JP2007510401A5 - - Google Patents
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- Publication number
- JP2007510401A5 JP2007510401A5 JP2006534123A JP2006534123A JP2007510401A5 JP 2007510401 A5 JP2007510401 A5 JP 2007510401A5 JP 2006534123 A JP2006534123 A JP 2006534123A JP 2006534123 A JP2006534123 A JP 2006534123A JP 2007510401 A5 JP2007510401 A5 JP 2007510401A5
- Authority
- JP
- Japan
- Prior art keywords
- isoquinolin
- present
- bases
- pyrazolo
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LHCPRYRLDOSKHK-UHFFFAOYSA-N 7-deaza-8-aza-adenine Chemical compound NC1=NC=NC2=C1C=NN2 LHCPRYRLDOSKHK-UHFFFAOYSA-N 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 description 1
- GUKPFROHOFPSBS-UHFFFAOYSA-N 6,8-dimethyl-2h-isoquinolin-1-one Chemical compound C1=CNC(=O)C=2C1=CC(C)=CC=2C GUKPFROHOFPSBS-UHFFFAOYSA-N 0.000 description 1
- BZUZJVLPAKJIBP-UHFFFAOYSA-N 6-amino-1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one Chemical compound O=C1N=C(N)N=C2NNC=C21 BZUZJVLPAKJIBP-UHFFFAOYSA-N 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical class N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 1
- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical compound C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50879203P | 2003-10-02 | 2003-10-02 | |
| PCT/US2004/032265 WO2005035545A2 (en) | 2003-10-02 | 2004-09-30 | Single nucleotide polymorphism analysis of highly polymorphic target sequences |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007510401A JP2007510401A (ja) | 2007-04-26 |
| JP2007510401A5 true JP2007510401A5 (https=) | 2007-08-09 |
Family
ID=34434930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534123A Pending JP2007510401A (ja) | 2003-10-02 | 2004-09-30 | 高度に多型の標的配列の一塩基多型分析 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7348146B2 (https=) |
| EP (1) | EP1670928A4 (https=) |
| JP (1) | JP2007510401A (https=) |
| AU (1) | AU2004279810A1 (https=) |
| CA (1) | CA2540551A1 (https=) |
| WO (1) | WO2005035545A2 (https=) |
Families Citing this family (35)
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|---|---|---|---|---|
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| US20070048758A1 (en) * | 2005-06-09 | 2007-03-01 | Epoch Biosciences, Inc. | Improved primer-based amplification methods |
| JP4713514B2 (ja) * | 2006-02-20 | 2011-06-29 | エフ．ホフマン−ラ ロシュ アーゲー | 改善された標識試薬 |
| WO2007106690A2 (en) * | 2006-03-15 | 2007-09-20 | Siemens Healthcare Diagnostics Inc. | Degenerate nucleobase analogs |
| CA2663618A1 (en) * | 2006-09-11 | 2008-06-05 | Southern Research Institute | Azole nucleosides and use as inhibitors of rna and dna viral polymerases |
| US8145433B2 (en) * | 2007-10-25 | 2012-03-27 | Canon U.S. Life Sciences, Inc. | High-resolution melting analysis |
| US9534255B2 (en) | 2008-12-17 | 2017-01-03 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| EP3249053A1 (en) | 2009-03-27 | 2017-11-29 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| TW201100427A (en) | 2009-03-31 | 2011-01-01 | Arqule Inc | Substituted heterocyclic compounds |
| CN101659952B (zh) * | 2009-07-14 | 2012-07-18 | 上海之江生物科技有限公司 | 锁核酸和小沟结合物共修饰核酸片段 |
| WO2011066312A1 (en) | 2009-11-25 | 2011-06-03 | Elitech Holding B.V. | Minor groove binder (mgb)-oligonucleotide mirna antagonists |
| WO2012097353A1 (en) * | 2011-01-14 | 2012-07-19 | Life Technologies Corporation | Methods, compositions, and kits for detecting rare cells |
| US9085800B2 (en) | 2011-03-23 | 2015-07-21 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
| US8969003B2 (en) | 2011-03-23 | 2015-03-03 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
| JP2013081448A (ja) * | 2011-05-02 | 2013-05-09 | Arkray Inc | 遺伝子変異検出用プローブ |
| ES2537189T3 (es) | 2011-05-24 | 2015-06-03 | Elitech Holding B.V. | Detección de estafilococos áureos resistentes a la meticilina |
| US10752954B2 (en) * | 2013-03-14 | 2020-08-25 | The Trustees Of The University Of Pennsylvania | Method for detecting mutations in single cells or single molecules |
| WO2014159063A1 (en) | 2013-03-14 | 2014-10-02 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
| US9328384B2 (en) | 2013-05-13 | 2016-05-03 | Elitechgroup B.V. | Droplet digital PCR with short minor groove probes |
| DK3041854T3 (da) * | 2013-08-08 | 2020-03-02 | Scripps Research Inst | En fremgangsmåde til stedspecifik enzymatisk mærkning af nukleinsyrer in vitro gennem inkorporering af unaturlige nukleotider |
| EP3052656B1 (en) * | 2013-09-30 | 2018-12-12 | President and Fellows of Harvard College | Methods of determining polymorphisms |
| GB201317355D0 (en) * | 2013-10-01 | 2013-11-13 | Epistem Ltd | Mutation Analysis |
| EP3230467A1 (en) | 2014-12-12 | 2017-10-18 | ELITechGroup B.V. | Methods and compositions for detecting antibiotic resistant bacteria |
| WO2016094607A2 (en) | 2014-12-12 | 2016-06-16 | Elitechgroup B.V. | Methods and compositions for detecting antibiotic resistant bacteria |
| NO344051B1 (en) * | 2017-05-04 | 2019-08-26 | Patogen As | Novel virus in Fish and Method for detection |
| AU2018300069C1 (en) | 2017-07-11 | 2025-11-20 | Synthorx, Inc. | Incorporation of unnatural nucleotides and methods thereof |
| WO2019028419A1 (en) | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES |
| US10677728B2 (en) | 2017-08-17 | 2020-06-09 | Elitechgroup B.V. | Duplex stabilizing fluorescence quenchers for nucleic acid probes |
| US11155713B2 (en) | 2018-05-29 | 2021-10-26 | Elitechgroup, Inc. | Carborhodamine compounds and methods of preparation thereof |
| KR20260039812A (ko) | 2019-02-06 | 2026-03-20 | 신톡스, 인크. | Il-2 콘쥬게이트 및 이의 사용 방법 |
| JP7475445B2 (ja) * | 2019-11-19 | 2024-04-26 | エスエフシー カンパニー リミテッド | 消光子およびこの用途 |
| CA3210985A1 (en) * | 2021-03-12 | 2022-09-15 | Sarah KANE | Multiplexed genotyping assays with a single probe using fluorescent amplitude tuning |
| WO2023076908A1 (en) * | 2021-10-25 | 2023-05-04 | Gt Molecular, Inc. | Off-target blocking sequences to improve target discrimination by polymerase chain reaction |
| JP7276571B1 (ja) | 2022-06-20 | 2023-05-18 | 凸版印刷株式会社 | フラップエンドヌクレアーゼの蛍光基質における三重鎖構造の形成効率を向上させる方法 |
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| US6579680B2 (en) * | 2000-02-28 | 2003-06-17 | Corning Incorporated | Method for label-free detection of hybridized DNA targets |
| WO2002012263A1 (en) * | 2000-08-03 | 2002-02-14 | Roche Diagnostics Gmbh | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses |
| JP4709959B2 (ja) * | 2001-06-14 | 2011-06-29 | 国立大学法人東京工業大学 | ヌクレオシドホスホロアミダイト化合物 |
| DE10142643A1 (de) * | 2001-08-31 | 2003-04-24 | Clondiag Chip Tech Gmbh | Detektion von Wechselwirkungen auf Sonden-Arrays |
-
2004
- 2004-09-29 US US10/954,955 patent/US7348146B2/en not_active Expired - Lifetime
- 2004-09-30 WO PCT/US2004/032265 patent/WO2005035545A2/en not_active Ceased
- 2004-09-30 JP JP2006534123A patent/JP2007510401A/ja active Pending
- 2004-09-30 EP EP04789416A patent/EP1670928A4/en not_active Withdrawn
- 2004-09-30 CA CA002540551A patent/CA2540551A1/en not_active Abandoned
- 2004-09-30 AU AU2004279810A patent/AU2004279810A1/en not_active Abandoned
-
2008
- 2008-01-28 US US12/020,908 patent/US7718374B2/en not_active Expired - Lifetime
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