JP2007500750A - テトラヒドロカルバゾール誘導体およびそれらの薬学的使用 - Google Patents
テトラヒドロカルバゾール誘導体およびそれらの薬学的使用 Download PDFInfo
- Publication number
- JP2007500750A JP2007500750A JP2006533613A JP2006533613A JP2007500750A JP 2007500750 A JP2007500750 A JP 2007500750A JP 2006533613 A JP2006533613 A JP 2006533613A JP 2006533613 A JP2006533613 A JP 2006533613A JP 2007500750 A JP2007500750 A JP 2007500750A
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydro
- carbazol
- bromo
- chloro
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*c1cccc(NN=C2[Cn]CCCC2=O)c1 Chemical compound C*c1cccc(NN=C2[Cn]CCCC2=O)c1 0.000 description 4
- OWFQYITVIASELA-UHFFFAOYSA-N COc(cc1)ccc1C(NC(CCC1)c2c1c1cc(Br)ccc1[nH]2)=O Chemical compound COc(cc1)ccc1C(NC(CCC1)c2c1c1cc(Br)ccc1[nH]2)=O OWFQYITVIASELA-UHFFFAOYSA-N 0.000 description 1
- OERQBJZPNQUMSB-UHFFFAOYSA-N Cc(cc1)ccc1C(NC(CCC1)c2c1c1cc(Br)ccc1[nH]2)=O Chemical compound Cc(cc1)ccc1C(NC(CCC1)c2c1c1cc(Br)ccc1[nH]2)=O OERQBJZPNQUMSB-UHFFFAOYSA-N 0.000 description 1
- RQJJJEPZUUJDOD-UHFFFAOYSA-N Cc(cc1)ccc1S(NC(CCC1)c2c1c(cc(cc1)Br)c1[nH]2)(=O)=O Chemical compound Cc(cc1)ccc1S(NC(CCC1)c2c1c(cc(cc1)Br)c1[nH]2)(=O)=O RQJJJEPZUUJDOD-UHFFFAOYSA-N 0.000 description 1
- VYKYOUCSYLQIJD-FMIVXFBMSA-N O=C(/C=C/c1ccccc1)NC(CCC1)c2c1c1cc(Br)ccc1[nH]2 Chemical compound O=C(/C=C/c1ccccc1)NC(CCC1)c2c1c1cc(Br)ccc1[nH]2 VYKYOUCSYLQIJD-FMIVXFBMSA-N 0.000 description 1
- HJVKWXMBCFDFQI-UHFFFAOYSA-N O=C(c1ccccc1)NC(CCC1)c2c1c(cc(cc1)Br)c1[nH]2 Chemical compound O=C(c1ccccc1)NC(CCC1)c2c1c(cc(cc1)Br)c1[nH]2 HJVKWXMBCFDFQI-UHFFFAOYSA-N 0.000 description 1
- TXFFKXTVYMUXME-QGZVFWFLSA-N O=C(c1ccccc1F)N[C@H](CCC1)c2c1c1cc(Cl)ccc1[nH]2 Chemical compound O=C(c1ccccc1F)N[C@H](CCC1)c2c1c1cc(Cl)ccc1[nH]2 TXFFKXTVYMUXME-QGZVFWFLSA-N 0.000 description 1
- VJROLBQKZIHYNY-UHFFFAOYSA-N [O-][N+](c(cc1)ccc1C(NC(CCC1)c2c1c1cc(Br)ccc1[nH]2)=O)=O Chemical compound [O-][N+](c(cc1)ccc1C(NC(CCC1)c2c1c1cc(Br)ccc1[nH]2)=O)=O VJROLBQKZIHYNY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47797203P | 2003-06-12 | 2003-06-12 | |
| US49778703P | 2003-08-26 | 2003-08-26 | |
| PCT/US2004/018180 WO2005005386A1 (en) | 2003-06-12 | 2004-06-07 | Tetrahydrocarbazole derivatives and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2007500750A true JP2007500750A (ja) | 2007-01-18 |
Family
ID=34068099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533613A Pending JP2007500750A (ja) | 2003-06-12 | 2004-06-07 | テトラヒドロカルバゾール誘導体およびそれらの薬学的使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7419997B2 (pt) |
| EP (1) | EP1646610B1 (pt) |
| JP (1) | JP2007500750A (pt) |
| KR (1) | KR20060017544A (pt) |
| AU (1) | AU2004256052A1 (pt) |
| BR (1) | BRPI0411245A (pt) |
| CA (1) | CA2528336A1 (pt) |
| CO (1) | CO5660264A2 (pt) |
| DE (1) | DE602004022169D1 (pt) |
| ES (1) | ES2327416T3 (pt) |
| IL (1) | IL172087A0 (pt) |
| MA (1) | MA27879A1 (pt) |
| NO (1) | NO20055750L (pt) |
| RU (1) | RU2005138126A (pt) |
| WO (1) | WO2005005386A1 (pt) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007509057A (ja) * | 2003-10-15 | 2007-04-12 | カイロン コーポレイション | ウイルス阻害のための組成物および方法 |
| JP2008520741A (ja) * | 2004-11-23 | 2008-06-19 | ピーティーシー セラピューティクス， インコーポレイテッド | 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| EP1737461B1 (en) | 2004-03-15 | 2012-12-12 | PTC Therapeutics, Inc. | Carboline derivatives useful in the inhibition of angiogenesis |
| WO2006012310A2 (en) * | 2004-06-25 | 2006-02-02 | Genzyme Corporation | Carbazole derivatives for treating polycystic kidney disease |
| US20090170906A1 (en) * | 2004-11-22 | 2009-07-02 | Kristjan Gudmundsson | Hcv inhibitors |
| WO2019005841A1 (en) * | 2017-06-26 | 2019-01-03 | Rutgers, The State University Of New Jersey | THERAPEUTIC COMPOUNDS AND METHODS FOR TREATING INFECTION |
| US10882821B1 (en) | 2017-09-26 | 2021-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04334367A (ja) * | 1991-01-18 | 1992-11-20 | Hoechst Roussel Pharmaceut Inc | 置換された１，２，３，４−テトラヒドロシクロペント〔ｂ〕インドール、１，２，３，３ａ，４，８ａ−ヘキサヒドロシクロペント〔ｂ〕インドールおよび関連化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9008108D0 (en) * | 1990-04-10 | 1990-06-06 | Bayer Ag | Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles |
| GB0015904D0 (en) * | 2000-06-28 | 2000-08-23 | Hoffmann La Roche | Inhibitors of HPV E1 helicase enzyme |
| DE10164564B4 (de) * | 2001-12-14 | 2007-05-16 | Zentaris Gmbh | Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR) |
-
2004
- 2004-06-07 US US10/560,016 patent/US7419997B2/en not_active Expired - Fee Related
- 2004-06-07 BR BRPI0411245-8A patent/BRPI0411245A/pt not_active IP Right Cessation
- 2004-06-07 AU AU2004256052A patent/AU2004256052A1/en not_active Abandoned
- 2004-06-07 CA CA002528336A patent/CA2528336A1/en not_active Abandoned
- 2004-06-07 JP JP2006533613A patent/JP2007500750A/ja active Pending
- 2004-06-07 WO PCT/US2004/018180 patent/WO2005005386A1/en active Application Filing
- 2004-06-07 ES ES04776370T patent/ES2327416T3/es active Active
- 2004-06-07 DE DE602004022169T patent/DE602004022169D1/de active Active
- 2004-06-07 KR KR1020057023780A patent/KR20060017544A/ko not_active Application Discontinuation
- 2004-06-07 EP EP04776370A patent/EP1646610B1/en active Active
- 2004-06-07 RU RU2005138126/04A patent/RU2005138126A/ru not_active Application Discontinuation
-
2005
- 2005-11-21 IL IL172087A patent/IL172087A0/en unknown
- 2005-12-05 NO NO20055750A patent/NO20055750L/no not_active Application Discontinuation
- 2005-12-09 MA MA28645A patent/MA27879A1/fr unknown
- 2005-12-15 CO CO05126691A patent/CO5660264A2/es not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04334367A (ja) * | 1991-01-18 | 1992-11-20 | Hoechst Roussel Pharmaceut Inc | 置換された１，２，３，４−テトラヒドロシクロペント〔ｂ〕インドール、１，２，３，３ａ，４，８ａ−ヘキサヒドロシクロペント〔ｂ〕インドールおよび関連化合物 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007509057A (ja) * | 2003-10-15 | 2007-04-12 | カイロン コーポレイション | ウイルス阻害のための組成物および方法 |
| JP2008520741A (ja) * | 2004-11-23 | 2008-06-19 | ピーティーシー セラピューティクス， インコーポレイテッド | 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール |
| US8946444B2 (en) | 2004-11-23 | 2015-02-03 | Ptc Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control |
Also Published As
| Publication number | Publication date |
|---|---|
| US7419997B2 (en) | 2008-09-02 |
| EP1646610A1 (en) | 2006-04-19 |
| NO20055750L (no) | 2006-01-06 |
| WO2005005386A1 (en) | 2005-01-20 |
| US20060148857A1 (en) | 2006-07-06 |
| NO20055750D0 (no) | 2005-12-05 |
| CA2528336A1 (en) | 2005-01-20 |
| MA27879A1 (fr) | 2006-05-02 |
| CO5660264A2 (es) | 2006-07-31 |
| KR20060017544A (ko) | 2006-02-23 |
| DE602004022169D1 (de) | 2009-09-03 |
| ES2327416T3 (es) | 2009-10-29 |
| AU2004256052A1 (en) | 2005-01-20 |
| RU2005138126A (ru) | 2006-07-27 |
| IL172087A0 (en) | 2009-02-11 |
| BRPI0411245A (pt) | 2006-07-18 |
| EP1646610B1 (en) | 2009-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070607 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20101019 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20110315 |