JP2007518822A5 - - Google Patents
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- Publication number
- JP2007518822A5 JP2007518822A5 JP2006551391A JP2006551391A JP2007518822A5 JP 2007518822 A5 JP2007518822 A5 JP 2007518822A5 JP 2006551391 A JP2006551391 A JP 2006551391A JP 2006551391 A JP2006551391 A JP 2006551391A JP 2007518822 A5 JP2007518822 A5 JP 2007518822A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- group
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53898004P | 2004-01-23 | 2004-01-23 | |
| PCT/US2005/002270 WO2005070930A2 (en) | 2004-01-23 | 2005-01-24 | Tetrahydrocarboline compounds as anticancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007518822A JP2007518822A (ja) | 2007-07-12 |
| JP2007518822A5 true JP2007518822A5 (ko) | 2008-01-31 |
Family
ID=34807249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551391A Pending JP2007518822A (ja) | 2004-01-23 | 2005-01-24 | 抗癌剤としてのテトラヒドロカルボリン化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7855295B2 (ko) |
| EP (1) | EP1706404A2 (ko) |
| JP (1) | JP2007518822A (ko) |
| CN (1) | CN1910183A (ko) |
| AU (1) | AU2005206570A1 (ko) |
| BR (1) | BRPI0506977A (ko) |
| CA (1) | CA2554150A1 (ko) |
| MX (1) | MXPA06008211A (ko) |
| WO (1) | WO2005070930A2 (ko) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4671123B2 (ja) | 2003-06-23 | 2011-04-13 | 小野薬品工業株式会社 | 新規三環性複素環化合物 |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| SG151267A1 (en) | 2004-03-15 | 2009-04-30 | Ptc Therapeutics Inc | Carboline derivatives useful in the inhibition of angiogenesis |
| EP1829874B1 (en) | 2004-12-22 | 2014-02-12 | Ono Pharmaceutical Co., Ltd. | Tricyclic compound and use thereof |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US20100120717A1 (en) | 2006-10-09 | 2010-05-13 | Brown Jason W | Kinase inhibitors |
| WO2008103470A2 (en) | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| US11202775B2 (en) | 2007-09-25 | 2021-12-21 | Minerva Biotechnologies Corporation | Methods for treatment of cancer |
| WO2009042815A1 (en) * | 2007-09-25 | 2009-04-02 | Minerva Biotechnologies Corp. | Methods for treatment of cancer |
| EP2050747A1 (en) * | 2007-10-12 | 2009-04-22 | BioAlliance Pharma | Dimers of harmol or of its derivatives and uses thereof |
| EP2240481A1 (en) | 2008-01-11 | 2010-10-20 | Albany Molecular Research, Inc. | (1-azinone) -substituted pyridoindoles as mch antagonists |
| CN101591348B (zh) * | 2008-05-30 | 2011-07-27 | 首都医科大学 | 四氢咔啉酰氨基酸苄酯及其制备方法和应用 |
| CN101597289B (zh) * | 2008-06-02 | 2011-09-21 | 首都医科大学 | 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用 |
| JP2012528181A (ja) | 2009-05-27 | 2012-11-12 | ピーティーシー セラピューティクス，インコーポレーテッド | 置換テトラヒドロβ−カルボリンの製造方法 |
| WO2010138685A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
| US8697662B2 (en) | 2009-05-27 | 2014-04-15 | Ptc Therapeutics, Inc. | Methods for treating Kaposi sarcoma |
| PL2434891T3 (pl) | 2009-05-27 | 2020-12-28 | Ptc Therapeutics, Inc. | Sposoby leczenia nowotworu złośliwego i stanów nienowotworowych |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| WO2011003005A1 (en) * | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| US8629158B2 (en) * | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| WO2011003012A1 (en) * | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
| FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
| RU2572818C2 (ru) | 2010-07-06 | 2016-01-20 | Оно Фармасьютикал Ко., Лтд. | Производное тетрагидрокарболина |
| WO2012088124A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof |
| WO2012088038A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof |
| EP2687531B1 (en) | 2011-03-18 | 2016-07-13 | ONO Pharmaceutical Co., Ltd. | Tetrahydrocarboline derivative |
| DK2802328T3 (en) * | 2012-01-09 | 2018-06-14 | X Chem Inc | TRYPTOLIN DERIVATIVES WITH KINASE INHIBITIVE ACTIVITY AND APPLICATIONS THEREOF |
| CN103087062B (zh) * | 2013-01-19 | 2015-06-03 | 安徽师范大学 | N-磺酰基取代-β-四氢咔啉衍生物的制备方法 |
| ES2654161T3 (es) * | 2013-05-28 | 2018-02-12 | Astrazeneca Ab | Compuestos químicos |
| CN113527289A (zh) * | 2015-09-23 | 2021-10-22 | 米纳瓦生物技术公司 | 筛选分化干细胞的试剂的方法 |
| JP2019001715A (ja) * | 2015-10-30 | 2019-01-10 | 協和発酵キリン株式会社 | 三環性化合物 |
| CN107428758B (zh) * | 2015-11-12 | 2020-08-04 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的用途 |
| CN106967063B (zh) * | 2017-03-21 | 2019-01-11 | 浙江大学 | 1-三氟甲基-1,2,3,4-四氢-β-咔啉衍生物及其制备方法 |
| EP3664803A4 (en) | 2017-08-01 | 2021-05-05 | PTC Therapeutics, Inc. | DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS |
| WO2020072675A1 (en) | 2018-10-02 | 2020-04-09 | Northwestern University | Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c) |
| CN110791389B (zh) * | 2019-09-30 | 2021-06-01 | 义乌欧风汽车用品有限公司 | 一种除胶剂及其制备方法和应用 |
| AU2022425632A1 (en) * | 2021-12-31 | 2024-05-30 | Ptc Therapeutics, Inc. | Carboline compounds and use thereof |
| WO2024099898A1 (en) * | 2022-11-07 | 2024-05-16 | Merck Patent Gmbh | Substituted bi-and tricyclic hset inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE136032T1 (de) | 1987-07-20 | 1996-04-15 | Duphar Int Res | 8,9-anellierte 1,2,3,4-tetrahydro-beta-carbolin- derivate |
| EP0357122A3 (en) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties |
| JPH03287586A (ja) | 1990-04-02 | 1991-12-18 | Taisho Pharmaceut Co Ltd | テトラヒドロ―β―カルボリン誘導体 |
| JP3287586B2 (ja) | 1991-07-09 | 2002-06-04 | キヤノン株式会社 | カラー画像処理方法、及びカラー画像処理装置 |
| US5206377A (en) * | 1991-12-05 | 1993-04-27 | Whitby Research, Inc. | Compounds useful as antiproliferative agents |
| US5622960A (en) | 1992-04-14 | 1997-04-22 | The United States Of America As Represented By The Department Of Health And Human Services | Topoisomerase II inhibitors and therapeutic uses therefor |
| PT891187E (pt) | 1996-04-04 | 2002-06-28 | Hoffmann La Roche | Utilizacao de derivados de tetrahidro-beta-carbolinos como agentes antimestaticos |
| FR2796644B1 (fr) | 1999-07-23 | 2001-09-07 | Adir | Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
| US6720331B2 (en) * | 2001-04-03 | 2004-04-13 | National Sun Yat-Sen University | 1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents |
| JP2005508968A (ja) * | 2001-10-19 | 2005-04-07 | トランス テック ファーマ，インコーポレイテッド | ＰＴＰ阻害剤としてのβ−カルボリン誘導体 |
-
2005
- 2005-01-24 JP JP2006551391A patent/JP2007518822A/ja active Pending
- 2005-01-24 EP EP05711958A patent/EP1706404A2/en not_active Withdrawn
- 2005-01-24 CN CNA2005800030203A patent/CN1910183A/zh active Pending
- 2005-01-24 AU AU2005206570A patent/AU2005206570A1/en not_active Abandoned
- 2005-01-24 WO PCT/US2005/002270 patent/WO2005070930A2/en active Application Filing
- 2005-01-24 CA CA002554150A patent/CA2554150A1/en not_active Abandoned
- 2005-01-24 US US11/042,474 patent/US7855295B2/en not_active Expired - Fee Related
- 2005-01-24 MX MXPA06008211A patent/MXPA06008211A/es unknown
- 2005-01-24 BR BRPI0506977-7A patent/BRPI0506977A/pt not_active IP Right Cessation
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