JP2007514778A5 - - Google Patents
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- Publication number
- JP2007514778A5 JP2007514778A5 JP2006545626A JP2006545626A JP2007514778A5 JP 2007514778 A5 JP2007514778 A5 JP 2007514778A5 JP 2006545626 A JP2006545626 A JP 2006545626A JP 2006545626 A JP2006545626 A JP 2006545626A JP 2007514778 A5 JP2007514778 A5 JP 2007514778A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- formulation according
- container
- weight
- low molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 16
- 238000013329 compounding Methods 0.000 claims description 15
- 238000009472 formulation Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 9
- -1 2-trimethylsilylethyl Chemical group 0.000 claims description 8
- 239000002736 nonionic surfactant Substances 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 6
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 claims description 6
- 229940127093 camptothecin Drugs 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 6
- 229920000053 polysorbate 80 Polymers 0.000 claims description 6
- 229940068968 polysorbate 80 Drugs 0.000 claims description 6
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 2
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 claims description 2
- 229920002593 Polyethylene Glycol 800 Polymers 0.000 claims description 2
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 229920000847 nonoxynol Polymers 0.000 claims description 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 229950008882 polysorbate Drugs 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53015403P | 2003-12-17 | 2003-12-17 | |
| US60/530,154 | 2003-12-17 | ||
| PCT/US2004/036191 WO2005060871A1 (en) | 2003-12-17 | 2004-11-01 | Pharmaceutical formulations of camptothecins and process for making same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012176425A Division JP2012214509A (ja) | 2003-12-17 | 2012-08-08 | カンプトテシン医薬処方物およびその製法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007514778A JP2007514778A (ja) | 2007-06-07 |
| JP2007514778A5 true JP2007514778A5 (enExample) | 2008-12-18 |
| JP5654723B2 JP5654723B2 (ja) | 2015-01-14 |
Family
ID=34710158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545626A Expired - Fee Related JP5654723B2 (ja) | 2003-12-17 | 2004-11-01 | カンプトテシン医薬処方物およびその製法 |
| JP2012176425A Pending JP2012214509A (ja) | 2003-12-17 | 2012-08-08 | カンプトテシン医薬処方物およびその製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012176425A Pending JP2012214509A (ja) | 2003-12-17 | 2012-08-08 | カンプトテシン医薬処方物およびその製法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1694242B1 (enExample) |
| JP (2) | JP5654723B2 (enExample) |
| CN (1) | CN1893892B (enExample) |
| AU (1) | AU2004305494B2 (enExample) |
| CA (1) | CA2548078C (enExample) |
| DK (1) | DK1694242T3 (enExample) |
| MX (1) | MXPA06006710A (enExample) |
| WO (1) | WO2005060871A1 (enExample) |
| ZA (1) | ZA200604757B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT200500310A (es) | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| CN100592871C (zh) * | 2008-03-14 | 2010-03-03 | 浙江林学院 | 一种杀虫剂组合物及其加工方法 |
| SG11201407765VA (en) * | 2012-05-24 | 2015-01-29 | Innopharma Inc | Aprepitant injectable formulations |
| CN102911197B (zh) * | 2012-10-19 | 2015-05-06 | 杭州海杭生物医药科技有限公司 | 喜树碱硅杂衍生物、含该衍生物的组合物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW406020B (en) * | 1993-09-29 | 2000-09-21 | Bristol Myers Squibb Co | Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent |
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| AU718799C (en) * | 1996-08-19 | 2004-02-12 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
| EP1017675B1 (en) * | 1997-02-14 | 2006-06-14 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
| US6057303A (en) * | 1998-10-20 | 2000-05-02 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic Camptothecin derivatives |
-
2004
- 2004-11-01 CA CA002548078A patent/CA2548078C/en not_active Expired - Fee Related
- 2004-11-01 CN CN2004800377708A patent/CN1893892B/zh not_active Expired - Fee Related
- 2004-11-01 AU AU2004305494A patent/AU2004305494B2/en not_active Ceased
- 2004-11-01 EP EP04800502.9A patent/EP1694242B1/en not_active Expired - Lifetime
- 2004-11-01 DK DK04800502.9T patent/DK1694242T3/da active
- 2004-11-01 MX MXPA06006710A patent/MXPA06006710A/es active IP Right Grant
- 2004-11-01 JP JP2006545626A patent/JP5654723B2/ja not_active Expired - Fee Related
- 2004-11-01 WO PCT/US2004/036191 patent/WO2005060871A1/en not_active Ceased
-
2006
- 2006-06-09 ZA ZA2006/04757A patent/ZA200604757B/en unknown
-
2012
- 2012-08-08 JP JP2012176425A patent/JP2012214509A/ja active Pending
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