JP2007267878A - Medical double-chamber container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical container in which peeling work of a partition part and a communication prevention part is easy and careless peeling of the communication prevention part scarcely occurs and which is the medical container at least divided into two chambers by a partition part, and having a communication prevention part preventing the communication between a medical agent chamber and a discharge port. <P>SOLUTION: This medical double chamber container 1 is provided with a container body 2 divided into the two chambers by the partition part 9, the discharge port 3, and the communication prevention part 10 preventing the communication of the discharge port 3. The communication prevention part 10 has two corner part linear portions 10d and 10e positioned in the lower part of the partition part 9. This medical double chamber container 1 is provided with a protection part 11 provided in a position close to the communication prevention part 10 and being in non-contact with the communication prevention part 10 and protecting the two corner part linear portions of the communication prevention part 10. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an infusion container in which a drug can be prepared and blended in a drug solution such as an infusion solution.

  In infusion, two or more kinds of liquids (chemical solutions) may be mixed and used. In this case, conventionally, two separately prepared chemicals are prepared by mixing at the time of use. Recently, by quickly administering the drug solution and preventing forgetting to mix etc., the drug chamber of one medical container is divided into two drug chambers by a detachable partition, A so-called multi-chamber medical container that separates and stores a drug that deteriorates and deteriorates with time when mixed in advance has been used.

However, there is a risk of administering the drug to the patient without mixing. For this reason, a method has been devised that ensures that the medicines stored in the respective storage units are mixed and then administered to the patient. For example, as in JP-A-2002-136570 (Patent Document 1), the medicine chamber is divided by a detachable partition, and is further a partition that separates the medicine discharge port and the compartment that stores the medicine. A container having a weak seal for discharging has been proposed. In addition, the applicant of the present application has proposed a device provided with a communication blocking portion that is provided in the vicinity of the discharge port and blocks communication between the first medicine chamber and the discharge port (Japanese Patent Laid-Open No. 2005-288022: Patent). Reference 2).
JP 2002-136570 A (Patent Document 1) Japanese Patent Laying-Open No. 2005-288022 (Patent Document 2)

In those of Patent Documents 1 and 2, it is impossible to administer the drug unless the weak seal portion for discharge or the communication inhibition portion provided near the discharge port is peeled off. It is possible to sufficiently alert the operator that it is necessary to mix the chemicals filled in the two chambers, that is, to separate the partition weak seal. For this reason, it can prevent that the chemical | medical solution of 2 chambers is administered without being mixed.
Furthermore, in the thing of patent document 2, it originates also in that the communication inhibition part is carrying out substantially reverse U-shape, and the peeling is easier than the thing of patent document 1, and it is simultaneous or a series of peeling work of a partition part. Thus, peeling can be performed, and the preparation for administration is easy. However, if excessive pressure is applied to the first drug chamber where the communication hindering part is provided during transportation or preparation for administration, the possibility that only the communication hindering part peels cannot be denied. . It is conceivable to increase the sealing strength of the communication hindering part, but conversely, this makes it difficult to peel off the communication hindering part at the time of administration preparation, and it cannot peel to the end of the weak seal for communication hampering, so There is a possibility that it will not be completely discharged.
Therefore, the present invention provides a medical device that is divided into at least two chambers by a partitioning portion, each of which is filled with a medicine, and further including a communication inhibiting portion that inhibits communication between the first medicine chamber and the discharge port. Even if pressure is applied to the first drug chamber in which the separation part and the communication hindering part are easily peeled off and the communication hindering part is provided during transportation or preparation for administration. It is an object of the present invention to provide a medical container that is unlikely to cause peeling of the inhibition portion and reliably peels to the end of the weak seal for communication inhibition.

What achieves the above object is as follows.
(1) A container body made of a flexible material, having an upper end portion and a lower end portion, and partitioned into a first drug chamber and a second drug chamber by a partitioning portion whose internal space can be peeled, A discharge port provided at a lower end of one drug chamber, a first drug stored in the first drug chamber, a second drug stored in the second drug chamber, and the first A medical multi-chamber container provided with a removable communication inhibiting portion that inhibits communication between the drug chamber and the discharge port,
The communication inhibiting portion extends from the lower end of the container body in the direction of the partition so as to surround the upper end of the discharge port, and forms a partition section partitioned from the first drug chamber; and The communication hindering portion includes at least one corner portion formed on a peripheral edge portion on the first drug chamber side, and the medical multi-chamber container is closer to the first drug chamber side than the communication hinder portion. A medical multi-chamber provided with a peelable protection portion for protecting the corner portion of the communication inhibition portion provided at a position close to the communication inhibition portion and not in contact with the communication inhibition portion container.

(2) The communication inhibition part is located between the partition part and the discharge port, and extends in the lateral direction of the container main body, and extends from the vicinity of one end of the upper linear part, and the lower end of the container main body. A first side linear part reaching the part, a second side linear part extending from near the other end of the upper linear part and reaching the lower end part of the container body, and the upper linear part A first corner linear portion connecting the first side linear portions; and a second corner linear portion connecting the upper linear portion and the second side linear portion. The medical multi-chamber container according to (1), wherein the protection section protects the first corner linear portion and the second corner linear portion of the communication inhibition portion.
(3) The medical multi-chamber container according to (1) or (2), wherein the seal strength of the protection portion is equal to or greater than the seal strength of the communication inhibition portion.
(4) The seal strength of the weak seal portion for protection is greater than the seal strength of the weak seal portion for partitioning, and is equal to or greater than the seal strength of the weak seal portion for blocking communication ( A medical multi-chamber container according to 1) or (2).
(5) The seal strength of the partition portion is greater than the seal strength of the communication inhibition portion, and the seal strength of the protection portion is greater than the seal strength of the partition portion (1) or (2 ) Medical multi-chamber container.
(6) The above-mentioned protective part is a continuous linear protective part that encloses the upper part of the corner part, and the end part extends to the lower end part side of the container body so as not to reach the lower end part. The medical multi-chamber container according to any one of 1) to (5).
(7) The protection portion has a start end in a vicinity of a lower end portion of the first side linear portion of the communication inhibition portion and at a position separated from the lower end side seal portion, and the first corner linear shape Enveloping the upper portion of the second linear portion of the communication inhibiting portion, and spaced apart from the lower seal portion of the second side linear portion of the communication inhibiting portion The medical multi-chamber container according to any one of the above (2) to (5), which is a continuous linear protective portion that terminates at the position where it is placed.

(8) The protection part has a starting end near the center or upper part of the first side linear part of the communication inhibition part, the first corner linear part, the upper linear part, The continuous linear protective portion that encloses the upper portion of the second corner linear portion and terminates at the central portion or near the upper portion of the second side linear portion of the communication inhibition portion (2 ] The medical multi-chamber container according to any one of (5) to (5).
(9) The medical multi-chamber container according to any one of (6) to (8), wherein an end of the continuous linear protection portion has a width that decreases toward the start end and the end.
(10) The continuous linear protection part according to any one of (6) to (9), wherein the continuous linear protection part has a deficient part provided in a portion located above the upper linear part of the communication inhibition part. The medical multi-chamber container as described.
(11) The protection unit is a first corner protection unit provided at a position close to the first corner linear part of the communication inhibition unit and on the first drug chamber side; and (2) thru | or (5) which is a division | segmentation type | mold protection part which has a 2nd corner | angular part protection part provided in the position which adjoins the 2nd corner | angular part linear part and becomes the said 1st chemical | medical agent chamber side. The medical multi-chamber container according to any one of the above.
(12) The split type protection section includes an upper linear section protection section provided in a portion located above the upper linear section of the communication inhibition section. Chamber container.
(13) The split type protection portion is located near the first side linear portion or / and the second side linear portion of the communication inhibition portion and on the first drug chamber side The medical multi-chamber container according to the above (11) or (12), which is provided with a side protection part provided on the medical device.
(14) The medical multi-chamber container includes a second protection part provided at a position close to the protection part and spaced from the protection part when viewed from the communication inhibition part. (13) The medical multi-chamber container according to any one of (13).
(15) The partition portion includes a central weak seal portion and two side seal portions that are continuous with both end portions of the central weak seal portion and are less likely to peel or not peel from the central weak seal portion. The medical multi-chamber container according to any one of 1) to (14).
(16) The medical multi-chamber container according to (15), wherein the central weak seal portion is provided above the communication inhibition portion and above the protection portion.
(17) In the medical multi-chamber container, the protective part and the communication inhibiting part are peeled off simultaneously with or subsequent to peeling of the partitioning part by pressing the second drug chamber (1) ) To the medical multi-chamber container according to any one of (16).

In the medical multi-chamber container of the present invention, the communication inhibiting portion extends from the lower end portion of the container body in the direction of the partition portion so as to surround the upper end portion of the discharge port, thereby forming a partition portion partitioned from the first drug chamber. The communication hindering portion includes at least one corner formed on a peripheral edge on the first drug chamber side, and the medical multi-chamber container is more It is a medicine chamber side, is provided in a position close to the communication hindering part and not in contact with the communication hindering part, and includes a peelable protection part for protecting the corner part of the communication hindering part. .
For this reason, since the corner | angular part of a communication inhibition part is protected by the protection part, even if a pressure is loaded to the 1st chemical | medical agent chamber in which the communication inhibition part is provided during conveyance or a storage, a communication inhibition part Can be prevented, and it is not necessary to increase the sealing strength of the communication hindering part, but it can be set to a lower level, the separation work of the partition part and the communication hindering part is not lowered, and the weak seal for hindering communication It can be easily peeled to the end of the part.

Hereinafter, the medical multi-chamber container of the present invention will be described in detail with reference to the accompanying drawings. FIG. 1 is a front view of a medical multi-chamber container according to an embodiment of the present invention.
The medical multi-chamber container 1 of the present invention is made of a flexible material, has an upper end portion 5 and a lower end portion 6, and has a first drug chamber 21 and a second portion by a partition portion 9 from which an internal space can be peeled off. The container main body 2 divided into the drug chambers 22, the first drug stored in the first drug chamber 21, the second drug stored in the second drug chamber 22, and the first drug chamber 21. The discharge port 3 provided at the lower end of the first gas chamber and the peelable communication inhibiting portion 10 that inhibits the communication between the first drug chamber 21 and the discharge port 3 are provided.
The communication inhibiting part 10 extends in the direction of the partition part so as to surround the upper end part of the discharge port 3 from the lower end part 6 of the container body 2, and forms a partition part 23 partitioned from the first drug chamber 21. The communication inhibition unit 10 includes at least one corner 10 formed on the peripheral edge on the first drug chamber 21 side. The medical multi-chamber container 1 is provided on the first drug room side 21 with respect to the communication inhibition unit 10, close to the communication inhibition unit 10 and not in contact with the communication inhibition unit. A peelable protective part 11 for protecting the part 10 is provided.

As shown in FIG. 1, the medical multi-chamber container 1 of the present invention includes a container body 2, a first medicine, a second medicine, a discharge port 3, and a mixed injection port 4.
In addition, as shown in FIG. 1, the container body 2 of the present invention includes a first drug chamber 21, a second drug chamber 22, a partition portion 9, a communication inhibition portion 10, a discharge port attachment portion 27, A mixed injection port mounting portion 28 and a medicine injection portion 29 are provided.
The container body 2 includes an upper end portion 5 and a lower end portion 6. In this example, the upper end portion 5 is formed by the upper end side seal portion 5, and the lower end portion 6 is formed by the lower end side seal portion 6. In addition, the upper end part 5 and the lower end part 6 may not be a seal part.
The container body 2 is preferably formed into a cylindrical shape by an inflation molding method. The container body 2 may be manufactured by various methods such as a blow molding method. In addition, the container body 2 has a cylindrical body sealed at the entire outer periphery, only the upper and lower ends are sealed, one sheet is folded in two, and a portion other than a bent portion (side portion 7 or 8) It may be a bag-like object such as one sealed on the three sides.

  Moreover, the side parts 7 and 8 which are strong seal parts may be provided in the side of the container main body 2. FIG. Further, as shown in FIG. 1, the lower end side seal portion 6 of the container body 2 has a discharge port mounting portion 27 for mounting the discharge port 3 and a drug injection for injecting a drug into the first drug chamber 21. A portion 29 is provided. The discharge port attachment portion 27 and the medicine injection portion 29 are non-seal portions where a part of the lower end side seal portion 6 communicates between the inside of the container body 2 and the outside. In addition, although it is preferable that the chemical | medical agent injection | pouring part 29 is provided in the lower end side seal part 6, it does not need to be. The upper end side seal portion 5 is provided with a mixed injection port mounting portion 28 for mounting a mixed injection port. The mixed injection port mounting portion 28 is a non-seal portion in which a part of the upper end side seal portion 5 is communicated with the inside of the container main body and the outside.

As shown in FIG. 1, the container body 2 is divided into a first drug chamber 21 and a second drug chamber 22 by a partitioning portion 9. The partition portion 9 is formed by a central weak seal portion 9a and side weak seal portions 9b formed on both side portions of the central weak seal portion 9a. In the Example of this invention, the partition part 9 is provided so that the whole horizontal direction of the chemical | medical agent chamber of the container main body 2 may be crossed, as shown in FIG. The central weak seal portion 9 a is located in the central portion of the partition portion 9, and the side weak seal portion 9 b is provided so as to reach the side seal portions 7 and 8 of the container body 2. The center weak seal part 9a and the side weak seal part 9b are formed by fusing the sheet material of the container body 2 so as to be peelable in a strip shape. With such a configuration, only the central weak seal portion 9a is formed in the vicinity of the center of the medicine chamber, and side weak seal portions 9b are formed on both sides thereof so as to overlap the central weak seal portion 9a. Further, in this embodiment, the side weak seal portion 9b is wider than the central weak seal portion 9a, and its upper edge is curved toward the upper end side of the container body as it goes toward the side portion. Yes. For this reason, when the 2nd chemical | medical agent chamber 22 is compressed, the chemical | medical agent in the chemical | medical agent chamber 22 is comprised so that it may go to the center weak seal | sticker part 9a.
In the medical multi-chamber container 1 of this embodiment, the side weak seal portion 9b is wider than the central weak seal portion 9a, but may have the same or narrow width. Good.

The partition part 9 of the embodiment peels off when one of the drug chambers is strongly pressed with a finger or the like (for example, when pressed or squeezed), and the first drug chamber 21 and the second drug chamber 22 are peeled off. Can communicate with each other. Further, the central weak seal portion 9a is more easily separated from the side weak seal portion 9b when the second drug chamber 22 is compressed.
Moreover, the side weak seal part 9b of an Example becomes a thing which is hard to peel from the center weak seal part 9a and the communication inhibition part 10. FIG.
The separation strength of the partition portion 9 (the weak central seal portion 9a) is not peeled by the pressure applied to the container body 2 in the form of two-fold packaging during transportation, and the container body 2 is strongly pressed with fingers (squeezed). It is preferable that it peels occasionally. The partition portion 9 is preferably formed by fusing the container body 2. The fusion is preferably thermal fusion, high frequency fusion, ultrasonic fusion or the like. Since the container body 2 has the two drug chambers 21 and 22 divided into the partition portions 9 in this way, drugs of different components can be mixed aseptically in the container body 2. Moreover, in the Example shown in FIG. 1, although the partition part 9 is provided horizontally linearly with respect to the container main body 2, it is not limited to this. In addition, in the Example of this invention, although the partition part 9 of the container main body is comprised by the center weak seal part 9a and the side weak seal part 9b, it is not limited to this, The center weak seal part 9a You may comprise only.

  The peel strength (initial peel strength) of the partition portion 9 (central weak seal portion 9a) is preferably 0.1 to 5 N / 10 mm, and particularly preferably 0.3 to 3 N / 10 mm. If the seal strength is within this range, the central weak seal part will not be accidentally peeled off during transportation or storage, and the work of peeling the central weak seal part is easy. If the peel strength is within this range, the partitioning part 9 will not be accidentally peeled off during transportation or storage, and the work of peeling off the partitioning part 9 is easy. Further, if the peel strength is within this range, the partition portion 9 (central weak seal portion 9a) is surely peeled before the communication inhibition portion 10 and the side weak seal portion 9b.

The peeling strength of the side weak seal portion 9b according to the embodiment of the present invention is larger than that of the communication inhibition portion 10. Moreover, it is preferable that the side weak seal part 9b does not peel in a normal usage method. The side weak seal portion 9b is preferably formed by fusing the container body 2 by heat fusion, high frequency fusion, ultrasonic fusion or the like. Note that the side weak seal portion may be a strong seal portion that cannot be peeled off.
The peel strength (initial peel strength) of the side weak seal portion 9b is preferably 3N / 10 mm or more, and particularly preferably 4N / 10 mm or more. Further, as the difference in seal strength (initial difference in peel strength) between the center weak seal portion and the side weak seal portion, the seal strength of the side weak seal portion is the seal strength of the central weak seal portion (initial peel strength). Therefore, it is preferably 3 to 30 N / 10 mm, particularly 4 to 25 N / 10 mm larger. By doing so, when any one of the drug chambers is pressed, the entire partition portion 9 is prevented from being peeled off at a stretch, and at least peeling from the central weak seal portion 9a is ensured.
A specific method for measuring the peel strength can be performed as follows. Measurement when medical multi-chamber container is cut at 10 mm length in the width direction of the container, and each sealing piece is peeled off at a pulling speed of 300 mm / min. The average value.

In the embodiment of the present invention, the side weak seal portions 9b are formed on both sides of the partition portion 9, but the side weak seal portions 9b may not be formed, and an easily peelable central weak seal. The container body 2 may be partitioned only by the portion 9a.
When the side weak seal portion 9b is provided, the length of the central weak seal portion 9a (excluding the side weak seal portion 9b) is 0.2 to 0.8 with respect to the lateral width of the drug chamber. preferable. In particular, it is preferably 0.3 to 0.7. Specifically, the length of the central weak seal portion 9a is preferably 70 to 110 mm, particularly 80 to 100 mm when the width is 190 mm, although it depends on the width of the drug chamber. The width of the central weak seal portion 9a is preferably 8 to 20 mm, particularly 10 to 15 mm. The width of the side weak seal portion 9b is preferably 6 to 50 mm, particularly 8 to 30 mm.
Since the length of the central weak seal portion 9a is as described above, the communication inhibiting portion 10 can be easily peeled with one action.

Moreover, it is preferable that the partition part 9 (central weak seal part 9a) is provided in the position which becomes above the communication inhibition part 10, as shown in FIG. Moreover, it is preferable that the side weak seal part 9b is provided in the both sides of the position which becomes the upper direction of the communication inhibition part 10, as shown in the figure. By providing the partitioning portion 9 at such a position, when the partitioning portion 9 (the central weak seal portion 9a) is peeled off, the portion where the communication inhibiting portion 10 of the container body 2 is formed is greatly expanded, so that communication is possible. The inhibition part 10 becomes easy to peel.
Note that the side weak seal portion 9b may be a seal portion that cannot be substantially peeled off. The portion corresponding to the side weak seal portion 9b is not necessarily a peelable seal, and the portion may be a strong seal portion. In addition, the partition part 9 or the side weak seal part 9b does not need to be formed in strip | belt shape (not shown). For example, the partition part 9 may be formed in V shape, a semicircle shape, and a semi-elliptical shape. Moreover, the partition part 9 (central weak seal part 9a) may become what peels easily by being produced thinly. Further, in this embodiment, since the discharge port 3 and the communication inhibiting portion 10 are provided near the center of the lower portion of the container main body 2, the central weak seal portion 9a (the portion formed only) is also correspondingly provided. It is provided near the center. When the discharge port 3 and the communication inhibiting part 10 are provided at positions close to the side of the container body 2, the central weak seal part 9 a (the part formed only) is also provided on the side of the container body 2. It is preferable to provide it at a position near the side from the center of the direction.
The volume ratio between the first drug chamber 21 and the second drug chamber 22 divided by the partition 9 is preferably 1: 1 to 1: 5.

The container body 2 preferably has a water vapor barrier property. As the degree of water vapor barrier property, the water vapor permeability is preferably 50 g / m ² · 24 hrs · 40 ° C. · 90% RH or less, more preferably 10 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. More preferably, it is 1 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. This water vapor permeability is measured by the method described in JIS K7129 (Method A).
Thus, when the container main body 2 has water vapor | steam barrier property, the evaporation of the water from the inside of the medical multi-chamber container 1 can be prevented. As a result, it is possible to prevent reduction and concentration of the medicine (specifically, chemical solution) to be filled. Moreover, the invasion of water vapor from the outside of the medical multi-chamber container 1 can be prevented.

  When polyolefin is contained as a material for forming such a container body 2, the usefulness of the present invention is great. Therefore, in the present invention, it is preferable that the material for forming the container body 2 includes polyolefins. Particularly preferable materials for forming the container body 2 include polyolefins such as polyethylene (PE), polypropylene (PP), polybutadiene, and ethylene-vinyl acetate copolymer (EVA), styrene-butadiene copolymer and styrene. -Flexible by blending styrene thermoplastic elastomer such as ethylene-butylene-styrene block copolymer or olefin thermoplastic elastomer such as ethylene-propylene copolymer, ethylene-butene copolymer, propylene-α olefin copolymer A softened resin may be used. This material is preferable in that it has high strength and flexibility, heat resistance (particularly heat resistance during sterilization) and water resistance, and is particularly excellent in workability and can reduce manufacturing costs.

Further, when the above blend resin is used, two or more kinds of materials having different melting points are used, and the upper end side seal portion 5, the lower end side seal portion 6, the side portions 7 and 8, and the partition of the container body 2 are used. It is possible to easily and satisfactorily set the seal conditions of the portion 9 (the central weak seal portion 9a and the side weak seal portion 9b) and the communication inhibition portion 10 and stabilize the peel strength of each seal portion.
The container body 2 may have a single-layer structure (single-layer body) made of the materials described above, and a plurality of layers (particularly layers of different materials) are stacked for various purposes. It may be a multilayer laminate. In the case of a multilayer laminate, a plurality of resin layers may be stacked, or a metal layer may be stacked on at least one resin layer. In the case where a plurality of resin layers are stacked, the advantages of the respective resins can be provided together. For example, the impact resistance of the container body 2 can be improved or anti-blocking properties can be imparted. Moreover, in the case of a thing which has a metal layer, the gas barrier property of the container main body 2 etc. can be improved. For example, when a film such as an aluminum foil is laminated, the gas barrier property can be improved and the transparency of the container body 2 can be maintained, and the internal visibility can be ensured. In addition, when the container main body 2 is a multilayer laminated body, it is preferable that the material which forms the inner surface part is the material mentioned above.

The thickness of the sheet material constituting the container body 2 is appropriately determined according to the layer configuration and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.), and is not particularly limited. In general, the thickness is preferably about 100 to 550 μm, more preferably about 200 to 400 μm. Moreover, as the container main body 2, it is preferable to use an extruded film or a blown tube having a tensile elastic modulus of 500 MPa or less, preferably 50 to 300 MPa.
The container body 2 is produced by blow molding using the resin, is formed by fusing the peripheral edges of two sheets formed of the resin, and is formed of one sheet of the resin. Any of the one formed by folding the sheet and fusing the peripheral edge, or the one formed by extrusion molding using the above resin and fusing the peripheral edge of the opening may be used.

A medicine is stored in the medicine chambers 21 and 22 of the container body 2. The drug chambers 21 and 22 preferably contain different components. As such a drug (infusion solution), for example, it is necessary to mix two or more drugs at the time of infusion, such as peritoneal dialysis solution, transcentral vein infusion, transperipheral vein injection, liquid nutrient, etc. Some are preferable. Examples of the infusion include physiological saline, electrolyte solution, Ringer's solution, high calorie infusion, glucose solution, water for injection, amino acid electrolyte solution, and the like, but are not limited thereto. For example, a glucose electrolyte solution is stored in one of the drug rooms and an amino acid solution is stored in the other, and water-soluble vitamins such as vitamin B1, vitamin B2, vitamin B6, vitamin C, panthenol, and nicotinamide are stabilized in both chambers. It can be sorted and stored as appropriate in consideration of the properties and the like.
In addition, the upper end side seal portion 5 of the container body 2 is provided with a hole (hanging portion) 25 for hanging on a hanger or the like. Furthermore, a film such as an aluminum foil may be laminated on the container body 2 in order to impart oxygen barrier properties, light shielding properties, etc., in order to maintain the quality of the drug. Or you may provide the resin film which has these thin films as an intermediate | middle layer.

In this embodiment, the communication inhibiting part 10 is formed by a communication inhibiting seal part. The communication inhibiting portion 1010 is formed so as to surround the upper end portion of the discharge port 3. A partition portion 23 partitioned from the first drug chamber 21 is formed by the communication inhibition portion 10. This partition 23 is an empty room. However, the partition part 23 may contain a predetermined liquid (for example, water for injection or physiological saline). Moreover, although the partition part 23 may be a dry state, it may be filled with the trace amount liquid for sterilization. Further, a passage through which some water vapor or medicine passes through the communication inhibiting part 10 may be formed so as to communicate with the first medicine chamber 21 at the above level. The communication inhibition part 10 can be formed by heat-sealing (thermal fusion, high-frequency fusion, ultrasonic fusion) so that the sheet material can be peeled.
It is preferable that the communication inhibition part 10 is formed at a position below the central weak seal part 9a portion of the partition part 9. By being formed in such a position, when the first drug chamber 21 or the second drug chamber 22 is pressed (for example, when pressed or squeezed), the communication inhibiting unit 10 is peeled off as described above. It becomes easy to do.

  As shown in FIG. 1, the communication inhibition unit 10 includes at least one corner 10 formed on the peripheral edge that is on the first drug chamber 21 side. In particular, in the embodiment shown in FIG. 1, the communication inhibiting portion 10 is formed in an inverted U shape. Specifically, the communication inhibiting part 10 is located between the partition part 9 and the discharge port 3 and extends from the upper linear part 10a extending in the lateral direction of the container main body 2 and from the vicinity of one end of the upper linear part 10a. The first side linear portion 10b reaching the lower end side seal portion 6 and the second side line extending from the vicinity of the other end of the upper linear portion 10a and reaching the lower end side seal portion 6 of the container body 2. The first linear portion 10d, the upper linear portion 10a, and the second side linear portion 10c that connect the upper portion 10c, the upper linear portion 10a, and the first side linear portion 10b. And a second corner linear portion 10e to be connected. In addition, the communication inhibition part 10 is not limited to such a thing, For example, it is an inverted V shape, and is a thing with only one corner | angular part which has a vertex (corner | corner) above a discharge port. There may be.

The strength for peeling off the communication inhibition part 10 is lower than that of the side weak seal part 9b.
Moreover, the medical multi-chamber container 1 may be one in which the communication inhibiting part 10 is peeled off after the partition part 9 (central weak seal part 9a) is peeled by pressing the first drug chamber 21. . If it is such, the 1st chemical | medical agent chamber 21 of the container main body 2 is pressed, and the communication inhibition part 10 can be peeled with the force of the fluid at the time of peeling of the partition part 9. FIG.
The seal strength (initial peel strength) of the communication inhibiting portion is preferably 1 to 25 N / 10 mm, and particularly preferably 2 to 20 N / 10 mm. Moreover, it is preferable that the width | variety (band width) of a communication inhibition part is 2-20 mm, especially 3-18 mm.

The medical multi-chamber container 1 includes a protection unit 11 that protects the communication inhibition unit 10.
The protection part 11 that protects the communication inhibiting part 10 in the medical multi-chamber container 1 of the present invention is formed so as not to contact the communication inhibiting part 10. That is, as in the embodiment shown in FIG. 1, the weak seal non-forming portion 12 exists between the communication inhibition portion 10 and the protection portion 11. Since the protective part 11 is not adjacent to the communication blocking part 10 in this way, even if the protective weak seal is peeled off due to an inadvertent impact, the peeling is once terminated by the weak seal non-forming part 12. Further, it is possible to prevent the communication hindering part 10 from being peeled off continuously from the peeling of the protective part 11. The separation distance between the communication inhibition part 10 and the protection part 11 (in this embodiment, the width of the weak seal non-formed part 12) is preferably 0.1 to 10 mm, and particularly preferably 0.3 to 7 mm.
Furthermore, it is preferable that the protection part 11 is provided so as to be separated from the lower end side seal part 6 (in other words, not in contact with the lower end side seal part). By doing in this way, it becomes what does not protect the connection part with the lower end side seal part 6 of the 1st side part linear part 10b of the communication inhibition part 10, and the 2nd side part linear part 10c, and normal peeling The peelability of the connecting portion between the first side linear portion 10b and the second side linear portion 10c and the lower end side seal portion 6 at the time of work is not hindered. And the separation distance of the protection part 10 and the lower end side seal part 6 of a container main body has preferable 2-100 mm, and 5-80 mm is especially preferable.

And it is preferable that the sealing strength of the protection part 11 is larger than the sealing strength of the communication inhibition part 10. By doing in this way, careless peeling of the communication inhibiting part 10 can be inhibited by the protection part 11, and the peelability of the communication inhibiting part 10 during normal peeling work is not lowered. It is preferable that the seal strength (initial peel strength) of the protection portion 11 is set so as to completely cover the upper portion of the corner line of the communication inhibition portion 10.
Further, the seal strength of the protection unit 11 may be the same as or greater than the seal strength of the communication inhibition unit 10. By doing in this way, careless peeling of the communication hindering part 10 can be inhibited by the protection part 11, and the peelability of the partition part 9 during normal peeling work is not lowered. The seal strength of the protection portion 11 may be the same as or greater than the seal strength of the partition portion 9 (in this embodiment, the central weak seal portion 9a).
In particular, the seal strength of the partition portion 9 (central weak seal portion 9a) is greater than the seal strength of the communication inhibition portion 10, and the seal strength of the protection portion 11 is greater than the seal strength of the partition portion 9 (central weak seal portion 9a). It may be large. By doing in this way, careless peeling of the communication hindering part 10 can be inhibited by the protection part 11, and the peelability of the communication hindering part 10 and the partition part 9 during normal peeling work is not lowered.
Moreover, as a form of the protection part 11, you may be like the medical multiple-chamber container 1 of the Example shown in FIG. The protection part 11 is a continuous linear protection part that encloses the upper part of the corner part and extends so that the end part does not reach the lower end part 6 on the lower end part side of the container body 2.

  The protection part 11 in this embodiment has a start end in the vicinity of the lower end of the first side linear part 10b of the communication inhibiting part 10 and at a position separated from the lower end side seal part 6, and the first corner linear form The upper portion of the portion 10d, the upper linear portion 10a, and the second corner linear portion 10e is encapsulated, in the vicinity of the lower end portion of the second side linear portion 10c and at a position separated from the lower end side seal portion 6. It is a continuous linear protective part that terminates. In the protection part 11 in this embodiment, a weak seal non-forming part 13 a is provided between the starting end and the lower end side seal part 6, and a weak seal non-forming part 13 b is provided between the terminal end and the lower end side seal part 6. Is formed. If it is such a continuous linear protection part, the communication inhibiting part 10 is uniformly protected except for the end part of the side linear part connected to the lower end side seal part 6, and the communication inhibiting part 10 Inadvertent peeling can be prevented, and the peelability of the end portion of the side linear portion of the communication inhibiting portion 10 during normal peeling work is not inhibited.

The protection part 11 in this embodiment is a continuous linear protection part as described above, and extends in the lateral direction of the container body 2 and protects the upper linear part 10a of the communication inhibition part 10. The protection part 11a, the first side linear part protection part 11b protecting the first side linear part 10b, and the second side linear part protecting the second side linear part 10c The protection part 11c, the 1st corner | angular part protection part 11d which protects the 1st corner | angular part linear part 10d, and the 2nd corner | angular part protection part 11e which protects the 2nd corner | angular part linear part 10e are provided. .
And the continuous linear protection part 11 is the weak seal defect | deletion provided in the part located in the upper part of the upper linear part 10a of the communication inhibition part 10 like the medical multiple-chamber container 20 of the Example shown in FIG. The part 15 may be provided. By providing such a weak seal deficient portion 15, the protective portion 11 can be easily peeled off during the peeling operation. Further, even if such a weak seal defect portion 15 is provided, the protection of the two corner portions of the communication inhibition portion 10 is not substantially reduced. As shown in FIG. 2, the weak seal deficient portion 15 preferably has a shape in which the width becomes narrower from the upper edge toward the lower edge of the upper linear portion 10a. In addition, it is preferable to provide two weak seal deficient portions 15 symmetrically with respect to the midpoint of the upper linear portion 10a. However, the present invention is not limited to this, and the weak seal missing portion 15 is not limited to the inner portion of the upper linear portion 10a. One provided in the vicinity of the point or two or more provided in the upper linear portion 10a may be used. Moreover, the weak seal | sticker defect | deletion part 15 may extend from the upper edge of the upper linear part 10a, may reach | attain a lower edge, or may terminate in the middle.

  Further, like the medical multi-chamber container 30 of the embodiment shown in FIG. 3, the end of the continuous linear protection part 11 may be narrowed toward the start and end. In particular, in the continuous linear protection part 11 shown in FIG. 3, the width is gradually narrowed toward the start end and the end. That is, in the continuous linear protection part 11 of this medical multi-chamber container 30, the part which protects the 1st side linear part 10b and the 2nd side linear part 10c of the communication inhibition part 10 is the end. The width becomes narrower toward the part. Also in this embodiment, the two corners to be protected of the communication inhibiting portion 10 can be sufficiently protected, and peeling at the time of peeling work is easy.

  And like the medical multi-chamber container 40 of the Example shown in FIG. 4, as the continuous linear protection part 11, as mentioned above, in the part located in the upper part of the upper linear part 10a of the communication inhibition part 10 While providing the weak seal | sticker defect | deletion part 15 provided, as mentioned above, the edge part of the continuous linear protection part 11 may become narrow toward a start end and a termination | terminus.

Moreover, as a form of a protection part, the thing like the medical multiple-chamber container 50 of the Example shown in FIG. 5 may be sufficient, for example.
The protection part 51 of this embodiment has a start end near the center or upper part of the first side linear part 10b of the communication inhibiting part 10, and includes the first corner linear part 10d and the upper linear part 10a. The upper portion of the second corner linear portion 10e is encapsulated and is a continuous linear protective portion that terminates near the center or upper portion of the second side linear portion 10c. The protection part 51 of this embodiment extends in the lateral direction of the container body 2, and includes an upper linear part protection part 51a that protects the upper linear part 10a of the communication inhibition part 10, and a first corner linear part 10d. A first corner protection portion 51b that protects and a second corner portion protection portion 51c that protects the second corner linear portion 10e are provided. The difference between the protective part 11 and the protective part 51 described above is that, in the protective part 51, the separation distance between the start and end points and the lower end side seal part 6 is longer than that of the protective part 11 in FIG. It is. The protective part 51 protects the first corner linear part 10d, the upper linear part 10a, and the second corner linear part 10e, but the first side linear part 10b and the second linear part 10e are protected. The side linear portion 10c is not substantially protected. Even in this embodiment, the two corners to be protected of the communication inhibiting portion 10 can be sufficiently protected, and the protective portion 51 is short as a whole, and therefore, peeling at the time of peeling work is easy. Become.
And it is preferable that the width | variety (band width) of a protection part is 1-20 mm, especially 3-18 mm. Note that the width of the protective portion may not be uniform.

Further, like the medical multi-chamber container 60 of the embodiment shown in FIG. 6, the second protection unit 16 provided in a position close to the protection unit 11 and separated from the protection unit 11 when viewed from the communication inhibition unit 10. May be provided.
The second protection part 16 is formed so as not to contact the protection part 11. That is, as in the embodiment shown in FIG. 6, a weak seal non-formation portion exists between the second protection portion 16 and the protection portion 11. Furthermore, it is preferable that the 2nd protection part 16 is provided so that it may space apart from the lower end side seal part 6 (in other words, it may not contact a lower end side seal part). By doing in this way, the peelability of the connection part with the lower end side seal part 6 of the 1st side part linear part 10b and the 2nd side part linear part 10c at the time of normal peeling operation | work is not inhibited.
And it is preferable that it is 1-20 mm as a width | variety of the protection part 11 in this Example, It is especially preferable that it is 3-9 mm. In addition, the width of the second protection part 16 is preferably 1 to 20 mm, and particularly preferably 3 to 9 mm. In addition, the width | variety of each weak seal part does not need to be uniform. And as a separation distance of the 2nd protection part 16 and the protection part 11, it is preferable that it is 0.1-10 mm, and it is especially preferable that it is 0.3-7 mm. In addition, the seal strength of the second protective weak seal portion is preferably 1 to 25 N / 10 mm, and more preferably 2 to 20 N / mm. Further, the seal strength of the second protection portion is preferably equal to the seal strength of the protection portion 11, and may be slightly higher or slightly lower.

Moreover, as a form of a protection part, the thing like the medical multiple-chamber container 70 of the Example shown in FIG. 7 may be sufficient, for example.
The protection part 71 of this embodiment includes a first corner part protection part 71a provided at a position close to the first corner part linear part 10d of the communication inhibition part 10 and on the first medicine chamber 21 side. This is a split type protection part having a second corner part protection part 71b provided at a position close to the second corner part linear part 10e and on the first medicine chamber side. That is, in the protection part 71 of this embodiment, only the first corner linear part 10d and the second corner linear part 10e of the communication inhibiting part 10 are protected.

Further, like the multi-chamber container 80 of the embodiment shown in FIG. 8, even in the case of the above-described split type protective unit, the communication blocking unit 10 is similar to the linear protective unit 11 shown in FIG. 1 and described above. An upper linear portion protection portion 71c that protects the upper linear portion 10a, a first side linear portion protection portion 71d that protects the first side linear portion 10b, and a second side linear portion 10c. You may have the 2nd side part linear part protection part 71e to protect. The upper linear part protection part 71c, the first side linear part protection part 71d, and the second side linear part protection part 71e may all be included, but the upper linear part protection part 71c may be included. Any one of the first side linear part protection part 71d and the second side linear part protection part 71e may be provided. For example, it is good also as what has only the upper side linear part protection part 71c, and what has only the 1st side part linear part protection part 71d and the 2nd side part linear part protection part 71e.
And in the split type protection part 71 of this embodiment, the shape of each protection part is a form in which a continuous weak protection part is provided with a non-weak seal forming part. That is, in the split type protection unit 71 of this embodiment, each protection unit extends a predetermined length with a predetermined width. As a width | variety of the protection part 71, it is preferable that it is 1-20 mm, especially 3-18 mm. Note that the width of the protective portion may not be uniform.

Further, like the medical multi-chamber container 90 of the embodiment shown in FIG. 9, the shape of each protection portion 71 in the above-described split-type protection portion may be circular. Furthermore, the shape of each protection part may be elliptical, semicircular, polygonal, or the like. The area of each protection unit ^71, preferably 3mm ² ~250m 2 about, in ^particular, 19 mm 2 to 200 mm ² is preferred.
In the medical multi-chamber container 90 shown in FIG. 9, the protection unit 71 includes an upper linear part protection part 71 c that protects the upper linear part 10 a of the communication inhibition part 10, and the first side linear part 10 b. It has the 1st side part linear part protection part 71d which protects, and the 2nd side part linear part protection part 71e which protects the 2nd side part linear part 10c. The upper linear part protection part 71c, the first side linear part protection part 71d, and the second side linear part protection part 71e may all be included, but the upper linear part protection part 71c may be included. Any one of the first side linear part protection part 71d and the second side linear part protection part 71e may be provided. For example, it is good also as what has only the upper side linear part protection part 71c, and has only the 1st side part linear part protection part 71d and the 2nd side part linear part protection part 71e.

And as for the separation distance of the communication inhibition part 10 and protection part in the division | segmentation type | mold protection part mentioned above, 0.1-10 mm is preferable, and 0.3-7 mm is especially preferable.
In any of the medical multi-chamber containers described above, the central weak seal portion 9a is provided above the communication inhibition portion 10 and above the protection portions 11, 51, 71. Further, the lateral width of the container body 2 in the formation region of the protection parts 11, 51, 71 is narrower than the lateral width of the container body 2 in the formation region of the central weak seal portion 9a. Further, the medical multi-chamber container of any of the embodiments presses the second drug chamber 22 to simultaneously or subsequently with the separation of the partition portion 9 (specifically, the central weak seal portion 9a), the protective portion. In addition, the communication hindering part is peeled off. For this reason, peeling work is easy.
Moreover, the discharge port 3 and the mixed injection port 4 are provided in the medical multi-chamber container of any of the above-described embodiments.
For example, as shown in FIG. 1, the discharge port 3 is attached to a discharge port attachment portion 27 formed in the lower end side seal portion 6 of the container body 2. The discharge port mounting portion 27 is provided at the center of the lower end side seal portion 6. Specifically, as shown in FIG. 1, the container body 2 is fixed to the lower end side seal portion 6. A well-known thing can be used as a discharge port. The mixed injection port 4 is provided so as to communicate with the second medicine chamber 22. Specifically, as shown in FIG. 1, the container body 2 is fixed to a mixed injection port attachment portion 28 formed in the upper end side seal portion 5. A well-known port can be used as the mixed injection port.

FIG. 1 is a front view of a medical multi-chamber container according to an embodiment of the present invention. FIG. 2 is a front view of a medical multi-chamber container according to another embodiment of the present invention. FIG. 3 is a front view of a medical multi-chamber container according to another embodiment of the present invention. FIG. 4 is a front view of a medical multi-chamber container according to another embodiment of the present invention. FIG. 5 is a front view of a medical multi-chamber container according to another embodiment of the present invention. FIG. 6 is a front view of a medical multi-chamber container according to another embodiment of the present invention. FIG. 7 is a front view of a medical multi-chamber container according to another embodiment of the present invention. FIG. 8 is a front view of a medical multi-chamber container according to another embodiment of the present invention. FIG. 9 is a front view of a medical multi-chamber container according to another embodiment of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical multiple-chamber container 2 Container main body 3 Discharge port 9 Partition part 10 Communication inhibition part 11 Protection part 21 1st chemical | medical agent chamber 22 2nd chemical | medical agent chamber

Claims (17)

A container body made of a flexible material, having an upper end portion and a lower end portion, and partitioned into a first drug chamber and a second drug chamber by a partitioning portion from which an internal space can be peeled, and the first drug A discharge port provided at a lower end of the chamber, a first drug stored in the first drug chamber, a second drug stored in the second drug chamber, and the first drug chamber And a multi-chamber container for medical use comprising a detachable communication inhibiting portion that inhibits communication between the exhaust port and the discharge port,
The communication inhibiting portion extends from the lower end of the container body in the direction of the partition so as to surround the upper end of the discharge port, and forms a partition section partitioned from the first drug chamber; and The communication hindering portion includes at least one corner portion formed on a peripheral edge portion on the first drug chamber side, and the medical multi-chamber container is closer to the first drug chamber side than the communication hinder portion. And provided with a detachable protection part for protecting the corner part of the communication inhibition part provided at a position close to the communication inhibition part and not in contact with the communication inhibition part. Medical multi-chamber container. The communication inhibiting portion is located between the partition portion and the discharge port, and extends from the upper linear portion extending in the lateral direction of the container main body and from the vicinity of one end of the upper linear portion to the lower end portion of the container main body. A first side linear part, a second side linear part extending from the vicinity of the other end of the upper linear part and reaching the lower end of the container body, the upper linear part, and the first linear part. A first corner linear portion connecting the side linear portions, and a second corner linear portion connecting the upper linear portion and the second side linear portion, The medical multi-chamber container according to claim 1, wherein the protection part protects the first corner linear part and the second corner linear part of the communication inhibition part. The medical multi-chamber container according to claim 1 or 2, wherein the seal strength of the protection portion is equal to or greater than the seal strength of the communication inhibition portion. The seal strength of the weak seal portion for protection is greater than the seal strength of the weak seal portion for partition, and is equal to or greater than the seal strength of the weak seal portion for communication inhibition. A multi-chamber container for medical use according to 1. The medical use according to claim 1 or 2, wherein a seal strength of the partition portion is greater than a seal strength of the communication inhibition portion, and a seal strength of the protection portion is greater than a seal strength of the partition portion. Multi-chamber container. The said protection part is a continuous linear protection part which encloses the upper part of the said corner | angular part, and an edge part is extended in the said lower end part side of the said container main body so that this lower end part may not be reached. A medical multi-chamber container according to any one of the above. The protection portion has a start end near a lower end portion of the first side linear portion of the communication inhibition portion and at a position separated from the lower end seal portion, and the first corner linear portion, The upper linear portion, the upper portion of the second corner linear portion is encapsulated, in the vicinity of the lower end portion of the second side linear portion of the communication inhibition portion and at a position separated from the lower end seal portion. 6. The medical multi-chamber container according to any one of claims 2 to 5, wherein the medical multi-chamber container is a continuous linear protective portion that terminates. The protection part has a start end near the center or upper part of the first side linear part of the communication inhibiting part, and the first corner linear part, the upper linear part, the second linear part, and the second linear part. 6. A continuous linear protective portion enclosing an upper portion of the corner linear portion and terminating at a central portion or near the upper portion of the second side linear portion of the communication inhibiting portion. The medical multi-chamber container according to any one of the above. The medical multi-chamber container according to any one of claims 6 to 8, wherein an end of the continuous linear protection portion has a width that decreases toward the start end and the end. The medical multi-chamber according to any one of claims 6 to 9, wherein the continuous linear protection part has a deficient part provided in a portion of the communication inhibition part located above the upper linear part. container. The protection part includes a first corner part protection part provided at a position close to the first corner part linear part of the communication inhibition part and on the first medicine chamber side, and the second corner part protection part. The medical device according to any one of claims 2 to 5, wherein the medical device is a split type protective portion having a second corner portion protection portion provided at a position near the corner linear portion and on the first medicine chamber side. Multi-chamber container. The medical multi-chamber container according to claim 11, wherein the split-type protection part includes an upper linear part protection part provided at a portion of the communication inhibition part located above the upper linear part. The split type protection unit is provided at a position close to the first side linear part and / or the second side linear part of the communication inhibition unit and on the first drug chamber side. The medical multi-chamber container according to claim 11 or 12, further comprising a side protection part. 14. The medical multi-chamber container includes a second protection part provided at a position close to the protection part and spaced from the protection part when viewed from the communication inhibition part. A multi-chamber container for medical use according to 1. 15. The partition includes a central weak seal portion and two side seal portions that are continuous with both ends of the central weak seal portion and are less likely to peel or not peel from the central weak seal portion. A medical multi-chamber container according to any one of the above. The medical multi-chamber container according to claim 15, wherein the central weak seal portion is provided so as to be above the communication inhibition portion and above the protection portion. 17. The medical multi-chamber container is one in which the protective part and the communication inhibiting part are peeled off simultaneously with or subsequent to peeling of the partitioning part by pressing the second drug chamber. The medical multi-chamber container according to any one of the above.

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