JP2007532953A5 - - Google Patents
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- JP2007532953A5 JP2007532953A5 JP2007507379A JP2007507379A JP2007532953A5 JP 2007532953 A5 JP2007532953 A5 JP 2007532953A5 JP 2007507379 A JP2007507379 A JP 2007507379A JP 2007507379 A JP2007507379 A JP 2007507379A JP 2007532953 A5 JP2007532953 A5 JP 2007532953A5
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- JP
- Japan
- Prior art keywords
- solution
- ppm
- amount
- component
- effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000243 solution Substances 0.000 claims description 131
- 239000007788 liquid Substances 0.000 claims description 29
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 28
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 28
- 230000000845 anti-microbial effect Effects 0.000 claims description 25
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 24
- 239000000872 buffer Substances 0.000 claims description 20
- 239000007864 aqueous solution Substances 0.000 claims description 17
- -1 poly (oxypropylene) Polymers 0.000 claims description 16
- 229920001400 block copolymer Polymers 0.000 claims description 15
- 230000001939 inductive effect Effects 0.000 claims description 14
- 239000002736 nonionic surfactant Substances 0.000 claims description 13
- 239000004094 surface-active agent Substances 0.000 claims description 13
- 229960003080 taurine Drugs 0.000 claims description 12
- 239000001913 cellulose Substances 0.000 claims description 10
- 229920002678 cellulose Polymers 0.000 claims description 10
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 8
- 239000004599 antimicrobial Substances 0.000 claims description 8
- 210000000170 cell membrane Anatomy 0.000 claims description 7
- 229940123208 Biguanide Drugs 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 6
- 229920002413 Polyhexanide Polymers 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000006172 buffering agent Substances 0.000 claims description 4
- 239000002738 chelating agent Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 150000004283 biguanides Chemical class 0.000 claims description 3
- 230000000451 tissue damage Effects 0.000 claims description 3
- 231100000827 tissue damage Toxicity 0.000 claims description 3
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 2
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 claims description 2
- 230000000249 desinfective effect Effects 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims description 2
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
- 229920002359 Tetronic® Polymers 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 6
- 239000004327 boric acid Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 3
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 2
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical class CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 2
- 229950010221 alexidine Drugs 0.000 description 2
- 125000000656 azaniumyl group Chemical group [H][N+]([H])([H])[*] 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 239000000411 inducer Substances 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
- RXGSAYBOEDPICZ-UHFFFAOYSA-N 2-[6-[[amino-(diaminomethylideneamino)methylidene]amino]hexyl]-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)N RXGSAYBOEDPICZ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 229920000289 Polyquaternium Polymers 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/820,486 US7578996B2 (en) | 2004-04-07 | 2004-04-07 | Cetylpyridinium chloride as an antimicrobial agent in ophthalmic compositions |
| PCT/US2005/011009 WO2005097960A1 (en) | 2004-04-07 | 2005-03-31 | Cetylpyridinium chloride as an antimicrobial agent in ophthalmic compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532953A JP2007532953A (ja) | 2007-11-15 |
| JP2007532953A5 true JP2007532953A5 (enExample) | 2008-05-15 |
Family
ID=34972927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507379A Pending JP2007532953A (ja) | 2004-04-07 | 2005-03-31 | 眼科用組成物における抗微生物剤としての塩化セチルピリジニウム |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7578996B2 (enExample) |
| EP (1) | EP1733014B1 (enExample) |
| JP (1) | JP2007532953A (enExample) |
| CN (1) | CN1942571B (enExample) |
| AT (1) | ATE426655T1 (enExample) |
| AU (1) | AU2005230851B2 (enExample) |
| BR (1) | BRPI0509654A (enExample) |
| CA (1) | CA2562546C (enExample) |
| DE (1) | DE602005013498D1 (enExample) |
| ES (2) | ES2321214T3 (enExample) |
| WO (1) | WO2005097960A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2634101A1 (en) * | 2005-12-20 | 2007-07-05 | Douglas G. Vanderlaan | Method for removing unreacted components from hydrogel ophthalmic lenses |
| US20070264226A1 (en) * | 2006-05-10 | 2007-11-15 | Karagoezian Hampar L | Synergistically enhanced disinfecting solutions |
| US8759321B2 (en) * | 2007-06-13 | 2014-06-24 | Bausch & Lomb Incorporated | Ophthalmic composition with hyaluronic acid and polymeric biguanide |
| TWI551305B (zh) * | 2007-08-31 | 2016-10-01 | 諾華公司 | 相對黏稠封裝溶液之用途 |
| US9096819B2 (en) | 2008-01-31 | 2015-08-04 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer |
| US20110046033A1 (en) * | 2008-01-31 | 2011-02-24 | Jinzhong Zhang | Multipurpose Lens Care Solution with Benefits to Corneal Epithelial Barrier Function |
| US8119112B2 (en) * | 2008-01-31 | 2012-02-21 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid |
| US20100286010A1 (en) * | 2008-09-03 | 2010-11-11 | Erning Xia | Ophthalmic Compositions with Hyaluronic Acid |
| US9125405B2 (en) * | 2008-10-28 | 2015-09-08 | Bausch & Lomb Incorporated | Contact lens solution with a tertiary amine oxide |
| WO2012080918A2 (en) * | 2010-12-14 | 2012-06-21 | Ecolab Usa Inc. | Wear resistant antimicrobial compositions and methods of use |
| US9872843B2 (en) * | 2011-10-08 | 2018-01-23 | Next Science, Llc | Antimicrobial compositions and methods employing same |
| WO2013067544A1 (en) * | 2011-11-06 | 2013-05-10 | Nbip, Llc | Anti-microbial compositions and related methods |
| CN102552914A (zh) * | 2012-01-31 | 2012-07-11 | 江西科伦药业有限公司 | 一种能同时调节pH值及渗透压的组合物及其制备方法 |
| US8324171B1 (en) | 2012-02-06 | 2012-12-04 | Bausch & Lomb Incorporated | Ophthalmic compositions containing diglycine |
| US8664180B2 (en) | 2012-02-06 | 2014-03-04 | Bausch & Lomb Incorporated | Ophthalmic compositions containing diglycine |
| CN102835398A (zh) * | 2012-09-28 | 2012-12-26 | 山东潍坊润丰化工有限公司 | 一种二氯吡啶酸胆碱水剂和原药的制备方法 |
| MX380775B (es) * | 2014-03-24 | 2025-03-12 | Johnson & Son Inc S C | Composiciones que contienen uno o varios ingredientes corrosivos que tienen toxicidad reducida y método de obtención. |
| GB201621050D0 (en) * | 2016-12-12 | 2017-01-25 | Provita Eurotech Ltd | Antimicrobial compositions |
| EP3784354A1 (en) * | 2018-04-27 | 2021-03-03 | Allergan, Inc. | Sodium chlorite compositions with enhanced anti-microbial efficacy and reduced toxicity |
| JP7253128B2 (ja) * | 2018-06-13 | 2023-04-06 | 京都バイオファーマ製薬株式会社 | デプシペプチド系抗生物質を含有する外用組成物 |
| US11253625B2 (en) * | 2018-06-27 | 2022-02-22 | Bausch & Lomb Incorporated | Ophthalmic device packaging solutions comprising a poloxamine/erythritol mixture |
| GB201813229D0 (en) | 2018-08-14 | 2018-09-26 | Ocutec Ltd | Formulation |
| AU2019343188A1 (en) * | 2018-09-21 | 2021-05-20 | Aufbau Medical Innovations Limited | Compositions and methods for glaucoma |
| WO2021110975A1 (en) * | 2019-12-05 | 2021-06-10 | Cis Pharma Ag | High hyaluronate multi-purpose disinfection solutions for ophthalmic applications |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
| USB724600I5 (enExample) * | 1968-04-26 | |||
| AR207548A1 (es) * | 1972-08-11 | 1976-10-15 | Flow Pharma Inc | Composicion acuosa para limpiar y tratar lentes de contacto |
| US4043911A (en) | 1975-03-24 | 1977-08-23 | Baylor College Of Medicine | Sterilization of holding tanks and toilet bowls by quaternary compounds |
| US4758595A (en) | 1984-12-11 | 1988-07-19 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US4908147A (en) | 1986-02-19 | 1990-03-13 | Ciba-Geigy Corporation | Aqueous self preserving soft contact lens solution and method |
| US5110493A (en) | 1987-09-11 | 1992-05-05 | Syntex (U.S.A.) Inc. | Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant |
| IE920838A1 (en) | 1991-03-18 | 1992-09-23 | Allergan Inc | Contact lens disinfecting compositions |
| US5252246A (en) | 1992-01-10 | 1993-10-12 | Allergan, Inc. | Nonirritating nonionic surfactant compositions |
| WO1994027436A1 (en) | 1993-05-20 | 1994-12-08 | Decicco Benedict T | Preservative systems with enhanced antimicrobial activity |
| JP3297969B2 (ja) | 1994-12-26 | 2002-07-02 | ライオン株式会社 | 点眼剤 |
| EP0855187A3 (en) | 1997-01-24 | 2001-01-17 | Senju Pharmaceutical Co., Ltd. | Agent for contact lenses |
| US20030228393A1 (en) * | 2002-05-31 | 2003-12-11 | Zhao Iris Ginron | Multi-phase food & beverage |
| US6020375A (en) | 1997-06-13 | 2000-02-01 | Senju Pharmaceutical Co., Ltd. | Bactericidal composition |
| US6482799B1 (en) * | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| JP3677421B2 (ja) * | 1999-12-27 | 2005-08-03 | 扶桑薬品工業株式会社 | 涙液分泌促進組成物 |
| JP4074067B2 (ja) | 2000-04-25 | 2008-04-09 | 和光純薬工業株式会社 | 抗原生生物製剤 |
| KR20020041118A (ko) * | 2000-11-27 | 2002-06-01 | 김용철 박홍양 | 가금류의 뉴캐슬병의 치료 및 예방 제제 |
| TW200300448A (en) * | 2001-11-21 | 2003-06-01 | Novartis Ag | Conditioning solution for contact lenses |
| WO2003047559A1 (en) * | 2001-12-05 | 2003-06-12 | Mitokor, Inc. | Use of polycyclic phenolic compounds for the treatment of opthalmic diseases |
| US20040120916A1 (en) * | 2002-12-23 | 2004-06-24 | Advanced Medical Optics, Inc. | Contact lens care compositions, methods of use and preparation which protect ocular tissue membrane integrity |
-
2004
- 2004-04-07 US US10/820,486 patent/US7578996B2/en active Active
-
2005
- 2005-03-31 ES ES05763160T patent/ES2321214T3/es not_active Expired - Lifetime
- 2005-03-31 ES ES200650070A patent/ES2323827B1/es not_active Expired - Fee Related
- 2005-03-31 WO PCT/US2005/011009 patent/WO2005097960A1/en not_active Ceased
- 2005-03-31 AT AT05763160T patent/ATE426655T1/de not_active IP Right Cessation
- 2005-03-31 DE DE602005013498T patent/DE602005013498D1/de not_active Expired - Lifetime
- 2005-03-31 BR BRPI0509654-5A patent/BRPI0509654A/pt not_active Application Discontinuation
- 2005-03-31 EP EP05763160A patent/EP1733014B1/en not_active Expired - Lifetime
- 2005-03-31 AU AU2005230851A patent/AU2005230851B2/en not_active Ceased
- 2005-03-31 CA CA2562546A patent/CA2562546C/en not_active Expired - Fee Related
- 2005-03-31 CN CN200580011933XA patent/CN1942571B/zh not_active Expired - Fee Related
- 2005-03-31 JP JP2007507379A patent/JP2007532953A/ja active Pending
-
2009
- 2009-05-21 US US12/470,375 patent/US20090318512A1/en not_active Abandoned
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