JP2007524105A5 - - Google Patents
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- Publication number
- JP2007524105A5 JP2007524105A5 JP2007500291A JP2007500291A JP2007524105A5 JP 2007524105 A5 JP2007524105 A5 JP 2007524105A5 JP 2007500291 A JP2007500291 A JP 2007500291A JP 2007500291 A JP2007500291 A JP 2007500291A JP 2007524105 A5 JP2007524105 A5 JP 2007524105A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- population
- partner
- agents
- bind
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011230 binding agent Substances 0.000 claims 33
- 239000000126 substance Substances 0.000 claims 32
- 238000000034 method Methods 0.000 claims 19
- 239000012491 analyte Substances 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 238000001514 detection method Methods 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 239000012636 effector Substances 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 210000000987 immune system Anatomy 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000000873 masking effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0404187.7A GB0404187D0 (en) | 2004-02-25 | 2004-02-25 | Binding agents |
| PCT/GB2005/000704 WO2005083431A2 (en) | 2004-02-25 | 2005-02-25 | Binding agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007524105A JP2007524105A (ja) | 2007-08-23 |
| JP2007524105A5 true JP2007524105A5 (https=) | 2008-04-10 |
Family
ID=32050854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007500291A Pending JP2007524105A (ja) | 2004-02-25 | 2005-02-25 | 結合物質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080107660A1 (https=) |
| EP (1) | EP1723418A2 (https=) |
| JP (1) | JP2007524105A (https=) |
| GB (1) | GB0404187D0 (https=) |
| WO (1) | WO2005083431A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4547324B2 (ja) * | 2005-11-24 | 2010-09-22 | シャープ株式会社 | タンパク質認識構造体、タンパク質認識基板、及びこれらの製造方法 |
| GB0707870D0 (en) | 2007-04-23 | 2007-05-30 | Selected Antibodies Ltd | Assay Devices and Methods and Components for use Therein |
| GB0716160D0 (en) * | 2007-08-17 | 2007-09-26 | Biotransformations Ltd | Materials and methods for treating cancers which express folate receptors |
| CA2697032C (en) | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| EP2356131A4 (en) * | 2008-12-08 | 2012-09-12 | Tegopharm Corp | MASKING LIGANDS FOR REVERSIBLE INHIBITION OF VERSATILE COMPOUNDS |
| US8895702B2 (en) * | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
| US20100189651A1 (en) * | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| JP5861223B2 (ja) * | 2009-02-23 | 2016-02-16 | サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. | プロタンパク質およびその使用方法 |
| WO2011101435A1 (en) * | 2010-02-19 | 2011-08-25 | Novo Nordisk A/S | Activatable constructs |
| JP6130307B2 (ja) | 2011-03-17 | 2017-05-17 | ザ ユニバーシティ オブ バーミンガム | 再指向性免疫療法 |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| US9791436B2 (en) | 2012-09-12 | 2017-10-17 | The University Of Queensland | Protease-based biosensor |
| WO2014193973A2 (en) | 2013-05-28 | 2014-12-04 | Dcb-Usa Llc | Antibody locker for the inactivation of protein drug |
| AU2014321138A1 (en) | 2013-09-12 | 2016-04-28 | The University Of Queensland | Bimolecular protease-based biosensor |
| UA129760C2 (uk) | 2013-12-17 | 2025-07-30 | Дженентек, Інк. | Анти-cd3 антитіло та спосіб його застосування |
| US10441649B2 (en) | 2015-02-02 | 2019-10-15 | The University Of Birmingham | Targeting moiety peptide epitope complexes having a plurality of T-cell epitopes |
| US20160362469A1 (en) * | 2015-06-12 | 2016-12-15 | Tianxin Wang | Methods for protein modification in pharmaceutical applications |
| ES2873846T5 (en) | 2015-11-19 | 2025-06-23 | Revitope Ltd | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
| AU2017259794B2 (en) | 2016-05-02 | 2023-04-13 | Encodia, Inc. | Macromolecule analysis employing nucleic acid encoding |
| WO2018093821A1 (en) | 2016-11-15 | 2018-05-24 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| EA201991353A1 (ru) | 2016-12-09 | 2019-11-29 | Двухвалентные антитела, маскированные спирализованными спиралями | |
| MA47613A (fr) * | 2017-02-22 | 2020-01-01 | Aleta Biotherapeutics Inc | Compositions et procédés de traitement du cancer |
| MX2020004559A (es) | 2017-10-31 | 2020-10-05 | Encodia Inc | Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico. |
| EP3963070A4 (en) | 2019-04-30 | 2023-02-22 | Encodia, Inc. | METHODS OF PREPARATION OF ANALYTES AND RELATED KITS |
| CA3177239A1 (en) * | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Protease-activated t cell bispecific antibodies |
| AU2021374594B2 (en) | 2020-11-04 | 2026-03-05 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates |
| CA3196539A1 (en) | 2020-11-04 | 2022-05-12 | Chi-Chung Li | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| KR20230100732A (ko) | 2020-11-04 | 2023-07-05 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이성 항체의 피하 투여 |
| CA3213632A1 (en) | 2021-04-30 | 2022-11-03 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| US12291575B2 (en) | 2021-05-14 | 2025-05-06 | Genentech, Inc. | Methods for treatment of CD20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849478A (en) * | 1986-08-14 | 1998-12-15 | Cashman; Daniel P. | Blocked-polymerase polynucleotide immunoassay method and kit |
| GB9322156D0 (en) * | 1993-10-27 | 1993-12-15 | Univ Newcastel Upon Tyne | Activation of molecules |
| US5468785A (en) * | 1994-04-15 | 1995-11-21 | University Of Akron | Cobaloxime photoinitiated free radical polymerizations |
| AU5509296A (en) * | 1995-05-03 | 1996-11-21 | Colin Henry Self | Bispecific antibodies in which the binding capability is rev ersibly inhibited by a photocleavable moiety |
| AU3567099A (en) * | 1998-04-16 | 1999-11-01 | Packard Bioscience Company | Analysis of polynucleotide sequence |
| AU5003299A (en) * | 1998-07-17 | 2000-02-07 | Emory University | Methods for detecting and mapping genes, mutations and variant polynucleotide sequences |
| US6203989B1 (en) * | 1998-09-30 | 2001-03-20 | Affymetrix, Inc. | Methods and compositions for amplifying detectable signals in specific binding assays |
| WO2002066656A2 (en) * | 2001-01-04 | 2002-08-29 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Detection of protein conformation using a split ubiquitin reporter system |
| WO2002060488A1 (en) * | 2001-01-30 | 2002-08-08 | Universite Catholique De Louvain | Anti-tumor compounds |
| US20030082191A1 (en) * | 2001-08-29 | 2003-05-01 | Poduslo Joseph F. | Treatment for central nervous system disorders |
-
2004
- 2004-02-25 GB GBGB0404187.7A patent/GB0404187D0/en not_active Ceased
-
2005
- 2005-02-25 JP JP2007500291A patent/JP2007524105A/ja active Pending
- 2005-02-25 WO PCT/GB2005/000704 patent/WO2005083431A2/en not_active Ceased
- 2005-02-25 EP EP05717788A patent/EP1723418A2/en not_active Withdrawn
- 2005-02-25 US US10/590,840 patent/US20080107660A1/en not_active Abandoned
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