacridin-9-amine;chloride Chemical compound [Cl-].C1=CC=C2C([NH3+])=C(CCCC3)C3=NC2=C1 ZUFVXZVXEJHHBN-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 201000003723 learning disability Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 239000002664 nootropic agent Substances 0.000 description 1
- 230000001777 nootropic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229960005222 phenazone Drugs 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- FAQJJMHZNSSFSM-UHFFFAOYSA-N phenylglyoxylic acid Chemical compound OC(=O)C(=O)C1=CC=CC=C1 FAQJJMHZNSSFSM-UHFFFAOYSA-N 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- HSSLDCABUXLXKM-UHFFFAOYSA-N resorufin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3N=C21 HSSLDCABUXLXKM-UHFFFAOYSA-N 0.000 description 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
- 125000004426 substituted alkynyl group Chemical group 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 125000003375 sulfoxide group Chemical group 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229960003565 tacrine hydrochloride Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53297803P | 2003-12-29 | 2003-12-29 | |
| PCT/US2004/043547 WO2005066143A2 (en) | 2003-12-29 | 2004-12-28 | Benzo[d]isoxazol-3-ol daao inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007534657A JP2007534657A (ja) | 2007-11-29 |
| JP2007534657A5 true JP2007534657A5 (enExample) | 2008-01-17 |
Family
ID=34748836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547443A Pending JP2007534657A (ja) | 2003-12-29 | 2004-12-28 | ベンゾ［ｄ］イソオキサゾール阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7166725B2 (enExample) |
| EP (1) | EP1711478A2 (enExample) |
| JP (1) | JP2007534657A (enExample) |
| KR (1) | KR20060128978A (enExample) |
| CN (3) | CN101798291A (enExample) |
| AU (1) | AU2004312511A1 (enExample) |
| BR (1) | BRPI0417910A (enExample) |
| CA (1) | CA2552098A1 (enExample) |
| CZ (1) | CZ2006426A3 (enExample) |
| IL (1) | IL176607A0 (enExample) |
| NZ (1) | NZ548213A (enExample) |
| PL (1) | PL380766A1 (enExample) |
| RU (1) | RU2384574C2 (enExample) |
| WO (1) | WO2005066143A2 (enExample) |
| ZA (1) | ZA200605384B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004312530A1 (en) | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
| CA2472806A1 (en) | 2004-05-18 | 2005-11-18 | Petro-Canada | Compositions and methods for treating turf insect pests and diseases such as fungal infestations |
| JP2009500425A (ja) | 2005-07-06 | 2009-01-08 | セプラコア インコーポレーテッド | エスゾピクロン及びトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミン又はトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法 |
| BRPI0706365A2 (pt) | 2006-01-06 | 2011-03-22 | Sepracor Inc | Cicloalquilaminas como inibidores da recaptação de monoamina |
| NZ569608A (en) * | 2006-01-06 | 2011-09-30 | Sepracor Inc | Tetralone-based monoamine reuptake inhibitors |
| EP1988085B8 (en) | 2006-02-21 | 2015-01-28 | Toyama Chemical Co., Ltd. | Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionate ester and intermediate for the process |
| DK2816024T3 (en) | 2006-03-31 | 2017-10-30 | Sunovion Pharmaceuticals Inc | CHIRALE AMINER |
| US7884124B2 (en) * | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
| US20080082066A1 (en) * | 2006-10-02 | 2008-04-03 | Weyerhaeuser Co. | Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks |
| US9357768B2 (en) | 2006-10-05 | 2016-06-07 | Suncor Energy Inc. | Herbicidal composition with increased herbicidal efficacy |
| US20090099248A1 (en) * | 2007-01-18 | 2009-04-16 | Sepracor Inc. | Inhibitors of d-amino acid oxidase |
| US7902252B2 (en) * | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| AU2008259841B2 (en) | 2007-05-31 | 2015-02-05 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
| ES2619731T3 (es) | 2008-06-26 | 2017-06-26 | Suncor Energy Inc. | Formulación fungicida para hierba de césped mejorada con pigmento |
| WO2010017418A1 (en) * | 2008-08-07 | 2010-02-11 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
| EP2389187B1 (en) | 2009-01-20 | 2016-11-16 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical |
| WO2011017634A2 (en) * | 2009-08-07 | 2011-02-10 | Sepracore Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
| AU2011301171C1 (en) | 2010-09-09 | 2015-09-10 | Nutrien Ag Solutions (Canada) Inc. | Synergistic paraffinic oil and boscalid fungicides |
| AU2012381990B2 (en) | 2012-06-04 | 2017-02-23 | Nutrien Ag Solutions (Canada) Inc. | Formulations containing paraffinic oil and anti-settling agent |
| WO2014025993A1 (en) | 2012-08-08 | 2014-02-13 | The Johns Hopkins University | Inhibitors of d-amino acid oxidase |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| CN103435561B (zh) * | 2013-08-19 | 2016-08-10 | 上海交通大学 | 一种新型d-氨基酸氧化酶抑制剂及其制备和应用 |
| WO2015147742A1 (en) * | 2014-03-24 | 2015-10-01 | Kaohsiung Chang Gung Memorial Hospital | Use of benzoic acid salt in the manufactue of a composition for preventing or treating dementia or mild cognitive impairment |
| CN105801511B (zh) * | 2016-04-22 | 2018-01-02 | 山西大学 | 一种1,2‑苯并异恶唑啉‑3‑酮的制备方法 |
| US11008277B2 (en) | 2016-06-13 | 2021-05-18 | Syneurx International (Taiwan) Corp. | Co-crystals of sodium benzoate and uses thereof |
| US10815184B2 (en) | 2016-06-13 | 2020-10-27 | Syneurx International (Taiwan) Corp. | Co-crystals of lithium benzoate and uses thereof |
| CA2938096C (en) | 2016-08-04 | 2019-02-26 | Suncor Energy Inc. | Stabilized emulsions |
| US11369579B2 (en) | 2016-10-24 | 2022-06-28 | Syneurx International (Taiwan) Corp. | Polymorphic forms of sodium benzoate and uses thereof |
| US10336679B2 (en) | 2016-10-24 | 2019-07-02 | Syneurx International (Taiwan) Corp. | Polymorphic forms of sodium benzoate and uses thereof |
| JP6550426B2 (ja) * | 2017-07-26 | 2019-07-24 | カオシュン・チャン・グン・メモリアル・ホスピタル | 認知症または軽度認知障害を予防または治療する組成物を製造するための安息香酸塩の使用 |
| WO2019043635A1 (en) | 2017-09-01 | 2019-03-07 | Richter Gedeon Nyrt. | COMPOUNDS INHIBITING THE ACTIVITY OF D-AMINO ACID OXIDASE |
| US10336724B2 (en) * | 2017-10-18 | 2019-07-02 | Syneurx International (Taiwan) Corp. | D-amino acid oxidase inhibitors and therapeutic uses thereof |
| US10098861B1 (en) | 2017-10-24 | 2018-10-16 | Syneurx International (Taiwan) Corp. | Pharmaceutical composition comprising sodium benzoate compound and clozapine, and uses thereof |
| WO2020150831A1 (en) | 2019-01-25 | 2020-07-30 | Suncor Energy Inc. | Photosensitizer compounds, methods of manufacture and application to plants |
| CN113677204B (zh) | 2019-02-15 | 2024-03-05 | 桑科能源股份有限公司 | 原卟啉ix衍生物改善植物健康的用途 |
| CN117362246B (zh) * | 2023-12-04 | 2024-03-12 | 烟台海川化学制品有限公司 | 一种3-苯基-1,4,2-二恶唑-5-酮的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58177915A (ja) * | 1982-04-12 | 1983-10-18 | Green Cross Corp:The | 抗血栓剤 |
| US4738709A (en) * | 1985-01-10 | 1988-04-19 | Ppg Industries, Inc. | Herbicidally active substituted benzisoxazoles |
| JPH0477476A (ja) * | 1990-07-19 | 1992-03-11 | Sankyo Co Ltd | 抗潰瘍剤 |
| CA2146755A1 (en) * | 1992-10-28 | 1994-05-11 | Kenji Takeda | Novel 1,2-benzoisoxazole derivative or its salt and brain-protecting agent comprising the same |
| ES2208690T3 (es) * | 1994-08-30 | 2004-06-16 | Sankyo Company Limited | Isoxazol. |
| US5484763A (en) * | 1995-02-10 | 1996-01-16 | American Cyanamid Company | Substituted benzisoxazole and benzisothiazole herbicidal agents |
| US5620997A (en) * | 1995-05-31 | 1997-04-15 | Warner-Lambert Company | Isothiazolones |
| DE19960917A1 (de) * | 1999-12-17 | 2001-06-21 | Bayer Ag | Neue 3-Oxo-2,1-benzisoxazol-1(3H)-carboxamide zur Behandlung von ZNS-Erkrankungen |
| JP2001247462A (ja) * | 2000-03-07 | 2001-09-11 | Otsuka Pharmaceut Co Ltd | ウレアーゼ阻害剤 |
| CA2559105A1 (en) | 2004-03-16 | 2005-09-29 | Janssen Pharmaceutica N.V. | Benzisoxazoles |
-
2004
- 2004-12-28 CN CN201010150424A patent/CN101798291A/zh active Pending
- 2004-12-28 NZ NZ548213A patent/NZ548213A/en unknown
- 2004-12-28 JP JP2006547443A patent/JP2007534657A/ja active Pending
- 2004-12-28 BR BRPI0417910-2A patent/BRPI0417910A/pt not_active Application Discontinuation
- 2004-12-28 CA CA002552098A patent/CA2552098A1/en not_active Abandoned
- 2004-12-28 CZ CZ20060426A patent/CZ2006426A3/cs unknown
- 2004-12-28 PL PL380766A patent/PL380766A1/pl not_active Application Discontinuation
- 2004-12-28 RU RU2006127436/04A patent/RU2384574C2/ru not_active IP Right Cessation
- 2004-12-28 WO PCT/US2004/043547 patent/WO2005066143A2/en not_active Ceased
- 2004-12-28 ZA ZA200605384A patent/ZA200605384B/en unknown
- 2004-12-28 US US11/024,151 patent/US7166725B2/en not_active Expired - Lifetime
- 2004-12-28 CN CN2010105590539A patent/CN102010382A/zh active Pending
- 2004-12-28 CN CN2004800422050A patent/CN1922157B/zh not_active Expired - Fee Related
- 2004-12-28 EP EP04815603A patent/EP1711478A2/en not_active Withdrawn
- 2004-12-28 AU AU2004312511A patent/AU2004312511A1/en not_active Abandoned
- 2004-12-28 KR KR1020067015383A patent/KR20060128978A/ko not_active Ceased
-
2006
- 2006-06-28 IL IL176607A patent/IL176607A0/en unknown
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