JP2007526238A5 - - Google Patents
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- Publication number
- JP2007526238A5 JP2007526238A5 JP2006532814A JP2006532814A JP2007526238A5 JP 2007526238 A5 JP2007526238 A5 JP 2007526238A5 JP 2006532814 A JP2006532814 A JP 2006532814A JP 2006532814 A JP2006532814 A JP 2006532814A JP 2007526238 A5 JP2007526238 A5 JP 2007526238A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- folic acid
- immunogen
- drug
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 8
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 235000019152 folic acid Nutrition 0.000 claims 4
- 239000011724 folic acid Substances 0.000 claims 4
- 229960000304 folic acid Drugs 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 206010025135 lupus erythematosus Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- -1 dinitrophenyl Chemical group 0.000 claims 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 2
- 102000006815 folate receptor Human genes 0.000 claims 2
- 108020005243 folate receptor Proteins 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46833003P | 2003-05-06 | 2003-05-06 | |
| PCT/US2004/014097 WO2004100983A2 (en) | 2003-05-06 | 2004-05-06 | Treatment of lupus targeting the macrophages or the folate receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007526238A JP2007526238A (ja) | 2007-09-13 |
| JP2007526238A5 true JP2007526238A5 (https=) | 2009-01-08 |
Family
ID=33452201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532814A Pending JP2007526238A (ja) | 2003-05-06 | 2004-05-06 | マクロファージまたは葉酸受容体を標的とする狼瘡治療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20060204565A1 (https=) |
| EP (1) | EP1622646B1 (https=) |
| JP (1) | JP2007526238A (https=) |
| CA (1) | CA2524441C (https=) |
| WO (1) | WO2004100983A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101979095A (zh) | 2001-05-02 | 2011-02-23 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| JP4801348B2 (ja) | 2002-05-06 | 2011-10-26 | エンドサイト，インコーポレイテッド | ビタミンを標的とした造影剤 |
| WO2004110250A2 (en) * | 2003-05-30 | 2004-12-23 | Purdue Research Foundation | Diagnostic method for atherosclerosis |
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| RU2007128036A (ru) * | 2004-12-23 | 2009-01-27 | Пердью Рисерч Фаундейшн (Us) | Способ получения изображения позитронно-эмиссионной томографией |
| EP1904183B1 (en) | 2005-07-05 | 2014-10-15 | Purdue Research Foundation | Pharmaceutical composition for the treatment of osteoarthritis |
| US8795633B2 (en) | 2005-09-23 | 2014-08-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| CN101678116A (zh) | 2006-05-11 | 2010-03-24 | 根特大学 | 通过唾液酸粘附素靶向巨噬细胞 |
| WO2008127298A2 (en) * | 2006-10-24 | 2008-10-23 | Subroto Chatterjee | Staphylococcal enterotoxin b peptide compositions and methods of use |
| JP2010509570A (ja) | 2006-11-03 | 2010-03-25 | パーデュー・リサーチ・ファウンデーション | エクスビボフローサイトメトリーの方法および装置 |
| US8586595B2 (en) * | 2007-02-07 | 2013-11-19 | Purdue Research Foundation | Positron emission tomography imaging method |
| US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| WO2008148001A2 (en) * | 2007-05-25 | 2008-12-04 | Purdue Research Foundation | Method of imaging localized infections |
| CN101784565B (zh) | 2007-06-25 | 2014-12-10 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| CN101909441B (zh) | 2007-10-25 | 2015-05-13 | 恩多塞特公司 | 微管蛋白抑制剂及其制备方法 |
| CA2800693A1 (en) | 2010-05-28 | 2011-12-01 | Purdue Research Foundation | Delivery of therapeutic agents to inflamed tissues using folate-targeted agents |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| BR112015008365A2 (pt) | 2012-10-16 | 2017-07-04 | Endocyte Inc | composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente |
| WO2017030893A1 (en) | 2015-08-14 | 2017-02-23 | Endocyte, Inc. | Method of imaging with a chelating compound |
| CN114377017A (zh) * | 2020-10-21 | 2022-04-22 | 复旦大学 | 叶酸和叶酸修饰在诱导B细胞免疫耐受和靶向mIgM阳性表达的B细胞淋巴瘤中的用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713249A (en) * | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| US5266333A (en) * | 1985-03-06 | 1993-11-30 | American Cyanamid Company | Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone |
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| EP1005372B1 (en) * | 1997-06-20 | 2002-01-02 | Tanox Pharma B.V. | Anti-cd40l immunotoxins for the treatment of diseases |
| KR20010041010A (ko) * | 1998-02-17 | 2001-05-15 | 메다렉스, 인코포레이티드 | Ｆｃ 수용체 리간드를 사용하여 마크로파지 매개 질환을치료하고 진단하는 방법 |
| CN1441676B (zh) * | 2000-03-31 | 2012-08-22 | 普渡研究基金会 | 用配体-免疫原缀合物治疗的方法 |
| CN101979095A (zh) * | 2001-05-02 | 2011-02-23 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
| EP2168598A1 (en) * | 2001-09-28 | 2010-03-31 | Purdue Research Foundation | Method of Treatment Using Ligand-Immunogen Conjugates |
| US20050164906A1 (en) * | 2001-12-21 | 2005-07-28 | Applied Research Systems Ars Holding N.V. | Novel raf/ras binding compounds |
| JP4801348B2 (ja) * | 2002-05-06 | 2011-10-26 | エンドサイト，インコーポレイテッド | ビタミンを標的とした造影剤 |
-
2004
- 2004-05-06 US US10/552,569 patent/US20060204565A1/en not_active Abandoned
- 2004-05-06 EP EP04751467A patent/EP1622646B1/en not_active Expired - Lifetime
- 2004-05-06 WO PCT/US2004/014097 patent/WO2004100983A2/en not_active Ceased
- 2004-05-06 JP JP2006532814A patent/JP2007526238A/ja active Pending
- 2004-05-06 CA CA2524441A patent/CA2524441C/en not_active Expired - Fee Related
-
2007
- 2007-11-30 US US11/948,656 patent/US20080119475A1/en not_active Abandoned
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