JP2007528887A5 - - Google Patents

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Publication number
JP2007528887A5
JP2007528887A5 JP2007502403A JP2007502403A JP2007528887A5 JP 2007528887 A5 JP2007528887 A5 JP 2007528887A5 JP 2007502403 A JP2007502403 A JP 2007502403A JP 2007502403 A JP2007502403 A JP 2007502403A JP 2007528887 A5 JP2007528887 A5 JP 2007528887A5
Authority
JP
Japan
Prior art keywords
tetrahydro
benzazepine
piperazinyl
cyclopentyl
cyclobutyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007502403A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007528887A (ja
Filing date
Publication date
Priority claimed from GBGB0405628.9A external-priority patent/GB0405628D0/en
Application filed filed Critical
Publication of JP2007528887A publication Critical patent/JP2007528887A/ja
Publication of JP2007528887A5 publication Critical patent/JP2007528887A5/ja
Pending legal-status Critical Current

Links

JP2007502403A 2004-03-12 2005-03-10 神経学的および精神医学的障害の治療のためのベンズアゼピン誘導体 Pending JP2007528887A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0405628.9A GB0405628D0 (en) 2004-03-12 2004-03-12 Novel compounds
PCT/GB2005/000939 WO2005087746A1 (en) 2004-03-12 2005-03-10 Benzazepine derivatives for the treatment of neurological and psychiatric disorders

Publications (2)

Publication Number Publication Date
JP2007528887A JP2007528887A (ja) 2007-10-18
JP2007528887A5 true JP2007528887A5 (https=) 2008-05-01

Family

ID=32117578

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007502403A Pending JP2007528887A (ja) 2004-03-12 2005-03-10 神経学的および精神医学的障害の治療のためのベンズアゼピン誘導体

Country Status (5)

Country Link
US (1) US20070185089A1 (https=)
EP (1) EP1730114A1 (https=)
JP (1) JP2007528887A (https=)
GB (1) GB0405628D0 (https=)
WO (1) WO2005087746A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2133340B1 (en) 2002-12-20 2013-01-16 Glaxo Group Limited Novel benzazepine derivatives
WO2005123723A1 (en) * 2004-06-18 2005-12-29 Glaxo Group Limited 3-cycloalkylbenzazepines as histamine h3 antagonists
GB0418267D0 (en) * 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
GB0513886D0 (en) 2005-07-06 2005-08-10 Glaxo Group Ltd Novel compounds
GB0525957D0 (en) * 2005-12-21 2006-02-01 Astrazeneca Ab Methods
US20080051387A1 (en) * 2006-06-09 2008-02-28 Yuelian Xu Tetrahydropyrido[3,4-d]pyrimidines and related analogues
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
CN103382174A (zh) 2006-06-23 2013-11-06 雅培制药有限公司 作为组胺h3受体调节物的环丙胺衍生物
KR20110036044A (ko) * 2008-07-18 2011-04-06 다케다 파머수티컬 컴패니 리미티드 벤즈아제핀 유도체들 및 히스타민 ｈ3 길항제로서 이들의 용도
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
AR083718A1 (es) 2010-05-11 2013-03-20 Sanofi Aventis Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas
WO2011143155A1 (en) * 2010-05-11 2011-11-17 Sanofi Substituted n-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
TW201206889A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
WO2011143162A1 (en) 2010-05-11 2011-11-17 Sanofi Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
JP5833105B2 (ja) 2010-05-11 2015-12-16 サノフイ 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用
EP2569297A1 (en) 2010-05-11 2013-03-20 Sanofi Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
WO2018140599A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
US20200385364A1 (en) * 2017-01-26 2020-12-10 Araxes Pharma Llc Fused n-heterocyclic compounds and methods of use thereof
US11639346B2 (en) 2017-05-25 2023-05-02 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
AU2018271990A1 (en) 2017-05-25 2019-12-12 Araxes Pharma Llc Covalent inhibitors of KRAS
MX2021000887A (es) 2018-08-01 2021-03-31 Araxes Pharma Llc Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer.
EP4216952A4 (en) * 2020-09-24 2024-11-20 NFlection Therapeutics, Inc. TREATMENT OF COGNITIVE DYSFUNCTION WITH PYRROLOPYRIDINE-ANILINE COMPOUNDS
CN114324715B (zh) * 2021-01-05 2023-06-02 海南鑫开源医药科技有限公司 7,8-二甲氧基-1,3-二氢-2h-3-苯并氮杂卓-2-酮中有关物质的检测方法
CN113831357A (zh) * 2021-09-08 2021-12-24 桂林理工大学 一种便捷的6-苯基-咪唑[2,1-b]噻唑的Michal加成反应

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
JPH07509694A (ja) * 1992-05-14 1995-10-26 ベイラー・カレッジ・オブ・メディシン 突然変異したステロイドホルモン受容体，その使用方法および遺伝子治療のための分子スイッチ
US5364791A (en) * 1992-05-14 1994-11-15 Elisabetta Vegeto Progesterone receptor having C. terminal hormone binding domain truncations
DE4332168A1 (de) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4429079A1 (de) * 1994-08-17 1996-02-22 Thomae Gmbh Dr K Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP1539704A1 (en) * 2002-08-20 2005-06-15 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
EP2133340B1 (en) * 2002-12-20 2013-01-16 Glaxo Group Limited Novel benzazepine derivatives

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