JP2007524105A5 - - Google Patents
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- Publication number
- JP2007524105A5 JP2007524105A5 JP2007500291A JP2007500291A JP2007524105A5 JP 2007524105 A5 JP2007524105 A5 JP 2007524105A5 JP 2007500291 A JP2007500291 A JP 2007500291A JP 2007500291 A JP2007500291 A JP 2007500291A JP 2007524105 A5 JP2007524105 A5 JP 2007524105A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- population
- partner
- agents
- bind
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011230 binding agent Substances 0.000 claims 33
- 239000000126 substance Substances 0.000 claims 32
- 238000000034 method Methods 0.000 claims 19
- 239000012491 analyte Substances 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 238000001514 detection method Methods 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 239000012636 effector Substances 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 210000000987 immune system Anatomy 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000000873 masking effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0404187.7A GB0404187D0 (en) | 2004-02-25 | 2004-02-25 | Binding agents |
| PCT/GB2005/000704 WO2005083431A2 (en) | 2004-02-25 | 2005-02-25 | Binding agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007524105A JP2007524105A (ja) | 2007-08-23 |
| JP2007524105A5 true JP2007524105A5 (https=) | 2008-04-10 |
Family
ID=32050854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007500291A Pending JP2007524105A (ja) | 2004-02-25 | 2005-02-25 | 結合物質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080107660A1 (https=) |
| EP (1) | EP1723418A2 (https=) |
| JP (1) | JP2007524105A (https=) |
| GB (1) | GB0404187D0 (https=) |
| WO (1) | WO2005083431A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4547324B2 (ja) * | 2005-11-24 | 2010-09-22 | シャープ株式会社 | タンパク質認識構造体、タンパク質認識基板、及びこれらの製造方法 |
| GB0707870D0 (en) | 2007-04-23 | 2007-05-30 | Selected Antibodies Ltd | Assay Devices and Methods and Components for use Therein |
| GB0716160D0 (en) * | 2007-08-17 | 2007-09-26 | Biotransformations Ltd | Materials and methods for treating cancers which express folate receptors |
| US20090304719A1 (en) | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| US8895702B2 (en) | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
| WO2010077643A1 (en) * | 2008-12-08 | 2010-07-08 | Tegopharm Corporation | Masking ligands for reversible inhibition of multivalent compounds |
| RU2636046C2 (ru) | 2009-01-12 | 2017-11-17 | Сайтомкс Терапьютикс, Инк | Композиции модифицированных антител, способы их получения и применения |
| AU2010215761B2 (en) | 2009-02-23 | 2017-04-06 | Cytomx Therapeutics, Inc | Proproteins and methods of use thereof |
| WO2011101435A1 (en) * | 2010-02-19 | 2011-08-25 | Novo Nordisk A/S | Activatable constructs |
| CN103561771B (zh) | 2011-03-17 | 2019-01-04 | 伯明翰大学 | 重新定向的免疫治疗 |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| WO2014040129A1 (en) * | 2012-09-12 | 2014-03-20 | The University Of Queensland | Protease-based biosensor |
| WO2014193973A2 (en) | 2013-05-28 | 2014-12-04 | Dcb-Usa Llc | Antibody locker for the inactivation of protein drug |
| EP3044322A4 (en) | 2013-09-12 | 2017-09-06 | The University Of Queensland | Bimolecular protease-based biosensor |
| IL263466B2 (en) | 2013-12-17 | 2023-10-01 | Genentech Inc | Anti-CD3 antibodies and methods of using them |
| US10441649B2 (en) | 2015-02-02 | 2019-10-15 | The University Of Birmingham | Targeting moiety peptide epitope complexes having a plurality of T-cell epitopes |
| US20160362469A1 (en) * | 2015-06-12 | 2016-12-15 | Tianxin Wang | Methods for protein modification in pharmaceutical applications |
| FI3377103T4 (fi) | 2015-11-19 | 2025-04-16 | Revitope Limited | Funktionaalinen vasta-ainefragmenttikomplementointi kaksikomponenttiselle järjestelmälle epätoivottujen solujen uudelleenohjattua tappamista varten |
| EP3452591B1 (en) | 2016-05-02 | 2023-08-16 | Encodia, Inc. | Macromolecule analysis employing nucleic acid encoding |
| JP7784795B2 (ja) | 2016-11-15 | 2025-12-12 | ジェネンテック， インコーポレイテッド | 抗ｃｄ２０／抗ｃｄ３二重特異性抗体による処置のための投与 |
| BR112019011564A2 (pt) | 2016-12-09 | 2019-10-22 | Seattle Genetics Inc | anticorpos bivalentes mascarados por hélices superenroladas |
| AU2018225164A1 (en) * | 2017-02-22 | 2019-09-19 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| JP7390027B2 (ja) * | 2017-10-31 | 2023-12-01 | エンコディア， インコーポレイテッド | 核酸エンコーディングおよび／または標識を使用する解析のためのキット |
| CN114072499B (zh) | 2019-04-30 | 2024-08-06 | Encodia公司 | 用于制备分析物的方法和相关试剂盒 |
| KR20230025667A (ko) * | 2020-06-19 | 2023-02-22 | 에프. 호프만-라 로슈 아게 | 프로테아제 활성화된 t 세포 이중특이성 항체 |
| TWI874719B (zh) | 2020-11-04 | 2025-03-01 | 美商建南德克公司 | 用抗cd20/抗cd3雙特異性抗體進行治療之給藥 |
| JP7716473B2 (ja) | 2020-11-04 | 2025-07-31 | ジェネンテック， インコーポレイテッド | 抗ｃｄ２０／抗ｃｄ３二重特異性抗体の皮下投薬 |
| AU2021374594B2 (en) | 2020-11-04 | 2026-03-05 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates |
| CA3213632A1 (en) | 2021-04-30 | 2022-11-03 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| EP4337330A1 (en) | 2021-05-14 | 2024-03-20 | Genentech, Inc. | Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849478A (en) * | 1986-08-14 | 1998-12-15 | Cashman; Daniel P. | Blocked-polymerase polynucleotide immunoassay method and kit |
| GB9322156D0 (en) * | 1993-10-27 | 1993-12-15 | Univ Newcastel Upon Tyne | Activation of molecules |
| US5468785A (en) * | 1994-04-15 | 1995-11-21 | University Of Akron | Cobaloxime photoinitiated free radical polymerizations |
| EP0871673B1 (en) * | 1995-05-03 | 2006-04-05 | Bioenhancementsments Ltd. | Bispecific antibodies in which the binding capability is reversibly inhibited by a photocleavable moiety |
| WO1999053102A1 (en) * | 1998-04-16 | 1999-10-21 | Packard Bioscience Company | Analysis of polynucleotide sequence |
| EP1112378A1 (en) * | 1998-07-17 | 2001-07-04 | GeneTag Technology, Inc. | Methods for detecting and mapping genes, mutations and variant polynucleotide sequences |
| US6203989B1 (en) * | 1998-09-30 | 2001-03-20 | Affymetrix, Inc. | Methods and compositions for amplifying detectable signals in specific binding assays |
| EP1349943A2 (en) * | 2001-01-04 | 2003-10-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Detection of protein conformation using a split ubiquitin reporter system |
| US20040097586A1 (en) * | 2001-01-30 | 2004-05-20 | Andre Trouet | Anti-tumor compounds |
| US20030082191A1 (en) * | 2001-08-29 | 2003-05-01 | Poduslo Joseph F. | Treatment for central nervous system disorders |
-
2004
- 2004-02-25 GB GBGB0404187.7A patent/GB0404187D0/en not_active Ceased
-
2005
- 2005-02-25 EP EP05717788A patent/EP1723418A2/en not_active Withdrawn
- 2005-02-25 US US10/590,840 patent/US20080107660A1/en not_active Abandoned
- 2005-02-25 JP JP2007500291A patent/JP2007524105A/ja active Pending
- 2005-02-25 WO PCT/GB2005/000704 patent/WO2005083431A2/en not_active Ceased
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