JP2007506718A5 - - Google Patents
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- Publication number
- JP2007506718A5 JP2007506718A5 JP2006527485A JP2006527485A JP2007506718A5 JP 2007506718 A5 JP2007506718 A5 JP 2007506718A5 JP 2006527485 A JP2006527485 A JP 2006527485A JP 2006527485 A JP2006527485 A JP 2006527485A JP 2007506718 A5 JP2007506718 A5 JP 2007506718A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- heterocyclyl
- benzimidazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 43
- -1 C 6-10 aryl-C (═O) — Chemical group 0.000 claims 9
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 claims 1
- RKMGSPRWXNPRIL-UHFFFAOYSA-N 4-chloro-n-(1,2-diphenylbenzimidazol-5-yl)benzenesulfonamide Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)NC1=CC=C(N(C(=N2)C=3C=CC=CC=3)C=3C=CC=CC=3)C2=C1 RKMGSPRWXNPRIL-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- KMRQTKCSEXESBS-UHFFFAOYSA-N n-(1,2-dimethylbenzimidazol-5-yl)-4-methylbenzenesulfonamide Chemical compound C=1C=C2N(C)C(C)=NC2=CC=1NS(=O)(=O)C1=CC=C(C)C=C1 KMRQTKCSEXESBS-UHFFFAOYSA-N 0.000 claims 1
- KVIRKFGPTSFUFW-UHFFFAOYSA-N n-(1,2-diphenylbenzimidazol-5-yl)-4-(trifluoromethyl)benzenesulfonamide Chemical compound C1=CC(C(F)(F)F)=CC=C1S(=O)(=O)NC1=CC=C(N(C(=N2)C=3C=CC=CC=3)C=3C=CC=CC=3)C2=C1 KVIRKFGPTSFUFW-UHFFFAOYSA-N 0.000 claims 1
- NTBFJPXEJMSAPX-UHFFFAOYSA-N n-(1,2-diphenylbenzimidazol-5-yl)benzenesulfonamide Chemical compound C=1C=CC=CC=1S(=O)(=O)NC(C=C1N=2)=CC=C1N(C=1C=CC=CC=1)C=2C1=CC=CC=C1 NTBFJPXEJMSAPX-UHFFFAOYSA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302570A SE0302570D0 (sv) | 2003-09-26 | 2003-09-26 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| PCT/GB2004/004112 WO2005030761A1 (en) | 2003-09-26 | 2004-09-24 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007506718A JP2007506718A (ja) | 2007-03-22 |
| JP2007506718A5 true JP2007506718A5 (enExample) | 2007-11-08 |
Family
ID=29246979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527485A Pending JP2007506718A (ja) | 2003-09-26 | 2004-09-24 | ベンゾイミダゾール誘導体、それを含む組成物、その製造方法およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070072853A1 (enExample) |
| EP (1) | EP1673369A1 (enExample) |
| JP (1) | JP2007506718A (enExample) |
| AR (1) | AR045822A1 (enExample) |
| SE (1) | SE0302570D0 (enExample) |
| TW (1) | TW200524594A (enExample) |
| WO (1) | WO2005030761A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302572D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302571D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| JP2008514595A (ja) * | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | 化合物、それを含有する組成物、その製造及びその使用ｉｉ |
| WO2006033629A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Benzimidazole derivatives and their use as cannabinoid receptor ligands |
| WO2006033632A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Benzimidazole derivatives and their use as cannabinoid receptor ligands I |
| WO2006033627A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Compounds, compositions containing them, preparation thereof and uses thereof iiii |
| BRPI0515897A (pt) * | 2004-09-24 | 2008-08-12 | Astrazeneca Ab | composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto |
| BRPI0517925A (pt) | 2004-11-02 | 2008-10-21 | Pfizer | derivados de sulfonil benzimidazol |
| CN101365686A (zh) | 2005-12-21 | 2009-02-11 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的杂环衍生物 |
| TW200745049A (en) | 2006-03-23 | 2007-12-16 | Astrazeneca Ab | New crystalline forms |
| TW200808769A (en) * | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| ATE532770T1 (de) | 2006-09-05 | 2011-11-15 | Kyowa Hakko Kirin Co Ltd | Imidazolderivat |
| US20110086853A1 (en) * | 2009-10-08 | 2011-04-14 | William Brown | Therapeutic Compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE666351A (enExample) * | 1964-07-02 | |||
| FR5354M (enExample) * | 1965-09-10 | 1967-09-11 | ||
| DE4237597A1 (de) * | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
| DE4237557A1 (de) * | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
| DE4237617A1 (de) * | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| DE19945787A1 (de) * | 1999-09-24 | 2001-03-29 | Boehringer Ingelheim Pharma | Arylsulfonamid-substituierte Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7115645B2 (en) * | 2000-01-14 | 2006-10-03 | Schering Aktiengesellschaft | 1,2 diarylbenzimidazoles and their pharmaceutical use |
| CN1301975C (zh) * | 2000-01-14 | 2007-02-28 | 舍林股份公司 | 用于治疗与小胶质细胞活化有关的疾病的1,2－二芳基苯并咪唑衍生物 |
| SE0101387D0 (sv) * | 2001-04-20 | 2001-04-20 | Astrazeneca Ab | Novel compounds |
| MXPA05004434A (es) * | 2002-10-24 | 2005-07-26 | Sterix Ltd | Inhibidores de 11-beta-hidroxi esteroide deshidrogenasa tipo 1 y tipo 2. |
| SE0301701D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0301699D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302572D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302571D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
-
2003
- 2003-09-26 SE SE0302570A patent/SE0302570D0/xx unknown
-
2004
- 2004-09-24 AR ARP040103470A patent/AR045822A1/es not_active Application Discontinuation
- 2004-09-24 WO PCT/GB2004/004112 patent/WO2005030761A1/en not_active Ceased
- 2004-09-24 JP JP2006527485A patent/JP2007506718A/ja active Pending
- 2004-09-24 TW TW093129066A patent/TW200524594A/zh unknown
- 2004-09-24 US US10/572,826 patent/US20070072853A1/en not_active Abandoned
- 2004-09-24 EP EP04768655A patent/EP1673369A1/en not_active Withdrawn
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