JP2007510648A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007510648A5 JP2007510648A5 JP2006538315A JP2006538315A JP2007510648A5 JP 2007510648 A5 JP2007510648 A5 JP 2007510648A5 JP 2006538315 A JP2006538315 A JP 2006538315A JP 2006538315 A JP2006538315 A JP 2006538315A JP 2007510648 A5 JP2007510648 A5 JP 2007510648A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- taxoid
- acid
- omega
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 5
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 4
- WPPTYUSIXLFOKZ-BYOOWSCBSA-N O([C@H]1[C@H]2[C@@](C([C@H](OC(=O)C3CC3)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](OC(=O)C3CC3)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 WPPTYUSIXLFOKZ-BYOOWSCBSA-N 0.000 claims 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 2
- LWYWOSNAYMUZAZ-DDQWWYRKSA-N chembl450955 Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)CC)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)O)C(=O)C1=CC=CC(OC)=C1 LWYWOSNAYMUZAZ-DDQWWYRKSA-N 0.000 claims 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 229960004488 linolenic acid Drugs 0.000 claims 2
- JTFSQGOZNMBTHL-YIFABKNJSA-N sb-t-1103 Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)CC)OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)O)C(=O)C1=CC=CC=C1 JTFSQGOZNMBTHL-YIFABKNJSA-N 0.000 claims 2
- FMGFMSYAVIRKIH-OMBWZAKXSA-N sb-t-1104 Chemical compound O([C@@H]1[C@]2(O)C[C@@H](C(=C([C@@H](OC(=O)C3CC3)C(=O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4(C31)OC(C)=O)C2(C)C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)CC(C)C)C(=O)C1=CC=CC=C1 FMGFMSYAVIRKIH-OMBWZAKXSA-N 0.000 claims 2
- PZOIEGMACMYQQY-YIFABKNJSA-N sb-t-1213 Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)CC)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)O)C(=O)C1=CC=CC=C1 PZOIEGMACMYQQY-YIFABKNJSA-N 0.000 claims 2
- MXWOSKYQGCYTDP-OYEWMILSSA-N sb-t-1216 Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3(C21)OC(C)=O)=O)OC(=O)N(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)O)C(=O)C1=CC=CC=C1 MXWOSKYQGCYTDP-OYEWMILSSA-N 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- -1 SB-T-11033 Chemical compound 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- BWKDAMBGCPRVPI-ZQRPHVBESA-N ortataxel Chemical compound O([C@@H]1[C@]23OC(=O)O[C@H]2[C@@H](C(=C([C@@H](OC(C)=O)C(=O)[C@]2(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]21)OC(C)=O)C3(C)C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)CC(C)C)C(=O)C1=CC=CC=C1 BWKDAMBGCPRVPI-ZQRPHVBESA-N 0.000 claims 1
- 229950001094 ortataxel Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51578303P | 2003-10-30 | 2003-10-30 | |
| US60/515,783 | 2003-10-30 | ||
| PCT/US2004/036027 WO2005041881A2 (en) | 2003-10-30 | 2004-10-28 | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007510648A JP2007510648A (ja) | 2007-04-26 |
| JP2007510648A5 true JP2007510648A5 (https=) | 2007-12-13 |
| JP4884228B2 JP4884228B2 (ja) | 2012-02-29 |
Family
ID=34549443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538315A Expired - Lifetime JP4884228B2 (ja) | 2003-10-30 | 2004-10-28 | タキソイド−脂肪酸コンジュゲート及びその医薬組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7820839B2 (https=) |
| EP (1) | EP1703904B1 (https=) |
| JP (1) | JP4884228B2 (https=) |
| CN (1) | CN1901901B (https=) |
| AU (1) | AU2004285529A1 (https=) |
| CA (1) | CA2544128A1 (https=) |
| WO (1) | WO2005041881A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1901901B (zh) | 2003-10-30 | 2012-07-04 | 纽约州州立大学研究基金会 | 紫杉醇-脂肪酸结合物及其药物组合物 |
| WO2007021957A2 (en) | 2005-08-12 | 2007-02-22 | Research Foundation Of State University Of New York | Fluorotaxoids |
| WO2008021242A2 (en) * | 2006-08-10 | 2008-02-21 | The Research Foundation Of State University Of New York | Fluorotaxoid-fatty acid conjugates and pharmaceutical compositions thereof |
| CN101225094A (zh) * | 2007-01-18 | 2008-07-23 | 天津和美生物技术有限公司 | 具有抗癌活性的蒽醌四环类化合物 |
| WO2008092084A2 (en) | 2007-01-26 | 2008-07-31 | Centocor, Inc. | Injectable non-aqueous suspension with high concentration of therapeutic agent |
| WO2014145817A2 (en) | 2013-03-15 | 2014-09-18 | Children's Medical Center Corporation | Novel therapeutic target for the treatment of cancers and related therapies and methods |
| CN106390122A (zh) * | 2015-07-31 | 2017-02-15 | 舟山三合生物科技有限公司 | 化疗类抗癌药口服制剂组合物 |
| CN105343004A (zh) * | 2015-09-14 | 2016-02-24 | 东北林业大学 | 一种二十二碳六烯酸靶向多西紫杉醇纳米药物的制备方法 |
| WO2017214260A1 (en) * | 2016-06-07 | 2017-12-14 | Targagenix, Inc. | Nanoemulsion compositions of taxoid drugs, and methods for the use thereof to target cancer cells and cancer stem cells |
| CN112996501A (zh) * | 2017-12-20 | 2021-06-18 | 塔佳吉尼克斯公司 | 癌症中紫杉类纳米乳剂与免疫疗法的联合 |
| CN110201182B (zh) * | 2019-06-21 | 2022-09-27 | 山东大学 | 一种紫杉醇-dha-右旋糖酐偶联聚合物及其合成方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500858B2 (en) * | 1994-10-28 | 2002-12-31 | The Research Foundation Of The State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| US6100411A (en) * | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| US6458976B1 (en) * | 1994-10-28 | 2002-10-01 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| US5919815A (en) * | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| WO1997044026A1 (en) * | 1996-05-22 | 1997-11-27 | Neuromedica, Inc. | Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere |
| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| HK1040486A1 (zh) * | 1999-03-09 | 2002-06-14 | Luitpold Pharmaceuticals, Inc. | 脂肪酸-抗癌共軛和其用途 |
| CN1901901B (zh) | 2003-10-30 | 2012-07-04 | 纽约州州立大学研究基金会 | 紫杉醇-脂肪酸结合物及其药物组合物 |
-
2004
- 2004-10-28 CN CN2004800393077A patent/CN1901901B/zh not_active Expired - Lifetime
- 2004-10-28 EP EP04810113A patent/EP1703904B1/en not_active Expired - Lifetime
- 2004-10-28 AU AU2004285529A patent/AU2004285529A1/en not_active Abandoned
- 2004-10-28 JP JP2006538315A patent/JP4884228B2/ja not_active Expired - Lifetime
- 2004-10-28 US US10/577,573 patent/US7820839B2/en active Active
- 2004-10-28 CA CA002544128A patent/CA2544128A1/en not_active Abandoned
- 2004-10-28 WO PCT/US2004/036027 patent/WO2005041881A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhang et al. | Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer | |
| JP2007510648A5 (https=) | ||
| Ojima | Guided molecular missiles for tumor-targeting chemotherapy—case studies using the second-generation taxoids as warheads | |
| AU2009334476B2 (en) | Nutraceuticals containing nitro fatty acids | |
| PH12021550756A1 (en) | Compositions and methods for treating and/or preventing cardiovascular disease | |
| GEP20125464B (en) | Dha esters and use thereof in treatment and prevention of cardiovascular disease | |
| EA200970374A1 (ru) | Лечение антиаритмическими средствами и омега-3 жирными кислотами и их комбинированным продуктом | |
| NO20080855L (no) | Behandling med azetidinon-baserte kolesterol absorpsjonsinhibitorer og omega-3 fettsyrer og et kombinasjonsprodukt derav | |
| JP2007523049A5 (https=) | ||
| MX378496B (es) | Metodos para reducir riesgo de evento cardiovascular en sujeto con terapia con estatina. | |
| HK1206248A1 (en) | Compositions of statins and omega-3 fatty acids | |
| JP2005515774A5 (https=) | ||
| CY1115725T1 (el) | Ενωσεις, συνθεσεις και μεθοδοι για την θεραπευτικη αγωγη των βητα-αμυλοειδικων ασθενειων και συνουκλεϊνοπαθειων | |
| NO20076382L (no) | Anvendelse av dokosaheksaenglyserider i behandlingen av tumorese sykdommer | |
| JP2010053122A5 (https=) | ||
| JP2008540484A5 (https=) | ||
| JP2009516719A5 (https=) | ||
| JP2014114256A5 (https=) | ||
| EP4327870A3 (en) | Method for improving white matter integrity in hyperphenylalaninemia and phenylketonuria patients | |
| JP2020511488A5 (https=) | ||
| Thomason | UAB's Alys Stephens Center presents Yo-Yo Ma Dec. 6 | |
| RU2005106680A (ru) | Способ проведения интрастата для брахитерапии рака пищевода | |
| JP2007022978A5 (https=) | ||
| Freeman et al. | " Omega-3 fatty acids: Evidence basis for treatment and future research in psychiatry": Correction. | |
| UA112329C2 (uk) | Композиція проліків, що містить кон'югат аспірину з гідроморфоном, та спосіб лікування захворювання |