JP2007509902A - 薬理学的に活性のある薬剤の送達のためのナノ粒子 - Google Patents

薬理学的に活性のある薬剤の送達のためのナノ粒子 Download PDF

Info

Publication number
JP2007509902A
JP2007509902A JP2006537242A JP2006537242A JP2007509902A JP 2007509902 A JP2007509902 A JP 2007509902A JP 2006537242 A JP2006537242 A JP 2006537242A JP 2006537242 A JP2006537242 A JP 2006537242A JP 2007509902 A JP2007509902 A JP 2007509902A
Authority
JP
Japan
Prior art keywords
nanoparticles
dna
nanoparticle
antigen
tat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006537242A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007509902A5 (OSRAM
Inventor
エンソーリ，バルバラ
カプート，アントネラ
ラウス，ミケーレ
トンデッリ，ルイーザ
スパーナッチ，カティア
Original Assignee
イスティチュート スペリオーレ ディ サニータ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イスティチュート スペリオーレ ディ サニータ filed Critical イスティチュート スペリオーレ ディ サニータ
Publication of JP2007509902A publication Critical patent/JP2007509902A/ja
Publication of JP2007509902A5 publication Critical patent/JP2007509902A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006537242A 2003-11-03 2004-11-03 薬理学的に活性のある薬剤の送達のためのナノ粒子 Pending JP2007509902A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0325625A GB2407501A (en) 2003-11-03 2003-11-03 Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell
PCT/EP2004/012420 WO2005048997A1 (en) 2003-11-03 2004-11-03 Nanoparticles for delivery of a pharmacologically active agent

Publications (2)

Publication Number Publication Date
JP2007509902A true JP2007509902A (ja) 2007-04-19
JP2007509902A5 JP2007509902A5 (OSRAM) 2007-11-29

Family

ID=29725850

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006537242A Pending JP2007509902A (ja) 2003-11-03 2004-11-03 薬理学的に活性のある薬剤の送達のためのナノ粒子

Country Status (5)

Country Link
US (1) US20060280798A1 (OSRAM)
EP (1) EP1701711A1 (OSRAM)
JP (1) JP2007509902A (OSRAM)
GB (1) GB2407501A (OSRAM)
WO (1) WO2005048997A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010163364A (ja) * 2009-01-13 2010-07-29 Univ Of Tsukuba 四級化アミノ基を有する架橋ポリマー由来のポリマー微粒子と核酸の複合体
CN110808137A (zh) * 2019-11-13 2020-02-18 山东师范大学 一种磁性富集材料、水体细菌检测试剂盒及应用

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877250B2 (en) 2005-12-20 2014-11-04 Bridgestone Corporation Hollow nano-particles and method thereof
US20100196280A1 (en) * 2006-06-08 2010-08-05 Katrin Claudia Fischer Functionalized solid polymer nanoparticles for diagnostic and therapeutic applications
WO2008011165A2 (en) 2006-07-21 2008-01-24 Nektar Therapeutics Al, Corporation Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
WO2008085556A2 (en) 2006-09-12 2008-07-17 University Of South Florida Surfactant-free nanoparticles for drug delivery
FR2909094A1 (fr) * 2006-11-28 2008-05-30 Arkema France Memoire optique 3d comprenant des particules multicouches comprenant un monomere photoactif porteur d'un groupement photoisomerisable.
WO2009056344A1 (en) * 2007-11-02 2009-05-07 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Core-shell macromolecules for specific cell nucleus or/and cell matrix staining
US20090311335A1 (en) * 2008-06-12 2009-12-17 Scott Jenkins Combination of a triptan and an nsaid
ES2527600T3 (es) * 2008-12-31 2015-01-27 Bridgestone Corporation Procedimiento de formación de nanopartículas formando primero el núcleo, nanopartícula y composición
US9062144B2 (en) 2009-04-03 2015-06-23 Bridgestone Corporation Hairy polymeric nanoparticles with first and second shell block polymer arms
US10099227B2 (en) 2009-08-25 2018-10-16 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
CN102625710A (zh) 2009-08-25 2012-08-01 艾格尼丝·奥斯塔芬 携氧的抗湍流的高密度亚微米颗粒的合成
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
IT1397011B1 (it) * 2009-10-14 2012-12-20 Univ Ferrara Nanoparticella del tipo core-shell idonea per la veicolazione di oligonucleotidi terapeutici in tessuti bersaglio e suo impiego per la preparazione di un medicamento per il trattamento della distrofia muscolare di duchenne.
US9115222B2 (en) 2009-12-29 2015-08-25 Bridgestone Corporation Well defined, highly crosslinked nanoparticles and method for making same
KR20130100290A (ko) 2010-08-30 2013-09-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 협착성 병변을 위한 전단 제어 방출 및 혈전 용해 치료법
CA2839689C (en) * 2011-06-17 2018-05-01 Evonik Roehm Gmbh Coating composition suitable for pharmaceutical or nutraceutical dosage forms
US9428604B1 (en) 2011-12-30 2016-08-30 Bridgestone Corporation Nanoparticle fillers and methods of mixing into elastomers
WO2015026947A1 (en) * 2013-08-21 2015-02-26 The Regents Of The University Of California Composition and methods for culturing cells
HU231309B1 (hu) 2014-02-25 2022-11-28 Darholding Kft. Nanostrukturált Indomethacint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás előállításukra
CA3194232A1 (en) 2020-09-29 2022-04-07 Daniel Beard Stroke treatment
WO2022109274A1 (en) * 2020-11-20 2022-05-27 Nouryon Chemicals International B.V. Fluorescent polymers and solutions thereof for scale control in aqueous systems
AU2021391823A1 (en) 2020-12-03 2023-06-29 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
IL307454A (en) 2021-04-07 2023-12-01 Battelle Memorial Institute Technologies for rapid design, construction, testing, learning to identify and use non-viral vectors
US20230212639A1 (en) * 2022-01-05 2023-07-06 City University Of Hong Kong Core-shell nanoparticles, methods of producing the same, and uses thereof for detecting extracellular polymeric substances
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
WO2025122954A1 (en) 2023-12-08 2025-06-12 Battelle Memorial Institute Use of dna origami nanostructures for molecular information based data storage systems

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001322347A (ja) * 2000-03-27 2001-11-20 Eastman Kodak Co インクジェット印刷方法
JP2001524531A (ja) * 1997-12-01 2001-12-04 イスティテュート スペリオーレ ディ サニタ 予防的および治療的ワクチン接種用のＨＩＶ−１のＴａｔまたはその誘導体
JP2002534220A (ja) * 1999-01-12 2002-10-15 クアナム メディカル コーポレイション 腔内ステント用の重合体組成物
WO2003045356A1 (en) * 2000-11-20 2003-06-05 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings
WO2003057199A1 (de) * 2002-01-09 2003-07-17 Röhm GmbH & Co. KG Haft- und bindemittel für dermale oder transdermale therapiesysteme

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723218A (en) * 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
DE19614136A1 (de) * 1996-04-10 1997-10-16 Inst Neue Mat Gemein Gmbh Verfahren zur Herstellung agglomeratfreier nanoskaliger Eisenoxidteilchen mit hydrolysebeständigem Überzug
EP0934082B1 (de) * 1996-10-23 2002-07-17 SKW Trostberg Aktiengesellschaft Verfahren zur herstellung von biologisch aktiven polymernanopartikel-nucleinsäure-konjugaten
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
US6974706B1 (en) * 2003-01-16 2005-12-13 University Of Florida Research Foundation, Inc. Application of biosensors for diagnosis and treatment of disease
WO2002000191A2 (de) * 2000-06-29 2002-01-03 Bernina Biosystems Gmbh Bdellosomen
DE10118852A1 (de) * 2001-04-17 2002-10-31 Fricker Gert Bdellosomen
DE10203907A1 (de) * 2002-01-31 2003-08-21 Karlsruhe Forschzent Fluoreszierende Nanoteilchen und deren Herstellung

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001524531A (ja) * 1997-12-01 2001-12-04 イスティテュート スペリオーレ ディ サニタ 予防的および治療的ワクチン接種用のＨＩＶ−１のＴａｔまたはその誘導体
JP2002534220A (ja) * 1999-01-12 2002-10-15 クアナム メディカル コーポレイション 腔内ステント用の重合体組成物
JP2001322347A (ja) * 2000-03-27 2001-11-20 Eastman Kodak Co インクジェット印刷方法
WO2003045356A1 (en) * 2000-11-20 2003-06-05 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings
JP2005510539A (ja) * 2001-11-23 2005-04-21 ザ プロクター アンド ギャンブル カンパニー 複数のコーティングを有する医薬剤形
WO2003057199A1 (de) * 2002-01-09 2003-07-17 Röhm GmbH & Co. KG Haft- und bindemittel für dermale oder transdermale therapiesysteme
JP2005519054A (ja) * 2002-01-09 2005-06-30 レーム ゲゼルシャフト ミツト ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト 皮膚または経皮吸収治療システムのための接着剤および結合剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010163364A (ja) * 2009-01-13 2010-07-29 Univ Of Tsukuba 四級化アミノ基を有する架橋ポリマー由来のポリマー微粒子と核酸の複合体
CN110808137A (zh) * 2019-11-13 2020-02-18 山东师范大学 一种磁性富集材料、水体细菌检测试剂盒及应用

Also Published As

Publication number Publication date
GB2407501A (en) 2005-05-04
GB0325625D0 (en) 2003-12-10
WO2005048997A1 (en) 2005-06-02
EP1701711A1 (en) 2006-09-20
US20060280798A1 (en) 2006-12-14

Similar Documents

Publication Publication Date Title
JP2007509902A (ja) 薬理学的に活性のある薬剤の送達のためのナノ粒子
Xiang et al. Delivery of DNA vaccines: an overview on the use of biodegradable polymeric and magnetic nanoparticles
ES2344303T3 (es) Particulas que comprenden un nucleo de nanoparticulas de fosfato calcico, una biomolecula y un acido biliar, los metodos de produccion y el uso terapeutico de las mismas.
Bhavsar et al. Polymeric nano-and microparticle technologies for oral gene delivery
US9950051B2 (en) Formulations
Kreuter Nanoparticles—a historical perspective
EP2464341B1 (en) Immunomodulatory compositions comprising a polymer matrix and an oil phase
Rose et al. A strong adjuvant based on glycol-chitosan-coated lipid-polymer hybrid nanoparticles potentiates mucosal immune responses against the recombinant Chlamydia trachomatis fusion antigen CTH522
Castaldello et al. DNA prime and protein boost immunization with innovative polymeric cationic core-shell nanoparticles elicits broad immune responses and strongly enhance cellular responses of HIV-1 tat DNA vaccination
JP2003528024A (ja) 製剤化された核酸分子の無針注入
Chen et al. Pollen-mimetic metal–organic frameworks with tunable spike-like nanostructures that promote cell interactions to improve antigen-specific humoral immunity
Avila et al. Gene delivery and immunomodulatory effects of plasmid DNA associated with Branched Amphiphilic Peptide Capsules
CN104338126B (zh) 一种具有治疗或预防hpv病毒的疫苗组合物及其应用
JP2012515201A (ja) 改変された生分解速度論を有する多孔性構造
Voltan et al. Preparation and characterization of innovative protein-coated poly (methylmethacrylate) core-shell nanoparticles for vaccine purposes
US20070275071A1 (en) Use of Microparticles for Antigen Delivery
Panda Nanotechnology in vaccine development
Singh et al. Applications of nanotechnology in vaccine delivery
White et al. Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants
Dong et al. Nano-delivery vehicles/adjuvants for DNA vaccination against HIV
WO2021081043A1 (en) Mucus penetrating particle compositions and methods of use thereof enhancing immune response
Singh et al. Surface-charged poly (lactide-co-glycolide) microparticles as novel antigen delivery systems
Prajapati et al. Formulation Development and Evaluation of Dextran Nanoparticles Enclosed with Recombinant Typhoid (Ty21a) Antigen
Jain et al. Non-condensing polymeric gene delivery systems: Principles and applications
Chablani Formulation and in vivo Evaluation of Particulate Breast Cancer Vaccine

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071010

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071010

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110119

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110701