JP2007513180A - 喘息の処置および予防 - Google Patents

喘息の処置および予防 Download PDF

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Publication number
JP2007513180A
JP2007513180A JP2006542824A JP2006542824A JP2007513180A JP 2007513180 A JP2007513180 A JP 2007513180A JP 2006542824 A JP2006542824 A JP 2006542824A JP 2006542824 A JP2006542824 A JP 2006542824A JP 2007513180 A JP2007513180 A JP 2007513180A
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JP
Japan
Prior art keywords
composition
amino acid
acid
phospholipid
surfactant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006542824A
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English (en)
Japanese (ja)
Other versions
JP2007513180A5 (enExample
Inventor
チャールズ ジー. コッチレーン,
Original Assignee
ザ スクリプス リサーチ インスティテュート
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Publication date
Application filed by ザ スクリプス リサーチ インスティテュート filed Critical ザ スクリプス リサーチ インスティテュート
Publication of JP2007513180A publication Critical patent/JP2007513180A/ja
Publication of JP2007513180A5 publication Critical patent/JP2007513180A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/395Alveolar surfactant peptides; Pulmonary surfactant peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0082Lung surfactant, artificial mucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2006542824A 2003-12-04 2004-12-03 喘息の処置および予防 Withdrawn JP2007513180A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52678703P 2003-12-04 2003-12-04
PCT/US2004/040665 WO2005055994A1 (en) 2003-12-04 2004-12-03 Treatment and preventions of asthma

Publications (2)

Publication Number Publication Date
JP2007513180A true JP2007513180A (ja) 2007-05-24
JP2007513180A5 JP2007513180A5 (enExample) 2007-12-27

Family

ID=34676656

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006542824A Withdrawn JP2007513180A (ja) 2003-12-04 2004-12-03 喘息の処置および予防

Country Status (6)

Country Link
US (1) US20070129297A1 (enExample)
EP (1) EP1694314A4 (enExample)
JP (1) JP2007513180A (enExample)
AU (1) AU2004296206A1 (enExample)
CA (1) CA2549160A1 (enExample)
WO (1) WO2005055994A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520577A (ja) * 2004-11-15 2008-06-19 ディスカバリー ラボラトリーズ,インコーポレイテッド 肺表面活性物質配合物を凍結乾燥により生成する方法並びにその配合物及び利用
JP2011506396A (ja) * 2007-12-13 2011-03-03 グラクソ グループ リミテッド 肺送達用組成物

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005061088A1 (en) * 2003-12-22 2005-07-07 Finlay Warren H Powder formation by atmospheric spray-freeze drying
WO2005073246A2 (en) * 2004-01-20 2005-08-11 Discovery Laboratories, Inc. Method for preparing kl4 lung surfactant
JPWO2007001094A1 (ja) * 2005-06-29 2009-01-22 相男 李 人工肺サーファクタント組成物
WO2007005672A2 (en) * 2005-06-30 2007-01-11 The Scripps Research Institute Treatment and prevention of respiratory diseases and conditions
EP2035010B1 (en) * 2006-06-09 2012-10-03 Erasmus University Medical Center Rotterdam Modulation of the immune system by inositol phospholipids
EP2063903A1 (en) * 2006-09-19 2009-06-03 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
EP2170270B1 (en) * 2007-06-05 2016-01-13 Paka Pulmonary Pharmaceuticals, Inc. Compositions for delivering medicaments into the lungs, uses thereof
WO2010068754A2 (en) * 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
JP5801206B2 (ja) 2009-01-30 2015-10-28 アルファベータ・エービーAlphaBeta AB アルツハイマー病の治療のための化合物および方法
WO2010107487A2 (en) * 2009-03-18 2010-09-23 Wu Nian Lipid-drug conjugates for drug delivery
AU2010356144B2 (en) 2010-06-24 2015-06-04 Alphabeta Ab Compound and method for treatment of Alzheimer's disease and familial dementia
JP6227523B2 (ja) 2011-04-05 2017-11-08 アルファベータ・エービーAlphaBeta AB 治療の方法においておよび化合物のスクリーニングのために有用なアミロドーシスターゲット
WO2013081452A1 (en) 2011-11-30 2013-06-06 Erasmus University Medical Center Rotterdam Phosphatidylinositol
US20210379141A1 (en) * 2016-04-11 2021-12-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating and preventing lung disease
WO2017180546A1 (en) * 2016-04-11 2017-10-19 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating and preventing lung disease
JP2024505225A (ja) * 2021-01-29 2024-02-05 サインパス ファルマ,インク. 肺損傷を減少させ、肺機能を改善し、炎症促進性サイトカインを低下させる脂質

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916117A (en) * 1986-12-24 1990-04-10 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
US6613734B2 (en) * 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US6013619A (en) * 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US5734014A (en) * 1992-08-11 1998-03-31 Tsumura & Co. Elafin derivative
AU5171293A (en) * 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
US5301644A (en) * 1993-06-16 1994-04-12 Kohler Co. Fuel shut-off mechanism for internal combustion engines
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
US5878912A (en) * 1995-12-26 1999-03-09 Stein; Myron Duct disinfecting method and apparatus
US5780440A (en) * 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
US5976574A (en) * 1996-12-31 1999-11-02 Inhale Therapeutic Systems Processes for spray drying hydrophobic drugs in organic solvent suspensions
US6051257A (en) * 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
US5973574A (en) * 1997-04-21 1999-10-26 Eastman Kodak Company Oscillator system with corrective frequency modulation
US5833084A (en) * 1997-07-18 1998-11-10 Chang; Hsi-Te Modular rack
US6284282B1 (en) * 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
WO2000027360A1 (en) * 1998-11-10 2000-05-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Treatment set containing lungsurfactant compositions
US6223455B1 (en) * 1999-05-03 2001-05-01 Acusphere, Inc. Spray drying apparatus and methods of use
NZ536796A (en) * 2002-04-25 2007-03-30 Scripps Research Inst Treatment and prevention of pulmonary conditions comprising at least one lung surfactant polypeptide and at least one protease inhibitor, lipase inhibitor or an anti-oxidant

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520577A (ja) * 2004-11-15 2008-06-19 ディスカバリー ラボラトリーズ,インコーポレイテッド 肺表面活性物質配合物を凍結乾燥により生成する方法並びにその配合物及び利用
JP2011506396A (ja) * 2007-12-13 2011-03-03 グラクソ グループ リミテッド 肺送達用組成物

Also Published As

Publication number Publication date
EP1694314A4 (en) 2009-07-01
EP1694314A1 (en) 2006-08-30
WO2005055994A1 (en) 2005-06-23
US20070129297A1 (en) 2007-06-07
AU2004296206A1 (en) 2005-06-23
CA2549160A1 (en) 2005-06-23

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