JP2007505050A - ペプチドデホルミラーゼ阻害剤としてのイソキサゾール類 - Google Patents
ペプチドデホルミラーゼ阻害剤としてのイソキサゾール類 Download PDFInfo
- Publication number
- JP2007505050A JP2007505050A JP2006525630A JP2006525630A JP2007505050A JP 2007505050 A JP2007505050 A JP 2007505050A JP 2006525630 A JP2006525630 A JP 2006525630A JP 2006525630 A JP2006525630 A JP 2006525630A JP 2007505050 A JP2007505050 A JP 2007505050A
- Authority
- JP
- Japan
- Prior art keywords
- isoxazole
- carboxylic acid
- unsubstituted
- substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- IPRUSVAMLKVLGU-UHFFFAOYSA-N COc(cc1)ccc1SCc1cc(C(O)=O)n[o]1 Chemical compound COc(cc1)ccc1SCc1cc(C(O)=O)n[o]1 IPRUSVAMLKVLGU-UHFFFAOYSA-N 0.000 description 1
- 0 C[C@](C(*)*)ON=CC(*)=O Chemical compound C[C@](C(*)*)ON=CC(*)=O 0.000 description 1
- NJZRMFUTHVHUTD-UHFFFAOYSA-N Cc(cc1)ccc1SCc1cc(C(O)=O)n[o]1 Chemical compound Cc(cc1)ccc1SCc1cc(C(O)=O)n[o]1 NJZRMFUTHVHUTD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301323 | 2003-09-12 | ||
| US50310403P | 2003-09-15 | 2003-09-15 | |
| PCT/DK2004/000604 WO2005026133A1 (en) | 2003-09-12 | 2004-09-10 | Isoxazoles as peptide deformylase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007505050A true JP2007505050A (ja) | 2007-03-08 |
| JP2007505050A5 JP2007505050A5 (enExample) | 2007-11-01 |
Family
ID=34315138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525630A Withdrawn JP2007505050A (ja) | 2003-09-12 | 2004-09-10 | ペプチドデホルミラーゼ阻害剤としてのイソキサゾール類 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1664000A1 (enExample) |
| JP (1) | JP2007505050A (enExample) |
| WO (1) | WO2005026133A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101541964B (zh) * | 2006-08-02 | 2011-09-28 | 科学与工业研究会 | 作为用于研发分枝杆菌特异性抑制剂的工具的肽脱甲酰基酶 |
| US9040538B2 (en) | 2009-05-21 | 2015-05-26 | Universite Laval | Pyrimidines as novel therapeutic agents |
| MD4557C1 (ro) | 2011-05-06 | 2018-10-31 | Egis Gyogysszegyar Nyilvanosan Mukodo Reszvenytarsasag | Procedeu de obţinere a rivaroxabanului şi un compus intermediar utilizat în acest procedeu |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1134837A (en) * | 1979-10-05 | 1982-11-02 | Ronald G. Micetich | Alkylthioalkyl-isoxanzoles and -isoxazolines |
| DE3742266A1 (de) * | 1987-12-12 | 1989-06-22 | Basf Ag | 2-tert.-butyl-5-isoxazolylmethylthio-3(2h)-pyridazin-3-on-derivate |
| ES2328563T3 (es) * | 2001-04-05 | 2009-11-16 | Smithkline Beecham Corporation | Inhibidores de peptido desformilasa. |
-
2004
- 2004-09-10 WO PCT/DK2004/000604 patent/WO2005026133A1/en not_active Ceased
- 2004-09-10 EP EP04762824A patent/EP1664000A1/en not_active Withdrawn
- 2004-09-10 JP JP2006525630A patent/JP2007505050A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1664000A1 (en) | 2006-06-07 |
| WO2005026133A1 (en) | 2005-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070910 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070910 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20081216 |