JP2007528409A - プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 - Google Patents
プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 Download PDFInfo
- Publication number
- JP2007528409A JP2007528409A JP2007503004A JP2007503004A JP2007528409A JP 2007528409 A JP2007528409 A JP 2007528409A JP 2007503004 A JP2007503004 A JP 2007503004A JP 2007503004 A JP2007503004 A JP 2007503004A JP 2007528409 A JP2007528409 A JP 2007528409A
- Authority
- JP
- Japan
- Prior art keywords
- aat
- functionally active
- less
- active portion
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D1/00—Cigars; Cigarettes
- A24D1/002—Cigars; Cigarettes with additives, e.g. for flavouring
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Materials Engineering (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55185604P | 2004-03-09 | 2004-03-09 | |
| PCT/US2005/007959 WO2005086915A2 (en) | 2004-03-09 | 2005-03-09 | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007528409A true JP2007528409A (ja) | 2007-10-11 |
| JP2007528409A5 JP2007528409A5 (enExample) | 2009-08-06 |
Family
ID=34976236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503004A Pending JP2007528409A (ja) | 2004-03-09 | 2005-03-09 | プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7914771B2 (enExample) |
| EP (1) | EP1737499A4 (enExample) |
| JP (1) | JP2007528409A (enExample) |
| AU (1) | AU2005221151A1 (enExample) |
| CA (1) | CA2559062A1 (enExample) |
| WO (1) | WO2005086915A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016528234A (ja) * | 2013-08-05 | 2016-09-15 | フォールマン、ジェラルド | 喫煙の悪影響を減らす新規手段 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060257324A1 (en) | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
| JP2007528409A (ja) * | 2004-03-09 | 2007-10-11 | アリバ ファーマシューティカルズ, インコーポレイテッド | プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 |
| US7973005B2 (en) * | 2006-02-09 | 2011-07-05 | Kamada Ltd. | Alpha-1 antitrypsin for treating exacerbation episodes of pulmonary diseases |
| WO2008053199A1 (en) * | 2006-10-30 | 2008-05-08 | Astrazeneca Ab | Combination therapy for the treatment of respiratory diseases |
| GB0716026D0 (en) * | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| UA124083C2 (uk) * | 2011-06-28 | 2021-07-21 | ІНГІБРЕКС, Інк. | Злитий серпіновий поліпептид і спосіб його застосування |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| BR112013033801A2 (pt) | 2011-06-28 | 2017-12-19 | Inhibrx Llc | proteína de fusão isolada, e, método para tratar ou aliviar um sintoma de uma doença ou distúrbio inflamatórios |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| EP2758065B1 (en) * | 2011-12-30 | 2021-06-23 | Grifols, S.A. | Alpha1-proteinase inhibitor for use in delaying the onset or progression of pulmonary exacerbations |
| US20160011207A1 (en) * | 2012-12-07 | 2016-01-14 | Virginia Commonwealth University | Diagnosis and therapy of chronic inflammation-induced disorders |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| US20210085764A1 (en) * | 2016-12-22 | 2021-03-25 | Kamada Ltd. | Dry powder formulations of alpha-1 antitrypsin |
| EP3915574A1 (en) * | 2020-05-27 | 2021-12-01 | Grifols Worldwide Operations Limited | Method for the treatment of cytokine release syndrome |
| CA3202852A1 (en) | 2020-12-01 | 2022-06-09 | Reverspah Llc | Methods and compositions for treating chronic obstructive pulmonary disease, asthma, pneumonia, bronchitis, cystic fibrosis and pulmonary edema, interstitial lung disease, sarcoidosis, idiopathic pulmonary fibrosis, a cute respiratory distress syndrome, and pulmonary arterial hypertension |
| US11324694B1 (en) * | 2021-10-28 | 2022-05-10 | Cmpd Licensing, Llc | Nebulization formulations for delivery to lower respiratory tract |
| WO2023091081A2 (en) * | 2021-11-16 | 2023-05-25 | Agency For Science, Technology And Research | Inhalable recombinant protein powder formulation for treating genetic and autoimmune disorders |
| EP4480493A1 (en) | 2023-06-22 | 2024-12-25 | AATEC Medical GmbH | A recombinant human alpha-1 antitrypsin glycoprotein for treating non-viral inflammatory diseases of the lung |
Citations (4)
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| JPH1045799A (ja) * | 1982-08-13 | 1998-02-17 | Zymogenetics Inc | 形質転換酵母を用いて製造した蛋白質 |
| WO2003035610A1 (en) * | 2001-10-26 | 2003-05-01 | Shionogi & Co., Ltd. | Sulfonamide derivative having mmp inhibitory activity |
| JP2003523393A (ja) * | 2000-02-25 | 2003-08-05 | アラキス リミテッド | 呼吸器疾患治療用メタロプロティナーゼ阻害剤 |
| WO2003091242A1 (en) * | 2002-04-26 | 2003-11-06 | Takeda Pharmaceutical Company Limited | Novel thiol derivative, process for producing the same and use thereof |
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| US4083372A (en) | 1976-05-24 | 1978-04-11 | Robert Boden | Cigarette-simulating inhaler |
| US4393884A (en) | 1981-09-25 | 1983-07-19 | Jacobs Allen W | Demand inhaler for oral administration of tobacco, tobacco-like, or other substances |
| US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4752576A (en) * | 1984-06-14 | 1988-06-21 | Chiron Corporation | Expression of α-1 antitrypsin in yeast |
| US4732973A (en) * | 1984-06-14 | 1988-03-22 | Chiron Corporation | Active site modified protease α-1-antitrypsin inhibitors |
| US4837148A (en) * | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
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| US5008242A (en) * | 1986-12-24 | 1991-04-16 | John Lezdey | Treatment of inflammation using 1-antichymotrypsin |
| US5290762A (en) * | 1986-12-24 | 1994-03-01 | John Lezdey | Treatment of inflammation |
| JP2656944B2 (ja) * | 1987-04-30 | 1997-09-24 | クーパー ラボラトリーズ | タンパク質性治療剤のエアロゾール化 |
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| JP2007528409A (ja) * | 2004-03-09 | 2007-10-11 | アリバ ファーマシューティカルズ, インコーポレイテッド | プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 |
-
2005
- 2005-03-09 JP JP2007503004A patent/JP2007528409A/ja active Pending
- 2005-03-09 CA CA002559062A patent/CA2559062A1/en not_active Abandoned
- 2005-03-09 WO PCT/US2005/007959 patent/WO2005086915A2/en not_active Ceased
- 2005-03-09 US US11/077,276 patent/US7914771B2/en not_active Expired - Fee Related
- 2005-03-09 EP EP05725249A patent/EP1737499A4/en not_active Withdrawn
- 2005-03-09 AU AU2005221151A patent/AU2005221151A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1045799A (ja) * | 1982-08-13 | 1998-02-17 | Zymogenetics Inc | 形質転換酵母を用いて製造した蛋白質 |
| JP2003523393A (ja) * | 2000-02-25 | 2003-08-05 | アラキス リミテッド | 呼吸器疾患治療用メタロプロティナーゼ阻害剤 |
| WO2003035610A1 (en) * | 2001-10-26 | 2003-05-01 | Shionogi & Co., Ltd. | Sulfonamide derivative having mmp inhibitory activity |
| WO2003091242A1 (en) * | 2002-04-26 | 2003-11-06 | Takeda Pharmaceutical Company Limited | Novel thiol derivative, process for producing the same and use thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016528234A (ja) * | 2013-08-05 | 2016-09-15 | フォールマン、ジェラルド | 喫煙の悪影響を減らす新規手段 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050201951A1 (en) | 2005-09-15 |
| CA2559062A1 (en) | 2005-09-22 |
| AU2005221151A1 (en) | 2005-09-22 |
| WO2005086915A2 (en) | 2005-09-22 |
| WO2005086915A3 (en) | 2006-03-23 |
| EP1737499A4 (en) | 2009-07-22 |
| US7914771B2 (en) | 2011-03-29 |
| EP1737499A2 (en) | 2007-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080307 |
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