JP2007502815A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007502815A5 JP2007502815A5 JP2006523861A JP2006523861A JP2007502815A5 JP 2007502815 A5 JP2007502815 A5 JP 2007502815A5 JP 2006523861 A JP2006523861 A JP 2006523861A JP 2006523861 A JP2006523861 A JP 2006523861A JP 2007502815 A5 JP2007502815 A5 JP 2007502815A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- hydrogen
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 11
- -1 Cyano, Hydroxyl Chemical group 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 7
- 125000004438 haloalkoxy group Chemical group 0.000 claims 7
- 125000005841 biaryl group Chemical group 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004043 oxo group Chemical group O=* 0.000 claims 5
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000004452 carbocyclyl group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical class 0.000 claims 2
- 150000003857 carboxamides Chemical class 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical class 0.000 claims 2
- 150000003536 tetrazoles Chemical class 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 C*(C)C(*C(*)PN)P Chemical compound C*(C)C(*C(*)PN)P 0.000 description 1
- VMAQYKGITHDWKL-UHFFFAOYSA-N CC(C(N1)=O)NC1=O Chemical compound CC(C(N1)=O)NC1=O VMAQYKGITHDWKL-UHFFFAOYSA-N 0.000 description 1
- PTXFGUVCXVEZET-UHFFFAOYSA-N CC(C(N1)=O)SC1=O Chemical compound CC(C(N1)=O)SC1=O PTXFGUVCXVEZET-UHFFFAOYSA-N 0.000 description 1
- GOMAEJQBTWAPAN-UHFFFAOYSA-N CC(C(NC(O)=N1)=O)C1=O Chemical compound CC(C(NC(O)=N1)=O)C1=O GOMAEJQBTWAPAN-UHFFFAOYSA-N 0.000 description 1
- MQTSFGICUKJYPJ-UHFFFAOYSA-N CC(C(NO1)=O)C1=O Chemical compound CC(C(NO1)=O)C1=O MQTSFGICUKJYPJ-UHFFFAOYSA-N 0.000 description 1
- UFBYAWNYMSDOMX-UHFFFAOYSA-N CN(C(N1)=O)N=CC1=O Chemical compound CN(C(N1)=O)N=CC1=O UFBYAWNYMSDOMX-UHFFFAOYSA-N 0.000 description 1
- SHCJTIUGKXHXGW-UHFFFAOYSA-N CN(C(N1)=O)OC1=O Chemical compound CN(C(N1)=O)OC1=O SHCJTIUGKXHXGW-UHFFFAOYSA-N 0.000 description 1
- RHYBFKMFHLPQPH-UHFFFAOYSA-N CN(CC(N1)=O)C1=O Chemical compound CN(CC(N1)=O)C1=O RHYBFKMFHLPQPH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49654903P | 2003-08-20 | 2003-08-20 | |
| PCT/US2004/024381 WO2005019151A1 (en) | 2003-08-20 | 2004-08-17 | Ppar modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007502815A JP2007502815A (ja) | 2007-02-15 |
| JP2007502815A5 true JP2007502815A5 (cg-RX-API-DMAC10.html) | 2007-09-20 |
Family
ID=34216018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523861A Pending JP2007502815A (ja) | 2003-08-20 | 2004-08-17 | Ｐｐａｒ調節因子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060257987A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1660428A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2007502815A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2536089A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2005019151A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2341513C2 (ru) | 2001-06-12 | 2008-12-20 | Веллстат Терапьютикс Корпорейшн | Соединения для лечения метаболических заболеваний |
| ES2530235T3 (es) | 2003-02-13 | 2015-02-27 | Wellstat Therapeutics Corporation | Compuestos para el tratamiento de trastornos metabólicos |
| UA87467C2 (xx) | 2003-09-19 | 2009-07-27 | Янссен Фармацевтика Н.В | 4-((феноксіалкіл)тіо)феноксіоцтова кислота та її аналоги$4-((феноксиалкил)тио)феноксиуксусная кислота и ее аналоги |
| CA2539403C (en) | 2003-09-19 | 2013-11-19 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| US7622491B2 (en) * | 2004-08-13 | 2009-11-24 | Metabolex Inc. | Modulators of PPAR and methods of their preparation |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JPWO2006057448A1 (ja) * | 2004-11-26 | 2008-06-05 | 武田薬品工業株式会社 | アリールアルカン酸誘導体 |
| FR2882361A1 (fr) * | 2005-02-22 | 2006-08-25 | Aventis Pharma Sa | Nouveaux derives de 3-aryl-1,2-benzisoxazole, compositions les contenant et leur utilisation |
| EP1916234B1 (en) * | 2005-07-29 | 2014-11-12 | Takeda Pharmaceutical Company Limited | Cyclopropanecarboxylic acid compound |
| CN101296914B (zh) | 2005-08-26 | 2012-07-18 | 盐野义制药株式会社 | 具有ppar激动活性的衍生物 |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| UA95613C2 (ru) | 2005-11-09 | 2011-08-25 | Уеллстат Терепьютикс Корпорейшн | Соединения для лечения расстройсв метаболизма |
| PE20080188A1 (es) * | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
| TW200838526A (en) | 2006-12-01 | 2008-10-01 | Astellas Pharma Inc | Carboxylic acid derivatives |
| FR2917084B1 (fr) * | 2007-06-05 | 2009-07-17 | Galderma Res & Dev | Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques. |
| US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
| IN2013CN01340A (cg-RX-API-DMAC10.html) * | 2010-07-23 | 2015-08-07 | Connexios Life Sciences Pvt Ltd | |
| EP2803664B1 (en) | 2012-01-12 | 2018-11-21 | Jiangsu Hengrui Medicine Co. Ltd. | Tetrahydrobenzofurane derivatives as gpr40 agonists for the treatment of diabetes |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| CN105473133A (zh) | 2013-04-30 | 2016-04-06 | 欧缇托匹克公司 | 干粉制剂及使用方法 |
| CN103524518B (zh) * | 2013-06-07 | 2017-05-10 | Tcl集团股份有限公司 | 轮状四烯类荧光化合物、制备方法和应用及电致发光器件 |
| JP6594351B2 (ja) * | 2014-06-16 | 2019-10-23 | ジョンソン、マッセイ、パブリック、リミテッド、カンパニー | 新規中間体を含むアルキル化アリールピペラジン及びアルキル化アリールピペリジン化合物の製造方法 |
| CA3076353A1 (en) | 2017-09-22 | 2019-03-28 | Otitopic Inc. | Dry powder compositions with magnesium stearate |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| WO2021169769A1 (zh) * | 2020-02-28 | 2021-09-02 | 四川科伦博泰生物医药股份有限公司 | 芳香族化合物及其药物组合物和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8600261A1 (es) * | 1983-06-24 | 1985-10-01 | Yamanouchi Pharma Co Ltd | Un compuesto fenoxi |
| JP2002503202A (ja) * | 1996-02-02 | 2002-01-29 | メルク エンド カンパニー インコーポレーテッド | 抗糖尿病薬 |
| DE69941777D1 (de) * | 1998-03-10 | 2010-01-21 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| DE60216094T2 (de) * | 2001-06-07 | 2007-06-06 | Eli Lilly And Co., Indianapolis | Modulatoren der peroxisom-proliferator-aktivierten rezeptoren (ppar) |
| CN1543451A (zh) * | 2001-06-07 | 2004-11-03 | 过氧化物酶体增生剂激活的受体的调节剂 |
-
2004
- 2004-08-17 JP JP2006523861A patent/JP2007502815A/ja active Pending
- 2004-08-17 EP EP04779442A patent/EP1660428A1/en not_active Withdrawn
- 2004-08-17 US US10/566,291 patent/US20060257987A1/en not_active Abandoned
- 2004-08-17 CA CA002536089A patent/CA2536089A1/en not_active Abandoned
- 2004-08-17 WO PCT/US2004/024381 patent/WO2005019151A1/en not_active Ceased