JP2007508039A5 - - Google Patents
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- Publication number
- JP2007508039A5 JP2007508039A5 JP2006527276A JP2006527276A JP2007508039A5 JP 2007508039 A5 JP2007508039 A5 JP 2007508039A5 JP 2006527276 A JP2006527276 A JP 2006527276A JP 2006527276 A JP2006527276 A JP 2006527276A JP 2007508039 A5 JP2007508039 A5 JP 2007508039A5
- Authority
- JP
- Japan
- Prior art keywords
- layer
- medical product
- agent
- polysulfone
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003795 chemical substances by application Substances 0.000 claims 20
- 229920003288 polysulfone Polymers 0.000 claims 20
- 230000001028 anti-proliferant Effects 0.000 claims 9
- 239000002260 anti-inflammatory agent Substances 0.000 claims 8
- 239000003146 anticoagulant agent Substances 0.000 claims 8
- 229920001477 hydrophilic polymer Polymers 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 7
- -1 caprolactone diol Chemical class 0.000 claims 5
- 229920000954 Polyglycolide Polymers 0.000 claims 4
- 229940121363 anti-inflammatory agents Drugs 0.000 claims 4
- 229920001400 block copolymer Polymers 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 238000000151 deposition Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate dianion Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 229960002897 Heparin Drugs 0.000 claims 3
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 229920002988 biodegradable polymer Polymers 0.000 claims 3
- 239000004621 biodegradable polymer Substances 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 229960005188 collagen Drugs 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 229920001610 polycaprolactone Polymers 0.000 claims 3
- 239000004633 polyglycolic acid Substances 0.000 claims 3
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 claims 2
- 229940074726 OPHTHALMOLOGIC ANTIINFLAMMATORY AGENTS Drugs 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 239000004695 Polyether sulfone Substances 0.000 claims 2
- 229920000491 Polyphenylsulfone Polymers 0.000 claims 2
- 229920001451 Polypropylene glycol Polymers 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims 2
- 229920002496 poly(ether sulfone) Polymers 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 229920000728 polyester Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- ZNLAHAOCFKBYRH-UHFFFAOYSA-N 1,4-dioxane-2,3-dione Chemical compound O=C1OCCOC1=O ZNLAHAOCFKBYRH-UHFFFAOYSA-N 0.000 claims 1
- 102100001249 ALB Human genes 0.000 claims 1
- 101710027066 ALB Proteins 0.000 claims 1
- 102000007469 Actins Human genes 0.000 claims 1
- 108010085238 Actins Proteins 0.000 claims 1
- 229940045110 Chitosan Drugs 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N Chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- 229940012952 Fibrinogen Drugs 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 229940019698 Fibrinogen containing hemostatics Drugs 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229940014259 Gelatin Drugs 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 241000023320 Luma <angiosperm> Species 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinylpyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- KHEDIYCQDPMFKF-UHFFFAOYSA-M OC(=O)COS([O-])(=O)=O Chemical compound OC(=O)COS([O-])(=O)=O KHEDIYCQDPMFKF-UHFFFAOYSA-M 0.000 claims 1
- 229960001592 Paclitaxel Drugs 0.000 claims 1
- 229920002230 Pectic acid Polymers 0.000 claims 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N Pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000903 Polyhydroxyalkanoate Polymers 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 239000004721 Polyphenylene oxide Substances 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N Sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229940032147 Starch Drugs 0.000 claims 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N Triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 1
- YFHICDDUDORKJB-UHFFFAOYSA-N Trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N Valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 1
- 229920002494 Zein Polymers 0.000 claims 1
- 229940093612 Zein Drugs 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive Effects 0.000 claims 1
- 229940050528 albumin Drugs 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 claims 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
- 229960004853 betadex Drugs 0.000 claims 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001808 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 150000002596 lactones Chemical class 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-L oxalate Chemical compound [O-]C(=O)C([O-])=O MUBZPKHOEPUJKR-UHFFFAOYSA-L 0.000 claims 1
- 229920003250 poly(2-hydroxyethyl methacrylate) Polymers 0.000 claims 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) polymer Polymers 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920001707 polybutylene terephthalate Polymers 0.000 claims 1
- 229920002721 polycyanoacrylate Polymers 0.000 claims 1
- 229920000570 polyether Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000010318 polygalacturonic acid Substances 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 229920001444 polymaleic acid Polymers 0.000 claims 1
- 229920000098 polyolefin Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 239000001294 propane Substances 0.000 claims 1
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 238000005670 sulfation reaction Methods 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 239000005019 zein Substances 0.000 claims 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N β-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10345132.3 | 2003-09-29 | ||
| DE10345132 | 2003-09-29 | ||
| US51629503P | 2003-11-03 | 2003-11-03 | |
| US60/516,295 | 2003-11-03 | ||
| DE102004020856.5 | 2004-04-28 | ||
| DE102004020856A DE102004020856A1 (de) | 2003-09-29 | 2004-04-28 | Biokompatible, biostabile Beschichtung von medizinischen Oberflächen |
| US57158204P | 2004-05-17 | 2004-05-17 | |
| US60/571,582 | 2004-05-17 | ||
| PCT/DE2004/002184 WO2005032611A2 (de) | 2003-09-29 | 2004-09-29 | Biokompatible, biostabile beschichtung von medizinischen oberflächen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007508039A JP2007508039A (ja) | 2007-04-05 |
| JP2007508039A5 true JP2007508039A5 (es) | 2010-08-26 |
| JP4861178B2 JP4861178B2 (ja) | 2012-01-25 |
Family
ID=34306136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527276A Expired - Fee Related JP4861178B2 (ja) | 2003-09-29 | 2004-09-29 | 生体適合性および生物学的安定性を有する医療用品表面コーティング |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP4861178B2 (es) |
| DE (1) | DE102004020856A1 (es) |
| OA (1) | OA13261A (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070160641A1 (en) * | 2006-01-12 | 2007-07-12 | Eun-Hyun Jang | Coated medical devices and methods of making the same |
| EP2386322B1 (de) * | 2006-07-03 | 2017-12-27 | Hemoteq AG | Herstellung, Verfahren und Verwendung von wirkstofffreisetzenden Medizinprodukten zur permanenten Offenhaltung von Blutgefässen |
| DE112008000881A5 (de) * | 2007-01-21 | 2010-01-21 | Hemoteq Ag | Medizinprodukt zur Behandlung von Verschlüssen von Körperdurchgängen und zur Prävention drohender Wiederverschlüsse |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| DE102008043724A1 (de) | 2008-11-13 | 2010-05-20 | Biotronik Vi Patent Ag | Erhöhung der Effizienz pharmazeutische Wirkstoffe-freisetzender Medizinprodukte durch Kombination mit einem Inhibitor des Transportproteins P-Glycoprotein |
| ES2550634T3 (es) | 2009-07-10 | 2015-11-11 | Boston Scientific Scimed, Inc. | Uso de nanocristales para un balón de suministro de fármaco |
| JP5933434B2 (ja) | 2009-07-17 | 2016-06-08 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 薬剤送達バルーンの製造方法 |
| CN102274550B (zh) * | 2010-06-13 | 2014-11-26 | 上海微创医疗器械（集团）有限公司 | 一种介入医疗器械 |
| WO2012031236A1 (en) | 2010-09-02 | 2012-03-08 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| US11439798B2 (en) | 2017-04-24 | 2022-09-13 | Longeviti Neuro Solutions Llc | Cerebral spinal fluid shunt plug |
| US11045632B2 (en) | 2017-04-24 | 2021-06-29 | Longeviti Neuro Solutions Llc | Cerebral spinal fluid shunt plug |
| DE102018110582A1 (de) * | 2018-05-03 | 2019-11-07 | Biotronik Ag | Verminderung der Rissbildung in Polymerschichten von abbaubaren Scaffolds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0432141A3 (en) * | 1984-03-30 | 1991-08-21 | Osteonics Biomaterials, Inc. | A femoral stem for permanent implantation into the natural femur |
| US5192326A (en) * | 1990-12-21 | 1993-03-09 | Pfizer Hospital Products Group, Inc. | Hydrogel bead intervertebral disc nucleus |
| JP2580423B2 (ja) * | 1991-02-27 | 1997-02-12 | 三井東圧化学株式会社 | 外科用フィラメントの製造方法 |
| US20020055710A1 (en) * | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
| IL115321A (en) * | 1994-09-16 | 2000-08-31 | Univ Ramot | Thromboresistant surface treatment for biomaterials |
| DE19539449A1 (de) * | 1995-10-24 | 1997-04-30 | Biotronik Mess & Therapieg | Verfahren zur Herstellung intraluminaler Stents aus bioresorbierbarem Polymermaterial |
| US20030171804A1 (en) * | 1997-06-24 | 2003-09-11 | Werner Krause | Stents coated with fluoroalkyl groups |
| JP4101460B2 (ja) * | 1997-10-09 | 2008-06-18 | 帝人株式会社 | フッ素原子を有するポリスルホンを含む抗血栓性に優れた医療用材料 |
| DE69939005D1 (de) * | 1998-10-13 | 2008-08-14 | Gambro Lundia Ab | Biokompatibler polymerfilm |
| KR100783299B1 (ko) * | 1998-12-31 | 2007-12-10 | 안지오테크 파마슈티칼즈, 인코포레이티드 | 생활성 피막을 갖는 스텐트 이식편 |
| EP1347794A2 (en) * | 2000-11-27 | 2003-10-01 | Medtronic, Inc. | Stents and methods for preparing stents from wires having hydrogel coating layers thereon |
| US7771468B2 (en) * | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
| CN1568166A (zh) * | 2001-10-15 | 2005-01-19 | 荷姆泰克股份有限公司 | 预防再狭窄的涂层支架 |
| JP2004131566A (ja) * | 2002-10-09 | 2004-04-30 | Asahi Kasei Corp | 分岐ポリエチレンオキシド−合成高分子ブロック共重合体 |
| US7279174B2 (en) * | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
-
2004
- 2004-04-28 DE DE102004020856A patent/DE102004020856A1/de not_active Withdrawn
- 2004-09-29 JP JP2006527276A patent/JP4861178B2/ja not_active Expired - Fee Related
-
2006
- 2006-09-29 OA OA1200600103A patent/OA13261A/en unknown
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