JP2007523093A - 非CpG核酸を使用した全身性免疫活性化法 - Google Patents
非CpG核酸を使用した全身性免疫活性化法 Download PDFInfo
- Publication number
- JP2007523093A JP2007523093A JP2006553373A JP2006553373A JP2007523093A JP 2007523093 A JP2007523093 A JP 2007523093A JP 2006553373 A JP2006553373 A JP 2006553373A JP 2006553373 A JP2006553373 A JP 2006553373A JP 2007523093 A JP2007523093 A JP 2007523093A
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- tumor
- cells
- cldc
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/780,294 US20050181035A1 (en) | 2004-02-17 | 2004-02-17 | Systemic immune activation method using non CpG nucleic acids |
| PCT/US2005/005336 WO2005079511A2 (en) | 2004-02-17 | 2005-02-17 | SYSTEM IMMUNE ACTIVATION METHOD USING NON CpG NUCLEIC ACIDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523093A true JP2007523093A (ja) | 2007-08-16 |
| JP2007523093A5 JP2007523093A5 (https=) | 2008-04-03 |
Family
ID=34838562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553373A Pending JP2007523093A (ja) | 2004-02-17 | 2005-02-17 | 非CpG核酸を使用した全身性免疫活性化法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050181035A1 (https=) |
| EP (1) | EP1718149A4 (https=) |
| JP (1) | JP2007523093A (https=) |
| AU (1) | AU2005215020A1 (https=) |
| CA (1) | CA2556229A1 (https=) |
| WO (1) | WO2005079511A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011515490A (ja) * | 2008-03-25 | 2011-05-19 | ジュバリス・バイオセラピューティクス・インコーポレイテッド | カチオン性脂質−dna複合体(cldc)の投与による免疫応答の増強 |
| JP2012526734A (ja) * | 2009-05-14 | 2012-11-01 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 鳥類において増強された免疫応答 |
| JP2020509039A (ja) * | 2017-03-02 | 2020-03-26 | ダンディ バイオサイエンス インコーポレイテッドDandi Bioscience Inc | 免疫抑制因子制御物質を含む多重ドメインカプセル、その製造方法、及びこれを含む免疫調節組成物 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| EP0855184A1 (en) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| ES2572834T3 (es) | 1999-02-17 | 2016-06-02 | Csl Limited | Complejos inmunogénicos y métodos relacionados con los mismos |
| NZ517929A (en) * | 1999-09-25 | 2004-02-27 | Univ Iowa Res Found | Immunostimulatory nucleic acids |
| US11576958B2 (en) | 2013-02-07 | 2023-02-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| KR20160122849A (ko) | 2014-02-28 | 2016-10-24 | 바이엘 애니멀 헬스 게엠베하 | 면역자극성 플라스미드 |
| CN108064176A (zh) | 2015-04-22 | 2018-05-22 | 库瑞瓦格股份公司 | 用于治疗肿瘤疾病的含有rna的组合物 |
| SG10202000891UA (en) | 2015-07-31 | 2020-03-30 | Bayer Animal Health Gmbh | Enhanced immune response in porcine species |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999066879A2 (en) * | 1998-06-25 | 1999-12-29 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| WO2003101375A2 (en) * | 2002-05-30 | 2003-12-11 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957735A (en) * | 1984-06-12 | 1990-09-18 | The University Of Tennessee Research Corporation | Target-sensitive immunoliposomes- preparation and characterization |
| US5043164A (en) * | 1989-01-17 | 1991-08-27 | The University Of Tennessee Research Corporation | Blood-stable, cholesterol-free liposomes |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5693622A (en) * | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5676954A (en) * | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| US5705187A (en) * | 1989-12-22 | 1998-01-06 | Imarx Pharmaceutical Corp. | Compositions of lipids and stabilizing materials |
| US5858784A (en) * | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5643578A (en) * | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
| EP0646178A1 (en) * | 1992-06-04 | 1995-04-05 | The Regents Of The University Of California | expression cassette with regularoty regions functional in the mammmlian host |
| JP3351476B2 (ja) * | 1993-01-22 | 2002-11-25 | 三菱化学株式会社 | リン脂質誘導体及びそれを含有するリポソーム |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| DE69429337T3 (de) * | 1993-04-02 | 2012-08-30 | Anticancer Inc. | Verfahren zur verabreichung von förderlichen zusammensetzungen auf die haarfollikel |
| US5679647A (en) * | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| WO1995026204A1 (en) * | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| EP1167379A3 (en) * | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5820873A (en) * | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5703057A (en) * | 1995-04-07 | 1997-12-30 | Board Of Regents The University Of Texas System | Expression library immunization |
| US5705385A (en) * | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5981501A (en) * | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| US5976567A (en) * | 1995-06-07 | 1999-11-02 | Inex Pharmaceuticals Corp. | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5830878A (en) * | 1995-06-07 | 1998-11-03 | Megabios Corporation | Cationic lipid: DNA complexes for gene targeting |
| US5817856A (en) * | 1995-12-11 | 1998-10-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiation-protective phospholipid and method |
| US6121247A (en) * | 1996-03-29 | 2000-09-19 | The Johns Hopkins University | Therapy for allergic diseases |
| US5853719A (en) * | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| AU733310C (en) * | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| EP1003531B1 (en) * | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| US6977245B2 (en) * | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| US20020156033A1 (en) * | 2000-03-03 | 2002-10-24 | Bratzler Robert L. | Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer |
| JP2004501955A (ja) * | 2000-06-30 | 2004-01-22 | アイネックス ファーマシューティカルズ コーポレイション | リポソーム抗新生物薬剤およびその使用 |
| US20030082228A1 (en) * | 2001-05-09 | 2003-05-01 | Inex Pharmaceuticals Corporation | Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents |
| US20040009944A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
-
2004
- 2004-02-17 US US10/780,294 patent/US20050181035A1/en not_active Abandoned
-
2005
- 2005-02-17 AU AU2005215020A patent/AU2005215020A1/en not_active Abandoned
- 2005-02-17 EP EP05723350A patent/EP1718149A4/en not_active Withdrawn
- 2005-02-17 JP JP2006553373A patent/JP2007523093A/ja active Pending
- 2005-02-17 WO PCT/US2005/005336 patent/WO2005079511A2/en not_active Ceased
- 2005-02-17 CA CA002556229A patent/CA2556229A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999066879A2 (en) * | 1998-06-25 | 1999-12-29 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| WO2003101375A2 (en) * | 2002-05-30 | 2003-12-11 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011515490A (ja) * | 2008-03-25 | 2011-05-19 | ジュバリス・バイオセラピューティクス・インコーポレイテッド | カチオン性脂質−dna複合体(cldc)の投与による免疫応答の増強 |
| JP2012526734A (ja) * | 2009-05-14 | 2012-11-01 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 鳥類において増強された免疫応答 |
| JP2020509039A (ja) * | 2017-03-02 | 2020-03-26 | ダンディ バイオサイエンス インコーポレイテッドDandi Bioscience Inc | 免疫抑制因子制御物質を含む多重ドメインカプセル、その製造方法、及びこれを含む免疫調節組成物 |
| JP2020510663A (ja) * | 2017-03-02 | 2020-04-09 | ダンディ バイオサイエンス インコーポレイテッドDandi Bioscience Inc | 免疫活性物質を含む多重ドメインカプセル、その製造方法、及びこれを含む免疫調節組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050181035A1 (en) | 2005-08-18 |
| AU2005215020A1 (en) | 2005-09-01 |
| EP1718149A2 (en) | 2006-11-08 |
| WO2005079511A3 (en) | 2006-01-19 |
| CA2556229A1 (en) | 2005-09-01 |
| EP1718149A4 (en) | 2010-06-09 |
| WO2005079511A2 (en) | 2005-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6693086B1 (en) | Systemic immune activation method using nucleic acid-lipid complexes | |
| US20040247662A1 (en) | Systemic immune activation method using nucleic acid-lipid complexes | |
| US7741300B2 (en) | Methods of using nucleic acid vector-lipid complexes | |
| CN1805758B (zh) | 核酸和细胞疫苗的组分 | |
| US5705151A (en) | Gene therapy for T cell regulation | |
| AU704012B2 (en) | Gene therapy for effector cell regulation | |
| JP2000503853A (ja) | 抗原特異的免疫応答を生起させる遺伝子発現ベクターおよびその使用方法 | |
| US20090010948A1 (en) | Anti-tumor vaccines delivered by dendritic cells devoid of interleukin-10 | |
| WO1996036366A9 (en) | Gene therapy for effector cell regulation | |
| JP2005247709A (ja) | 制御性t細胞の活性を制御する方法および組成物 | |
| JP2011036251A (ja) | ウイルスベクターおよびその遺伝子治療のための使用 | |
| JP2007523093A (ja) | 非CpG核酸を使用した全身性免疫活性化法 | |
| WO2021259206A1 (zh) | 针对sars-cov-2病毒的dna疫苗及其用途 | |
| Goldman | Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders | |
| JPH10505339A (ja) | 腫瘍疾患の治療のための生ワクチン | |
| JP2008526763A (ja) | 予防又は治療目的のmhcクラスi拘束性エピトープに対する免疫応答の誘導、増強及び保持方法 | |
| Yurina | DNA Vaccine: Mechanism of Action and factors which increase its efficacy | |
| WO2006099574A2 (en) | Cockroach allergen gene expression and delivery systems and uses | |
| KR20250089555A (ko) | 면역요법 조성물 및 사용 방법 | |
| Egilmez | Cytokines as vaccine adjuvants | |
| CN118119399A (zh) | 包含IL-4和/或IL-13 RNA的mRNA疫苗及其用途 | |
| JP2003026599A (ja) | Il−15遺伝子を応用したワクチンアジュバント | |
| US20030202962A1 (en) | Gene therapy for effector cell regulation | |
| MXPA05010222A (es) | Metodos y composiciones para tratar y prevenir condiciones inflamatorias. | |
| HK1081869A (en) | Method and composition for regulating the activity of regulatory t cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080213 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080213 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110621 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120124 |