JP2007515477A5 - - Google Patents
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- Publication number
- JP2007515477A5 JP2007515477A5 JP2006546907A JP2006546907A JP2007515477A5 JP 2007515477 A5 JP2007515477 A5 JP 2007515477A5 JP 2006546907 A JP2006546907 A JP 2006546907A JP 2006546907 A JP2006546907 A JP 2006546907A JP 2007515477 A5 JP2007515477 A5 JP 2007515477A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound
- alkyl
- imidazol
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 119
- 125000000217 alkyl group Chemical group 0.000 claims 72
- 229910052757 nitrogen Inorganic materials 0.000 claims 57
- 125000003545 alkoxy group Chemical group 0.000 claims 56
- -1 pyridinyloxy, morpholinyloxy Chemical group 0.000 claims 47
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 30
- 229910052736 halogen Inorganic materials 0.000 claims 22
- 150000002367 halogens Chemical class 0.000 claims 22
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 17
- 229910052799 carbon Inorganic materials 0.000 claims 16
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 125000004104 aryloxy group Chemical group 0.000 claims 12
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 12
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 125000002541 furyl group Chemical group 0.000 claims 4
- 125000002883 imidazolyl group Chemical group 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- 125000000335 thiazolyl group Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 3
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006720 (C1-C6) alkyl (C6-C10) aryl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- VREFAMCZIOMYFK-UHFFFAOYSA-N 2-[[6,7-dimethoxy-2-(thiophen-3-ylmethyl)-3,4-dihydro-1h-isoquinolin-1-yl]methoxy]-n,n-diethylbenzamide Chemical compound CCN(CC)C(=O)C1=CC=CC=C1OCC1C2=CC(OC)=C(OC)C=C2CCN1CC1=CSC=C1 VREFAMCZIOMYFK-UHFFFAOYSA-N 0.000 claims 1
- PCNIPVVBTMMIEQ-UHFFFAOYSA-N 2-[[6,7-dimethoxy-2-[(2-phenyl-1h-imidazol-5-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]methoxy]-n,n-diethylbenzamide Chemical compound CCN(CC)C(=O)C1=CC=CC=C1OCC1C2=CC(OC)=C(OC)C=C2CCN1CC1=CN=C(C=2C=CC=CC=2)N1 PCNIPVVBTMMIEQ-UHFFFAOYSA-N 0.000 claims 1
- YUGWMYFHKHHGNI-UHFFFAOYSA-N 3-[[6,7-dimethoxy-2-(thiophen-3-ylmethyl)-3,4-dihydro-1h-isoquinolin-1-yl]methoxy]-n,n-diethylbenzamide Chemical compound CCN(CC)C(=O)C1=CC=CC(OCC2C3=CC(OC)=C(OC)C=C3CCN2CC2=CSC=C2)=C1 YUGWMYFHKHHGNI-UHFFFAOYSA-N 0.000 claims 1
- YMEOEBRFNSUUJT-UHFFFAOYSA-N 4-[2-[(1,5-dimethylimidazol-4-yl)methyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=C(C)N(C)C=N1 YMEOEBRFNSUUJT-UHFFFAOYSA-N 0.000 claims 1
- LXJCTHZOSGFCOP-UHFFFAOYSA-N 4-[2-[(2-butyl-1h-imidazol-5-yl)methyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound N1C(CCCC)=NC=C1CN1C(C=2C=CC(=CC=2)C(=O)N(CC)CC)C2=CC(OC)=C(OC)C=C2CC1 LXJCTHZOSGFCOP-UHFFFAOYSA-N 0.000 claims 1
- HLIMTWYICXMCKD-UHFFFAOYSA-N 4-[2-[(3,5-dimethylimidazol-4-yl)methyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=C(C)N=CN1C HLIMTWYICXMCKD-UHFFFAOYSA-N 0.000 claims 1
- QIDJKUJBUGYBGE-UHFFFAOYSA-N 4-[2-[(3-benzylimidazol-4-yl)methyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=CN=CN1CC1=CC=CC=C1 QIDJKUJBUGYBGE-UHFFFAOYSA-N 0.000 claims 1
- RTVCFKQAEIZFJM-UHFFFAOYSA-N 4-[2-[[1-(benzenesulfonyl)pyrrol-2-yl]methyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=CC=CN1S(=O)(=O)C1=CC=CC=C1 RTVCFKQAEIZFJM-UHFFFAOYSA-N 0.000 claims 1
- UQNRRKMVXSBYTQ-UHFFFAOYSA-N 4-[5,8-dimethoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=C(OC)C=CC(OC)=C2CCN1CC1=C(C)N=CN1 UQNRRKMVXSBYTQ-UHFFFAOYSA-N 0.000 claims 1
- CSMQPIOAAYGZBR-UHFFFAOYSA-N 4-[6,7-dihydroxy-2-[(2-phenyl-1h-imidazol-5-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(O)=C(O)C=C2CCN1CC1=CN=C(C=2C=CC=CC=2)N1 CSMQPIOAAYGZBR-UHFFFAOYSA-N 0.000 claims 1
- DNYYISMHVHKZFO-UHFFFAOYSA-N 4-[6,7-dimethoxy-2-[(1-methylimidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=CN(C)C=N1 DNYYISMHVHKZFO-UHFFFAOYSA-N 0.000 claims 1
- RLXZTGFVQYNTBF-UHFFFAOYSA-N 4-[6,7-dimethoxy-2-[(2-methyl-1h-imidazol-5-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=CN=C(C)N1 RLXZTGFVQYNTBF-UHFFFAOYSA-N 0.000 claims 1
- LAPVPKCOLXGDNG-UHFFFAOYSA-N 4-[6,7-dimethoxy-2-[(2-phenyl-1,3-thiazol-5-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=CN=C(C=2C=CC=CC=2)S1 LAPVPKCOLXGDNG-UHFFFAOYSA-N 0.000 claims 1
- NYFWHBSSQCPVDB-UHFFFAOYSA-N 4-[6,7-dimethoxy-2-[(2-phenyl-1h-imidazol-5-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=CN=C(C=2C=CC=CC=2)N1 NYFWHBSSQCPVDB-UHFFFAOYSA-N 0.000 claims 1
- PJBHDWCFWIINNR-UHFFFAOYSA-N 4-[6,7-dimethoxy-2-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=CN=CN1C PJBHDWCFWIINNR-UHFFFAOYSA-N 0.000 claims 1
- IXOHGORMTFULBX-UHFFFAOYSA-N 4-[6,7-dimethoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=C(C)N=CN1 IXOHGORMTFULBX-UHFFFAOYSA-N 0.000 claims 1
- KWNILKNTIZGZCC-UHFFFAOYSA-N 4-[6,7-dimethoxy-2-[(5-phenyl-1h-pyrazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=CNN=C1C1=CC=CC=C1 KWNILKNTIZGZCC-UHFFFAOYSA-N 0.000 claims 1
- KSSJGEKLMMDTLQ-UHFFFAOYSA-N 4-[6-bromo-7-methoxy-2-[(2-phenyl-1h-imidazol-5-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(Br)C=C2CCN1CC1=CN=C(C=2C=CC=CC=2)N1 KSSJGEKLMMDTLQ-UHFFFAOYSA-N 0.000 claims 1
- CZZSAHANBRGYFL-UHFFFAOYSA-N 4-[6-bromo-7-methoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(Br)C=C2CCN1CC1=C(C)N=CN1 CZZSAHANBRGYFL-UHFFFAOYSA-N 0.000 claims 1
- GFURLOQVALNNMF-UHFFFAOYSA-N 4-[7-cyclobutyloxy-6-methoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC3CCC3)=C(OC)C=C2CCN1CC1=C(C)NC=N1 GFURLOQVALNNMF-UHFFFAOYSA-N 0.000 claims 1
- BBKPBEBXRQQPPA-UHFFFAOYSA-N 4-[7-ethoxy-6-methoxy-2-[(2-phenyl-1h-imidazol-5-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1CC=2C=C(OC)C(OCC)=CC=2C(C=2C=CC(=CC=2)C(=O)N(CC)CC)N1CC(N=1)=CNC=1C1=CC=CC=C1 BBKPBEBXRQQPPA-UHFFFAOYSA-N 0.000 claims 1
- XYBVLVCXDNHTLD-UHFFFAOYSA-N 4-[7-ethoxy-6-methoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]-n,n-diethylbenzamide Chemical compound C1CC=2C=C(OC)C(OCC)=CC=2C(C=2C=CC(=CC=2)C(=O)N(CC)CC)N1CC=1N=CNC=1C XYBVLVCXDNHTLD-UHFFFAOYSA-N 0.000 claims 1
- FEHOIKSXGRBMMF-UHFFFAOYSA-N 4-[[6,7-dimethoxy-2-(thiophen-3-ylmethyl)-3,4-dihydro-1h-isoquinolin-1-yl]methoxy]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1OCC1C2=CC(OC)=C(OC)C=C2CCN1CC1=CSC=C1 FEHOIKSXGRBMMF-UHFFFAOYSA-N 0.000 claims 1
- NSOAYVKNFNTRAX-UHFFFAOYSA-N 4-[[6,7-dimethoxy-2-[(2-phenyl-1h-imidazol-5-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1CC1C2=CC(OC)=C(OC)C=C2CCN1CC1=CN=C(C=2C=CC=CC=2)N1 NSOAYVKNFNTRAX-UHFFFAOYSA-N 0.000 claims 1
- IDXRLCDAGBGJRD-UHFFFAOYSA-N 4-[[6,7-dimethoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]methoxy]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1OCC1C2=CC(OC)=C(OC)C=C2CCN1CC1=C(C)N=CN1 IDXRLCDAGBGJRD-UHFFFAOYSA-N 0.000 claims 1
- DWFHPRDETZVXGK-UHFFFAOYSA-N 4-[[6,7-dimethoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1CC1C2=CC(OC)=C(OC)C=C2CCN1CC1=C(C)N=CN1 DWFHPRDETZVXGK-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 1
- 239000003377 acid catalyst Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- YYHVNVYLIBPECH-UHFFFAOYSA-N methyl 5-[[1-[4-(diethylcarbamoyl)phenyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl]methyl]-1h-imidazole-4-carboxylate Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OC)=C(OC)C=C2CCN1CC1=C(C(=O)OC)N=CN1 YYHVNVYLIBPECH-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- TUJLLQUBRGSHJV-XMMPIXPASA-N n,n-diethyl-4-[(1r)-6-hydroxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]benzamide Chemical class C1=CC(C(=O)N(CC)CC)=CC=C1[C@@H]1C2=CC=C(O)C=C2CCN1CC1=C(C)N=CN1 TUJLLQUBRGSHJV-XMMPIXPASA-N 0.000 claims 1
- VCXYSWWAKZPWAW-RUZDIDTESA-N n,n-diethyl-4-[(1r)-6-methoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1[C@@H]1C2=CC=C(OC)C=C2CCN1CC1=C(C)N=CN1 VCXYSWWAKZPWAW-RUZDIDTESA-N 0.000 claims 1
- TUJLLQUBRGSHJV-DEOSSOPVSA-N n,n-diethyl-4-[(1s)-6-hydroxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1[C@H]1C2=CC=C(O)C=C2CCN1CC1=C(C)N=CN1 TUJLLQUBRGSHJV-DEOSSOPVSA-N 0.000 claims 1
- VCXYSWWAKZPWAW-VWLOTQADSA-N n,n-diethyl-4-[(1s)-6-methoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1[C@H]1C2=CC=C(OC)C=C2CCN1CC1=C(C)N=CN1 VCXYSWWAKZPWAW-VWLOTQADSA-N 0.000 claims 1
- TUJLLQUBRGSHJV-UHFFFAOYSA-N n,n-diethyl-4-[6-hydroxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC=C(O)C=C2CCN1CC1=C(C)N=CN1 TUJLLQUBRGSHJV-UHFFFAOYSA-N 0.000 claims 1
- VCXYSWWAKZPWAW-UHFFFAOYSA-N n,n-diethyl-4-[6-methoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydro-1h-isoquinolin-1-yl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC=C(OC)C=C2CCN1CC1=C(C)N=CN1 VCXYSWWAKZPWAW-UHFFFAOYSA-N 0.000 claims 1
- WIJVSWRXXBWDJW-UHFFFAOYSA-N n,n-diethyl-4-[6-methoxy-2-[(5-methyl-1h-imidazol-4-yl)methyl]-7-phenylmethoxy-3,4-dihydro-1h-isoquinolin-1-yl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C1C2=CC(OCC=3C=CC=CC=3)=C(OC)C=C2CCN1CC1=C(C)NC=N1 WIJVSWRXXBWDJW-UHFFFAOYSA-N 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000005551 pyridylene group Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- AYOCQODSVOEOHO-UHFFFAOYSA-N NC(OC(N)=O)=O Chemical compound NC(OC(N)=O)=O AYOCQODSVOEOHO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0303542A SE0303542D0 (sv) | 2003-12-22 | 2003-12-22 | 1,2,3,4-Tetrahydroisoquinoline derivaties, preparations thereof and uses thereof |
| PCT/SE2004/001939 WO2005061484A1 (en) | 2003-12-22 | 2004-12-20 | 1,2,3,4-tetrahydroisoquinoline derivatives, preparations thereof and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007515477A JP2007515477A (ja) | 2007-06-14 |
| JP2007515477A5 true JP2007515477A5 (https=) | 2008-01-24 |
Family
ID=30768857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546907A Pending JP2007515477A (ja) | 2003-12-22 | 2004-12-20 | １，２，３，４−テトラヒドロイソキノリン誘導体、それらの製造法および使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090023728A1 (https=) |
| EP (1) | EP1699779A1 (https=) |
| JP (1) | JP2007515477A (https=) |
| KR (1) | KR20060127903A (https=) |
| CN (1) | CN1918147A (https=) |
| AU (1) | AU2004303736B2 (https=) |
| BR (1) | BRPI0417936A (https=) |
| CA (1) | CA2550643A1 (https=) |
| IL (1) | IL176074A0 (https=) |
| MX (1) | MXPA06007040A (https=) |
| NO (1) | NO20063353L (https=) |
| SE (1) | SE0303542D0 (https=) |
| WO (1) | WO2005061484A1 (https=) |
| ZA (1) | ZA200605026B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105130893B (zh) * | 2015-09-08 | 2018-04-10 | 大连理工大学 | 一种1‑苄基‑6‑甲氧羰甲基四氢异喹啉衍生物、制备方法及其抗血小板聚集的应用 |
| RU2020126188A (ru) * | 2018-01-10 | 2022-02-10 | Альинки Байофарма | Соединения тетрагидроизохинолина |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003218374A1 (en) * | 2002-03-28 | 2003-10-13 | Neurogen Corporation | Substituted tetrahydroisoquinolines as c5a receptor modulators |
-
2003
- 2003-12-22 SE SE0303542A patent/SE0303542D0/xx unknown
-
2004
- 2004-12-20 BR BRPI0417936-6A patent/BRPI0417936A/pt not_active IP Right Cessation
- 2004-12-20 EP EP04809112A patent/EP1699779A1/en not_active Withdrawn
- 2004-12-20 CA CA002550643A patent/CA2550643A1/en not_active Abandoned
- 2004-12-20 US US10/596,546 patent/US20090023728A1/en not_active Abandoned
- 2004-12-20 KR KR1020067014795A patent/KR20060127903A/ko not_active Withdrawn
- 2004-12-20 WO PCT/SE2004/001939 patent/WO2005061484A1/en not_active Ceased
- 2004-12-20 JP JP2006546907A patent/JP2007515477A/ja active Pending
- 2004-12-20 MX MXPA06007040A patent/MXPA06007040A/es unknown
- 2004-12-20 AU AU2004303736A patent/AU2004303736B2/en not_active Ceased
- 2004-12-20 CN CNA200480041965XA patent/CN1918147A/zh active Pending
-
2006
- 2006-05-31 IL IL176074A patent/IL176074A0/en unknown
- 2006-06-19 ZA ZA200605026A patent/ZA200605026B/en unknown
- 2006-07-19 NO NO20063353A patent/NO20063353L/no not_active Application Discontinuation
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