JP2007246402A - Liquid formulation for internal use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid formulation for internal use while improving uncomfortable taste or smell of herbal drugs, excellent in herbal drug-like flavor without damaging the feeling of actual effect of the herbal drug. <P>SOLUTION: This liquid formulation for internal use is characterized by blending (A) an herbal drug tincture agent and/or galenical extract, with (B) a natural aromatic having a same origin with the (A) the herbal drug tincture agent and/or galenical extract (hereinafter abbreviated as the same origin herb-based aromatic), e.g. the natural aromatic obtained by carbon dioxide extraction, steam distillation or absolute method. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a liquid for internal use. More specifically, the present invention relates to a liquid preparation for internal use having a flavor that has a herbal-like aroma and does not impair the effectiveness of the herbal medicine while improving the unpleasant taste exhibited by the herbal medicine.

Many liquid products for internal use have been developed so far because they are easy to take, and many products containing herbal medicines as active ingredients have been put into practical use. However, many herbal medicines have an unpleasant taste and odor, and there is a problem that the merit of taking the medicine, which is easy to take, is impaired due to the uncomfortable feeling at the time of taking.
In order to solve this problem, a method in which a polyhydric alcohol and a sweetener are used in combination (Patent Document 1) has been introduced. However, if these components are added in an amount sufficient to mask the unpleasant taste of a herbal medicine, Later, sweetness and stickiness remained in the mouth, and the overall flavor of the solution was impaired. In addition, even though the unpleasant taste can be masked, the unpleasant smell is not improved.

Moreover, although the method of mix | blending caramel with the liquid for internal use which mix | blended the crude drug was introduced in patent document 2, there is also sweetness in caramel, and if there is much usage amount, sweetness will be in a mouth like patent document 1. Problems such as remaining, and the flavor of the caramel baked confectionery modulates the flavor of the liquid composition, making it difficult to understand that it is a liquid medicine containing herbal medicines, resulting in a flavor that does not have a medicinal effect due to herbal medicine blending The problem was left.
In addition, since caramel is also a colorant, there remains a problem that when a sufficient amount is added, the liquid color of the liquid becomes brown and the appearance is impaired.

  In addition, methods for improving the taste of components having an unpleasant taste using fruit flavors and flavors have been introduced (Patent Documents 3 to 10). Although these techniques improve the ease of drinking, the flavor of the liquid composition is greatly modulated. Therefore, in the case of a liquid preparation containing a herbal medicine, like the caramel of Patent Document 2, the flavor of the herbal medicine is not felt.

JP2002-363105 JP2004-161679 JP-A-11-209266 JP2004-321178 JP 05-146253) JP 05-163154 JP 10-167988 JP2000-262259 JP 11-012159 JP2003-231647

  An object of the present invention is to solve the above conventional problems and achieve the following objects. That is, an object of the present invention is to provide a liquid for internal use that improves the unpleasant taste and smell of a herbal medicine, has a herbal-like flavor, does not impair the herbal effectiveness, and is comfortable to drink.

  As a result of diligent research to achieve the above object, the present inventors have found that in an internal liquid solution containing a crude drug tincture / extract having an unpleasant flavor, The inventors have found that the problem can be solved by containing a fragrance prepared from animals and plants, and have reached the present invention. That is, this invention provides the following internal use liquid agent.

<1> (A) herbal tincture and / or herbal extract, and (B) natural fragrance having the same base as the herbal tincture and / or herbal extract of (A) (hereinafter referred to as the same crude drug system) Abbreviated as fragrance)
A liquid preparation for internal use characterized by comprising
<2> (B) The liquid medicine for internal use according to <1>, wherein the base drug substance fragrance is obtained by carbon dioxide extraction, steam distillation, or an absolute method.
<3> (A) herbal tincture, extract (herbal tincture and / or extract, the same applies hereinafter) and (B) the same crude drug-based fragrance is the following combination (A / B), <1> ~ <2> The liquid preparation for internal use as described.
(1) pepper tincture, extract / ginger oil (2) cinnamon tincture, extract / cinnamon oil or cassia oil (3) clove tincture, extract / clove oil (4) pepper tincture, Extract / Capsicum oil (5) Toki tincture, Extract / Angelica oil (6) Pepper tincture, Extract / Fennel oil (7) Pepper tincture, Extract / Anise oil (8) Pepper (turmeric) tincture, Extract / turmeric oil (9) Ginger cinnamon, extract / nutmeg oil (10) Pepper tincture, extract / peppermint oil <4> and further containing glucuronolactones and / or vitamins <1> to <3 > The liquid preparation for internal use as described.

  ADVANTAGE OF THE INVENTION According to this invention, the liquid agent composition for internal use which has the flavor excellent in the effective feeling of the crude drug can be obtained, improving the unpleasant taste of the liquid drug for internal use which mix | blended the crude drug.

Hereinafter, the present invention will be described in detail.
The liquid preparation for internal use of the present invention contains a herbal medicine (herbal medicine tincture, an extract) and a natural fragrance prepared from animals and plants of the same origin as the herbal medicine, and other ingredients as necessary.

(A) The herbal medicine tincture and the extract compounded in the liquid for internal use of the present invention mean a tincture and extract defined in the 14th revision Japanese Pharmacopoeia. That is, the tincture is a liquid preparation prepared by leaching a crude drug with ethanol or a mixture of ethanol and purified water. The extract is prepared by concentrating a crude drug leachate.

Specifically, for example, aloe, fennel, turmeric, yak, engosaku, ages, ogi, seisei, onji, guarana, kokushi, jiou, touki, eucommia, carrot, amarogentin, ougon, autaku, ouren, gajutsu, caskara sagrada , Cuckoo, ginseng, cynomolgus grass, calacon, cypress, pheasant, kyonin, yellowfin, wolfberry, kujin, kei-gai, keihi, ketsumeishi, kengoshi, gentian, gennoshouko, koujin, kobushi, koboku, burdock, gosh, trash, goshyu, trash Conzu Lango, Psycho, Sanshishi, Saffron, Sandscon, Giant, Shikon, Shiso, Peonies, Shajin, Shazen, Ja Scent, Shoyo, Shouma, Seishi, Sekisho, Senkyu, Senkotsu, Center Lilium grass, assembly, senbou, senso, senna, suzutsuku, sakuhakuhi, soyou, daiou, bamboo ginseng, chimo, chileta grass, chimpi, spruce, tunnin, tokon, nigaki, peony, peony, belladonnacon, yakuchi, yutan Examples include tinctures and extractants such as Japanese mugwort, ginger, hops, homica, bowie, maou, mokutsu, mokko, ryutan, gentian, luzonka, forsythia, senega, kikyo, gyoza, yokuinin, and ryugannik. These may be used individually by 1 type and may use 2 or more types together.
The content of the crude drug tincture / extract is 1 to 50,000 mg / 100 mL, preferably 10 to 10,000 mg / 100 mL in the internal liquid composition.

(B) The same basic crude drug based fragrance of the present invention is a natural fragrance obtained from a plant raw material having the same base as the (A) crude drug tincture and extract used in the liquid for internal use, for example, 1991 Published by the Japan Patent Office Publications prepared by various methods described in Part 1 of the collection of well-known and commonly used techniques (fragrances) can be used, but among them, the same base obtained by carbon dioxide extraction, steam distillation, or absolute method is preferred. The raw drug based fragrance is more preferably used, more preferably the same basic drug based fragrance obtained by carbon dioxide extraction and the absolute method. As an example of a preferable combination, for example,

(1) pepper tincture, extract / ginger oil (2) cinnamon tincture, extract / cinnamon oil or cassia oil (3) clove tincture, extract / clove oil (4) pepper tincture, Extract / Capsicum oil (5) Toki tincture, Extract / Angelica oil (6) Pepper tincture, Extract / Fennel oil (7) Pepper tincture, Extract / Anise oil (8) Pepper (turmeric) tincture, Extract / turmeric oil (9) cucumber tincture, extract / nutmeg oil (10) peppermint, extract / peppermint oil, etc.

The content of the same base drug substance fragrance is 0.01 to 1,000 mg / 100 mL, preferably 0.1 to 100 mg / 100 mL, particularly preferably 0.5 to 50 mg / 100 mL in the internal liquid composition.
Moreover, the preferable content ratio of (A) / (B) is preferably A / B = 1 / 0.00001 to 1/1, particularly 1 / 0.0001 to 1 / 0.1. Within this range, the effect of the present invention is particularly good.

  The liquid composition for internal use of the present invention preferably contains glucuronolactones and vitamins in addition to (A) herbal tincture and extract (B) the same crude drug-based fragrance.

  Glucuronolactones include glucuronic acid and glucuronate in addition to glucuronolactone. As the glucuronate, potassium salt, sodium salt, calcium salt, magnesium salt and the like are preferably used. These may be used alone or in combination. In the case of combined use, a ratio of glucuronolactone: glucuronic acid (salt) = 1: 99 to 99: 1 is preferable, and a ratio of glucuronolactone: glucuronic acid (salt) = 10: 90 to 50:50 is more preferable. . The total content of glucuronolactone in the liquid composition for internal use is preferably 0.1% to 6.0% by mass, and more preferably 0.4% to 5.0%.

  Vitamins include vitamin B, vitamin B such as thiamine nitrate, vitamin B2 such as riboflavin phosphate, vitamin B3 such as nicotinamide, vitamin B6 such as pyridoxine hydrochloride, vitamin B12, vitamin D, vitamin E, ascorbic acid, etc. Vitamin C, calcium pantothenate and the like can be used. These may be used individually by 1 type and may use 2 or more types together. The compounding quantity in the liquid composition for internal use of a vitamin becomes like this. Preferably it is 0.001-500 mg / 100mL, More preferably, it is 0.005-300 mg / 100mL.

  In the internal use liquid preparation of the present invention, various components that can be contained in the internal use liquid preparation can be appropriately selected as long as the effects of the present invention are not impaired. Examples thereof include physiologically active ingredients, water-soluble polymers, sweeteners, pH adjusters, preservatives, solubilizers, flavoring agents, polyhydric alcohols, colorants and the like.

  Examples of the physiologically active ingredient include taurine, caffeine, royal jelly, iron compounds, dichloroacetic acid diisopropylamine, inositol, carnitine chloride, ornithine and the like. These may be used individually by 1 type and may use 2 or more types together.

  The water-soluble polymer is a preferred component in order to further improve the effects of the present invention. Examples of the water-soluble polymer include polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose and the like. These may be used individually by 1 type and may use 2 or more types together.

  As the sweetener, a high-intensity sweetener and other sweeteners such as sugar and sugar alcohol can be used, either of which may be used, or may be used in combination.

  As a high-intensity sweetener, aspartame, acesulfame potassium, achacha extract, licorice extract, saccharin, saccharin sodium, sucralose, stevia extract, neotame, thaumatin, dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, Examples include monoammonium glycyrrhizinate, aspartame, potassium acesulfame, licorice, saccharin, sodium saccharin, dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, sucralose, stevia, neotame, thaumatin and the like. These may be used alone or in combination of two or more.

  Examples of the other sweeteners include liquid sugar, fructose, fructose glucose liquid, reduced maltose water candy, glycerin, brown sugar, high fructose liquid sugar, glucose, powdered reduced maltose water candy, water candy, high glucose water candy, lactose, Sucrose, purified sucrose, purified sucrose spherical granules, honey, purified honey, erythritol, xylitol, D-sorbitol, D-sorbitol solution, maltitol, maltitol solution, maltol, maltitol solution, maltose, D-mannitol, simple syrup, etc. Is mentioned. These may be used individually by 1 type and may use 2 or more types together.

The pH adjuster is not particularly limited and may be appropriately selected depending on the intended purpose. For example, hydrochloric acid, phosphoric acid, citric acid, sodium citrate, succinic acid, acetic acid, tartaric acid, D-tartaric acid, sodium hydroxide , Magnesium hydroxide, sodium hydrogen carbonate, lactic acid, calcium lactate, glacial acetic acid, monosodium fumarate, maleic acid, anhydrous citric acid, DL-malic acid, and the like. These may be used alone or in combination of two or more.
Moreover, the pH of the liquid for internal use can be adjusted using the above pH adjuster, and the pH is usually preferably from pH 2.0 to 6.0, but when glucuronolactone and / or glucuronic acid is contained, the pH is stable. From the standpoint of properties, a pH of about 2.0 to 4.5 is more preferable.

  The preservative is not particularly limited and may be appropriately selected depending on the intended purpose.For example, benzoic acid, sodium benzoate, ethanol, sodium edetate, salicylic acid, sodium salicylate, phenyl salicylate, dibutylhydroxytoluene, paraoxy Examples include isobutyl benzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, and the like. These may be used individually by 1 type and may use 2 or more types together.

  Examples of the solubilizer include nonionic surfactants such as sucrose fatty acid esters, polyoxyethylene hydrogenated castor oils, polysorbates, and pluronics. Examples of the solvent include ethanol and water.

  The flavoring agent can be appropriately selected according to the purpose as long as the flavor of the herbal medicine and the same basic flavor is not concealed. For example, lemon flavor, orange flavor, lime flavor, grapefruit flavor, grape Flavors, apple flavors, herbal flavors and the like. These may be used individually by 1 type and may use 2 or more types together.

  The polyhydric alcohol is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include glycerin, propylene glycol, and polyethylene glycol. These may be used individually by 1 type and may use 2 or more types together.

  Examples of the colorant include caramel, β-carotene, various food colors (food yellow No. 1, food red No. 2, etc.) and the like. Examples of the stabilizer include edible salts of edetic acid, sodium chloride, and edible salts of pyrosulfite. Examples of the solubilizer include cyclodextrin and arginine. Examples of the corrigent include fruit juice.

  The liquid for internal use according to the present invention can be adjusted by a conventional method, and the method is not particularly limited, but usually, each component is mixed with purified water of a specified amount or less, the volume is adjusted to a specified amount, and if necessary. Obtained by filtration and sterilization. When an oil-soluble component such as vitamin A is contained, it may be emulsified or solubilized with a commonly used surfactant or solubilizer, or suspended using a dispersant.

The preferred embodiments of the present invention are listed below.
<1> (A) herbal medicine tincture and / or herbal medicine extract, and (B) the same bulk drug based fragrance, <2> (B) the same bulk drug based fragrance Is a fragrance obtained by carbon dioxide extraction, steam distillation, or an absolute method, the liquid for internal use according to <1>, <3> herbal tincture and extract, and the same base crude fragrance are the following combinations: , <1> to <2> internal use liquid preparations / shower tinctures, extract agents (tinctures and / or extracts, the same shall apply hereinafter) / ginger oil / keihi (nickel) tinctures, extract agents / cinnamon oils, Cassia oil / clove tincture, extract / clove oil / pepper tincture, extract / capsicum oil / pepper tincture, extract / angelica oil / shower tincture, extract / Fennel oil, fennel tincture, extract agent / Anise oil, oleander (turmeric) tincture, extract agent / turmeric oil, licorice tincture, extract agent / nutmeg oil / mint powder tincture, extract agent / peppermint oil <4><5> The internal use liquid preparation according to <1> to <3> containing chronolactones and / or vitamins, wherein the glucuronolactone is glucuronolactone and / or glucuronic acid. Solution for internal use <6> The solution for internal use according to <4>, wherein the vitamin is one or more selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, and nicotinamide

EXAMPLES Hereinafter, although an Example and a comparative example are given and this invention is demonstrated further more concretely, this invention is not limited to the following Example at all.
According to a conventional method, liquid preparations for internal use having the compositions shown in Tables 1 to 3 were prepared, filled into 100 ml brown glass bottles, and evaluated by the following methods. Each result is shown in Tables 1-4.

(I) Effect of suppressing unpleasant odor and taste Ten subjects took 20 ml of the liquid, and as an ease of drinking, the degree of unpleasant taste and odor was subjected to sensory evaluation according to the following evaluation criteria, and an average value was obtained.

[Score]
5 points: No unpleasant taste or odor is felt at all 4 points: Almost unpleasant taste or odor is not felt 3 points: Somewhat unpleasant taste or odor is felt 2 points: A fairly unpleasant taste or odor is felt 1 point: Feels a very unpleasant taste and smell

[Evaluation criteria]
◎ Ease of drinking Average score 4 points or more ○ Ease of drinking Average score 3 points or more and less than 4 points △ Ease of drinking Average point 2 points or more and less than 3 points × Ease of drinking Average point Less than 2 points

(Ii) Strength of crude drug-like flavor Ten subjects took 20 ml of the liquid, and the sensory evaluation of the feeling that the crude drug was contained was performed according to the following evaluation criteria to obtain an average value.
[Score]
4 points: Clearly feels that there are herbal medicines 3 points: Some feel that herbal medicines are contained 2 points: Does not feel that herbal medicines are contained 1 point: Does not feel that herbal medicines are contained

[Evaluation criteria]
◎ Feeling average point containing herbal medicines 3 or more ○ Feeling average point containing herbal medicines 2 or more, less than 3 points △ Feeling average point containing herbal medicines More than 1 point and less than 2 points × Herbal medicines are contained Feeling average score 1 point

Each composition of Tables 1-3 is represented by a numerical value in units of “mg” unless otherwise specified.

Claims (4)

(A) herbal tincture and / or herbal extract, and (B) natural perfume that has the same base as the herbal tincture and / or herbal extract of (A) (hereinafter abbreviated as the same herbal crude flavor)
A liquid preparation for internal use characterized by comprising (B) The liquid medicine for internal use according to claim 1, wherein the base drug substance fragrance is obtained by carbon dioxide extraction, steam distillation, or an absolute method.
(A) Herbal medicine tincture, extract (herbal medicine tincture and / or extract, the same shall apply hereinafter) and (B) the same crude drug based fragrance is the following combination (A / B). .
(1) pepper tincture, extract / ginger oil (2) cinnamon tincture, extract / cinnamon oil or cassia oil (3) clove tincture, extract / clove oil (4) pepper tincture, Extract / Capsicum oil (5) Toki tincture, Extract / Angelica oil (6) Pepper tincture, Extract / Fennel oil (7) Pepper tincture, Extract / Anise oil (8) Pepper (turmeric) tincture, Extract / turmeric oil (9) Nickel cuttlefish, extract / nutmeg oil (10) Pepper tincture, extract / peppermint oil Furthermore, the liquid for internal use of Claims 1-3 containing glucuronolactone and / or vitamins.