JP2007526238A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007526238A5 JP2007526238A5 JP2006532814A JP2006532814A JP2007526238A5 JP 2007526238 A5 JP2007526238 A5 JP 2007526238A5 JP 2006532814 A JP2006532814 A JP 2006532814A JP 2006532814 A JP2006532814 A JP 2006532814A JP 2007526238 A5 JP2007526238 A5 JP 2007526238A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- folic acid
- immunogen
- drug
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 8
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 235000019152 folic acid Nutrition 0.000 claims 4
- 239000011724 folic acid Substances 0.000 claims 4
- 229960000304 folic acid Drugs 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 206010025135 lupus erythematosus Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- -1 dinitrophenyl Chemical group 0.000 claims 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 2
- 102000006815 folate receptor Human genes 0.000 claims 2
- 108020005243 folate receptor Proteins 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46833003P | 2003-05-06 | 2003-05-06 | |
| PCT/US2004/014097 WO2004100983A2 (en) | 2003-05-06 | 2004-05-06 | Treatment of lupus targeting the macrophages or the folate receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007526238A JP2007526238A (ja) | 2007-09-13 |
| JP2007526238A5 true JP2007526238A5 (https=) | 2009-01-08 |
Family
ID=33452201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532814A Pending JP2007526238A (ja) | 2003-05-06 | 2004-05-06 | マクロファージまたは葉酸受容体を標的とする狼瘡治療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20060204565A1 (https=) |
| EP (1) | EP1622646B1 (https=) |
| JP (1) | JP2007526238A (https=) |
| CA (1) | CA2524441C (https=) |
| WO (1) | WO2004100983A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2445826C (en) | 2001-05-02 | 2014-03-25 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| DK2260875T3 (da) | 2002-05-06 | 2014-06-30 | Endocyte Inc | Folatreceptor-targetede billeddannelsesmidler |
| DE602004017452D1 (de) * | 2003-05-30 | 2008-12-11 | Purdue Research Foundation | Diagnoseverfahren für atherosklerose |
| JP5149620B2 (ja) | 2004-07-23 | 2013-02-20 | エンドサイト，インコーポレイテッド | ２価リンカーおよびその結合体 |
| RU2007128036A (ru) * | 2004-12-23 | 2009-01-27 | Пердью Рисерч Фаундейшн (Us) | Способ получения изображения позитронно-эмиссионной томографией |
| US20070009434A1 (en) * | 2005-07-05 | 2007-01-11 | Low Philip S | Imaging and therapeutic method using monocytes |
| US8795633B2 (en) | 2005-09-23 | 2014-08-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| CA2651866C (en) | 2006-05-11 | 2014-10-28 | Universiteit Gent | Sialoadhesin-related compositions and methods |
| WO2008127298A2 (en) * | 2006-10-24 | 2008-10-23 | Subroto Chatterjee | Staphylococcal enterotoxin b peptide compositions and methods of use |
| JP2010509570A (ja) | 2006-11-03 | 2010-03-25 | パーデュー・リサーチ・ファウンデーション | エクスビボフローサイトメトリーの方法および装置 |
| US8586595B2 (en) * | 2007-02-07 | 2013-11-19 | Purdue Research Foundation | Positron emission tomography imaging method |
| WO2008101231A2 (en) | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CN104127878A (zh) | 2007-03-14 | 2014-11-05 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| CA2688308A1 (en) * | 2007-05-25 | 2008-12-04 | Purdue Research Foundation | Method of imaging localized infections |
| BRPI0812970A2 (pt) | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugados contendo espaçadores hidrofílicos |
| US9187521B2 (en) | 2007-10-25 | 2015-11-17 | Endocyte, Inc. | Tubulysins and processes for preparing |
| CA2800693A1 (en) | 2010-05-28 | 2011-12-01 | Purdue Research Foundation | Delivery of therapeutic agents to inflamed tissues using folate-targeted agents |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| EP2908818A4 (en) | 2012-10-16 | 2016-07-13 | Endocyte Inc | CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE |
| EP3334466B1 (en) | 2015-08-14 | 2020-05-13 | Endocyte, Inc. | Method of imaging with a chelating compound |
| CN114377017A (zh) * | 2020-10-21 | 2022-04-22 | 复旦大学 | 叶酸和叶酸修饰在诱导B细胞免疫耐受和靶向mIgM阳性表达的B细胞淋巴瘤中的用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713249A (en) * | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| US5266333A (en) * | 1985-03-06 | 1993-11-30 | American Cyanamid Company | Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone |
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| EP1005372B1 (en) * | 1997-06-20 | 2002-01-02 | Tanox Pharma B.V. | Anti-cd40l immunotoxins for the treatment of diseases |
| US20020058284A1 (en) * | 1998-02-17 | 2002-05-16 | Jan G.J. Van De Winkel | Methods and compositions for treating macrophage-mediated diseases |
| PL211872B1 (pl) * | 2000-03-31 | 2012-07-31 | Purdue Research Foundation | Kompozycja farmaceutyczna |
| CA2445826C (en) * | 2001-05-02 | 2014-03-25 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
| KR20040053136A (ko) * | 2001-09-28 | 2004-06-23 | 펄듀 리서치 파운데이션 | 리간드-면역원 공액체를 이용한 치료 방법 |
| EP1465996B1 (en) * | 2001-12-21 | 2008-11-05 | Laboratoires Serono SA | Raf/ras binding compounds |
| DK2260875T3 (da) * | 2002-05-06 | 2014-06-30 | Endocyte Inc | Folatreceptor-targetede billeddannelsesmidler |
-
2004
- 2004-05-06 EP EP04751467A patent/EP1622646B1/en not_active Expired - Lifetime
- 2004-05-06 US US10/552,569 patent/US20060204565A1/en not_active Abandoned
- 2004-05-06 JP JP2006532814A patent/JP2007526238A/ja active Pending
- 2004-05-06 WO PCT/US2004/014097 patent/WO2004100983A2/en not_active Ceased
- 2004-05-06 CA CA2524441A patent/CA2524441C/en not_active Expired - Fee Related
-
2007
- 2007-11-30 US US11/948,656 patent/US20080119475A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007526238A5 (https=) | ||
| JP2008514290A5 (https=) | ||
| EE200300295A (et) | Kinuklidiinkarbamaadi derivaat, selle saamine ja kasutamine ravimi valmistamiseks, mis on ette nähtud respiratoorsete, kuseelundite või mao-soolte haiguste ravimiseks, ning seda sisaldav ravimkompositsioon | |
| JP2003503454A5 (https=) | ||
| JP2005500357A5 (https=) | ||
| EE200300312A (et) | Kinuklidiini derivaat, selle saamine ja kasutamine ravimi valmistamiseks, mis on ette nähtud respiratoorsete, kuseelundite või mao-soolte haiguste ravimiseks, ning seda sisaldav ravimkompositsioon | |
| IL183274A0 (en) | Method for producing sterile suspensions or lyophilisates of poorly soluble basic peptide complexes, pharmaceutical formulations containing the same, and use thereof as medicaments | |
| MD20070267A (en) | Gastroresistant pharmaceutical formulation containing rifaximin | |
| ATE468332T1 (de) | Phenyl-(4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin- - yi)aminderivate | |
| EP1635762A4 (en) | LOW-DOSED PHARMACEUTICAL POWDER FOR INHALATION | |
| EP1824442A4 (en) | PHARMACEUTICAL AND THERAPEUTIC COMPOSITIONS FROM THE GARCINIA MANGOSTANA L PLANT | |
| JP2010536849A5 (https=) | ||
| JP2007522094A5 (https=) | ||
| CY1112184T1 (el) | Πυριδοξαμινη για χρηση στην αγωγη της διαβητικης nεφροπαθειας στο διαβητη τυπου ii | |
| RU2005126412A (ru) | Сор1 для лечения воспалительных заболеваний кишечника | |
| WO2005111002A3 (de) | Substituierte cycloalkylderivate zur behandlung von atemswegerkrankungen | |
| CA2524441A1 (en) | Treatment of lupus targeting the macrophages or the folate receptor | |
| JP2009062388A5 (https=) | ||
| JP2007523135A5 (https=) | ||
| JP2006514116A5 (https=) | ||
| IL187575A (en) | Benzofuranyl derivatives ,pharmaceutical formulations comprising the same and use thereof in the preparation of medicaments for the treatment of 5-ht6-receptor related disorders | |
| PL1680112T3 (pl) | N-(5-adamantan-1-ylometoksypentylo)deoksynojirimycyna lub dopuszczalna farmaceutycznie sól stosowane w leczeniu oporności na insulinę | |
| WO2007030944A3 (en) | Methods of cardioprotection using dichloroacetate in combination with an inotrope | |
| ATE525359T1 (de) | Modulatoren der aktivität des glucokortikoidrezeptors von ap-1 und/oder von nf- kb und anwendung davon | |
| JP2009516719A5 (https=) |