JP2007516200A - α７ニコチン性アセチルコリン受容体に親和性を有するスピロ［１−アザビシクロ［２，２，２］オクタン−３，５’−オキサゾリジン］−２’−オン誘導体 - Google Patents
α７ニコチン性アセチルコリン受容体に親和性を有するスピロ［１−アザビシクロ［２，２，２］オクタン−３，５’−オキサゾリジン］−２’−オン誘導体 Download PDFInfo
- Publication number
- JP2007516200A JP2007516200A JP2006518343A JP2006518343A JP2007516200A JP 2007516200 A JP2007516200 A JP 2007516200A JP 2006518343 A JP2006518343 A JP 2006518343A JP 2006518343 A JP2006518343 A JP 2006518343A JP 2007516200 A JP2007516200 A JP 2007516200A
- Authority
- JP
- Japan
- Prior art keywords
- azabicyclo
- octane
- spiro
- oxazolidine
- thiophen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*(C[C@]1(C(CC2)CC*2C1)O1)C1=O Chemical compound C*(C[C@]1(C(CC2)CC*2C1)O1)C1=O 0.000 description 4
- OZZAIWJWSOXADJ-GFCCVEGCSA-N CC(C)N(C[C@]1(C(CC2)CCN2C1)O1)C1=O Chemical compound CC(C)N(C[C@]1(C(CC2)CCN2C1)O1)C1=O OZZAIWJWSOXADJ-GFCCVEGCSA-N 0.000 description 1
- PCLJPJDFFBIZIP-JTQLQIEISA-N CN(C[C@]1(C(CC2)CCN2C1)O1)C1=O Chemical compound CN(C[C@]1(C(CC2)CCN2C1)O1)C1=O PCLJPJDFFBIZIP-JTQLQIEISA-N 0.000 description 1
- XQDQRGMEQFOARI-UHFFFAOYSA-N O=C(N(C1)c2c[o]c(-c3ccccn3)c2)OC11C(CC2)CCN2C1 Chemical compound O=C(N(C1)c2c[o]c(-c3ccccn3)c2)OC11C(CC2)CCN2C1 XQDQRGMEQFOARI-UHFFFAOYSA-N 0.000 description 1
- XTRRCXIRWJJOSX-UHFFFAOYSA-N O=C(N(C1)c2ccc(-c3c[s]cc3)[s]2)OC11C(CC2)CCN2C1 Chemical compound O=C(N(C1)c2ccc(-c3c[s]cc3)[s]2)OC11C(CC2)CCN2C1 XTRRCXIRWJJOSX-UHFFFAOYSA-N 0.000 description 1
- ABONEISZOLWBCL-UHFFFAOYSA-N O=C(N(C1)c2ccc(-c3cccnc3)[s]2)OC11C(CC2)CCN2C1 Chemical compound O=C(N(C1)c2ccc(-c3cccnc3)[s]2)OC11C(CC2)CCN2C1 ABONEISZOLWBCL-UHFFFAOYSA-N 0.000 description 1
- PVGGZMABRLAWMR-UHFFFAOYSA-N O=C(N(C1)c2ccc(-c3cnccn3)[s]2)OC11C(CC2)CCN2C1 Chemical compound O=C(N(C1)c2ccc(-c3cnccn3)[s]2)OC11C(CC2)CCN2C1 PVGGZMABRLAWMR-UHFFFAOYSA-N 0.000 description 1
- TYAGAVRSOFABFO-VIFPVBQESA-N O=C(NC1)O[C@@]11C(CC2)CCN2C1 Chemical compound O=C(NC1)O[C@@]11C(CC2)CCN2C1 TYAGAVRSOFABFO-VIFPVBQESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48552303P | 2003-07-08 | 2003-07-08 | |
| PCT/GB2004/002904 WO2005005435A1 (en) | 2003-07-08 | 2004-07-06 | Spiro ′1-azabicyclo ′2.2.2!octan-3,5′-oxazolidin -2′-one! derivatives with affinity to the alpha7 nicotinic acetylcholine receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007516200A true JP2007516200A (ja) | 2007-06-21 |
| JP2007516200A5 JP2007516200A5 (https=) | 2007-08-09 |
Family
ID=34062082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006518343A Pending JP2007516200A (ja) | 2003-07-08 | 2004-07-06 | α７ニコチン性アセチルコリン受容体に親和性を有するスピロ［１−アザビシクロ［２，２，２］オクタン−３，５’−オキサゾリジン］−２’−オン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7514567B2 (https=) |
| EP (1) | EP1654264A1 (https=) |
| JP (1) | JP2007516200A (https=) |
| KR (1) | KR20060057569A (https=) |
| CN (1) | CN1829721A (https=) |
| AR (1) | AR045040A1 (https=) |
| AU (1) | AU2004255920B2 (https=) |
| BR (1) | BRPI0412382A (https=) |
| CA (1) | CA2531510A1 (https=) |
| IL (1) | IL172762A0 (https=) |
| MX (1) | MXPA06000231A (https=) |
| NO (1) | NO20060612L (https=) |
| NZ (1) | NZ545132A (https=) |
| SA (1) | SA04250212B1 (https=) |
| TW (1) | TW200524942A (https=) |
| WO (1) | WO2005005435A1 (https=) |
| ZA (1) | ZA200600154B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013503152A (ja) * | 2009-08-27 | 2013-01-31 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | オリゴフラン類、ポリフラン類、それらの作製および使用 |
| JP2013525288A (ja) * | 2010-04-16 | 2013-06-20 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 有害生物防除薬としての新規な複素環化合物 |
| JP2013535442A (ja) * | 2010-07-22 | 2013-09-12 | ノバルティス アーゲー | ２，３，５−三置換チオフェン化合物およびそれらの使用 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007006743A (es) * | 2004-12-15 | 2007-07-09 | Astrazeneca Ab | Ligandos del receptor de acetilcolina nicotinica. |
| WO2008021309A1 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Imidazolidin-2-one derivatives useful as pr modulators |
| WO2008021338A2 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Tricyclic oxazolidone derivatives useful as pr modulators |
| TW200815428A (en) | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
| US7538107B2 (en) | 2006-08-15 | 2009-05-26 | Wyeth | Oxazinan-2-one derivatives useful as PR modulators |
| US7649007B2 (en) | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
| US20100105685A1 (en) * | 2006-10-03 | 2010-04-29 | Galleon Pharmaceuticals, Inc. | S-Nitrosothiol Compounds and Related Derivatives |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| US8309577B2 (en) | 2008-04-23 | 2012-11-13 | Bristol-Myers Squibb Company | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands |
| US7863291B2 (en) * | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
| EP2583556B1 (de) * | 2008-07-17 | 2016-01-20 | Bayer CropScience AG | Heterocyclische Verbindungen als Schädlingsbekämpfungsmittel |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| UA107791C2 (en) * | 2009-05-05 | 2015-02-25 | Dow Agrosciences Llc | Pesticidal compositions |
| US8278320B2 (en) | 2009-10-28 | 2012-10-02 | Bristol-Myers Squibb Company | Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands |
| WO2011056573A1 (en) | 2009-10-28 | 2011-05-12 | Bristol-Myers Squibb Company | Azabicyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands |
| CN103025744A (zh) | 2010-04-30 | 2013-04-03 | 百时美施贵宝公司 | 作为α-7烟碱乙酰胆碱受体配体前药的氮杂二环胺N-氧化物化合物 |
| BR112013009823A2 (pt) | 2010-10-22 | 2016-07-05 | Bayer Ip Gmbh | novos compostos heterocíclicos como pesticidas |
| WO2013138617A1 (en) | 2012-03-16 | 2013-09-19 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
| JP2016503395A (ja) | 2012-10-31 | 2016-02-04 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 病害生物防除剤としての複素環化合物 |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| TWI703133B (zh) | 2014-12-23 | 2020-09-01 | 美商艾克斯基製藥公司 | ３,５-二胺基吡唑激酶抑制劑 |
| MX388576B (es) | 2016-06-07 | 2025-03-20 | Jacobio Pharmaceuticals Co Ltd | Derivados heterociclicos novedosos utiles como inhibidores de shp2. |
| EA202190196A1 (ru) | 2017-03-23 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| US20210393623A1 (en) | 2018-09-26 | 2021-12-23 | Jacobio Pharmaceuticals Co., Ltd. | Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61280497A (ja) * | 1985-05-10 | 1986-12-11 | イスラエル国 | キヌクリジン誘導体 |
| WO2001066546A1 (en) * | 2000-03-09 | 2001-09-13 | Mitsubishi Pharma Corporation | Spiro compounds, process for preparing the same and use thereof as drugs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE192157T1 (de) * | 1994-08-24 | 2000-05-15 | Astra Ab | Therapeutisch verwendbare spiro-azabicyclische verbindungen |
-
2004
- 2004-07-06 CN CNA2004800218491A patent/CN1829721A/zh active Pending
- 2004-07-06 MX MXPA06000231A patent/MXPA06000231A/es active IP Right Grant
- 2004-07-06 AU AU2004255920A patent/AU2004255920B2/en not_active Ceased
- 2004-07-06 KR KR1020067000400A patent/KR20060057569A/ko not_active Ceased
- 2004-07-06 US US10/563,271 patent/US7514567B2/en not_active Expired - Fee Related
- 2004-07-06 BR BRPI0412382-4A patent/BRPI0412382A/pt not_active IP Right Cessation
- 2004-07-06 EP EP04743249A patent/EP1654264A1/en not_active Withdrawn
- 2004-07-06 WO PCT/GB2004/002904 patent/WO2005005435A1/en not_active Ceased
- 2004-07-06 CA CA002531510A patent/CA2531510A1/en not_active Abandoned
- 2004-07-06 JP JP2006518343A patent/JP2007516200A/ja active Pending
- 2004-07-06 NZ NZ545132A patent/NZ545132A/en unknown
- 2004-07-07 AR ARP040102394A patent/AR045040A1/es not_active Application Discontinuation
- 2004-07-08 TW TW093120518A patent/TW200524942A/zh unknown
- 2004-07-11 SA SA04250212A patent/SA04250212B1/ar unknown
-
2005
- 2005-12-22 IL IL172762A patent/IL172762A0/en unknown
-
2006
- 2006-01-06 ZA ZA200600154A patent/ZA200600154B/en unknown
- 2006-02-08 NO NO20060612A patent/NO20060612L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61280497A (ja) * | 1985-05-10 | 1986-12-11 | イスラエル国 | キヌクリジン誘導体 |
| WO2001066546A1 (en) * | 2000-03-09 | 2001-09-13 | Mitsubishi Pharma Corporation | Spiro compounds, process for preparing the same and use thereof as drugs |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013503152A (ja) * | 2009-08-27 | 2013-01-31 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | オリゴフラン類、ポリフラン類、それらの作製および使用 |
| JP2013525288A (ja) * | 2010-04-16 | 2013-06-20 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 有害生物防除薬としての新規な複素環化合物 |
| JP2013535442A (ja) * | 2010-07-22 | 2013-09-12 | ノバルティス アーゲー | ２，３，５−三置換チオフェン化合物およびそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ545132A (en) | 2009-07-31 |
| CA2531510A1 (en) | 2005-01-20 |
| NO20060612L (no) | 2006-04-06 |
| AR045040A1 (es) | 2005-10-12 |
| AU2004255920A1 (en) | 2005-01-20 |
| US20060154945A1 (en) | 2006-07-13 |
| SA04250212B1 (ar) | 2009-08-11 |
| EP1654264A1 (en) | 2006-05-10 |
| CN1829721A (zh) | 2006-09-06 |
| TW200524942A (en) | 2005-08-01 |
| US7514567B2 (en) | 2009-04-07 |
| AU2004255920B2 (en) | 2008-05-15 |
| ZA200600154B (en) | 2007-04-25 |
| KR20060057569A (ko) | 2006-05-26 |
| MXPA06000231A (es) | 2006-04-11 |
| WO2005005435A1 (en) | 2005-01-20 |
| IL172762A0 (en) | 2006-04-10 |
| BRPI0412382A (pt) | 2006-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007516200A (ja) | α７ニコチン性アセチルコリン受容体に親和性を有するスピロ［１−アザビシクロ［２，２，２］オクタン−３，５’−オキサゾリジン］−２’−オン誘導体 | |
| AU2003224546B2 (en) | Heterocyclic compounds | |
| EP1539765B1 (en) | Biaryl diazabicycloalkane amides as nicotinic acetylcholine agonists | |
| RU2263114C2 (ru) | Соединения, лекарственные средства, способы лечения, способ получения соединений | |
| AU2003248590B2 (en) | Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists | |
| KR20040099448A (ko) | 티에닐 화합물 | |
| JP2008524208A (ja) | ニコチン性アセチルコリン受容体リガンド | |
| JP2007515479A (ja) | ニコチン性アセチルコリンレセプターリガンド | |
| EP1831212A1 (en) | Nicotinic acetycholine receptor ligands | |
| HK1077571B (en) | Biaryl diazabicycloalkane amides as nicotinic acetylcholine agonists | |
| CN101124232A (zh) | 烟碱乙酰胆碱受体的配体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070619 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070619 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100817 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20110201 |