JP2007500043A - コラーゲン及び脱灰骨基質を含んでなる架橋された組成物、その作製方法、及びその使用方法 - Google Patents

コラーゲン及び脱灰骨基質を含んでなる架橋された組成物、その作製方法、及びその使用方法 Download PDF

Info

Publication number
JP2007500043A
JP2007500043A JP2006521921A JP2006521921A JP2007500043A JP 2007500043 A JP2007500043 A JP 2007500043A JP 2006521921 A JP2006521921 A JP 2006521921A JP 2006521921 A JP2006521921 A JP 2006521921A JP 2007500043 A JP2007500043 A JP 2007500043A
Authority
JP
Japan
Prior art keywords
composition
dbm
collagen
crosslinked
cross
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006521921A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007500043A5 (https=
Inventor
マッケイ，ウィリアム・エフ
トリアンニ，マーク・ダブリュー
エヴェラエルツ，エフ・イェー・エル
ドラポー，スーザン・ジェイ
Original Assignee
ウォーソー・オーソペディック・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウォーソー・オーソペディック・インコーポレーテッド filed Critical ウォーソー・オーソペディック・インコーポレーテッド
Publication of JP2007500043A publication Critical patent/JP2007500043A/ja
Publication of JP2007500043A5 publication Critical patent/JP2007500043A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/102—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
JP2006521921A 2003-07-25 2004-07-22 コラーゲン及び脱灰骨基質を含んでなる架橋された組成物、その作製方法、及びその使用方法 Pending JP2007500043A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/626,571 US20050020506A1 (en) 2003-07-25 2003-07-25 Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
PCT/US2004/023557 WO2005011764A1 (en) 2003-07-25 2004-07-22 Crosslinked compositions comprising collagen and demineralized bone matrix

Publications (2)

Publication Number Publication Date
JP2007500043A true JP2007500043A (ja) 2007-01-11
JP2007500043A5 JP2007500043A5 (https=) 2007-08-23

Family

ID=34080454

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006521921A Pending JP2007500043A (ja) 2003-07-25 2004-07-22 コラーゲン及び脱灰骨基質を含んでなる架橋された組成物、その作製方法、及びその使用方法

Country Status (8)

Country Link
US (1) US20050020506A1 (https=)
EP (1) EP1648530A1 (https=)
JP (1) JP2007500043A (https=)
KR (1) KR20060052891A (https=)
CN (1) CN1842350A (https=)
AU (1) AU2004261150A1 (https=)
CA (1) CA2533758A1 (https=)
WO (1) WO2005011764A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011078764A (ja) * 2009-10-02 2011-04-21 Tyco Healthcare Group Lp 外科手術用組成物
JP2012512684A (ja) * 2008-12-19 2012-06-07 インダストリ バイオメディシェ インスブリ エスエー 骨インプラント基材及びその調製方法

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7918899B2 (en) * 2002-01-25 2011-04-05 Biomedical Design, Inc. Variably crosslinked tissue
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
US20050266390A1 (en) * 2004-06-01 2005-12-01 Yuichiro Ueda Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction
EP1796693A2 (en) * 2004-08-26 2007-06-20 Chandrashekhar P. Pathak Implantable tissue compositions and method
US8445278B2 (en) * 2005-03-01 2013-05-21 Medtronic, Inc. Process for producing decellularized biological tissues
US20070087059A1 (en) * 2005-10-17 2007-04-19 Frank Everaerts Bioactive delivery matrix compositions and methods
CN101365499A (zh) * 2005-11-01 2009-02-11 骨骼技术股份有限公司 骨基质组合物和方法
US20070248575A1 (en) * 2006-04-19 2007-10-25 Jerome Connor Bone graft composition
US7771741B2 (en) * 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
US7838022B2 (en) 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
US20100209470A1 (en) * 2006-05-01 2010-08-19 Warsaw Orthopedic, Inc. An Indiana Corporation Demineralized bone matrix devices
US8506983B2 (en) * 2006-05-01 2013-08-13 Warsaw Orthopedic, Inc. Bone filler material
US20070287991A1 (en) * 2006-06-08 2007-12-13 Mckay William F Devices and methods for detection of markers of axial pain with or without radiculopathy
US20080020012A1 (en) 2006-06-22 2008-01-24 Ju Young M Collagen scaffolds, medical implants with same and methods of use
US8093027B2 (en) * 2006-09-13 2012-01-10 University Of South Florida Method for producing biocomposite comprising collagen and polymer
US8048857B2 (en) 2006-12-19 2011-11-01 Warsaw Orthopedic, Inc. Flowable carrier compositions and methods of use
US8114428B2 (en) * 2007-03-08 2012-02-14 Sbf Synthetic Bone Factory Gmbh Methods for manufacturing a composition for treating bone and/or cartilage defects
WO2008147867A2 (en) * 2007-05-23 2008-12-04 Allergan, Inc. Cross-linked collagen and uses thereof
WO2008157492A2 (en) * 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
CA3062443C (en) * 2007-06-15 2022-03-15 Warsaw Orthopedic, Inc. Method of treating tissue
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2009009684A1 (en) * 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
US8202539B2 (en) * 2007-10-19 2012-06-19 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
CA2706491A1 (en) * 2007-12-12 2009-06-18 Osteotech, Inc. Bone/collagen composites and uses thereof
CN101496911B (zh) * 2008-01-28 2012-10-03 烟台正海生物技术有限公司 一种骨支架材料及其制备方法与应用
US8293813B2 (en) * 2008-03-05 2012-10-23 Biomet Manufacturing Corporation Cohesive and compression resistant demineralized bone carrier matrix
US9616153B2 (en) 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
US20090263507A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use
US20100119605A1 (en) * 2008-11-12 2010-05-13 Isenburg Jason C Compositions for tissue stabilization
JP5698680B2 (ja) * 2009-01-16 2015-04-08 ガイストリヒ・ファーマ・アクチェンゲゼルシャフトＧｅｉｓｔｌｉｃｈ Ｐｈａｒｍａ Ａｇ 皮膚再生のための方法および膜
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
GB0907323D0 (en) * 2009-04-29 2009-06-10 Dynea Oy Composite material comprising crosslinkable resin of proteinous material
FR2952306B1 (fr) * 2009-11-09 2012-03-30 Creaspine Composition aqueuse utilisee dans le traitement de la reparation de tissu conjonctif fibreux par laser
EP2380601B1 (en) * 2010-04-15 2013-03-20 National University of Ireland, Galway Multichannel collagen nerve conduit for nerve repair
KR20110117382A (ko) * 2010-04-21 2011-10-27 주식회사 메가젠임플란트 표면에 콜라겐이 결합된 이상인산칼슘 골대체재의 제조방법 및 그 방법에 의해 제조된 골대체재
US8658711B2 (en) * 2010-09-29 2014-02-25 Rutgers, The State University Of New Jersey Process for the synthesis of methacrylate-derivatized type-1 collagen and derivatives thereof
TWI815599B (zh) 2011-04-22 2023-09-11 美商惠氏有限責任公司 與難養芽胞梭菌（Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ）之突變毒素有關之組成物及彼之方法
CN102284083B (zh) * 2011-07-07 2013-12-18 中山大学 一种细胞外基质的改性方法
CN102716516B (zh) * 2012-05-11 2014-02-26 天津大学 虎杖甙修饰的胶原支架及其制备方法和应用
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
WO2014065863A1 (en) * 2012-10-22 2014-05-01 The Regents Of The University Of California Compositions and methods for promoting collagen-crosslinking
CN103920187B (zh) * 2013-04-16 2016-05-25 北京航空航天大学 一种丝素蛋白和脱钙骨基质复合的骨修复材料
CN107596443A (zh) * 2016-07-11 2018-01-19 复旦大学附属华山医院 一种无创性可示踪生物材料及其制备方法
US10743996B2 (en) 2017-03-24 2020-08-18 Robert L. Bundy Amnion putty for cartilage repair
CN108210985A (zh) * 2018-01-22 2018-06-29 陕西科技大学 一种基于人源胶原蛋白的高强度医用水凝胶及其制备方法
WO2020223480A1 (en) * 2019-04-30 2020-11-05 The General Hospital Corporation Systems and methods for magnet-induced assembly of tissue grafts
WO2021038562A1 (en) 2019-08-26 2021-03-04 Setbone Medical Ltd. Implant comprising a plurality of hardening states
WO2021255690A2 (en) 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
CN111825859A (zh) * 2020-07-23 2020-10-27 陕西科技大学 一种具有自修复功能的仿生电子皮肤医用支架材料及其制备方法
CN118806998B (zh) * 2024-09-18 2025-01-28 独步吾奇生物医疗科技(江苏)有限公司 一种自体颅骨回植基质的制备方法及其产品

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
JPH07275341A (ja) * 1994-04-14 1995-10-24 Terumo Corp コラーゲン製材および骨欠損部補綴材
JP2001521414A (ja) * 1997-02-13 2001-11-06 ベネディクト、ジェームズ エイ 移植可能なパテ状材料
US6311690B1 (en) * 1986-03-27 2001-11-06 Gensci Orthobiologics, Inc. Bone repair material and delayed drug delivery system
JP2003180815A (ja) * 2001-11-20 2003-07-02 Ed Geistlich Soehne Ag Fuer Chemische Industrie 軟骨の再構築のためのコラーゲンｉおよびコラーゲンｉｉを含有する再吸収可能細胞外マトリックス

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4472840A (en) * 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4722948A (en) * 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
US4789663A (en) * 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
US5273964A (en) * 1985-03-20 1993-12-28 Lemons J E Inorganic and organic composition for treatment of bone lesions
US4863732A (en) * 1987-12-16 1989-09-05 Collagen Corporation Injectable composition for inductive bone repair
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
WO1989009787A2 (en) * 1988-04-08 1989-10-19 Creative Biomolecules, Inc. Osteogenic devices
US5124273A (en) * 1988-06-30 1992-06-23 Kabushiki Kaisha Toshiba Automatic wiring method for semiconductor integrated circuit devices
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US6197325B1 (en) * 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5275954A (en) * 1991-03-05 1994-01-04 Lifenet Process for demineralization of bone using column extraction
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5513662A (en) * 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
FR2706768B1 (https=) * 1993-05-13 1995-12-01 Inoteb
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
IL110367A (en) * 1994-07-19 2007-05-15 Colbar Lifescience Ltd Collagen-based matrix
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US6180606B1 (en) * 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6287341B1 (en) * 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
MXPA97009909A (es) * 1995-06-06 2004-08-23 Gensci Regeneration Lab Inc Materiales osteogenicos modificados.
US5811401A (en) * 1995-11-30 1998-09-22 The Picower Institute For Medical Research Advanced glycosylation endproducts and methods of use therefor
US5869527A (en) * 1995-12-29 1999-02-09 Alteon Inc. 6-(N-carboxymethylamino)caproate, salts thereof and methods of use therefor
US6200606B1 (en) * 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US6368356B1 (en) * 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US6165487A (en) * 1996-09-30 2000-12-26 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
JP4388602B2 (ja) * 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US6045579A (en) * 1997-05-01 2000-04-04 Spinal Concepts, Inc. Adjustable height fusion device
US5948426A (en) * 1997-05-03 1999-09-07 Jefferies; Steven R. Method and article to induce hematopoietic expansion
US5972368A (en) * 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
US6117979A (en) * 1997-08-18 2000-09-12 Medtronic, Inc. Process for making a bioprosthetic device and implants produced therefrom
US6309659B1 (en) * 1997-09-02 2001-10-30 Gensci Orthobiologics, Inc. Reverse phase connective tissue repair composition
US20010014667A1 (en) * 1998-01-05 2001-08-16 Chen Charles C. Compositions with enhanced osteogenic potential, methods for making the same and therapeutic uses thereof
US20020076429A1 (en) * 1998-01-28 2002-06-20 John F. Wironen Bone paste subjected to irradiative and thermal treatment
US20020018796A1 (en) * 1998-01-28 2002-02-14 John F. Wironen Thermally sterilized bone paste
US6123731A (en) * 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6326018B1 (en) * 1998-02-27 2001-12-04 Musculoskeletal Transplant Foundation Flexible sheet of demineralized bone
US6437018B1 (en) * 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6030635A (en) * 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6458375B1 (en) * 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
US6293970B1 (en) * 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US6444252B1 (en) * 1998-11-20 2002-09-03 General Mills, Inc. Methods of preparation of gel products fortified with calcium
US6328765B1 (en) * 1998-12-03 2001-12-11 Gore Enterprise Holdings, Inc. Methods and articles for regenerating living tissue
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US20020090725A1 (en) * 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
AU6406700A (en) * 1999-03-16 2000-10-04 Regeneration Technologies, Inc. Molded implants for orthopedic applications
US7371408B1 (en) * 1999-06-07 2008-05-13 Wright Medical Technology, Inc. Bone graft substitute composition
CA2377435A1 (en) * 1999-06-29 2001-01-04 J. Alexander Marchosky Compositions and methods for forming and strengthening bone
US6340477B1 (en) * 2000-04-27 2002-01-22 Lifenet Bone matrix composition and methods for making and using same
DK177997B1 (da) * 2000-07-19 2015-02-23 Ed Geistlich Söhne Ag Für Chemische Ind Knoglemateriale og collagenkombination til opheling af beskadigede led
US20020072804A1 (en) * 2000-09-20 2002-06-13 Donda Russell S. Combination biological-non-biological material prosthetic implant and method
US6752831B2 (en) * 2000-12-08 2004-06-22 Osteotech, Inc. Biocompatible osteogenic band for repair of spinal disorders
US20020082697A1 (en) * 2000-12-22 2002-06-27 Damien Christopher J. Implantable osteogenic material

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US6311690B1 (en) * 1986-03-27 2001-11-06 Gensci Orthobiologics, Inc. Bone repair material and delayed drug delivery system
JPH07275341A (ja) * 1994-04-14 1995-10-24 Terumo Corp コラーゲン製材および骨欠損部補綴材
JP2001521414A (ja) * 1997-02-13 2001-11-06 ベネディクト、ジェームズ エイ 移植可能なパテ状材料
JP2003180815A (ja) * 2001-11-20 2003-07-02 Ed Geistlich Soehne Ag Fuer Chemische Industrie 軟骨の再構築のためのコラーゲンｉおよびコラーゲンｉｉを含有する再吸収可能細胞外マトリックス

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012512684A (ja) * 2008-12-19 2012-06-07 インダストリ バイオメディシェ インスブリ エスエー 骨インプラント基材及びその調製方法
US9770532B2 (en) 2008-12-19 2017-09-26 Industrie Biomediche Insubri S/A Bone implant matrix and method of preparing the same
JP2011078764A (ja) * 2009-10-02 2011-04-21 Tyco Healthcare Group Lp 外科手術用組成物

Also Published As

Publication number Publication date
CA2533758A1 (en) 2005-02-10
KR20060052891A (ko) 2006-05-19
EP1648530A1 (en) 2006-04-26
CN1842350A (zh) 2006-10-04
WO2005011764A1 (en) 2005-02-10
US20050020506A1 (en) 2005-01-27
AU2004261150A1 (en) 2005-02-10

Similar Documents

Publication Publication Date Title
JP2007500043A (ja) コラーゲン及び脱灰骨基質を含んでなる架橋された組成物、その作製方法、及びその使用方法
US6180606B1 (en) Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
US5707962A (en) Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US4795467A (en) Xenogeneic collagen/mineral preparations in bone repair
CA2859657C (en) Acellular tissue matrix particles and flowable products comprising them
US7811608B2 (en) Tissue repair compositions and methods for their manufacture and use
JP4275732B2 (ja) 骨移植マトリックス
US5162114A (en) Bone collagen matrix for xenogenic implants
US9198936B2 (en) Devices and methods for the regeneration of bony defects
CA2964501C (en) A biomaterial scaffold for regenerating the oral mucosa
JPH07171211A (ja) 線維芽細胞成長因子を装入した骨代替材料
US20010014667A1 (en) Compositions with enhanced osteogenic potential, methods for making the same and therapeutic uses thereof
WO2006031196A1 (en) Porous biomaterial-filler composite and a method for making the same
CN103108661A (zh) 再生性组织支架的制备
JP2010075718A (ja) 骨の再構成用の再吸収性細胞外マトリックス
JP4873555B2 (ja) アパタイト／コラーゲン複合体繊維を含む多孔体の製造方法
US20250339586A1 (en) Injectable mesh
WO2010050935A1 (en) Devices containing demineralized bone matrix particles
KR20240057836A (ko) 콜라겐, 및 폴리카프로락톤을 포함하는 치유성이 개선된 다공성 치주조직 재생용 차폐막 및 이의 제조방법
KR20240057835A (ko) 콜라겐, 히알루론산, 및 폴리카프로락톤을 포함하는 생체적합성이 개선된 다공성 치주조직 재생용 차폐막 및 이의 제조방법
JP2007050084A (ja) 骨再建材の製造方法および骨再建材ならびに骨組織誘導方法
KR20050023298A (ko) 케라틴 유래의 정형외과 재료
JPH06125976A (ja) 創傷治癒用基材

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20061011

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070703

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070703

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101115

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110426