JP2007517886A - 新規な化学化合物 - Google Patents

新規な化学化合物 Download PDF

Info

Publication number
JP2007517886A
JP2007517886A JP2006549383A JP2006549383A JP2007517886A JP 2007517886 A JP2007517886 A JP 2007517886A JP 2006549383 A JP2006549383 A JP 2006549383A JP 2006549383 A JP2006549383 A JP 2006549383A JP 2007517886 A JP2007517886 A JP 2007517886A
Authority
JP
Japan
Prior art keywords
thiazole
carboxylic acid
methoxyphenyl
formula
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006549383A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007517886A5 (https=
Inventor
長谷川 雅一
一也 鹿野
眞人 中野
真理子 山邊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JP2007517886A publication Critical patent/JP2007517886A/ja
Publication of JP2007517886A5 publication Critical patent/JP2007517886A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2006549383A 2004-01-09 2005-01-06 新規な化学化合物 Pending JP2007517886A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53526704P 2004-01-09 2004-01-09
US55197204P 2004-03-10 2004-03-10
PCT/US2005/000303 WO2005070042A2 (en) 2004-01-09 2005-01-06 Novel chemical compounds

Publications (2)

Publication Number Publication Date
JP2007517886A true JP2007517886A (ja) 2007-07-05
JP2007517886A5 JP2007517886A5 (https=) 2007-10-11

Family

ID=34811305

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006549383A Pending JP2007517886A (ja) 2004-01-09 2005-01-06 新規な化学化合物

Country Status (4)

Country Link
US (1) US20090270456A1 (https=)
EP (1) EP1718297A4 (https=)
JP (1) JP2007517886A (https=)
WO (1) WO2005070042A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008543735A (ja) * 2005-05-12 2008-12-04 セントロ デ インジエニエリア ジエネテイカ イ バイオテクノロジア 抗腫瘍化合物及びその医薬組成物
JP2013536193A (ja) * 2010-08-11 2013-09-19 ミレニアム ファーマシューティカルズ, インコーポレイテッド ヘテロアリール類およびその使用
JP2017518309A (ja) * 2014-06-05 2017-07-06 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺虫剤としての二環式化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070083A1 (es) 2005-06-08 2007-01-27 Smithkline Beecham Corp (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona
CA2626789A1 (en) * 2005-10-21 2007-04-26 Exelixis, Inc. Pyrimidinones as casein kinase ii (ck2) modulators
US8105581B2 (en) * 2005-12-01 2012-01-31 The Scripps Research Institute Compositions and methods for inducing neuronal differentiation
US12319713B2 (en) 2018-07-20 2025-06-03 Arkansas State University—Jonesboro 3,4-thiazolo-steroids and methods of making and using the same
WO2023192595A1 (en) * 2022-03-31 2023-10-05 Arkansas State University - Jonesboro Thiazole derivatives and methods of using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057240A1 (en) * 2000-12-22 2002-07-25 Ortho Mc Neil Pharmaceutical, Inc. Substituted triazole diamine derivatives as kinase inhibitors
WO2002081728A2 (en) * 2001-04-06 2002-10-17 Smithkline Beecham Corporation Quinoline inhibitors of hyak1 and hyak3 kinases
EP1321463A1 (en) * 2001-12-21 2003-06-25 Shire Biochem Inc. Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057240A1 (en) * 2000-12-22 2002-07-25 Ortho Mc Neil Pharmaceutical, Inc. Substituted triazole diamine derivatives as kinase inhibitors
WO2002081728A2 (en) * 2001-04-06 2002-10-17 Smithkline Beecham Corporation Quinoline inhibitors of hyak1 and hyak3 kinases
EP1321463A1 (en) * 2001-12-21 2003-06-25 Shire Biochem Inc. Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6010063084, DRIDI,K. et al, "Reaction of mercaptoacetate and halides containing activated methylenes with thiocarbamoylimidates:", Synthetic Communications, 1998, Vol.28, No.1, p.167−174 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008543735A (ja) * 2005-05-12 2008-12-04 セントロ デ インジエニエリア ジエネテイカ イ バイオテクノロジア 抗腫瘍化合物及びその医薬組成物
JP2013536193A (ja) * 2010-08-11 2013-09-19 ミレニアム ファーマシューティカルズ, インコーポレイテッド ヘテロアリール類およびその使用
JP2017518309A (ja) * 2014-06-05 2017-07-06 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺虫剤としての二環式化合物

Also Published As

Publication number Publication date
EP1718297A2 (en) 2006-11-08
US20090270456A1 (en) 2009-10-29
WO2005070042A2 (en) 2005-08-04
WO2005070042A3 (en) 2005-09-29
EP1718297A4 (en) 2009-09-02
WO2005070042A8 (en) 2006-08-24

Similar Documents

Publication Publication Date Title
EP1567112B1 (en) THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS
TWI791511B (zh) 細胞凋亡誘導劑
JP5463592B2 (ja) アデノシンa1レセプターアンタゴニストとしての新規化合物
WO2017076346A1 (zh) 作为tlr7激动剂的7-(噻唑-5-基)吡咯并嘧啶化合物
HU230059B1 (hu) Szubsztituált 2-tio-3,5-diciano-4-fenil-6-aminopiridinek, előállításuk, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
US20190352268A1 (en) Cannabinoid receptor mediating compounds
EP2919779A1 (en) Cannabinoid receptor mediating compounds
US20070249599A1 (en) Novel Chemical Compounds
JP2007520558A (ja) キナーゼ阻害剤として有用なピリミジノン化合物
JP4622047B2 (ja) 新規なヘテロ環カルボキサミド誘導体
JP2007517886A (ja) 新規な化学化合物
JP2007525475A (ja) 新規化学化合物
US20070072901A1 (en) 1-Amino-isoquinoline derivatives for the treatment of diseases associated with inappropriate alk5
CN101155791A (zh) 作为极体样激酶(plk)抑制剂药剂的噻唑烷酮
US7507834B2 (en) Substituted anilinopyrazoles
HK1083443B (en) Thiazolidin-4-ones for inhibiting hyak3 proteins
HK1114615A (en) Thiazolidinones as inhibitors of polo-like kinases (plk) as pharmaceutical agents

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070823

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070823

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101109

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110405