JP2007514460A - 増大した生物適合性を示すセンサー - Google Patents
増大した生物適合性を示すセンサー Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
Abstract
Description
Claims (67)
- 少なくとも頂部表面、底部表面、および第一末端を有する第一層、
第一層の底部表面に実質的に隣接する頂部表面を有する第二層、
計器との電気的接続に適合し、第一層の第一末端に隣接する第一接点、
第一層および第二層が第一層の頂部表面を通る開口部を有する空洞を定義し、該開口部が、第一層の第一末端からから離間されており、および
空洞の少なくとも20%を満たす試薬を包含するインビボで使用するための電気化学的バイオセンサーであって、該試薬が、電気的導電性マトリックスおよび酵素を包含し、
該マトリックスが、第一接点と電気的に接続している電気化学的バイオセンサー。 - 第一層が、非導電性材料から製造される請求項1記載の電気化学的バイオセンサー。
- 第二層が、非導電性材料から製造される請求項1記載の電気化学的バイオセンサー。
- 第一層が、ポリイミドから製造される請求項1記載の電気化学的バイオセンサー。
- 第一層が、約10μmと約130μmのあいだの平均厚さを有する請求項1記載の電気化学的バイオセンサー。
- 第一層が、約20μmと約50μmのあいだの平均厚さを有する請求項5記載の電気化学的バイオセンサー。
- 開口部が、面積Aを有し、および
試薬を横断しない開口部に平行に取られた空洞の各断面が、少なくともAの面積を有する請求項1記載の電気化学的バイオセンサー。 - 開口部に平行に取られた空洞の各断面が、少なくともAの面積を有する請求項1記載の電気化学的バイオセンサー。
- 開口部に平行に取られた空洞の断面が、それらが、開口部から遠くに取られるにしたがって単調に増大する面積を有する請求項8記載の電気化学的バイオセンサー。
- 空洞の体積対開口部の面積の比が、頂部表面と底部表面とのあいだの少なくともおよその距離である請求項1記載の電気化学的バイオセンサー。
- 請求項1による電気化学的センサーストリップ、および
センサー電極に電気信号を印加し、電気応答を測定するように適合された計器を包含する電気化学的バイオセンサーシステム。 - 試薬が体液中の分析物と反応するために選択され、および
計器が、体液中の分析物の濃度に対応する測定信号を生成するようにさらに適応される請求項11記載のシステム。 - 頂部表面と底部表面、
接点末端と検出末端、
接点末端のまたはその近くの第一接点および第二接点、
検出末端のまたはその近くの第一電極位置を有する第一層、
該第一電極位置の近くの第二電極位置、
第一電極位置の第一層内および第一電極位置の第一層によって定義された空洞であって、該空洞が頂部表面を通る開口部を有し、
空洞および第一接点を電気的に接続する第一導電体、および
第二電極位置と第二接点を電気的に接続する第二導電体を含む第一層上の少なくとも2つの導電体、
空洞の体積の少なくとも約20%を満たす導電性マトリックスであって、該マトリックスが試薬を包含し、および
第二電極位置に対照電極を包含する分析物の濃度または存在を試験するためのストリップ。 - 空洞が、開口部を除いて、分析物によって非透過性である1つまたは複数の材料により実質的に囲まれている請求項13記載のストリップ。
- 1つまたは複数の材料の少なくとも1つが、酸素透過性である請求項14記載のストリップ。
- 少なくとも1つの酸素透過性材料の1つまたは複数が、第一層の底部表面に隣接した配置される側面を有する請求項15記載のストリップ。
- 1つまたは複数の材料の少なくとも1つが、試薬に対する共反応体に透過可能である請求項14記載のストリップ。
- 空洞の少なくとも一部が、酸素透過可能である材料によって定義される請求項13記載のストリップ。
- 酸素透過可能である材料が、第一層の底部表面に隣接する請求項18記載のストリップ。
- 溶着が、空洞の体積の少なくとも約80%を満たす請求項13記載のストリップ。
- 第一導電体が、その空洞を少なくとも部分的に定義する空洞に拡張する請求項13記載のストリップ。
- 第一導電体が、第一層の頂部表面に沿って配置される請求項13記載のストリップ。
- 第一導電体が、第一層の底部表面に沿って配置される請求項13記載のストリップ。
- 導電性マトリックスが、空洞の体積の少なくとも約80%を満たす請求項13記載のストリップ。
- 導電性マトリックスが、空洞を実質的に満たす請求項13記載のストリップ。
- 基板、
参照電極、および
基板によって少なくとも部分的に定義される空洞を実質的に満たす作用電極を包含する電気化学的センサーであって、該作用電極が多孔性導電性マトリックスおよび酵素を包含し、
該参照電極が、液体試料を通して作用電極に電気的に接続可能である
電気化学的センサー。 - 導電性マトリックスが、炭素粒子を包含する請求項26記載の電気化学的センサー。
- 酵素が、グルコースオキシダーゼである請求項26記載の電気化学的センサー。
- 作用電極が、さらに触媒を包含する請求項26記載の電気化学的センサー。
- 触媒が、二酸化マンガンを包含する請求項29記載の電気化学的センサー。
- 作用電極が、さらに結合剤を包含する請求項26記載の電気化学的センサー。
- 結合剤が、重合体である請求項31記載の電気化学的センサー。
- 作用電極が、さらに触媒を包含する請求項31記載の電気化学的センサー。
- 触媒が、二酸化マンガンである請求項33記載の電気化学的センサー。
- 結合剤が、重合体である請求項33記載の電気化学的センサー。
- 空洞が、実質的に円筒形状を示す請求項26記載の電気化学的センサー。
- 空洞が、実質的にピラミッド円錐台の形状を有する請求項26記載の電気化学的センサー。
- 空洞が、実質的に円錐台の形状を有する請求項26記載の電気化学的センサー。
- 空洞が、小型表面および
小型表面と少なくとも同じくらい大きな表面積を有する大型表面を有し、および、
小型表面は、分析物が空洞を通過するのに十分に開放している請求項26記載の電気化学的センサー。 - 大型表面が、酸素透過可能な材料に隣接している請求項39記載の電気化学的センサー。
- 小型表面が、円形である請求項39記載の電気化学的センサー。
- 大型表面が、円形である請求項39記載の電気化学的センサー。
- 小型表面が、円形である請求項42記載の電気化学的センサー。
- 作用電極の第一表面が開放されており、これによって、試料が分析物の拡散を制限する層を通過することなく、電極に入ることができるように請求項26記載の電気化学的センサー。
- 生物学上の流体中の分析物に応答する活性領域を有するバイオセンサー、および
活性領域上に配置された中間面の膜を含むインビボで使用するためのバイオセンサー・システムであって、これによって分析物が、膜の少なくとも一部を通過して測定のためのバイオセンサーに達し、
該膜が活性領域から離間され、および
膜の一部が、活性領域の少なくとも2倍の表面領域を有する
バイオセンサー・システム。 - 膜の一部が、活性領域の膜の少なくとも4倍の表面積を有する請求項45記載のバイオセンサー・システム。
- 膜の一部が、活性領域の膜の少なくとも10倍の表面積を有する請求項45記載のバイオセンサー・システム。
- 膜の一部が、活性領域の膜の少なくとも100倍の表面積を有する請求項45記載のバイオセンサー・システム。
- 膜が、活性領域に接触しない請求項45記載のバイオセンサー・システム。
- 生物学上の流体中の分析物に応答する活性領域を有するバイオセンサー、および
活性領域上に配置された中間面の膜を含むインビボで使用するためのバイオセンサー・システムであって、これによって分析物が、膜の少なくとも一部を通って、流動体の外部体積から、バイオセンサーおよび膜によって定義された内部体積に入り、
内部体積のサイズが、少なくとも約s3/2/10であり、sが、センサーの活性領域の領域であり、および
内部体積が、バイオセンサーの活性領域と接触しているバイオセンサー・システム。 - 膜内の流動体中の分析物の拡散係数が、膜内の分析物の拡散係数と少なくともほぼ同じくらい高い、配置された請求項50記載のバイオセンサー・システム。
- 内部体積のサイズが、少なくとも約s3/2である請求項50記載のバイオセンサー・システム。
- 内部体積のサイズが、少なくとも約10s3/2である請求項50記載のバイオセンサー・システム。
- 生物学上の流動体中で分析物に応答する活性領域を有するバイオセンサー、および
活性領域上に配置された中間面の膜を含むインビボで使用するためのバイオセンサー・システムであって、これによって分析物が、膜の少なくとも一部を通って、流動体の外部体積から、バイオセンサーおよび膜によって定義された内部体積に入り、
中間面の膜が、それの最接近点で活性領域から約10μmと約100μmのあいだ離間されたバイオセンサー・システム。 - 分析物に敏感であるセンサー活性表面、および
活性表面の少なくとも一部を封入する膜を有する皮下空間に移植され得るセンサーヘッドを包含する
分析物の濃度または存在をインビボで試験するための皮下センサーであって、
該膜が、センサーが皮下組織に移植される際、活性表面から離間され、活性表面と膜とのあいだに内部体積を供する皮下センサー。 - 化学的試薬を包含する、請求項55記載の皮下センサー。
- 膜が、生物適合性接着剤によってセンサーヘッドに接続される請求項55記載の皮下センサー。
- 膜が、センサーヘッドに加熱封印される請求項55記載の皮下センサー。
- センサーが、測定のために電気化学的システムを使用する請求項55記載の皮下センサー。
- センサーが、分析物に透過可能である生物適合性重合体で被覆する請求項55記載の皮下センサー。
- センサーヘッドが、MPCで被覆される請求項60記載の皮下センサー。
- 膜が、半透過性透析中空繊維である請求項55記載の皮下センサー。
- 膜が、ポリアミドおよびポリスルホンからなる群から選択される材料から製造される請求項55記載の皮下センサー。
- センサーが、グルコース・センサーであり、および
膜が、約10kDと約100kDのあいだのカットオフを有する材料から製造される請求項55記載の皮下センサー。 - 内部体積が、リンガー溶液で満たされる請求項55記載の皮下センサー。
- 請求項55〜65いずれかに記載のセンサーを包含する皮下センサー。
- 請求項55によるセンサーを包含する皮下センサーの生物適合性を増大させる方法。
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Also Published As
Publication number | Publication date |
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US8180423B2 (en) | 2012-05-15 |
WO2005032362A2 (en) | 2005-04-14 |
DE602004026763D1 (de) | 2010-06-02 |
EP1681992B1 (en) | 2010-04-21 |
EP1681992B2 (en) | 2015-03-04 |
EP1681992A2 (en) | 2006-07-26 |
ES2341963T3 (es) | 2010-06-30 |
CA2541616A1 (en) | 2005-04-14 |
US20120209097A1 (en) | 2012-08-16 |
US20070007133A1 (en) | 2007-01-11 |
WO2005032362A3 (en) | 2005-06-09 |
ATE464834T1 (de) | 2010-05-15 |
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