JP2007508394A5 - - Google Patents
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- Publication number
- JP2007508394A5 JP2007508394A5 JP2006535601A JP2006535601A JP2007508394A5 JP 2007508394 A5 JP2007508394 A5 JP 2007508394A5 JP 2006535601 A JP2006535601 A JP 2006535601A JP 2006535601 A JP2006535601 A JP 2006535601A JP 2007508394 A5 JP2007508394 A5 JP 2007508394A5
- Authority
- JP
- Japan
- Prior art keywords
- piperazin
- ylethyl
- cyclobutanol
- chlorophenyl
- cyclohexanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- REBCRUZAHKPPJG-UHFFFAOYSA-N 1-[1-(4-bromophenyl)-2-piperazin-1-ylethyl]cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C=CC(Br)=CC=1)C1(O)CCC1 REBCRUZAHKPPJG-UHFFFAOYSA-N 0.000 claims 2
- -1 CF 3 Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 claims 1
- PZQVDLYPNAADGQ-KRWDZBQOSA-N 1-[(1r)-1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound OC1([C@@H](CN2CCNCC2)C=2C=C(Cl)C=CC=2)CCCCC1 PZQVDLYPNAADGQ-KRWDZBQOSA-N 0.000 claims 1
- PZQVDLYPNAADGQ-QGZVFWFLSA-N 1-[(1s)-1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound OC1([C@H](CN2CCNCC2)C=2C=C(Cl)C=CC=2)CCCCC1 PZQVDLYPNAADGQ-QGZVFWFLSA-N 0.000 claims 1
- QFIJRJZGJBEPSZ-UHFFFAOYSA-N 1-[1-(2-bromophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C(=CC=CC=1)Br)C1(O)CCCCC1 QFIJRJZGJBEPSZ-UHFFFAOYSA-N 0.000 claims 1
- FBPIYNSAIXRAKI-UHFFFAOYSA-N 1-[1-(2-fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclobutan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC1)C1=CC=CC=C1F FBPIYNSAIXRAKI-UHFFFAOYSA-N 0.000 claims 1
- BLTKKNKJEHRTJP-UHFFFAOYSA-N 1-[1-(2-fluorophenyl)-2-piperazin-1-ylethyl]cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C(=CC=CC=1)F)C1(O)CCC1 BLTKKNKJEHRTJP-UHFFFAOYSA-N 0.000 claims 1
- LBHZTGKCTKOYTN-UHFFFAOYSA-N 1-[1-(2-fluorophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C(=CC=CC=1)F)C1(O)CCCCC1 LBHZTGKCTKOYTN-UHFFFAOYSA-N 0.000 claims 1
- OPAKGKQKMQGOGL-UHFFFAOYSA-N 1-[1-(3,4-dichlorophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Cl)C(Cl)=CC=1)C1(O)CCCCC1 OPAKGKQKMQGOGL-UHFFFAOYSA-N 0.000 claims 1
- IAXITOGKMSXBJM-UHFFFAOYSA-N 1-[1-(3-bromo-4-methoxyphenyl)-2-piperazin-1-ylethyl]cyclooctan-1-ol Chemical compound C1=C(Br)C(OC)=CC=C1C(C1(O)CCCCCCC1)CN1CCNCC1 IAXITOGKMSXBJM-UHFFFAOYSA-N 0.000 claims 1
- BSNFRMQEINNSIJ-UHFFFAOYSA-N 1-[1-(3-bromo-4-methoxyphenyl)-2-piperazin-1-ylethyl]cyclopentan-1-ol Chemical compound C1=C(Br)C(OC)=CC=C1C(C1(O)CCCC1)CN1CCNCC1 BSNFRMQEINNSIJ-UHFFFAOYSA-N 0.000 claims 1
- DGBKDBRUKWAZBY-UHFFFAOYSA-N 1-[1-(3-bromophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclooctan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCCCCCC1)C1=CC=CC(Br)=C1 DGBKDBRUKWAZBY-UHFFFAOYSA-N 0.000 claims 1
- OBYMFFTYBMFUTN-UHFFFAOYSA-N 1-[1-(3-bromophenyl)-2-piperazin-1-ylethyl]cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Br)C=CC=1)C1(O)CCC1 OBYMFFTYBMFUTN-UHFFFAOYSA-N 0.000 claims 1
- HHRVKAJJFQQGMY-UHFFFAOYSA-N 1-[1-(3-bromophenyl)-2-piperazin-1-ylethyl]cycloheptan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Br)C=CC=1)C1(O)CCCCCC1 HHRVKAJJFQQGMY-UHFFFAOYSA-N 0.000 claims 1
- QIEWQGGMPRNSTF-UHFFFAOYSA-N 1-[1-(3-bromophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Br)C=CC=1)C1(O)CCCCC1 QIEWQGGMPRNSTF-UHFFFAOYSA-N 0.000 claims 1
- CZRBZQHNTQGFDV-UHFFFAOYSA-N 1-[1-(3-bromophenyl)-2-piperazin-1-ylethyl]cyclooctan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Br)C=CC=1)C1(O)CCCCCCC1 CZRBZQHNTQGFDV-UHFFFAOYSA-N 0.000 claims 1
- DHGBPKXIJTZIQH-UHFFFAOYSA-N 1-[1-(3-bromophenyl)-2-piperazin-1-ylethyl]cyclopentan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Br)C=CC=1)C1(O)CCCC1 DHGBPKXIJTZIQH-UHFFFAOYSA-N 0.000 claims 1
- CNGLIEZZMOIJGV-UHFFFAOYSA-N 1-[1-(3-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclobutan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC1)C1=CC=CC(Cl)=C1 CNGLIEZZMOIJGV-UHFFFAOYSA-N 0.000 claims 1
- ZFQGQANQGWASIE-UHFFFAOYSA-N 1-[1-(3-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclooctan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCCCCCC1)C1=CC=CC(Cl)=C1 ZFQGQANQGWASIE-UHFFFAOYSA-N 0.000 claims 1
- SIMGTBMOANUZIG-NNJIEVJOSA-N 1-[1-(3-chlorophenyl)-2-[(3r)-3-methylpiperazin-1-yl]ethyl]cyclohexan-1-ol Chemical compound C1CN[C@H](C)CN1CC(C1(O)CCCCC1)C1=CC=CC(Cl)=C1 SIMGTBMOANUZIG-NNJIEVJOSA-N 0.000 claims 1
- SBXWKBLGYGJAMJ-MCPYQZEQSA-N 1-[1-(3-chlorophenyl)-2-[(3r,5s)-3,5-dimethylpiperazin-1-yl]ethyl]cyclohexan-1-ol Chemical compound C1[C@@H](C)N[C@@H](C)CN1CC(C1(O)CCCCC1)C1=CC=CC(Cl)=C1 SBXWKBLGYGJAMJ-MCPYQZEQSA-N 0.000 claims 1
- SIMGTBMOANUZIG-BUSXIPJBSA-N 1-[1-(3-chlorophenyl)-2-[(3s)-3-methylpiperazin-1-yl]ethyl]cyclohexan-1-ol Chemical compound C1CN[C@@H](C)CN1CC(C1(O)CCCCC1)C1=CC=CC(Cl)=C1 SIMGTBMOANUZIG-BUSXIPJBSA-N 0.000 claims 1
- RMNOTTSKUONNGC-UHFFFAOYSA-N 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Cl)C=CC=1)C1(O)CCC1 RMNOTTSKUONNGC-UHFFFAOYSA-N 0.000 claims 1
- GNFBWBLHLHVEHI-UHFFFAOYSA-N 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cycloheptan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Cl)C=CC=1)C1(O)CCCCCC1 GNFBWBLHLHVEHI-UHFFFAOYSA-N 0.000 claims 1
- PZQVDLYPNAADGQ-UHFFFAOYSA-N 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Cl)C=CC=1)C1(O)CCCCC1 PZQVDLYPNAADGQ-UHFFFAOYSA-N 0.000 claims 1
- DIMZLFDDDJZTNC-UHFFFAOYSA-N 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclooctan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Cl)C=CC=1)C1(O)CCCCCCC1 DIMZLFDDDJZTNC-UHFFFAOYSA-N 0.000 claims 1
- BDZIOTCFFYFCSB-UHFFFAOYSA-N 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclopentan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Cl)C=CC=1)C1(O)CCCC1 BDZIOTCFFYFCSB-UHFFFAOYSA-N 0.000 claims 1
- APZLULIMMIJDAY-UHFFFAOYSA-N 1-[1-(3-fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclobutan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC1)C1=CC=CC(F)=C1 APZLULIMMIJDAY-UHFFFAOYSA-N 0.000 claims 1
- QWUVCZDEMPCCJX-UHFFFAOYSA-N 1-[1-(3-fluorophenyl)-2-piperazin-1-ylethyl]cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(F)C=CC=1)C1(O)CCC1 QWUVCZDEMPCCJX-UHFFFAOYSA-N 0.000 claims 1
- PIBZTCVMCNNFRR-UHFFFAOYSA-N 1-[1-(3-fluorophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(F)C=CC=1)C1(O)CCCCC1 PIBZTCVMCNNFRR-UHFFFAOYSA-N 0.000 claims 1
- ZNOWPRXCOCARHQ-UHFFFAOYSA-N 1-[1-(4-bromophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclobutan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC1)C1=CC=C(Br)C=C1 ZNOWPRXCOCARHQ-UHFFFAOYSA-N 0.000 claims 1
- WZKIGEMCGDZHTR-UHFFFAOYSA-N 1-[1-(4-bromophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=CC(Br)=CC=1)C1(O)CCCCC1 WZKIGEMCGDZHTR-UHFFFAOYSA-N 0.000 claims 1
- FGOFHUJIOVZZQE-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclobutan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC1)C1=CC=C(Cl)C=C1 FGOFHUJIOVZZQE-UHFFFAOYSA-N 0.000 claims 1
- HPBLUEOXHZOXFX-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)-2-piperazin-1-ylethyl]cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C=CC(Cl)=CC=1)C1(O)CCC1 HPBLUEOXHZOXFX-UHFFFAOYSA-N 0.000 claims 1
- KHWNQEDSMGUKSX-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=CC(Cl)=CC=1)C1(O)CCCCC1 KHWNQEDSMGUKSX-UHFFFAOYSA-N 0.000 claims 1
- UZVBARIHCIAPAS-UHFFFAOYSA-N 1-[1-(4-fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclobutan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC1)C1=CC=C(F)C=C1 UZVBARIHCIAPAS-UHFFFAOYSA-N 0.000 claims 1
- JMKKGNSMJRPWLW-UHFFFAOYSA-N 1-[1-(4-fluorophenyl)-2-piperazin-1-ylethyl]cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C=CC(F)=CC=1)C1(O)CCC1 JMKKGNSMJRPWLW-UHFFFAOYSA-N 0.000 claims 1
- IQHHTOSZORUSLE-UHFFFAOYSA-N 1-[1-(4-fluorophenyl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=CC(F)=CC=1)C1(O)CCCCC1 IQHHTOSZORUSLE-UHFFFAOYSA-N 0.000 claims 1
- KZMYISUBTLBMKL-UHFFFAOYSA-N 1-[2-(4-methylpiperazin-1-yl)-1-[3-(trifluoromethyl)phenyl]ethyl]cyclobutan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC1)C1=CC=CC(C(F)(F)F)=C1 KZMYISUBTLBMKL-UHFFFAOYSA-N 0.000 claims 1
- MCGGADLCNVOIBI-UHFFFAOYSA-N 1-[2-piperazin-1-yl-1-[3-(trifluoromethyl)phenyl]ethyl]cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(C=CC=1)C(F)(F)F)C1(O)CCC1 MCGGADLCNVOIBI-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000000966 norepinephrine reuptake Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51154203P | 2003-10-14 | 2003-10-14 | |
| US56146904P | 2004-04-12 | 2004-04-12 | |
| US57004004P | 2004-05-11 | 2004-05-11 | |
| US10/963,458 US7531543B2 (en) | 2003-10-14 | 2004-10-12 | Phenylpiperazine cycloalkanol derivatives and methods of their use |
| PCT/US2004/033674 WO2005037808A1 (en) | 2003-10-14 | 2004-10-13 | Phenylpiperazine cycloalkanol derivatives and methods of their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007508394A JP2007508394A (ja) | 2007-04-05 |
| JP2007508394A5 true JP2007508394A5 (https=) | 2007-11-29 |
Family
ID=34468490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006535601A Withdrawn JP2007508394A (ja) | 2003-10-14 | 2004-10-13 | フェニルピペラジンシクロアルカノール誘導体およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7531543B2 (https=) |
| EP (1) | EP1673358A1 (https=) |
| JP (1) | JP2007508394A (https=) |
| AU (1) | AU2004282166A1 (https=) |
| BR (1) | BRPI0415478A (https=) |
| CA (1) | CA2539763A1 (https=) |
| MX (1) | MXPA06003877A (https=) |
| WO (1) | WO2005037808A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7524846B2 (en) * | 2003-10-14 | 2009-04-28 | Wyeth | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use |
| US7517899B2 (en) * | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| US7414052B2 (en) * | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| CA2629807A1 (en) * | 2005-12-05 | 2007-06-14 | Wyeth | Process for preparing substituted aryl cycloalkanol derivatives |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2971955A (en) * | 1958-12-29 | 1961-02-14 | Abbott Lab | Cyclohexylcarbinol derivatives of piperazine |
| US3454554A (en) * | 1960-10-14 | 1969-07-08 | Colgate Palmolive Co | Aminoalkyliminodibenzyl compounds |
| CS175831B1 (https=) * | 1974-12-17 | 1977-05-31 | ||
| IL56369A (en) * | 1978-01-20 | 1984-05-31 | Erba Farmitalia | Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them |
| US4310524A (en) * | 1980-04-11 | 1982-01-12 | Richardson-Merrell, Inc. | TCA Composition and method for rapid onset antidepressant therapy |
| PH18686A (en) | 1981-05-26 | 1985-08-29 | Merck & Co Inc | 1-(3 halo-2-pyridinyl) piperazine |
| US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| CA1280421C (en) | 1985-07-02 | 1991-02-19 | Albert A. Carr | 1,4-disubstituted piperidinyl derivatives |
| CA1327795C (en) | 1987-08-14 | 1994-03-15 | Jules Freedman | Antidepressants which are aryloxy inadanamines |
| US4826844A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| KR100211713B1 (ko) | 1990-06-01 | 1999-08-02 | 슈테펜 엘. 네스비트 | (+)-알파-(2,3-디메톡시페닐)-1-[2-(4-플루오로페닐)에틸]-4-피페리딘메탄올 |
| US5502047A (en) * | 1993-03-22 | 1996-03-26 | Kavey; Neil B. | Treatment for insomnia |
| WO1997035586A1 (en) | 1996-03-25 | 1997-10-02 | Eli Lilly And Company | Method for treating pain |
| EA200000890A1 (ru) | 1998-03-02 | 2001-02-26 | Эли Лилли Энд Компани | Гидрохлорид флуоксетина для уменьшения "приливов" (приступообразных ощущений жара (при климактерическом синдроме)) |
| DE60039132D1 (de) | 1999-04-06 | 2008-07-17 | Sepracor Inc | O-Desmethylvenlafaxin-Succinat |
| US6465458B1 (en) * | 1999-07-01 | 2002-10-15 | Pharmacia & Upjohn Company | Method of treating or preventing chronic pain with a highly selective norepinephrine reuptake inhibitor |
| EP1864967A1 (en) | 2001-02-12 | 2007-12-12 | Wyeth | Method for preparing O-desmethyl-venlafaxine |
| EP1383495A1 (en) | 2001-03-29 | 2004-01-28 | Eli Lilly And Company | Duloxetine for treatment of hot flashes |
| EP1266659A1 (en) | 2001-06-11 | 2002-12-18 | Pantarhei Bioscience B.V. | Pyridoxal in combination with serotonin re-uptake inhibitor for the treatment of hot flushes |
| WO2003037334A1 (en) | 2001-10-31 | 2003-05-08 | Merck & Co., Inc. | Method for treating or preventing symptoms of hormonal variation including hot flashes |
| US6602911B2 (en) | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| JP2005526079A (ja) | 2002-03-15 | 2005-09-02 | サイプレス バイオサイエンス， インコーポレイテッド | 内蔵痛症候群を処置するためのｎｅおよび５−ｈｔ再取り込み阻害剤 |
| TW200402289A (en) * | 2002-05-17 | 2004-02-16 | Wyeth Corp | Methods of treating gastrointestinary and genitourinary pain disorders |
| EP1530476A1 (en) | 2002-08-14 | 2005-05-18 | Pharmacia & Upjohn Company LLC | Use of reboxetine for the treatment of hot flashes |
| US20040180879A1 (en) | 2002-10-15 | 2004-09-16 | Deecher Darlene Coleman | Novel method of treating vasomotor symptoms |
| US7345096B2 (en) * | 2002-10-15 | 2008-03-18 | Wyeth | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
| US20040152710A1 (en) | 2002-10-15 | 2004-08-05 | Deecher Darlene Coleman | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
| US7524846B2 (en) * | 2003-10-14 | 2009-04-28 | Wyeth | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use |
-
2004
- 2004-10-12 US US10/963,458 patent/US7531543B2/en not_active Expired - Fee Related
- 2004-10-13 MX MXPA06003877A patent/MXPA06003877A/es unknown
- 2004-10-13 BR BRPI0415478-9A patent/BRPI0415478A/pt not_active IP Right Cessation
- 2004-10-13 CA CA002539763A patent/CA2539763A1/en not_active Abandoned
- 2004-10-13 JP JP2006535601A patent/JP2007508394A/ja not_active Withdrawn
- 2004-10-13 WO PCT/US2004/033674 patent/WO2005037808A1/en not_active Ceased
- 2004-10-13 AU AU2004282166A patent/AU2004282166A1/en not_active Withdrawn
- 2004-10-13 EP EP04794907A patent/EP1673358A1/en not_active Withdrawn
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