JP2007516843A5 - - Google Patents
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- JP2007516843A5 JP2007516843A5 JP2006535455A JP2006535455A JP2007516843A5 JP 2007516843 A5 JP2007516843 A5 JP 2007516843A5 JP 2006535455 A JP2006535455 A JP 2006535455A JP 2006535455 A JP2006535455 A JP 2006535455A JP 2007516843 A5 JP2007516843 A5 JP 2007516843A5
- Authority
- JP
- Japan
- Prior art keywords
- target
- interaction
- nanostructure
- binding
- electric field
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003993 interaction Effects 0.000 claims 8
- 239000002086 nanomaterial Substances 0.000 claims 7
- 230000005684 electric field Effects 0.000 claims 5
- 230000001808 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000002441 reversible Effects 0.000 claims 3
- 229960001456 Adenosine Triphosphate Drugs 0.000 claims 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 claims 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-N Nicotinamide adenine dinucleotide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 238000004166 bioassay Methods 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 229940052665 NADH Drugs 0.000 claims 1
- 229920000272 Oligonucleotide Polymers 0.000 claims 1
- 238000001069 Raman spectroscopy Methods 0.000 claims 1
- 238000001237 Raman spectrum Methods 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 230000005489 elastic deformation Effects 0.000 claims 1
- 230000005611 electricity Effects 0.000 claims 1
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 230000005389 magnetism Effects 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 229950006238 nadide Drugs 0.000 claims 1
- 230000003287 optical Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
Claims (23)
- ナノ構造体および関連する構造体を標的に結合させ、ナノ構造体、関連する構造体、および標的の間の相互作用を可逆的に変化させることを含む方法。
- 前記可逆的変化が適用されるエネルギーに応答する、請求項1の方法。
- 前記適用されるエネルギーが、以下の:a)電界、b)DC電界、c)AC電界、d)容量電界、e)熱、f)電気、g)化学的、h)アデノシン三リン酸(ATP)、i)ニコチンアミドアデニンジヌクレオチド(NADH)、j)光量子性、k)磁性、l)動力学的、m)音響、n)超音波、o)マイクロ波、及びp)放射線、のうちの1つである、請求項2の方法。
- 前記可逆的変化が以下の:a)変形、b)弾性変形、c)非弾性変形、d)可塑性変形、e)角運動、f)分離距離、g)回転、h)直線変位及びi)らせん運動のうちの1つである、請求項1の方法。
- 前記可逆的変化が剪断力に対する応答である、請求項1の方法。
- 前記相互作用が共鳴エネルギーである、請求項1の方法。
- 前記共鳴エネルギーが双極子カプリング、4極子カプリング又は蛍光共鳴エネルギー移動である、請求項6の方法。
- 前記相互作用がプラスモン、近接場カプリング、光量子性、容量性、磁性、又は静電性である、請求項1の方法。
- 前記方法が、前記相互作用から生じる変化した特性を検出することをさらに含む、請求項1の方法。
- 前記変化した特性が発光、蛍光、光学的性質、色、磁界、電界、表面増強ラマン分散(SERS)またはラマンスペクトルの変化である、請求項9の方法。
- 前記ナノ構造体、前記関連する構造体、および前記標的の間の前記相互作用を可逆的に変化させることが空間的に独立している、請求項1の方法。
- 前記相互作用がa)溶液中、b)予めの情報のない固定された位置で、c)均一測定法において、d)不均一測定法において、又はe)インサイチュ測定法において起きる、請求項11の方法。
- 前記相互作用が予めの情報のある固定された位置で起きる、請求項11の方法。
- 前記方法がマイクロアレイまたはナノアレイ上で行われる、請求項13の方法。
- 以下の工程:
a. ナノ構造体を標的に結合させる工程;
b. 関連する構造体を標的に結合させる工程;
c. 前記ナノ構造体、前記関連する構造体、および前記標的間の相互作用を可逆的に変化させて情報を発生させる工程;および
d. 前記情報を検出する工程
を含む方法。 - 前記標的がa)核酸、b)タンパク質、c)無機表面又はd)ゲノム核酸である、請求項15の方法。
- 生物学的試料中の標的を検出することをさらに含む、請求項15の方法。
- 前記生物学的試料が顕微鏡スライド上の細胞または組織試料である、請求項17の方法。
- 前記標的が核酸である、請求項18の方法。
- 請求項15の方法であって、前記ナノ構造体が、所定の標的に対して選択的である標的結合要素をそこに結合して有する第1の標的結合領域をさらに有し;ここで、前記関連する構造体が、同じ所定の標的に対して選択的である第2の標的結合要素をそこに結合して有する第2の標的結合領域をさらに含んでなる、上記方法。
- 前記第1および第2の標的結合要素がオリゴヌクレオチドである、請求項20の方法。
- 前記標的が抗原であり、前記第1および第2の標的結合要素が、前記抗原に結合する抗体である、請求項20の方法。
- 溶液中で実施できるように改変され、工程c.が前記溶液から前記ナノ構造体または前記関連する構造体を取り出すことなく行われる、請求項15の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51304203P | 2003-10-20 | 2003-10-20 | |
PCT/US2004/034844 WO2005040755A2 (en) | 2003-10-20 | 2004-10-20 | Nanoscale transduction systems for detecting molecular interactions |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007516843A JP2007516843A (ja) | 2007-06-28 |
JP2007516843A5 true JP2007516843A5 (ja) | 2007-11-08 |
Family
ID=34520070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006535455A Pending JP2007516843A (ja) | 2003-10-20 | 2004-10-20 | 分子相互作用を検出するためのナノスケール変換システム |
Country Status (4)
Country | Link |
---|---|
US (1) | US20050176029A1 (ja) |
EP (1) | EP1678495A4 (ja) |
JP (1) | JP2007516843A (ja) |
WO (1) | WO2005040755A2 (ja) |
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US9868991B2 (en) * | 2010-03-26 | 2018-01-16 | The Regents Of The University Of California | Nanomotors and motion-based detection of biomolecular interactions |
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US10656149B2 (en) * | 2013-03-15 | 2020-05-19 | The Trustees Of Princeton University | Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis |
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US10792194B2 (en) | 2014-08-26 | 2020-10-06 | Curt G. Joa, Inc. | Apparatus and methods for securing elastic to a carrier web |
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-
2004
- 2004-10-20 EP EP04795939A patent/EP1678495A4/en not_active Ceased
- 2004-10-20 JP JP2006535455A patent/JP2007516843A/ja active Pending
- 2004-10-20 WO PCT/US2004/034844 patent/WO2005040755A2/en active Application Filing
- 2004-10-20 US US10/970,756 patent/US20050176029A1/en not_active Abandoned
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