JP2007521835A5 - - Google Patents
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- Publication number
- JP2007521835A5 JP2007521835A5 JP2006553250A JP2006553250A JP2007521835A5 JP 2007521835 A5 JP2007521835 A5 JP 2007521835A5 JP 2006553250 A JP2006553250 A JP 2006553250A JP 2006553250 A JP2006553250 A JP 2006553250A JP 2007521835 A5 JP2007521835 A5 JP 2007521835A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- effective amount
- treating
- dietary supplement
- suspected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 6
- 235000015872 dietary supplement Nutrition 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 1
- 230000001851 biosynthetic effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 1
- 239000011618 nicotinamide riboside Substances 0.000 claims 1
- 108010021066 nicotinamide riboside kinase Proteins 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54334704P | 2004-02-10 | 2004-02-10 | |
| PCT/US2005/004337 WO2005077091A2 (en) | 2004-02-10 | 2005-02-09 | Nicotinamide riboside kinase compositions and methods for using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007521835A JP2007521835A (ja) | 2007-08-09 |
| JP2007521835A5 true JP2007521835A5 (enExample) | 2008-05-22 |
Family
ID=34860407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553250A Pending JP2007521835A (ja) | 2004-02-10 | 2005-02-09 | ニコチンアミドリボシドキナーゼ組成物およびそれらの使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8197807B2 (enExample) |
| EP (1) | EP1723227A4 (enExample) |
| JP (1) | JP2007521835A (enExample) |
| AU (1) | AU2005211773B2 (enExample) |
| CA (1) | CA2555675A1 (enExample) |
| WO (1) | WO2005077091A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
| US8114626B2 (en) * | 2004-02-10 | 2012-02-14 | Trustees Of Dartmouth College | Yeast strain and method for using the same to produce nicotinamide riboside |
| ES2663226T3 (es) * | 2004-06-04 | 2018-04-11 | Washington University | Procedimientos y composiciones para tratar neuropatías |
| US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| CA2610854A1 (en) * | 2005-03-30 | 2006-10-05 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| US20060292099A1 (en) * | 2005-05-25 | 2006-12-28 | Michael Milburn | Treatment of eye disorders with sirtuin modulators |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| EP2124985A4 (en) * | 2007-01-26 | 2011-06-08 | Univ Washington | METHOD AND COMPOSITIONS FOR TREATING NERVOUS ELEMENTS |
| KR20210107895A (ko) | 2013-10-30 | 2021-09-01 | 크로마덱스 아이엔씨. | 피부 질환 치료에서의 국소적 사용을 위한 니코틴아미드 리보사이드 조성물 |
| US10485814B2 (en) | 2014-06-06 | 2019-11-26 | Glaxosmithkline Intellectual Property (No. 2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| CA2956163C (en) | 2014-07-24 | 2023-01-10 | W.R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| CN107428791B (zh) | 2015-03-09 | 2024-05-28 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| KR102426320B1 (ko) | 2015-03-16 | 2022-07-29 | 크로마덱스 아이엔씨. | 니코틴산 리보사이드 또는 니코틴아미드 리보사이드 조성물, 이의 환원 유도체, 및 이의 용도 |
| US20160317420A1 (en) * | 2015-05-01 | 2016-11-03 | The Procter & Gamble Company | Method of improving the appearance of skin and compositions therefor |
| US11013678B2 (en) | 2015-06-29 | 2021-05-25 | The Procter & Gamble Company | Multi-component skin care product |
| US9833398B2 (en) | 2016-01-11 | 2017-12-05 | The Procter & Gamble Company | Method of treating a skin condition and compositions therefor |
| CA3017254C (en) | 2016-03-16 | 2023-08-22 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| US10183036B2 (en) | 2016-04-20 | 2019-01-22 | ChromaDex Inc. | Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as NAD+ increasing precursors |
| CN120383644A (zh) | 2016-11-11 | 2025-07-29 | 英国贝尔法斯特女王大学 | 烟酰基核苷和还原的烟酰基核苷、其改性衍生物、磷酸化的类似物、腺苷二核苷酸共轭物、以及新颖结晶形式的有效且可规模化的合成 |
| AU2017367092B2 (en) | 2016-11-29 | 2022-11-03 | University Of Iowa Research Foundation | Use of NAD precursors for improving maternal health and/or offspring health |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| US10376528B2 (en) | 2017-03-10 | 2019-08-13 | Tecton Group, Llc | Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor |
| EP3642214A2 (en) | 2017-06-19 | 2020-04-29 | Gangadhara Ganapati | Nicotinamide riboside derivatives and their uses |
| CN110785161B (zh) | 2017-06-23 | 2023-06-20 | 宝洁公司 | 用于改善皮肤外观的组合物和方法 |
| CA3086535A1 (en) | 2017-12-22 | 2019-06-27 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
| EP3817717A1 (en) | 2018-07-03 | 2021-05-12 | The Procter & Gamble Company | Method of treating a skin condition |
| CA3110296A1 (en) | 2018-09-27 | 2020-04-02 | Societe Des Produits Nestle S.A. | Compositions and methods using at least one glycine or derivative thereof, at least one n-acetylcysteine or derivative thereof, and at least one nicotinamide riboside or nad+ precursor |
| WO2020131578A2 (en) | 2018-12-17 | 2020-06-25 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| US20220290122A1 (en) * | 2019-02-19 | 2022-09-15 | Whitehead Institute For Biomedical Research | Methods and agents for modulating mitochondrial nad levels |
| WO2020191359A1 (en) * | 2019-03-21 | 2020-09-24 | Fred Hutchinson Cancer Research Center | Cancer combination therapies utilizing a nicotinamide phosphoribosyltransferase inhibitor in combination with a nicotinamide adenine dinucleotide salvage pathway precursor |
| US20220168271A1 (en) * | 2019-03-29 | 2022-06-02 | Societe Des Produits Nestle S.A. | Compositions and methods for increasing t cell function |
| EP3986420A1 (en) | 2019-06-18 | 2022-04-27 | Mitopower LLC | Nicotinyl riboside compounds and their uses |
| CN110412157A (zh) * | 2019-07-17 | 2019-11-05 | 广州金评检测研究院有限公司 | 一种烟酰胺原料中烟酸的测定方法 |
| EP4471043A3 (en) | 2019-07-19 | 2025-03-05 | Biosynth AG | Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof |
| JP2023519536A (ja) | 2020-04-01 | 2023-05-11 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 神経学的疾患及び状態の予防及び治療のためのｎ－アセチルシステインとニコチンアミドリボシドとを含む組成物及び方法 |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| WO2022106407A1 (en) | 2020-11-18 | 2022-05-27 | Société des Produits Nestlé S.A. | Compositions and methods using a combination of oleuropein and nicotinamide riboside for cellular energy |
| CN112553178B (zh) * | 2020-12-25 | 2023-03-10 | 中山俊凯生物技术开发有限公司 | 热稳定性和活性增强的烟酰胺核糖激酶突变体及其编码基因和应用 |
| EP4401721A4 (en) | 2021-10-17 | 2025-10-15 | Univ Of South Alabama Foundation For Research And Commercialization | CANCER TREATMENT |
| LT7046B (lt) | 2022-04-15 | 2024-02-12 | Vilniaus Universitetas | Hidrolazės ir jų panaudojimas |
| CN115896062B (zh) * | 2022-08-10 | 2024-10-01 | 福建师范大学 | 一种烟酰胺核糖苷激酶突变体及其相关产品和应用 |
| LT7066B (lt) | 2023-11-17 | 2024-06-25 | Vilimas Vladas | Didelės talpos medžio sulos atitirpinimo būdas |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3023787A1 (de) | 1980-06-25 | 1982-01-21 | Studiengesellschaft Kohle mbH, 4330 Mülheim | Verfahren zur erhoehung der inkorporation und der expression von genetischem material in die kerne von intakten zellen mit hilfe von liposomen |
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| DE69031305T2 (de) | 1989-11-03 | 1998-03-26 | Univ Vanderbilt | Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| ATE272123T1 (de) | 1993-11-09 | 2004-08-15 | Ohio Med College | Stabile zellinie, die in der lage ist, das replikationsgen des adenoassoziertenvirus zu exprimieren |
| US5658785A (en) | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
| US5623054A (en) | 1994-06-23 | 1997-04-22 | The General Hospital Corporation | Crucifer AFT proteins and uses thereof |
| EP0796339A1 (en) | 1994-12-06 | 1997-09-24 | Targeted Genetics Corporation | Packaging cell lines for generation of high titers of recombinant aav vectors |
| ES2150832B1 (es) | 1996-06-12 | 2001-06-16 | Fichtel & Sachs Ag | Dispositivo de maniobra para la maniobra, en particular maniobra neumatica, de un embrague de friccion. |
| CA2269661A1 (en) | 1996-12-18 | 1998-06-25 | Targeted Genetics Corporation | Recombinase-activatable aav packaging cassettes for use in the production of aav vectors |
| GB9712370D0 (en) * | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
| US6146874A (en) | 1998-05-27 | 2000-11-14 | University Of Florida | Method of preparing recombinant adeno-associated virus compositions |
| EP1074617A3 (en) * | 1999-07-29 | 2004-04-21 | Research Association for Biotechnology | Primers for synthesising full-length cDNA and their use |
| AU1466401A (en) * | 1999-11-04 | 2001-05-14 | Incyte Genomics, Inc. | Human transferase molecules |
| CA2399776A1 (en) * | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US20030175925A1 (en) * | 2001-02-27 | 2003-09-18 | Oleg Kurnasov | Nicotinamide ribonucleoside kinase |
| CA2513148A1 (en) * | 2003-01-23 | 2004-08-05 | Eirx Therapeutics Limited | Kinases and gpcrs involved in apoptosis |
| AU2004315596B2 (en) * | 2003-08-29 | 2011-11-24 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis |
-
2005
- 2005-02-09 CA CA002555675A patent/CA2555675A1/en not_active Abandoned
- 2005-02-09 AU AU2005211773A patent/AU2005211773B2/en not_active Ceased
- 2005-02-09 WO PCT/US2005/004337 patent/WO2005077091A2/en not_active Ceased
- 2005-02-09 EP EP05722944A patent/EP1723227A4/en not_active Withdrawn
- 2005-02-09 JP JP2006553250A patent/JP2007521835A/ja active Pending
-
2006
- 2006-04-20 US US11/912,400 patent/US8197807B2/en active Active
- 2006-10-04 US US11/542,832 patent/US20070027095A1/en not_active Abandoned
-
2012
- 2012-04-12 US US13/445,289 patent/US8383086B2/en active Active
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