JP2007530493A - 痛みのある糖尿病性神経障害における疼痛を治療するためのペプチド化合物の新規使用 - Google Patents

痛みのある糖尿病性神経障害における疼痛を治療するためのペプチド化合物の新規使用 Download PDF

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Publication number
JP2007530493A
JP2007530493A JP2007504367A JP2007504367A JP2007530493A JP 2007530493 A JP2007530493 A JP 2007530493A JP 2007504367 A JP2007504367 A JP 2007504367A JP 2007504367 A JP2007504367 A JP 2007504367A JP 2007530493 A JP2007530493 A JP 2007530493A
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Prior art keywords
lower alkyl
pain
use according
unsubstituted
aryl
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JP2007504367A
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Japanese (ja)
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JP2007530493A5 (https=
Inventor
ラウシュコルプ−レフラー クリスティーネ
コッホ ブリギッテ
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UCB Pharma GmbH
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Schwarz Pharma AG
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Publication of JP2007530493A publication Critical patent/JP2007530493A/ja
Publication of JP2007530493A5 publication Critical patent/JP2007530493A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2007504367A 2004-03-26 2005-03-24 痛みのある糖尿病性神経障害における疼痛を治療するためのペプチド化合物の新規使用 Pending JP2007530493A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55649904P 2004-03-26 2004-03-26
EP04007360A EP1579858A1 (en) 2004-03-26 2004-03-26 Novel use of peptide compounds for treating pain in painful diabetic neuropathy
PCT/EP2005/003176 WO2005092313A1 (en) 2004-03-26 2005-03-24 Novel use of peptide compounds for treating pain in painful diabetic neuropathy

Publications (2)

Publication Number Publication Date
JP2007530493A true JP2007530493A (ja) 2007-11-01
JP2007530493A5 JP2007530493A5 (https=) 2008-04-10

Family

ID=34854637

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007504367A Pending JP2007530493A (ja) 2004-03-26 2005-03-24 痛みのある糖尿病性神経障害における疼痛を治療するためのペプチド化合物の新規使用

Country Status (15)

Country Link
US (1) US20060100157A1 (https=)
EP (2) EP1579858A1 (https=)
JP (1) JP2007530493A (https=)
CN (1) CN1938010B (https=)
AU (1) AU2005226928B2 (https=)
BR (1) BRPI0509211A (https=)
CA (1) CA2558311A1 (https=)
EA (1) EA012176B1 (https=)
MX (1) MXPA06010995A (https=)
NZ (1) NZ549668A (https=)
SG (1) SG151309A1 (https=)
TW (1) TW200701977A (https=)
UA (1) UA90467C2 (https=)
WO (1) WO2005092313A1 (https=)
ZA (1) ZA200607269B (https=)

Families Citing this family (24)

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DK1243262T3 (da) 2001-03-20 2006-10-02 Sanol Arznei Schwarz Gmbh Hidtil ukendt anvendelse af en peptidklasse af forbindelser til behandling af ikke-neuropatiske, inflammatoriske smerter
ES2185606T3 (es) 2001-03-21 2003-05-01 Sanol Arznei Schwarz Gmbh Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma.
JP4664924B2 (ja) 2003-12-02 2011-04-06 ウーツェーベー ファルマ ゲーエムベーハー 中枢神経因性疼痛の治療のためのペプチド化合物の新規使用
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
US20100256179A1 (en) * 2004-03-26 2010-10-07 Ucb Pharma Gmbh Combination therapy for pain in painful diabetic neuropathy
KR20070007931A (ko) 2004-04-16 2007-01-16 쉬바르츠파르마에이지 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
PL1781276T3 (pl) 2004-08-27 2010-11-30 Ucb Pharma Gmbh Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US20060252749A1 (en) * 2005-01-28 2006-11-09 Srz Properties, Inc. Lacosamide for add-on therapy of psychosis
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
US7902401B2 (en) * 2006-12-14 2011-03-08 Nps Pharmaceuticals, Inc. Fluorinated compounds
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
JP2009539792A (ja) * 2006-06-08 2009-11-19 シュヴァルツ・ファーマ・アーゲー 疼痛の医学的状態のための治療組合せ
EP1873527A1 (en) * 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
CN101466390B (zh) 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
WO2007144195A2 (en) 2006-06-15 2007-12-21 Schwarz Pharma Ag Pharmaceutical composition with synergistic anticonvulsant effect
CA2672494A1 (en) * 2006-12-14 2008-06-19 Nps Pharmaceuticals, Inc. Use of d-serine derivatives for the treatment of anxiety disorders
CA2774569A1 (en) * 2009-09-23 2011-03-31 The University Of North Carolina At Chapel Hill Novel n-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents
MX350056B (es) 2009-11-03 2017-08-25 Lupin Ltd Formulacion de liberacion modificada de lacosamida.
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
MX2013005974A (es) 2010-12-02 2013-07-29 Ucb Pharma Gmbh Formulacion de lacosamida de administracion una vez al dia.
CN109069480A (zh) 2015-12-30 2018-12-21 阿达玛斯医药公司 用于治疗与癫痫相关的病症的方法和组合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074297A1 (en) * 2001-03-21 2002-09-26 Schwarz Pharma Ag Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain
JP2002538106A (ja) * 1999-03-01 2002-11-12 エヌピーエス ファーマシューティカルズ インコーポレーテッド イソバレルアミド、イソ吉草酸、または関連化合物を用いてｃｎｓ活性の調節に影響を与えることによる、痙縮および痙攣を含む様々な病状の治療
JP2004505999A (ja) * 2000-08-17 2004-02-26 テバ　ファーマシューティカル　インダストリーズ　リミティド 疼痛および／または頭痛疾患の治療または予防のための、バルプロ酸アミドおよび２−バルプロエン酸アミドの誘導体の使用
JP2004506692A (ja) * 2000-08-25 2004-03-04 リサーチ　コーポレイション　テクノロジーズ，インコーポレイテッド アミノ酸鎮痙薬の新規用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US5585358A (en) * 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
DK1243262T3 (da) * 2001-03-20 2006-10-02 Sanol Arznei Schwarz Gmbh Hidtil ukendt anvendelse af en peptidklasse af forbindelser til behandling af ikke-neuropatiske, inflammatoriske smerter
JP4664924B2 (ja) * 2003-12-02 2011-04-06 ウーツェーベー ファルマ ゲーエムベーハー 中枢神経因性疼痛の治療のためのペプチド化合物の新規使用
US20060009384A1 (en) * 2003-12-05 2006-01-12 David Rudd Novel use of peptide compounds for treating status epilepticus or related conditions
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
KR20070007931A (ko) * 2004-04-16 2007-01-16 쉬바르츠파르마에이지 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
EP1604654A1 (en) * 2004-05-18 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating dyskinesia
EP1604656A1 (en) * 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
US7427601B2 (en) * 2004-06-24 2008-09-23 Schwarz Pharma Ag Method for treating tremor
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US20060252749A1 (en) * 2005-01-28 2006-11-09 Srz Properties, Inc. Lacosamide for add-on therapy of psychosis
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002538106A (ja) * 1999-03-01 2002-11-12 エヌピーエス ファーマシューティカルズ インコーポレーテッド イソバレルアミド、イソ吉草酸、または関連化合物を用いてｃｎｓ活性の調節に影響を与えることによる、痙縮および痙攣を含む様々な病状の治療
JP2004505999A (ja) * 2000-08-17 2004-02-26 テバ　ファーマシューティカル　インダストリーズ　リミティド 疼痛および／または頭痛疾患の治療または予防のための、バルプロ酸アミドおよび２−バルプロエン酸アミドの誘導体の使用
JP2004506692A (ja) * 2000-08-25 2004-03-04 リサーチ　コーポレイション　テクノロジーズ，インコーポレイテッド アミノ酸鎮痙薬の新規用途
WO2002074297A1 (en) * 2001-03-21 2002-09-26 Schwarz Pharma Ag Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain

Also Published As

Publication number Publication date
WO2005092313A1 (en) 2005-10-06
EP1737437A1 (en) 2007-01-03
BRPI0509211A (pt) 2007-08-28
SG151309A1 (en) 2009-04-30
AU2005226928A1 (en) 2005-10-06
ZA200607269B (en) 2008-04-30
EP1579858A1 (en) 2005-09-28
CN1938010B (zh) 2011-01-19
CA2558311A1 (en) 2005-10-06
UA90467C2 (ru) 2010-05-11
TW200701977A (en) 2007-01-16
CN1938010A (zh) 2007-03-28
MXPA06010995A (es) 2007-04-16
EA200601777A1 (ru) 2007-02-27
NZ549668A (en) 2010-07-30
US20060100157A1 (en) 2006-05-11
EA012176B1 (ru) 2009-08-28
AU2005226928B2 (en) 2010-05-13

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