JP2007530058A - 識別のための試金は混合するｍＲＮＡの安定性に影響を与える - Google Patents

識別のための試金は混合するｍＲＮＡの安定性に影響を与える Download PDF

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JP2007530058A
JP2007530058A JP2007505349A JP2007505349A JP2007530058A JP 2007530058 A JP2007530058 A JP 2007530058A JP 2007505349 A JP2007505349 A JP 2007505349A JP 2007505349 A JP2007505349 A JP 2007505349A JP 2007530058 A JP2007530058 A JP 2007530058A
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dna
sequence
mrna
expression vector
control
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JP2007530058A5 (https=
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キャステリック、タニア
シェネバル、ドミニク
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ノベーション ファーマシューティカルズ インク．
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Publication of JP2007530058A5 publication Critical patent/JP2007530058A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2007505349A 2004-04-01 2005-04-01 識別のための試金は混合するｍＲＮＡの安定性に影響を与える Pending JP2007530058A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/814,634 US7598079B2 (en) 1998-12-24 2004-04-01 Assay for identifying compounds which affect stability of mRNA
PCT/CA2005/000491 WO2005095615A1 (en) 2004-04-01 2005-04-01 Assay for identifying compounds which affect stability of mrna

Publications (2)

Publication Number Publication Date
JP2007530058A true JP2007530058A (ja) 2007-11-01
JP2007530058A5 JP2007530058A5 (https=) 2010-04-02

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JP2007505349A Pending JP2007530058A (ja) 2004-04-01 2005-04-01 識別のための試金は混合するｍＲＮＡの安定性に影響を与える

Country Status (6)

Country Link
US (3) US7598079B2 (https=)
EP (1) EP1774000A4 (https=)
JP (1) JP2007530058A (https=)
AU (1) AU2005229165A1 (https=)
CA (1) CA2603585A1 (https=)
WO (1) WO2005095615A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598079B2 (en) * 1998-12-24 2009-10-06 Novation Pharmaceuticals, Inc. Assay for identifying compounds which affect stability of mRNA
US8460864B2 (en) 2003-01-21 2013-06-11 Ptc Therapeutics, Inc. Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same
US8426194B2 (en) 2003-01-21 2013-04-23 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating VEGF expression
US9068234B2 (en) * 2003-01-21 2015-06-30 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating gene expression
WO2005049868A1 (en) * 2003-11-17 2005-06-02 Pct Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating her2 expression
ATE497009T1 (de) 2005-12-12 2011-02-15 King Faisal Specialist Hospital And Res Ct 3-nichttranslatierte hybridbereiche mit eignung zur effizienten proteinexpression in säugerzellen
US8283115B1 (en) 2007-06-20 2012-10-09 Ptc Therapeutics, Inc. Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation
US8283116B1 (en) 2007-06-22 2012-10-09 Ptc Therapeutics, Inc. Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation
WO2009155950A1 (en) 2008-06-27 2009-12-30 King Faisal Specialist Hospital And Research Centre Cloning-free method of generating transcriptionally and post-transcriptionally controllable expression active linear reporter constructs
AU2013315543A1 (en) * 2012-09-14 2015-04-09 Dicerna Pharmaceuticals, Inc. Methods and compostions for the specific inhibition of MYC by double-stranded RNA
RU2612497C2 (ru) * 2015-05-26 2017-03-09 Общество с ограниченной ответственностью "НекстГен" Оптимизированная нуклеотидная последовательность и фармацевтическая композиция на ее основе с пролонгированной экспрессией трансгена vegf

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072844A1 (en) * 2001-03-09 2002-09-19 Gene Stream Pty Ltd Novel expression vectors
JP2002533389A (ja) * 1998-12-24 2002-10-08 ノーベーション ファーマシューティカルズ インコーポレーテッド ｍＲＮＡ安定性に影響する化合物およびそのための使用
JP2002541767A (ja) * 1998-12-24 2002-12-10 ノーベーション ファーマシューティカルズ インコーポレーテッド ｍＲＮＡの安定性に影響する化合物を同定するためのアッセイ

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174666B1 (en) * 1992-03-27 2001-01-16 The United States Of America As Represented By The Department Of Health And Human Services Method of eliminating inhibitory/instability regions from mRNA
US5444149A (en) 1992-05-11 1995-08-22 Duke University Methods and compositions useful in the recognition, binding and expression of ribonucleic acids involved in cell growth, neoplasia and immunoregulation
US5587300A (en) 1994-04-26 1996-12-24 Wisconsin Ulumni Research Foundation Method to increase regulatory molecule production
CA2191583C (en) 1994-06-07 2007-03-27 Engin Ozkaynak Methods and compositions for modulating morphogenic protein expression
AUPM772494A0 (en) * 1994-08-30 1994-09-22 Austin Research Institute, The Improvements in production of proteins in host cells
US5731343A (en) 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
CA2282418A1 (en) 1997-03-05 1998-09-11 Scriptgen Pharmaceuticals, Inc. Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids
AU766146B2 (en) 1998-05-26 2003-10-09 University Of Medicine And Dentistry Of New Jersey System for reproducing and modulating stability and turnover of RNA molecules
US7598079B2 (en) 1998-12-24 2009-10-06 Novation Pharmaceuticals, Inc. Assay for identifying compounds which affect stability of mRNA
US8815517B2 (en) * 1999-12-28 2014-08-26 Ribonomics, Inc. Methods for identifying functionally related genes and drug targets
US7078171B2 (en) 2000-04-28 2006-07-18 Message Pharmaceutical, Inc. Methods for identifying novel nucleic acid regulatory elements and compounds that affect the regulation
US8426194B2 (en) 2003-01-21 2013-04-23 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating VEGF expression
US8460864B2 (en) 2003-01-21 2013-06-11 Ptc Therapeutics, Inc. Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same
US9068234B2 (en) 2003-01-21 2015-06-30 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating gene expression

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533389A (ja) * 1998-12-24 2002-10-08 ノーベーション ファーマシューティカルズ インコーポレーテッド ｍＲＮＡ安定性に影響する化合物およびそのための使用
JP2002541767A (ja) * 1998-12-24 2002-12-10 ノーベーション ファーマシューティカルズ インコーポレーテッド ｍＲＮＡの安定性に影響する化合物を同定するためのアッセイ
WO2002072844A1 (en) * 2001-03-09 2002-09-19 Gene Stream Pty Ltd Novel expression vectors

Also Published As

Publication number Publication date
US20090068654A1 (en) 2009-03-12
EP1774000A1 (en) 2007-04-18
EP1774000A4 (en) 2007-10-03
US20040231007A1 (en) 2004-11-18
CA2603585A1 (en) 2005-10-13
AU2005229165A1 (en) 2005-10-13
US20070190532A1 (en) 2007-08-16
WO2005095615A1 (en) 2005-10-13
US7598079B2 (en) 2009-10-06

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