JP2007528409A5 - - Google Patents
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- Publication number
- JP2007528409A5 JP2007528409A5 JP2007503004A JP2007503004A JP2007528409A5 JP 2007528409 A5 JP2007528409 A5 JP 2007528409A5 JP 2007503004 A JP2007503004 A JP 2007503004A JP 2007503004 A JP2007503004 A JP 2007503004A JP 2007528409 A5 JP2007528409 A5 JP 2007528409A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- aat
- use according
- functionally active
- halide salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 66
- -1 halide salt Chemical class 0.000 claims 22
- 239000000843 powder Substances 0.000 claims 12
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- 150000003841 chloride salts Chemical group 0.000 claims 8
- 230000005714 functional activity Effects 0.000 claims 8
- 210000004072 lung Anatomy 0.000 claims 6
- 102100022712 Alpha-1-antitrypsin Human genes 0.000 claims 4
- 241000208125 Nicotiana Species 0.000 claims 4
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 4
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 4
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 235000014633 carbohydrates Nutrition 0.000 claims 4
- 235000019504 cigarettes Nutrition 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 108010006035 Metalloproteases Proteins 0.000 claims 2
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims 2
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 2
- 102100026261 Metalloproteinase inhibitor 3 Human genes 0.000 claims 2
- 102100024289 Metalloproteinase inhibitor 4 Human genes 0.000 claims 2
- 108050006579 Metalloproteinase inhibitor 4 Proteins 0.000 claims 2
- 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 claims 2
- 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 claims 2
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 claims 2
- 229940124630 bronchodilator Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 230000001590 oxidative effect Effects 0.000 claims 2
- 239000000779 smoke Substances 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55185604P | 2004-03-09 | 2004-03-09 | |
| PCT/US2005/007959 WO2005086915A2 (en) | 2004-03-09 | 2005-03-09 | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007528409A JP2007528409A (ja) | 2007-10-11 |
| JP2007528409A5 true JP2007528409A5 (enExample) | 2009-08-06 |
Family
ID=34976236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503004A Pending JP2007528409A (ja) | 2004-03-09 | 2005-03-09 | プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7914771B2 (enExample) |
| EP (1) | EP1737499A4 (enExample) |
| JP (1) | JP2007528409A (enExample) |
| AU (1) | AU2005221151A1 (enExample) |
| CA (1) | CA2559062A1 (enExample) |
| WO (1) | WO2005086915A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060257324A1 (en) | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
| JP2007528409A (ja) * | 2004-03-09 | 2007-10-11 | アリバ ファーマシューティカルズ, インコーポレイテッド | プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 |
| US7973005B2 (en) * | 2006-02-09 | 2011-07-05 | Kamada Ltd. | Alpha-1 antitrypsin for treating exacerbation episodes of pulmonary diseases |
| WO2008053199A1 (en) * | 2006-10-30 | 2008-05-08 | Astrazeneca Ab | Combination therapy for the treatment of respiratory diseases |
| GB0716026D0 (en) * | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| UA124083C2 (uk) * | 2011-06-28 | 2021-07-21 | ІНГІБРЕКС, Інк. | Злитий серпіновий поліпептид і спосіб його застосування |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| BR112013033801A2 (pt) | 2011-06-28 | 2017-12-19 | Inhibrx Llc | proteína de fusão isolada, e, método para tratar ou aliviar um sintoma de uma doença ou distúrbio inflamatórios |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| EP2758065B1 (en) * | 2011-12-30 | 2021-06-23 | Grifols, S.A. | Alpha1-proteinase inhibitor for use in delaying the onset or progression of pulmonary exacerbations |
| US20160011207A1 (en) * | 2012-12-07 | 2016-01-14 | Virginia Commonwealth University | Diagnosis and therapy of chronic inflammation-induced disorders |
| EA201690335A1 (ru) * | 2013-08-05 | 2016-09-30 | Герард Форман | Новые средства для уменьшения негативных последствий курения |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| US20210085764A1 (en) * | 2016-12-22 | 2021-03-25 | Kamada Ltd. | Dry powder formulations of alpha-1 antitrypsin |
| EP3915574A1 (en) * | 2020-05-27 | 2021-12-01 | Grifols Worldwide Operations Limited | Method for the treatment of cytokine release syndrome |
| CA3202852A1 (en) | 2020-12-01 | 2022-06-09 | Reverspah Llc | Methods and compositions for treating chronic obstructive pulmonary disease, asthma, pneumonia, bronchitis, cystic fibrosis and pulmonary edema, interstitial lung disease, sarcoidosis, idiopathic pulmonary fibrosis, a cute respiratory distress syndrome, and pulmonary arterial hypertension |
| US11324694B1 (en) * | 2021-10-28 | 2022-05-10 | Cmpd Licensing, Llc | Nebulization formulations for delivery to lower respiratory tract |
| WO2023091081A2 (en) * | 2021-11-16 | 2023-05-25 | Agency For Science, Technology And Research | Inhalable recombinant protein powder formulation for treating genetic and autoimmune disorders |
| EP4480493A1 (en) | 2023-06-22 | 2024-12-25 | AATEC Medical GmbH | A recombinant human alpha-1 antitrypsin glycoprotein for treating non-viral inflammatory diseases of the lung |
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| PL1684719T3 (pl) * | 2003-11-14 | 2012-11-30 | Baxalta Inc | Kompozycje alfa 1-antytrypsyny i sposoby leczenia z zastosowaniem takich kompozycji |
| JP2007528409A (ja) * | 2004-03-09 | 2007-10-11 | アリバ ファーマシューティカルズ, インコーポレイテッド | プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 |
-
2005
- 2005-03-09 JP JP2007503004A patent/JP2007528409A/ja active Pending
- 2005-03-09 CA CA002559062A patent/CA2559062A1/en not_active Abandoned
- 2005-03-09 WO PCT/US2005/007959 patent/WO2005086915A2/en not_active Ceased
- 2005-03-09 US US11/077,276 patent/US7914771B2/en not_active Expired - Fee Related
- 2005-03-09 EP EP05725249A patent/EP1737499A4/en not_active Withdrawn
- 2005-03-09 AU AU2005221151A patent/AU2005221151A1/en not_active Abandoned
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