JP2007510648A5 - - Google Patents
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- Publication number
- JP2007510648A5 JP2007510648A5 JP2006538315A JP2006538315A JP2007510648A5 JP 2007510648 A5 JP2007510648 A5 JP 2007510648A5 JP 2006538315 A JP2006538315 A JP 2006538315A JP 2006538315 A JP2006538315 A JP 2006538315A JP 2007510648 A5 JP2007510648 A5 JP 2007510648A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- taxoid
- acid
- omega
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 5
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 4
- WPPTYUSIXLFOKZ-BYOOWSCBSA-N O([C@H]1[C@H]2[C@@](C([C@H](OC(=O)C3CC3)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](OC(=O)C3CC3)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 WPPTYUSIXLFOKZ-BYOOWSCBSA-N 0.000 claims 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 2
- LWYWOSNAYMUZAZ-DDQWWYRKSA-N chembl450955 Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)CC)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)O)C(=O)C1=CC=CC(OC)=C1 LWYWOSNAYMUZAZ-DDQWWYRKSA-N 0.000 claims 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 229960004488 linolenic acid Drugs 0.000 claims 2
- JTFSQGOZNMBTHL-YIFABKNJSA-N sb-t-1103 Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)CC)OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)O)C(=O)C1=CC=CC=C1 JTFSQGOZNMBTHL-YIFABKNJSA-N 0.000 claims 2
- FMGFMSYAVIRKIH-OMBWZAKXSA-N sb-t-1104 Chemical compound O([C@@H]1[C@]2(O)C[C@@H](C(=C([C@@H](OC(=O)C3CC3)C(=O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4(C31)OC(C)=O)C2(C)C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)CC(C)C)C(=O)C1=CC=CC=C1 FMGFMSYAVIRKIH-OMBWZAKXSA-N 0.000 claims 2
- PZOIEGMACMYQQY-YIFABKNJSA-N sb-t-1213 Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)CC)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)O)C(=O)C1=CC=CC=C1 PZOIEGMACMYQQY-YIFABKNJSA-N 0.000 claims 2
- MXWOSKYQGCYTDP-OYEWMILSSA-N sb-t-1216 Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3(C21)OC(C)=O)=O)OC(=O)N(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=C(C)C)O)C(=O)C1=CC=CC=C1 MXWOSKYQGCYTDP-OYEWMILSSA-N 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- -1 SB-T-11033 Chemical compound 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- BWKDAMBGCPRVPI-ZQRPHVBESA-N ortataxel Chemical compound O([C@@H]1[C@]23OC(=O)O[C@H]2[C@@H](C(=C([C@@H](OC(C)=O)C(=O)[C@]2(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]21)OC(C)=O)C3(C)C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)CC(C)C)C(=O)C1=CC=CC=C1 BWKDAMBGCPRVPI-ZQRPHVBESA-N 0.000 claims 1
- 229950001094 ortataxel Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51578303P | 2003-10-30 | 2003-10-30 | |
| US60/515,783 | 2003-10-30 | ||
| PCT/US2004/036027 WO2005041881A2 (en) | 2003-10-30 | 2004-10-28 | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007510648A JP2007510648A (ja) | 2007-04-26 |
| JP2007510648A5 true JP2007510648A5 (https=) | 2007-12-13 |
| JP4884228B2 JP4884228B2 (ja) | 2012-02-29 |
Family
ID=34549443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538315A Expired - Lifetime JP4884228B2 (ja) | 2003-10-30 | 2004-10-28 | タキソイド−脂肪酸コンジュゲート及びその医薬組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7820839B2 (https=) |
| EP (1) | EP1703904B1 (https=) |
| JP (1) | JP4884228B2 (https=) |
| CN (1) | CN1901901B (https=) |
| AU (1) | AU2004285529A1 (https=) |
| CA (1) | CA2544128A1 (https=) |
| WO (1) | WO2005041881A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005041881A2 (en) | 2003-10-30 | 2005-05-12 | The Research Foundation Of State University Of New York | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof |
| US7981926B2 (en) | 2005-08-12 | 2011-07-19 | Research Foundation Of State University Of New York | Fluorotaxoids |
| WO2008021242A2 (en) * | 2006-08-10 | 2008-02-21 | The Research Foundation Of State University Of New York | Fluorotaxoid-fatty acid conjugates and pharmaceutical compositions thereof |
| CN101225094A (zh) * | 2007-01-18 | 2008-07-23 | 天津和美生物技术有限公司 | 具有抗癌活性的蒽醌四环类化合物 |
| WO2008092084A2 (en) | 2007-01-26 | 2008-07-31 | Centocor, Inc. | Injectable non-aqueous suspension with high concentration of therapeutic agent |
| US9763905B2 (en) | 2013-03-15 | 2017-09-19 | The Children's Medical Center Corporation | Therapeutic target for the treatment of cancers and related therapies and methods |
| CN106390122A (zh) * | 2015-07-31 | 2017-02-15 | 舟山三合生物科技有限公司 | 化疗类抗癌药口服制剂组合物 |
| CN105343004A (zh) * | 2015-09-14 | 2016-02-24 | 东北林业大学 | 一种二十二碳六烯酸靶向多西紫杉醇纳米药物的制备方法 |
| JP7518604B2 (ja) * | 2016-06-07 | 2024-07-18 | タルガジェニックス，インコーポレイテッド | タキソイド薬物のナノエマルション組成物、並びに標的癌細胞及び癌幹細胞に対するその使用方法 |
| JP7450888B2 (ja) * | 2017-12-20 | 2024-03-18 | タルガジェニックス，インコーポレイテッド | がんにおける免疫療法との併用タキソイドナノエマルジョン |
| CN110201182B (zh) * | 2019-06-21 | 2022-09-27 | 山东大学 | 一种紫杉醇-dha-右旋糖酐偶联聚合物及其合成方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458976B1 (en) * | 1994-10-28 | 2002-10-01 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods |
| US6500858B2 (en) * | 1994-10-28 | 2002-12-31 | The Research Foundation Of The State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| US6100411A (en) * | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US5919815A (en) | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| ES2151277T3 (es) * | 1996-05-22 | 2000-12-16 | Protarga Inc | Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere. |
| WO2000053231A2 (en) * | 1999-03-09 | 2000-09-14 | Protarga, Inc. | Fatty acid-anticancer conjugates and uses thereof |
| WO2005041881A2 (en) | 2003-10-30 | 2005-05-12 | The Research Foundation Of State University Of New York | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof |
-
2004
- 2004-10-28 WO PCT/US2004/036027 patent/WO2005041881A2/en not_active Ceased
- 2004-10-28 EP EP04810113A patent/EP1703904B1/en not_active Expired - Lifetime
- 2004-10-28 CA CA002544128A patent/CA2544128A1/en not_active Abandoned
- 2004-10-28 CN CN2004800393077A patent/CN1901901B/zh not_active Expired - Lifetime
- 2004-10-28 JP JP2006538315A patent/JP4884228B2/ja not_active Expired - Lifetime
- 2004-10-28 US US10/577,573 patent/US7820839B2/en active Active
- 2004-10-28 AU AU2004285529A patent/AU2004285529A1/en not_active Abandoned
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