JP2007532649A - （４−アルキルピペラジニル）（フェニル）メタノン - Google Patents
（４−アルキルピペラジニル）（フェニル）メタノン Download PDFInfo
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- JP2007532649A JP2007532649A JP2007508407A JP2007508407A JP2007532649A JP 2007532649 A JP2007532649 A JP 2007532649A JP 2007508407 A JP2007508407 A JP 2007508407A JP 2007508407 A JP2007508407 A JP 2007508407A JP 2007532649 A JP2007532649 A JP 2007532649A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US56264304P | 2004-04-15 | 2004-04-15 | |
| PCT/US2005/012028 WO2005108378A2 (en) | 2004-04-15 | 2005-04-12 | Use of (4-alkylpiperazinyl) (phenyl) methanones in the treatment of alzheimer’s disease |
Publications (2)
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| JP2007532649A true JP2007532649A (ja) | 2007-11-15 |
| JP2007532649A5 JP2007532649A5 (https=) | 2008-05-29 |
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| EP (1) | EP1755605A2 (https=) |
| JP (1) | JP2007532649A (https=) |
| CN (1) | CN101022806A (https=) |
| AU (1) | AU2005240991A1 (https=) |
| CA (1) | CA2564068A1 (https=) |
| WO (1) | WO2005108378A2 (https=) |
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| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| IL283725B2 (en) | 2017-06-20 | 2024-04-01 | Imbria Pharmaceuticals Inc | Compositions and methods for increasing efficiency of cardiac metabolism |
| CN108329282B (zh) * | 2018-01-16 | 2022-01-07 | 新乡医学院 | 一种苯基哌嗪类衍生物及其制备方法和应用 |
| EP3866794B1 (en) | 2018-10-17 | 2024-12-04 | Imbria Pharmaceuticals, Inc. | Methods of treating rheumatic diseases using trimetazidine-based compounds |
| EP3976101A4 (en) | 2019-05-31 | 2023-06-21 | Imbria Pharmaceuticals, Inc. | FIBROSIS TREATMENT METHODS USING COMPOUNDS THAT PROMOTE GLUCOSE OXIDATION |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
| WO2022246115A1 (en) * | 2021-05-19 | 2022-11-24 | Cornell University | Apt1 and apt2 inhibitors and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS505389A (https=) * | 1973-01-29 | 1975-01-21 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693804A (en) * | 1994-11-17 | 1997-12-02 | Molecular Geriatrics Corporation | Substituted 1-aryl-3-piperazin-1'-yl propanones |
| DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
| US20040034019A1 (en) * | 2002-08-08 | 2004-02-19 | Ronald Tomlinson | Piperazine and piperidine derivatives |
| GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| AU2004245484A1 (en) * | 2003-06-02 | 2004-12-16 | Georgetown University | Neuroprotective benzoate and benzamide compounds |
-
2005
- 2005-04-12 EP EP05776434A patent/EP1755605A2/en not_active Withdrawn
- 2005-04-12 AU AU2005240991A patent/AU2005240991A1/en not_active Abandoned
- 2005-04-12 US US10/599,952 patent/US20090197891A1/en not_active Abandoned
- 2005-04-12 WO PCT/US2005/012028 patent/WO2005108378A2/en not_active Ceased
- 2005-04-12 CN CNA2005800194203A patent/CN101022806A/zh active Pending
- 2005-04-12 CA CA002564068A patent/CA2564068A1/en not_active Abandoned
- 2005-04-12 JP JP2007508407A patent/JP2007532649A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS505389A (https=) * | 1973-01-29 | 1975-01-21 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1755605A2 (en) | 2007-02-28 |
| WO2005108378A3 (en) | 2006-01-12 |
| CN101022806A (zh) | 2007-08-22 |
| US20090197891A1 (en) | 2009-08-06 |
| CA2564068A1 (en) | 2005-11-17 |
| WO2005108378A2 (en) | 2005-11-17 |
| AU2005240991A1 (en) | 2005-11-17 |
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