JP2007513872A - Cb1拮抗作用を示す化合物の新規の医学的用途および前記化合物を伴う組み合わせ治療 - Google Patents

Cb1拮抗作用を示す化合物の新規の医学的用途および前記化合物を伴う組み合わせ治療 Download PDF

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JP2007513872A
JP2007513872A JP2006536096A JP2006536096A JP2007513872A JP 2007513872 A JP2007513872 A JP 2007513872A JP 2006536096 A JP2006536096 A JP 2006536096A JP 2006536096 A JP2006536096 A JP 2006536096A JP 2007513872 A JP2007513872 A JP 2007513872A
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JP2007513872A5 (enExample
Inventor
アンテル ヨッヘン
グレゴリー ペーター−コリン
ヴァルトエック ハラルト
クラウゼ ギュンター
フーベルトゥス マリア ランゲ ヨセフス
クルーゼ クリス
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Abbott Products GmbH
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Solvay Pharmaceuticals GmbH
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JP2006536096A 2003-10-24 2004-10-22 Cb1拮抗作用を示す化合物の新規の医学的用途および前記化合物を伴う組み合わせ治療 Withdrawn JP2007513872A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03103961 2003-10-24
EP03103967 2003-10-27
PCT/EP2004/052639 WO2005039550A2 (en) 2003-10-24 2004-10-22 Novel medical uses of compounds showing cb1-antagonistic activity and combination treatment involving said compounds

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JP2007513872A true JP2007513872A (ja) 2007-05-31
JP2007513872A5 JP2007513872A5 (enExample) 2007-09-13

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JP2006536096A Withdrawn JP2007513872A (ja) 2003-10-24 2004-10-22 Cb1拮抗作用を示す化合物の新規の医学的用途および前記化合物を伴う組み合わせ治療

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EP (1) EP1753413A2 (enExample)
JP (1) JP2007513872A (enExample)
AU (1) AU2004283056A1 (enExample)
BR (1) BRPI0415851A (enExample)
CA (1) CA2543338A1 (enExample)
MX (1) MXPA06004434A (enExample)
RU (1) RU2006117627A (enExample)
WO (1) WO2005039550A2 (enExample)

Families Citing this family (12)

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EP1575901B1 (en) 2002-12-19 2012-10-10 Merck Sharp & Dohme Corp. Substituted amides
TW200528102A (en) * 2003-10-24 2005-09-01 Solvay Pharm Gmbh Novel medical combination treatment of obesity involving 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
MX2007003325A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa.
EP1830837B1 (en) 2004-09-20 2013-09-04 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
JP5149009B2 (ja) 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−CoAデサチュラーゼを阻害するためのピリダジン誘導体
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
AR051090A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AR051093A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP1921073A1 (en) 2006-11-10 2008-05-14 Laboratorios del Dr. Esteve S.A. 1,2,4-Triazole derivatives as sigma receptor inhibitors
WO2024154047A1 (en) * 2023-01-18 2024-07-25 Brien Holden Vision Institute Limited Compositions and/or methods for prevention and/or treatment of dry eye disorders

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Publication number Priority date Publication date Assignee Title
JP3003148B2 (ja) * 1989-01-05 2000-01-24 藤沢薬品工業株式会社 チアゾール化合物、その製造法およびそれを含有する医薬組成物
AU3201095A (en) * 1994-07-27 1996-02-22 G.D. Searle & Co. Substituted thiazoles for the treatment of inflammation
US5616601A (en) * 1994-07-28 1997-04-01 Gd Searle & Co 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US6492516B1 (en) * 1999-05-14 2002-12-10 Merck & Co., Inc. Compounds having cytokine inhibitory activity
KR100846614B1 (ko) * 2001-03-22 2008-07-16 솔베이 파마슈티칼스 비. 브이 Cb1-길항 활성을 갖는 4,5-디하이드로-1h-피라졸 유도체
CA2456606C (en) * 2001-09-21 2010-01-26 Solvay Pharmaceuticals B.V. 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
TWI231757B (en) * 2001-09-21 2005-05-01 Solvay Pharm Bv 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
US6974810B2 (en) * 2001-09-21 2005-12-13 Solvay Pharmaceuticals B.V. 4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity
UY27450A1 (es) * 2001-09-24 2003-04-30 Bayer Corp Preparación y uso de derivados de imidazol para el tratamiento de la obesidad
WO2003039451A2 (en) * 2001-11-08 2003-05-15 Fujisawa Pharmaceutical Co., Ltd. Thiazole pyridazinones as adenosine antagonists
TW200407110A (en) * 2001-11-23 2004-05-16 Astrazeneca Ab New use for the treatment of gastroesophageal reflux disease
WO2003063781A2 (en) * 2002-01-29 2003-08-07 Merck & Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
AR038966A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial de cb1
TW200412942A (en) * 2002-08-06 2004-08-01 Abbott Lab Appetite control method
HRP20050053A2 (en) * 2002-09-19 2005-04-30 Solvay Pharmaceuticals B.V. 1 h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands
GB0230087D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents

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