JP2007533299A5 - - Google Patents
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- JP2007533299A5 JP2007533299A5 JP2006534807A JP2006534807A JP2007533299A5 JP 2007533299 A5 JP2007533299 A5 JP 2007533299A5 JP 2006534807 A JP2006534807 A JP 2006534807A JP 2006534807 A JP2006534807 A JP 2006534807A JP 2007533299 A5 JP2007533299 A5 JP 2007533299A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- activity
- cell
- content
- galactosyltransferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 38
- 210000004027 cell Anatomy 0.000 claims 28
- 230000000694 effects Effects 0.000 claims 21
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 15
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 14
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 14
- 229930182830 galactose Natural products 0.000 claims 14
- 241000282414 Homo sapiens Species 0.000 claims 11
- 102000030902 Galactosyltransferase Human genes 0.000 claims 10
- 108060003306 Galactosyltransferase Proteins 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 230000013595 glycosylation Effects 0.000 claims 7
- 238000006206 glycosylation reaction Methods 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000012636 effector Substances 0.000 claims 5
- 150000004676 glycans Chemical class 0.000 claims 5
- 102000006471 Fucosyltransferases Human genes 0.000 claims 4
- 108010019236 Fucosyltransferases Proteins 0.000 claims 4
- 102000051366 Glycosyltransferases Human genes 0.000 claims 4
- 108700023372 Glycosyltransferases Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 3
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 230000005714 functional activity Effects 0.000 claims 3
- 230000006698 induction Effects 0.000 claims 3
- 229920001542 oligosaccharide Polymers 0.000 claims 3
- 150000002482 oligosaccharides Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000028327 secretion Effects 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 3
- 241000712891 Arenavirus Species 0.000 claims 2
- 241000589562 Brucella Species 0.000 claims 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 2
- 241000193468 Clostridium perfringens Species 0.000 claims 2
- 241000606678 Coxiella burnetii Species 0.000 claims 2
- 241000196324 Embryophyta Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000711950 Filoviridae Species 0.000 claims 2
- 241000589602 Francisella tularensis Species 0.000 claims 2
- LQEBEXMHBLQMDB-UHFFFAOYSA-N GDP-L-fucose Natural products OC1C(O)C(O)C(C)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C3=C(C(N=C(N)N3)=O)N=C2)O1 LQEBEXMHBLQMDB-UHFFFAOYSA-N 0.000 claims 2
- LQEBEXMHBLQMDB-JGQUBWHWSA-N GDP-beta-L-fucose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=C(C(NC(N)=N3)=O)N=C2)O1 LQEBEXMHBLQMDB-JGQUBWHWSA-N 0.000 claims 2
- 108010062427 GDP-mannose 4,6-dehydratase Proteins 0.000 claims 2
- 102000002312 GDPmannose 4,6-dehydratase Human genes 0.000 claims 2
- 102000002464 Galactosidases Human genes 0.000 claims 2
- 108010093031 Galactosidases Proteins 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 241000607142 Salmonella Species 0.000 claims 2
- 241000607768 Shigella Species 0.000 claims 2
- 208000001203 Smallpox Diseases 0.000 claims 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 241000607479 Yersinia pestis Species 0.000 claims 2
- 102000012086 alpha-L-Fucosidase Human genes 0.000 claims 2
- 108010061314 alpha-L-Fucosidase Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229940118764 francisella tularensis Drugs 0.000 claims 2
- 230000033581 fucosylation Effects 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000032258 transport Effects 0.000 claims 2
- 201000006266 variola major Diseases 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010060935 Alloimmunisation Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 241000193738 Bacillus anthracis Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000699800 Cricetinae Species 0.000 claims 1
- 206010014612 Encephalitis viral Diseases 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 102100037047 Fucose-1-phosphate guanylyltransferase Human genes 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101001029296 Homo sapiens Fucose-1-phosphate guanylyltransferase Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 108090000171 Interleukin-18 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 241000150452 Orthohantavirus Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- 241000606701 Rickettsia Species 0.000 claims 1
- 208000009359 Sezary Syndrome Diseases 0.000 claims 1
- 208000021388 Sezary disease Diseases 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-alpha-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-ABVWGUQPSA-N 0.000 claims 1
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 claims 1
- 241000607626 Vibrio cholerae Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- JMVSBFJBMXQNJW-GIXZANJISA-N all-trans-pentaprenyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O JMVSBFJBMXQNJW-GIXZANJISA-N 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 230000002155 anti-virotic effect Effects 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 229940065181 bacillus anthracis Drugs 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- SHZGCJCMOBCMKK-KGJVWPDLSA-N beta-L-fucose Chemical compound C[C@@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-KGJVWPDLSA-N 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000002949 hemolytic effect Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108010074108 interleukin-21 Proteins 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003071 polychlorinated biphenyls Chemical class 0.000 claims 1
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 201000004409 schistosomiasis Diseases 0.000 claims 1
- 230000009291 secondary effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 229940118696 vibrio cholerae Drugs 0.000 claims 1
- 201000002498 viral encephalitis Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0312229A FR2861080B1 (fr) | 2003-10-20 | 2003-10-20 | Anticorps presentant un taux de fucose et de galactose optimise |
| PCT/FR2004/002686 WO2005040221A1 (fr) | 2003-10-20 | 2004-10-20 | Correlation du ratio taux de fucose / taux de galactose d’anticorps anti rhesus d et anti hla-dr avec l’activite adcc |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007533299A JP2007533299A (ja) | 2007-11-22 |
| JP2007533299A5 true JP2007533299A5 (enExample) | 2011-02-17 |
Family
ID=34385294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534807A Pending JP2007533299A (ja) | 2003-10-20 | 2004-10-20 | 抗ｒｈｅｓｕｓ−ｄおよび抗ｈｌａ−ｄｒ抗体のフコース含量／ガラクトース含量の比とａｄｃｃ活性の間の関連 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070015239A1 (enExample) |
| EP (1) | EP1675873A1 (enExample) |
| JP (1) | JP2007533299A (enExample) |
| AU (1) | AU2004283924B2 (enExample) |
| BR (1) | BRPI0415565A (enExample) |
| CA (1) | CA2542881A1 (enExample) |
| FR (1) | FR2861080B1 (enExample) |
| IL (1) | IL174896A0 (enExample) |
| WO (1) | WO2005040221A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2892724B1 (fr) * | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| AU2013203482B2 (en) * | 2006-09-10 | 2015-08-27 | Glycotope Gmbh | Fully human high yield production system for improved antibodies and proteins |
| HRP20150307T1 (hr) * | 2006-09-10 | 2015-04-24 | Glycotope Gmbh | Upotreba ljudskih stanica podrijetlom iz ljudske leukemije za eksprimiranje protutijela |
| US7846434B2 (en) * | 2006-10-24 | 2010-12-07 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
| EP1920781B1 (en) * | 2006-11-10 | 2015-03-04 | Glycotope GmbH | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors |
| US20080227669A1 (en) * | 2007-03-12 | 2008-09-18 | Halliburton Energy Services, Inc. | Corrosion-inhibiting additives, treatment fluids, and associated methods |
| EP1995309A1 (en) * | 2007-05-21 | 2008-11-26 | Vivalis | Recombinant protein production in avian EBx® cells |
| US8080415B2 (en) | 2008-09-26 | 2011-12-20 | Eureka Therapeutics, Inc. | Modified host cells and uses thereof |
| AU2010233994A1 (en) * | 2009-04-07 | 2011-09-22 | Roche Glycart Ag | Bispecific anti-ErbB-3/anti-c-Met antibodies |
| HUE033758T2 (en) | 2009-10-26 | 2017-12-28 | Hoffmann La Roche | A method for producing glycosylated immunoglobulin |
| EP2374816B1 (en) | 2010-04-07 | 2016-09-28 | Agency For Science, Technology And Research | Binding molecules against Chikungunya virus and uses thereof |
| WO2011124635A1 (en) | 2010-04-07 | 2011-10-13 | Humalys | Binding molecules against chikungunya virus and uses thereof |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| EP2409712A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| EP2409989A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Method to improve glycosylation profile for antibody |
| JPWO2012105699A1 (ja) * | 2011-02-03 | 2014-07-03 | 株式会社イーベック | 補体依存性生物活性の高い抗体の産生法 |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| BR112014003110A2 (pt) * | 2011-08-10 | 2018-10-09 | Lab Francais Du Fractionnement | composição, método para produção de uma população altamente galactosilada de anticorpos, células epiteliais de glândula mamária e mamífero não humano tramsgênico |
| BR112014004065A2 (pt) | 2011-08-22 | 2017-03-14 | Glycotope Gmbh | micro-organismos carregando um antígeno de tumor |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| AR094781A1 (es) * | 2013-02-13 | 2015-08-26 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Anticuerpos anti-her2 (receptor 2 del factor de crecimiento epidérmico humano) altamente galactosilados y sus usos |
| BR112015019341A2 (pt) * | 2013-02-13 | 2017-08-22 | Lab Francais Du Fractionnement | Anticorpo anti-tnf-alfa, composição que compreende o anticorpo, método para produzir uma população de anticorpos, células epiteliais da glândula mamária, mamífero não humano transgênico, e, composição de anticorpo anti-tnf monoclonal |
| EP2956003A2 (en) | 2013-02-13 | 2015-12-23 | Laboratoire Français du Fractionnement et des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
| CA2905010A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN114181312A (zh) * | 2014-09-10 | 2022-03-15 | 豪夫迈·罗氏有限公司 | 半乳糖改造的免疫球蛋白1抗体 |
| FR3035879B1 (fr) * | 2015-05-07 | 2025-02-28 | Lab Francais Du Fractionnement | Mutants fc a activite fonctionnelle modifiee |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| EP3410849B1 (en) | 2016-02-05 | 2023-07-05 | Institut Pasteur | Use of inhibitors of adam12 as adjuvants in tumor therapies |
| CN110945028B (zh) | 2017-07-10 | 2023-09-08 | 国际药物发展生物技术公司 | 用非岩藻糖基化促凋亡抗cd19抗体与抗cd20抗体或化疗剂联合治疗b细胞恶性肿瘤 |
| EP3508499A1 (en) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof |
| BR112020023373A2 (pt) | 2018-05-18 | 2021-02-09 | Daiichi Sankyo Company, Limited | conjugado, composição, e, uso de um conjugado ou de uma composição |
| US20220372138A1 (en) | 2019-07-05 | 2022-11-24 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
| EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
| EP4175668A1 (en) | 2020-07-06 | 2023-05-10 | iOmx Therapeutics AG | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
| EP4491230A1 (en) | 2023-07-14 | 2025-01-15 | iOmx Therapeutics AG | Cross-specific antigen binding proteins (abp) targeting leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2, combinations and uses thereof |
| IL321673A (en) | 2022-12-23 | 2025-08-01 | Iomx Therapeutics Ag | LILRB1 and LILRB2 antigen-binding cross-specific proteins, their combinations and uses |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0316463A1 (en) * | 1987-11-13 | 1989-05-24 | Northwestern University | Murine hybridoma lym-1 and diagnostic antibody produced thereby |
| SE9203479L (sv) * | 1992-01-20 | 1993-07-21 | Rso Corp | Saett och anordning vid elektronisk identifiering |
| FR2776096B1 (fr) * | 1998-03-12 | 2000-06-23 | Commissariat Energie Atomique | Procede et systeme de lecture d'un ensemble dynamique d'etiquettes portant des codes d'identification distincts |
| FR2805637B1 (fr) * | 2000-02-25 | 2002-12-13 | Commissariat Energie Atomique | Procede de lecture d'etiquettes electroniques par identification simultanee de leur code |
| FR2807767B1 (fr) * | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| US6946292B2 (en) * | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| WO2004047000A2 (en) * | 2002-11-15 | 2004-06-03 | Sensitech Inc. | Rf identification tag for communicating condition information associated with an item |
| FR2859843B1 (fr) * | 2003-09-16 | 2005-12-23 | Commissariat Energie Atomique | Dispositif adressable par radiofrequence, systeme comportant une pluralite de tels dispositifs agences dans l'espace et procede d'adressage par activation d'un mode transparent |
-
2003
- 2003-10-20 FR FR0312229A patent/FR2861080B1/fr not_active Expired - Fee Related
-
2004
- 2004-10-20 AU AU2004283924A patent/AU2004283924B2/en not_active Ceased
- 2004-10-20 BR BRPI0415565-3A patent/BRPI0415565A/pt not_active Application Discontinuation
- 2004-10-20 WO PCT/FR2004/002686 patent/WO2005040221A1/fr not_active Ceased
- 2004-10-20 CA CA002542881A patent/CA2542881A1/fr not_active Abandoned
- 2004-10-20 JP JP2006534807A patent/JP2007533299A/ja active Pending
- 2004-10-20 US US10/575,333 patent/US20070015239A1/en not_active Abandoned
- 2004-10-20 EP EP04805250A patent/EP1675873A1/fr not_active Withdrawn
-
2006
- 2006-04-10 IL IL174896A patent/IL174896A0/en not_active IP Right Cessation
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