CN1901901B - 紫杉醇-脂肪酸结合物及其药物组合物 - Google Patents

紫杉醇-脂肪酸结合物及其药物组合物 Download PDF

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Publication number
CN1901901B
CN1901901B CN2004800393077A CN200480039307A CN1901901B CN 1901901 B CN1901901 B CN 1901901B CN 2004800393077 A CN2004800393077 A CN 2004800393077A CN 200480039307 A CN200480039307 A CN 200480039307A CN 1901901 B CN1901901 B CN 1901901B
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Prior art keywords
cancer
paclitaxel
omega
use according
group
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Expired - Lifetime
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CN2004800393077A
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Chinese (zh)
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CN1901901A (zh
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伊瓦奥·奥吉马
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Research Foundation of the State University of New York
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Research Foundation of the State University of New York
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2004800393077A 2003-10-30 2004-10-28 紫杉醇-脂肪酸结合物及其药物组合物 Expired - Lifetime CN1901901B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51578303P 2003-10-30 2003-10-30
US60/515,783 2003-10-30
PCT/US2004/036027 WO2005041881A2 (en) 2003-10-30 2004-10-28 Taxoid-fatty acid conjugates and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
CN1901901A CN1901901A (zh) 2007-01-24
CN1901901B true CN1901901B (zh) 2012-07-04

Family

ID=34549443

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800393077A Expired - Lifetime CN1901901B (zh) 2003-10-30 2004-10-28 紫杉醇-脂肪酸结合物及其药物组合物

Country Status (7)

Country Link
US (1) US7820839B2 (https=)
EP (1) EP1703904B1 (https=)
JP (1) JP4884228B2 (https=)
CN (1) CN1901901B (https=)
AU (1) AU2004285529A1 (https=)
CA (1) CA2544128A1 (https=)
WO (1) WO2005041881A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1901901B (zh) 2003-10-30 2012-07-04 纽约州州立大学研究基金会 紫杉醇-脂肪酸结合物及其药物组合物
WO2007021957A2 (en) 2005-08-12 2007-02-22 Research Foundation Of State University Of New York Fluorotaxoids
WO2008021242A2 (en) * 2006-08-10 2008-02-21 The Research Foundation Of State University Of New York Fluorotaxoid-fatty acid conjugates and pharmaceutical compositions thereof
CN101225094A (zh) * 2007-01-18 2008-07-23 天津和美生物技术有限公司 具有抗癌活性的蒽醌四环类化合物
WO2008092084A2 (en) 2007-01-26 2008-07-31 Centocor, Inc. Injectable non-aqueous suspension with high concentration of therapeutic agent
WO2014145817A2 (en) 2013-03-15 2014-09-18 Children's Medical Center Corporation Novel therapeutic target for the treatment of cancers and related therapies and methods
CN106390122A (zh) * 2015-07-31 2017-02-15 舟山三合生物科技有限公司 化疗类抗癌药口服制剂组合物
CN105343004A (zh) * 2015-09-14 2016-02-24 东北林业大学 一种二十二碳六烯酸靶向多西紫杉醇纳米药物的制备方法
WO2017214260A1 (en) * 2016-06-07 2017-12-14 Targagenix, Inc. Nanoemulsion compositions of taxoid drugs, and methods for the use thereof to target cancer cells and cancer stem cells
CN112996501A (zh) * 2017-12-20 2021-06-18 塔佳吉尼克斯公司 癌症中紫杉类纳米乳剂与免疫疗法的联合
CN110201182B (zh) * 2019-06-21 2022-09-27 山东大学 一种紫杉醇-dha-右旋糖酐偶联聚合物及其合成方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6458976B1 (en) * 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500858B2 (en) * 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
WO1997044026A1 (en) * 1996-05-22 1997-11-27 Neuromedica, Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
HK1040486A1 (zh) * 1999-03-09 2002-06-14 Luitpold Pharmaceuticals, Inc. 脂肪酸-抗癌共軛和其用途
CN1901901B (zh) 2003-10-30 2012-07-04 纽约州州立大学研究基金会 紫杉醇-脂肪酸结合物及其药物组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458976B1 (en) * 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes

Also Published As

Publication number Publication date
CN1901901A (zh) 2007-01-24
JP2007510648A (ja) 2007-04-26
US7820839B2 (en) 2010-10-26
WO2005041881A8 (en) 2006-06-29
EP1703904A2 (en) 2006-09-27
EP1703904A4 (en) 2011-01-19
EP1703904B1 (en) 2013-02-13
WO2005041881A3 (en) 2005-12-08
AU2004285529A1 (en) 2005-05-12
US20070088076A1 (en) 2007-04-19
JP4884228B2 (ja) 2012-02-29
CA2544128A1 (en) 2005-05-12
WO2005041881A2 (en) 2005-05-12

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Granted publication date: 20120704