JP2007236531A - Dissolution apparatus and dissolution method by that - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dissolution apparatus capable of automatically and accurately judging whether or not to additionally generate stock solution for dialysis and evading the failure that a large amount of the stock solution for the dialysis remains at the point of time of ending dialysis treatment while evading the situation that the stock solution for the dialysis runs short, and a dissolution method by that. <P>SOLUTION: The dissolution apparatus comprising a dissolver 6 for obtaining the stock solution for the dialysis, a reservoir 7 for tentatively housing the stock solution for the dialysis and a stock solution supply line L1 for supplying the stock solution for the dialysis housed inside the reservoir to the side of a dialyzer 4 is provided with a level sensor 8 capable of continuously detecting the residual amount of the stock solution for the dialysis inside the reservoir 7 in real time, an arithmetic means 10 for computing the reduction rate of the stock solution for the dialysis on the basis of the residual amount, and a judgement means 11 for estimating the time before the stock solution for the dialysis inside the reservoir 7 is used up from the reduction rate and judging whether or not the stock solution for the dialysis is to run short. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a dissolution apparatus for dissolving a dialysis powder drug at a predetermined concentration to obtain a dialysis stock solution and a dissolution method using the dissolution apparatus.

  Dialysis fluids used for the treatment of patients with renal failure in hospitals are generally divided into bicarbonate and acetic acid. Of these, bicarbonate-based dialysate does not contain sodium bicarbonate (hereinafter referred to as “bicarbonate”). It is prepared by mixing water with two types of drugs, called A agent and sodium bicarbonate (hereinafter referred to as B agent). In recent years, from the viewpoint of improving transportability, attempts have been made to dissolve these A agent and B agent powdered powder (hereinafter referred to as dialysis powder drug) before dialysis. With regard to B agent), the concentration tends to decrease over time, and it was difficult to prepare the next day after dialysis.

For this reason, dissolution work is required for each dialysis, and various types of dissolution apparatuses for dissolution have been proposed. For example, Patent Document 1 includes a dissolution tank (dilution tank) for dissolving a dialysis powder drug, and a storage tank (storage tank) for temporarily storing a dialysis stock solution generated in the dissolution tank. Has been disclosed. The dissolution apparatus sequentially feeds the dialysis stock solution accommodated in 1 to an artificial dialysate supply apparatus.
JP-A-57-159529

However, the above conventional melting apparatus has the following problems.
Because the dialysis stock solution that is dissolved and generated by a dissolution apparatus in a hospital or other medical institution is extremely large in volume and the number of patients is not constant, the amount used varies from day to day, and the reason is to avoid changes in the composition of the stock solution over time. , Generated in multiple batches. That is, when the stock solution for dialysis in the storage tank is reduced, an additional stock solution for dialysis is generated in the dissolution tank, and the situation where the stock solution for dialysis is insufficient is avoided.

  However, in a medical institution such as a normal hospital, a dialysis chamber in which a plurality of dialysis machines are installed and a lysis device that generates a dialysis stock solution (a dialysis stock solution (agent A and agent B) generated in the lysis device). To determine whether or not the dialysis stock solution in the storage tank is low, it is separate from the machine room where the dialysate supply device that mixes to produce the dialysate of a predetermined concentration is installed. There was a problem that medical personnel such as dialysis engineers had to frequently monitor both the dialysis room and the machine room.

  In addition, the medical staff visually determines the amount of the dialysis stock solution in the storage tank and determines whether or not additional generation is required. The dialysis treatment time for each patient is about 3 to 5 hours. Therefore, it is extremely difficult to predict a dialysis stock solution that will be used in the future. Therefore, in order to avoid interruption of dialysis treatment due to lack of dialysis stock solution, even if it seems that additional generation is not necessary just before the end of dialysis treatment, additional generation must be made just in case. There was also a problem that the stock solution for dialysis was highly likely to remain.

  The present invention has been made in view of such circumstances, and can automatically and accurately determine whether or not to additionally produce a dialysis stock solution, and the situation where the dialysis stock solution is insufficient. It is an object of the present invention to provide a dissolution apparatus and a dissolution method using the dissolution apparatus that can avoid the problem that a large amount of undiluted dialysis solution is left at the end of dialysis treatment while avoiding the above.

  The invention according to claim 1 is a dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and for dialysis obtained in the dissolution tank A dissolution apparatus comprising: a storage tank for temporarily storing a stock solution; and a stock solution supply line for supplying the dialysis stock solution stored in the storage tank to a plurality of dialysis devices for performing dialysis treatment on a patient. Stock solution amount detection means capable of continuously and in real time detecting the remaining amount of the dialysis stock solution in the storage tank, and dialysis in the storage tank based on the remaining amount detected continuously and in real time by the stock solution amount detection means A calculation means for calculating a reduction rate of the stock solution, and a time for the dialysis stock solution in the storage tank to be empty is estimated from the reduction rate of the dialysis stock solution calculated by the calculation means, and the dialysis stock solution to be supplied Whether or not Characterized in that a constant determining means.

  According to a second aspect of the present invention, in the dissolution apparatus according to the first aspect, the determination means includes an estimated time when the stock solution for dialysis in the storage tank is emptied, and a time at which all dialysis treatment by the dialysis apparatus is completed. And determining whether or not the dialysis stock solution is insufficient.

  According to a third aspect of the present invention, in the dissolution apparatus according to the first or second aspect, the stock solution amount detecting means comprises a sensor capable of detecting the liquid level of the dialysis stock solution in the storage tank continuously and in real time. It is characterized by that.

  According to a fourth aspect of the present invention, in the dissolution apparatus according to any one of the first to third aspects, the dissolution is performed on the condition that the dialysis stock solution to be supplied by the determination means is determined to be insufficient. A predetermined amount of powder drug for dialysis and water are automatically charged into a tank to obtain an additional dialysis solution.

  The invention according to claim 5 is the dissolution apparatus according to any one of claims 1 to 4, on the condition that the dialysis stock solution to be supplied by the determination means is determined to be insufficient. It is characterized by comprising a notification means for performing a predetermined notification that an additional dialysis solution is necessary in the tank.

  The invention according to claim 6 is the dissolution apparatus according to claim 4 or claim 5, wherein the dissolution tank is placed at a timing that takes into account the time required to obtain an additional stock solution for dialysis in the dissolution tank. A fixed amount of powder drug for dialysis and water is automatically added, or predetermined notification is performed by a notification means.

  The invention according to claim 7 is a dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and the dialysis drug obtained in the dissolution tank Dissolution method by dissolution apparatus comprising a storage tank for temporarily storing a stock solution, and a stock solution supply line for supplying the dialysis stock solution stored in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient In the storage tank, based on the stock amount detection step capable of continuously and in real time detecting the remaining amount of the dialysis stock solution in the storage tank, and the residual amount detected in the stock solution amount detection step continuously and in real time. A calculation step for calculating the rate of reduction of the dialysis stock solution in the cell, and the time until the dialysis stock solution in the storage tank becomes empty is estimated and supplied from the rate of reduction of the dialysis stock solution calculated in the calculation step No dialysis stock solution Further comprising either a whether a determination step to be characterized.

  According to an eighth aspect of the present invention, in the dissolution method using the dissolution apparatus according to the seventh aspect, in the determination step, the estimated time when the dialysis stock solution in the storage tank becomes empty and the dialysis treatment by the dialysis apparatus are all completed. And determining whether or not the dialysis stock solution is insufficient.

  A ninth aspect of the present invention is the dissolution method using the dissolution apparatus according to the seventh or eighth aspect, wherein the stock solution amount detection step can continuously and in real time detect the liquid level of the dialysis stock solution in the storage tank. The sensor is used.

  The invention according to claim 10 is based on the condition that in the dissolution method using the dissolution apparatus according to any one of claims 7 to 9, it is determined that the dialysis stock solution to be supplied by the determination step is insufficient. The dialysis powder drug and water are automatically added to the dissolution tank to obtain an additional dialysis stock solution.

  The invention according to claim 11 is based on the condition that, in the dissolution method using the dissolution apparatus according to any one of claims 7 to 10, it is determined that the dialysis stock solution to be supplied by the determination step is insufficient. A predetermined notification that an additional dialysis solution is required in the dissolution tank is provided.

  The invention according to claim 12 is the dissolution method using the dissolution apparatus according to claim 10 or claim 11, wherein the dissolution is performed at a timing that takes into account the time required to obtain an additional dialysis solution in the dissolution tank. A predetermined amount of powder drug for dialysis and water is automatically charged into the tank, or predetermined notification is performed by a notification means.

  According to the invention of claim 1 or claim 7, based on the decrease rate of the dialysis stock solution, the time until the dialysis stock solution in the storage tank becomes empty is calculated and estimated, and the dialysis stock solution to be supplied is insufficient. Therefore, it is possible to automatically and accurately determine whether or not an additional dialysis solution should be generated, and at the end of dialysis treatment while avoiding a situation where the dialysis solution is insufficient. Therefore, it is possible to avoid the problem that a large amount of dialysis stock solution is left over.

  According to the invention of claim 2 or claim 8, the determination means or the determination step compares the estimated time when the stock solution for dialysis in the storage tank is emptied with the time when the dialysis treatment by the dialysis device is all completed. In addition, since it is determined whether or not the dialysis stock solution is insufficient, it is possible to automatically determine whether or not the dialysis stock solution should be additionally generated with higher accuracy.

  According to the invention of claim 3 or claim 9, since the stock amount detecting means or the stock solution amount detecting step uses a sensor that can continuously and in real time detect the liquid level of the stock solution for dialysis in the storage tank, Thus, the remaining amount of the dialysis undiluted solution can be more reliably grasped, and it is possible to automatically determine whether or not the dialysis undiluted solution should be additionally generated with higher accuracy.

  According to the invention of claim 4 or claim 10, a predetermined amount of powdered drug for dialysis and water is automatically supplied to the dissolution tank on the condition that the dialysis stock solution to be supplied is determined to be insufficient by the determination means or the determination step. Therefore, the additional stock solution for dialysis is obtained, so that the burden on medical personnel such as dialysis engineers can be reduced and workability can be further improved.

  According to the invention of claim 5 or claim 11, additional dialysis stock solution is required in the dissolution tank, provided that it is determined that the dialysis stock solution to be supplied by the judging means or judging step is insufficient. Therefore, it is possible to automatically determine whether or not the dialysis stock solution should be additionally generated even in a dissolution apparatus that does not have an automatic supply means of water or a powder medicine for dialysis. .

  According to the invention of claim 6 or claim 12, a predetermined amount of powder drug and water for dialysis are automatically supplied to the dissolution tank at a timing that takes into account the time required to obtain an additional dialysis solution in the dissolution tank. Or a predetermined notification by the notification means, it is possible to more reliably avoid a situation where the dialysis stock solution is insufficient.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The dissolution apparatus according to the first embodiment is for obtaining a dialysis stock solution by dissolving a powder drug for dialysis at a predetermined concentration. As shown in FIG. It is a thing. A plurality of dialysis devices 4 (dialysis monitoring devices) and a central monitoring device 3 are installed in a dialysis chamber isolated from the machine room.

  Further, the dialysis stock solution (concentrated solutions of agent A and agent B) produced by the dissolving device 1 reaches the dialysate supply device 2 via the stock solution supply line L1 (L1a and L1b in FIG. 3), and is predetermined there. A dialysate having a concentration is prepared, and the dialysate is supplied to each dialyzer 4 (dialysis monitoring device) via dialysate supply lines L2 to L4. In addition, each dialysis apparatus 4 and the central monitoring apparatus 3, and the central monitoring apparatus 3 and the dissolution apparatus 1 are electrically connected by wiring D1-D3, D4, respectively.

  As shown in FIG. 2, the dissolving apparatus 1 includes a quantitative powder feeder 5, a dissolving tank 6, a storage tank 7, a level sensor 8 (stock solution amount detecting means), a calculating means 10, a determining means 11, and an input. It is mainly composed of the means 12. Although not shown, a dissolution apparatus having the same configuration as that shown in the figure is separately provided, and each of the A and B agents as a dialysis powder drug is dissolved and stirred to produce each dialysis stock solution. It has come to be able to do.

  The fixed-quantity powder feeder 5 is for charging a predetermined amount of powder drug for dialysis (A agent or B agent) into the dissolution tank 6, and its driving source is electrically connected to the determination means 11. Based on a control signal from the determination means 11, a predetermined amount of the powder drug for dialysis can be put into the dissolution tank 6. The dissolution tank 6 is connected to the water supply source A via the water supply line L5, and the dissolution tank 6 is dissolved in the dissolution tank 6 by opening the electromagnetic valve Vw disposed in the water supply line L5. Water is supplied.

  The dissolution tank 6 is charged with a predetermined amount of the powder drug for dialysis and water from the above-described quantitative powder feeder 5 and the water supply source A, and dissolves and agitates the powder drug for dialysis to prepare a dialysis stock solution (for each drug). The float switch 9 is disposed at a predetermined position in the internal storage space. That is, when water for dissolution is supplied into the dissolution tank 6 and the supply of the water is stopped when the water level reaches the float switch 9, a certain amount of water can be accommodated in the dissolution tank 6. It is like that. The supplied water and the dialysis powder drug are agitated by a stirring means (not shown) to obtain a dialysis stock solution having a substantially uniform concentration.

  A transfer line L6 is extended from the lower bottom of the dissolution tank 6, a transfer pump P1 is disposed in the middle thereof, and a tip of the transfer line L6 is connected to the storage tank 7. Thereby, if the transfer pump P <b> 1 is driven, the stock solution for dialysis obtained in the dissolution tank 6 reaches the inside of the storage tank 7.

  The storage tank 7 is for temporarily storing the dialysis stock solution obtained in the dissolution tank 6, from which only the necessary amount of the dialysis stock solution is supplied to the dialysate supply device 2 (a plurality of dialysis devices 4 side) described later. It is configured to be supplied sequentially. From the bottom of the storage tank 7, a stock solution supply line L1 (strictly, stock solution supply lines L1a and L1b extending from two storage tanks) is extended, and the tip thereof is connected to the dialysate supply device 2. . That is, the dialysis stock solution in the storage tank 7 is sent to the dialysis fluid supply device 2 to be a dialysis fluid having a predetermined concentration and then supplied to each dialysis device 4.

  On the other hand, a level sensor 8 (stock volume detection means) composed of a pressure gauge or the like is disposed on the lower surface of the storage tank 7, and the level sensor 8 continuously and continuously determines the remaining amount of the dialysis stock solution in the storage tank 7. It is configured so that it can be detected in real time. The pressure gauge as the level sensor 8 can detect the liquid pressure of the dialysis stock solution in the storage tank 7 over time in terms of the pressure applied to the bottom surface of the storage tank 7, and based on the detected liquid pressure. The amount of dialysis stock solution (the amount of residual solution) can be detected continuously and in real time.

  By detecting the liquid level in the storage tank 7 (or the remaining amount of the dialysis stock solution itself) continuously and in real time, the rate of decrease in the liquid level (decrease rate of the dialysis stock solution) is detected. If possible, other detection means (such as an ultrasonic liquid level sensor or a magnetostrictive linear displacement sensor) may be used instead of the pressure gauge.

  The level sensor 8 as such stock solution amount detection means is electrically connected to the calculation means 10. This computing means 10 computes the rate of reduction of the dialysis stock solution in the storage tank 7 based on the remaining amount detected continuously and in real time by the level sensor 8. That is, by detecting the liquid level of the dialysis stock solution in the storage tank 7 continuously and in real time, it is possible to determine the rate of decrease in the level (decrease rate of the dialysis stock solution), and for dialysis based on the rate of decrease. The consumption rate of the stock solution can be recognized.

  The calculation unit 10 is electrically connected to the determination unit 11. This determination means 11 calculates the time until the dialysis stock solution in the storage tank 7 becomes empty (the remaining liquid is substantially 0) from the reduction rate (liquid level reduction rate) of the dialysis stock solution calculated by the calculation means 10. And determining whether or not the dialysis stock solution to be supplied is insufficient. Moreover, the input means 12 is electrically connected to the determination means 11, The time when all the dialysis treatments by the dialysis apparatus 4 are complete | finished by this input means 12 (the scheduled time when the dialysis treatment of all the patients of the day is complete | finished) It is comprised so that it can input.

  Therefore, the determination means 11 compares the estimated time (insufficient time) when the stock solution for dialysis in the storage tank 7 is emptied with the time (dialysis end time) when all the dialysis treatments by the dialysis device 4 are completed. If it is determined whether or not the time at which the time has elapsed has passed the dialysis end time, it can be determined whether or not the dialysis stock solution is insufficient. Specifically, if the time after the elapse of the shortage time does not exceed the dialysis end time, the additional dialysis stock solution is unnecessary. To be judged.

  The input unit 12 may be configured to input other data such as the number of patients on the day, and the determination unit 11 determines whether or not the dialysis stock solution is insufficient with reference to the input data. It may be. Moreover, if the arithmetic means 10, the determination means 11, and the input means 12 are provided in the central monitoring apparatus 3, the input by the input means 12 etc., even if a medical worker such as a dialysis engineer usually in the dialysis room does not go to the machine room. Is possible.

  The determination means 11, the quantitative powder feeder 5 and the electromagnetic valve Vw are electrically connected. When the determination means 11 determines that the dialysis stock solution to be supplied is insufficient, a predetermined control signal is sent to the quantitative powder. It is comprised so that it may transmit to the drive source of the feeder 5 and the electromagnetic valve Vw. As a result, on the condition that the dialysis stock solution to be supplied by the determination means is determined to be insufficient, a predetermined amount of the dialysis powder drug and water are automatically added to the dissolution tank 6 to supply additional dialysis stock solution. Obtainable.

  Here, in order to obtain an additional undiluted dialysis solution in the dissolution tank 6, it takes a predetermined time for the introduction of water and the powder drug for dialysis, and for the dissolution and stirring operations. Therefore, in this embodiment, the time required to obtain an additional dialysis solution in the dissolution tank 6 is measured in advance, and a predetermined amount of dialysis is stored in the dissolution tank 6 at a timing that takes the required time into account. It will be controlled to automatically add the powder medicine and water.

  As shown in FIG. 3, the dialysate supply device 2 is connected to a water supply line Lw in which water metering means 13 for measuring the amount of water flowing and the metering pump Pa (piston pump) flows. In addition, a stock solution line L1a for flowing the stock solution for dialysis obtained by dissolving the A agent and a metering pump Pb (piston pump) and a stock solution line for flowing the stock solution for dialysis obtained by dissolving the B agent are connected. L1b, the dialysate storage tank 14, and the liquid feeding pump P2 are mainly comprised. The stock solution lines L1a and L1b communicate with the stock solution supply line L1 in FIG. Further, a concentration measurement unit for measuring the concentration of the dialysate prepared in FIG. 3 and a heating unit for heating the dialysate are omitted.

  After the water in the water supply line Lw passes through the water metering means 13, the dialysis fluid from the stock solution lines L1a and L1b is mixed to prepare a dialysis fluid having a predetermined concentration, and then the dialysis fluid is put into the dialysis fluid storage tank 14. Will be reached. The dialysate storage tank 14 is provided with a float switch SH and a float switch SL, and it is possible to detect that the liquid level of the dialysate in the dialysate storage tank 14 has reached the upper limit or the lower limit. Has been. However, the dialysate passes through the dialysate storage tank 14 so that the gas generated from the dialysate can be separated and removed. The dialysate from which the gas is separated and removed is driven by the liquid feed pump P2. Is supplied to each dialysis machine 4 via the dialysate supply lines L2 to L4.

  However, the dialysis treatment is performed on the patient by the dialysate supplied to each dialysis apparatus 4. In addition, data related to dialysis treatment (treatment conditions, treatment time, and the like) is transmitted and received between each dialysis device 4 and the central monitoring device 3, so that optimal and safe treatment is performed.

Next, the operation of the melting apparatus according to this embodiment will be described.
First, the time (dialysis end time) at which all the dialysis treatment by the dialysis device 4 is completed is input in advance by the input means 12. Then, the electromagnetic valve Vw is opened, water is introduced into the dissolution tank 6 until the float switch 9 detects the liquid level, and a predetermined amount of dialysis powder drug is introduced from the quantitative powder feeder 5, and the dialysis is performed. Dissolve and stir the powder powder for dialysis to obtain a dialysis stock solution.

  Usually, in the dissolution apparatus as in this embodiment, the volume that can be dissolved is only an amount corresponding to the amount of water determined by the float switch 9, and the amount of dialysis stock solution (for example, produced from one bag of dialysis powder medicine) In the case of the B stock solution, 11.34 L, and in the case of the A stock solution, 9 L) is set.

  Thereafter, the transfer pump P <b> 1 is driven to transfer the entire amount of the dialysis stock solution in the dissolution tank 6 to the storage tank 7. Then, when dialysis treatment is started, the dialysis solution supply device 2 is supplied to the dialysis solution supply device 2 via the stock solution supply line L1, where a dialysis solution having a predetermined concentration is prepared, and the prepared dialysis solution is supplied. The dialysis treatment is performed on the patient by being supplied to each dialysis apparatus 4.

  In the process of supplying the stock solution for dialysis by the dissolving device 1 as described above, the remaining amount of the stock solution for dialysis in the storage tank 7 is reduced according to the dialysate consumed in the dialyzer 4, and the liquid level is lowered for a while. Therefore, the remaining amount (liquid level) of the dialysis stock solution in the storage tank 7 is detected continuously and in real time by the level sensor 8 (stock solution amount detection step). Then, based on the remaining amount of the dialysis stock solution detected by the level sensor 8, the reduction rate (consumption rate) of the dialysis stock solution from one time point to the next time point is calculated by the calculation means 10 (calculation step).

  The reduction rate obtained in the calculation step is transmitted to the determination means 11, and the time until the dialysis stock solution in the storage tank 7 becomes empty is calculated and estimated from the reduction rate, and the estimated time and input are input. The dialysis end time input by means 12 is compared to determine whether or not the dialysis stock solution to be supplied is insufficient (determination step). In the present embodiment, for example, the time required for obtaining an additional dialysis solution is measured in advance, and the dissolution operation is performed until the time required for the determination means 11 to determine whether the additional necessity is required. It is configured to wait and then perform the melting operation.

  When it is determined in the determination step that the dialysis stock solution is insufficient, a control signal is transmitted to the drive source of the quantitative powder feeder 5 and the electromagnetic valve Vw, and a predetermined amount of dialysis powder drug and water are automatically supplied to the dissolution tank 6. To obtain additional stock solution for dialysis. However, as described above, the control signal waits until just before the time necessary to obtain an additional dialysis solution, and is then transmitted.

  However, since the dialysate supply device 2 applied in the present embodiment is for a large number of people (one that sends dialysate prepared from a single dialysate supply device to each of a plurality of dialysers), the dialysate is usually used. Adjustment is performed intermittently, and the remaining amount of the dialysis stock solution in the storage tank 7 also changes intermittently. Even in such a case, the remaining amount of the dialysis stock solution that changes intermittently can be averaged, and the reduction rate of the dialysis stock solution in the storage tank 7 can be calculated by the calculation means 10.

  In addition, as the dialysis treatment approaches, the number of patients on whom dialysis treatment is performed decreases sequentially, so that the rate of decrease in the dialysis stock solution also decreases. Therefore, it is preferable that the determination unit 11 determines whether or not the addition is necessary at a late stage (final stage) in which the dialysis treatment is performed. That is, as described above, the dialysis stock solution obtained by one dissolution is 9 L in the case of the A stock solution. Therefore, assuming that the A stock solution actually used per day is 200 L, 198 L of dialysis stock solution is used. The determination means 11 does not perform the determination until 22 dissolution operations (until the predetermined time elapses) when the dialysis is produced, and when the dialysis end time is about to be determined, the necessity of addition is determined based on the time. Also good. Although it is difficult to accurately grasp the amount of dialysis stock solution (200 L) used in the practice, for example, the dissolution operation is continued until roughly 15 bags (9 L × 15 bags = 135 L) stock solution is prepared. Thereafter, the dissolution may be continued while making an additional necessity determination based on the dialysis end time.

  Furthermore, when the dialysis stock solution remains in the dissolution tank 6, it is not necessary to further generate an additional dialysis stock solution. It is preferable that the dialysis stock solution does not remain.

  According to the present embodiment, the time until the dialysis stock solution in the storage tank 7 becomes empty is calculated and estimated based on the decrease rate of the dialysis stock solution, and whether or not the dialysis stock solution to be supplied is insufficient. Therefore, it is possible to automatically and accurately determine whether or not the dialysis stock solution should be additionally generated, and to avoid a situation where the dialysis stock solution is insufficient, at the end of dialysis treatment, The problem that the stock solution remains can be avoided.

  Further, on the condition that the dialysis stock solution to be supplied is determined to be insufficient by the determination means 11 or the determination step, a predetermined amount of powder drug for dialysis and water are automatically added to the dissolution tank 6 for additional dialysis. Since the stock solution is obtained, the burden on medical personnel such as dialysis engineers can be reduced, and workability can be further improved. Furthermore, the determination means 11 or the determination step compares the estimated time when the dialysis stock solution in the storage tank 7 is emptied with the time when all the dialysis treatments by the dialysis device 4 are completed, and whether or not the dialysis stock solution is insufficient. Therefore, it is possible to automatically determine whether or not to additionally produce a dialysis stock solution with higher accuracy.

  Furthermore, since the stock solution amount detecting means or the stock solution amount detecting step uses a sensor such as a pressure gauge capable of detecting the liquid level of the stock solution for dialysis in the storage tank 7 continuously and in real time, the stock solution for dialysis in the storage tank 7 is used. Therefore, it is possible to automatically determine whether or not to additionally produce a dialysis stock solution with higher accuracy. At the same time, a predetermined amount of powdered drug for dialysis and water are automatically charged into the dissolution tank 6 at a timing that takes into account the time required to obtain an additional dialysis concentrate in the dissolution tank 6, so that the dialysis stock solution It is possible to avoid the situation where it is insufficient.

  In particular, in this embodiment, since the capacity of the dissolution tank 6 is relatively small as described above (11.34 L for the B stock solution and 9 L for the A stock solution), the time required for one dissolution is short. It has become. For this reason, it is possible to delay the timing taking into account the time required to obtain an additional dialysis stock solution, to further improve the determination accuracy, and because the amount of dissolution at one time is small, the dialysis stock solution is wasted. Can be further reduced. In addition, according to this embodiment, even if it does not calculate | require correctly the usage-amount of the undiluted | stock solution for dialysis, it is made to operate | move so that it may melt | dissolve less than the anticipated usage-amount, and when a shortage arises, it can carry out additional dissolution automatically.

Next, a second embodiment according to the present invention will be described.
As in the first embodiment, the dissolution apparatus according to this embodiment is installed in a machine room in order to obtain a dialysis stock solution by dissolving a powder drug for dialysis to a predetermined concentration (see FIG. 1). As shown in FIG. 4, the dissolution tank 6, the storage tank 7, the level sensor 8 (stock solution amount detection means), the calculation means 10, the determination means 11, the input means 12, and the notification means 16 are mainly configured. Yes.

  The same components as those in the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted. Further, as in the first embodiment, dissolution devices having the same configuration as in FIG. 4 are separately disposed, and each of the A agent and the B agent as a dialysis powder drug is dissolved and stirred to be used for each dialysis. A stock solution can be generated, and as shown in FIG. 1, a stock solution for dialysis is supplied from each dissolving device to the dialysate supply device 2.

  The dissolution tank 6 is provided with a float type sensor 15 composed of a float shaft and a float in a part of the internal storage space so that the level of the supplied water can be detected by opening the electromagnetic valve Vw. It has become. Further, the dissolution tank 6 according to the present embodiment does not have means for automatically feeding the powder drug for dialysis like the quantitative powder feeder of the first embodiment, and is accommodated in a bottle or a bag. The powder drug for dialysis is manually added.

  The notifying unit 16 notifies that the additional dialysis solution is necessary in the dissolution tank 6 on the condition that the determination unit 11 determines that the dialysis stock solution to be supplied is insufficient. The notification means 16 may display a message indicating that an additional dialysis solution is necessary, for example, on a display means such as a screen, or may be notified by lighting or blinking with an LED or the like. Further, a speaker or the like may be provided separately and a warning sound may be emitted from the speaker. The notification means 16 may be installed either in the machine room or in the dialysis room. However, if it is installed in the dialysis room, the medical staff such as a dialysis engineer who is usually in the dialysis room can be surely alerted. it can.

Next, the operation of the melting apparatus according to this embodiment will be described.
First, the time (dialysis end time) at which all the dialysis treatment by the dialysis device 4 is completed is input in advance by the input means 12. Then, the electromagnetic valve Vw is opened manually, and water is poured into the dissolution tank 6 until the float switch 15 detects a desired liquid level, and a predetermined amount of powder drug for dialysis is manually poured. The dialysis powder drug is dissolved and stirred to obtain a dialysis stock solution.

  Usually, in the dissolution apparatus as in the present embodiment, the capacity of the dissolution tank 6 is relatively large (usually 100 to 200 L) in order to avoid that a medical worker such as a dialysis engineer frequently has to go to the machine room. On the other hand, the storage tank 7 is set to be relatively small (usually about 50 L) in order to avoid an increase in the size of the entire apparatus.

  Thereafter, the transfer pump P <b> 1 is driven to transfer the entire amount of the dialysis stock solution in the dissolution tank 6 to the storage tank 7. Then, when dialysis treatment is started, the dialysis solution supply device 2 is supplied to the dialysis solution supply device 2 via the stock solution supply line L1, where a dialysis solution having a predetermined concentration is prepared, and the prepared dialysis solution is supplied. The dialysis treatment is performed on the patient by being supplied to each dialysis apparatus 4.

  In the process of supplying the stock solution for dialysis by the dissolving device 1 as described above, the remaining amount of the stock solution for dialysis in the storage tank 7 is reduced according to the dialysate consumed in the dialyzer 4, and the liquid level is lowered for a while. Therefore, the remaining amount (liquid level) of the dialysis stock solution in the storage tank 7 is detected continuously and in real time by the level sensor 8 (stock solution amount detection step). Then, based on the remaining amount of the dialysis stock solution detected by the level sensor 8, the reduction rate (consumption rate) of the dialysis stock solution from one time point to the next time point is calculated by the calculation means 10 (calculation step).

  The reduction rate obtained in the calculation step is transmitted to the determination means 11, and the time until the dialysis stock solution in the storage tank 7 becomes empty is calculated and estimated from the reduction rate, and the estimated time and input are input. The dialysis end time input by means 12 is compared to determine whether or not the dialysis stock solution to be supplied is insufficient (determination step). When it is determined that the dialysis stock solution is insufficient in the determination step, a predetermined notification is made by the notification means 16, and a medical worker such as a dialysis engineer manually opens the electromagnetic valve Vw in accordance with this, and a desired amount of water is discharged. While supplying, a predetermined amount of powder drug for dialysis is put into the dissolution tank 6 manually to obtain an additional dialysis stock solution.

  Here, the time required for obtaining the additional dialysis solution in the dissolution tank 6 is measured in advance, and a predetermined notification is made by the notification means 16 at a timing taking into account the required time. Yes. Further, it is the same as in the first embodiment that the remaining amount of the dialysis stock solution that changes intermittently is averaged and the reduction rate of the dialysis stock solution in the storage tank 7 is calculated by the calculation means 10.

  According to the present embodiment, as in the first embodiment, the time until the dialysis stock solution in the storage tank 7 becomes empty is calculated and estimated based on the decrease rate of the dialysis stock solution, and the dialysis product to be supplied Since it is determined whether or not the stock solution is insufficient, it is possible to automatically and accurately determine whether or not the dialysis stock solution should be additionally generated, and dialysis while avoiding the shortage of the dialysis stock solution. The problem that a large amount of undiluted dialysis solution remains at the end of treatment can be avoided.

  In addition, on the condition that it is determined that the dialysis stock solution to be supplied by the determination means 11 or the determination step is insufficient, a predetermined notification that the additional dialysis stock solution is necessary is performed in the dissolution tank 6. Even in the dissolution apparatus 6 that does not include automatic supply means for the powder drug for dialysis, it is possible to automatically determine whether or not the dialysis stock solution should be additionally generated. Furthermore, the determination means 11 or the determination step compares the estimated time when the dialysis stock solution in the storage tank 7 is emptied with the time when all the dialysis treatments by the dialysis device 4 are completed, and whether or not the dialysis stock solution is insufficient. Therefore, it is possible to automatically determine whether or not to additionally produce a dialysis stock solution with higher accuracy.

  Furthermore, since the stock solution amount detecting means or the stock solution amount detecting step uses a sensor such as a pressure gauge capable of detecting the liquid level of the stock solution for dialysis in the storage tank 7 continuously and in real time, the stock solution for dialysis in the storage tank 7 is used. Therefore, it is possible to automatically determine whether or not to additionally produce a dialysis stock solution with higher accuracy. At the same time, since the notification means 16 performs a predetermined notification at a timing that takes into account the time required to obtain an additional dialysis solution in the dissolution tank 6, it is possible to more reliably avoid situations where the dialysis solution is insufficient. can do.

  In addition, since the dissolution tank 6 is provided with a float sensor 15 including a float shaft and a float that enables continuous liquid level measurement, the amount of water can be arbitrarily selected, and it is prepared by dissolution. The amount of the dialysis stock solution can be arbitrarily changed. Accordingly, since a small amount of dissolution can be performed in the dissolution tank 6 having a relatively large capacity, it is possible to delay the timing in consideration of the time required to obtain an additional dialysis stock solution, and the determination accuracy. In addition, since the amount of dissolution at one time is small, waste of the dialysis stock solution can be further reduced.

  Moreover, since the medical personnel such as a dialysis engineer goes to the machine room and puts the powder medicine for dialysis into the dissolution tank 6 in this embodiment, it is easy to judge the lack of visual observation, and the dialysis end time is not necessarily input. There is no need to keep it. However, when inputting the dialysis end time, displaying the amount of dissolution required for additional dissolution is useful for determining the amount of dissolution.

Next, a third embodiment according to the present invention will be described.
As in the previous embodiment, the dissolution apparatus according to this embodiment is installed in a machine room to dissolve a powder drug for dialysis at a predetermined concentration to obtain a dialysis stock solution (see FIG. 1). As shown, it is mainly composed of a dissolution tank 17, a storage tank 18, a level sensor 19 (stock solution amount detection means), a calculation means 10, a determination means 11, and an input means 12.

  In addition, the same code | symbol shall be attached | subjected to the component similar to previous embodiment, and the detailed description shall be abbreviate | omitted. Further, as in the previous embodiment, dissolution devices having the same configuration as in FIG. 5 are separately disposed, and each of the A and B agents as a dialysis powder drug is dissolved and stirred to prepare each dialysis stock solution. As shown in FIG. 1, a dialysis stock solution is supplied from each dissolving device to the dialysate supply device 2.

  The dissolution tank 17 has float switches SH (for upper limit detection) and SL (for lower limit detection) in a part of the internal storage space, and determines the water level supplied by opening the electromagnetic valve Vw. It is comprised so that. The dissolution tank 17 and the storage tank 18 are provided side by side, and both are connected by a transfer line L8 to which an electromagnetic valve V is connected. That is, if the electromagnetic valve V is opened, the dialysis stock solution in the dissolution tank 17 is fed into the storage tank 18 by gravity.

  The middle of the transfer line L8 and the upper part of the dissolution tank 17 are connected by a circulation line L7. A circulation pump P3 is connected to the middle of the circulation line L7, and a bottle B containing a powder drug for dialysis. Can be connected. Thus, if the circulation pump P3 is driven in a state where the electromagnetic valve V is closed, the water in the dissolution tank 17 circulates in the circulation line L7 and the bottle B, so that the dissolution and stirring are performed and a uniform concentration is obtained. A dialysis stock solution can be obtained. It should be noted that the bolt B is configured to be automatically replaced from an empty one to one containing a new dialysis powder drug when additional dissolution is required.

  Further, the determination means 11 according to the present embodiment is electrically connected to the drive source of the electromagnetic valve Vw and the circulation pump P3, and when the determination means 11 determines that the dialysis stock solution to be supplied is insufficient, The electromagnetic valve Vw is opened to automatically supply water into the dissolution tank 17, and the circulation pump P3 is driven to circulate the water in the circulation line L7 and the bottle B, and the dialysis stock solution in the bottle B is supplied. It is comprised so that it can melt | dissolve, stirring.

  Note that, as in the second embodiment, when the determination unit 11 determines that the dialysis stock solution to be supplied is insufficient, a notification unit that notifies that the additional dialysis stock solution is necessary is provided to the determination unit 11. You may comprise so that it may connect. However, in FIG. 5, reference numeral L <b> 9 indicates a ventilation line extending from the upper part of the dissolution tank 17 and the storage tank 18, and the electromagnetic valve V is opened so that the dialysis stock solution in the dissolution tank 17 enters the storage tank 18. In the process of being transferred, the air existing in the storage tank 18 is discharged, and the air can be introduced into the dissolution tank 17 by the amount of the dialysis stock solution decreased in the dissolution tank 17.

  Also in this embodiment, as in the previous embodiment, the time until the dialysis stock solution in the storage tank 18 becomes empty is calculated and estimated based on the decrease rate of the dialysis stock solution calculated by the calculation means 10. Since the determination means 11 determines whether or not the dialysis stock solution to be supplied is insufficient, it is possible to automatically and accurately determine whether or not the dialysis stock solution should be additionally generated. While avoiding a situation where the dialysis stock solution is insufficient, it is possible to avoid the problem that a large amount of the dialysis stock solution remains at the end of dialysis treatment.

  As mentioned above, although this embodiment was described, this invention is not limited to these, For example, a personal dialysis device (Equipped with a means for producing a dialysis fluid such as a dialysis fluid supply device for each dialysis device) in a dialysis chamber. It may be applied to the one provided. Even in this case, the remaining amount of the dialysis stock solution in the storage tank is continuously detected in real time, and the reduction rate of the dialysis stock solution is calculated based on the remaining amount, and the dialysis solution in the storage tank is calculated from the reduction rate. The time until the stock solution becomes empty can be estimated, and it can be determined whether or not the dialysis stock solution to be supplied is insufficient.

  In particular, if the float sensor 15 in the second embodiment is used in place of the float switch 9 in the first embodiment, the dissolution operation is automatically performed by the fixed-quantity powder feeder 5 while using a relatively small dissolution tank 6. Can be made. That is, by using the float sensor 15, a small amount of additional dissolution can be performed in the final dissolution stage just before the dialysis end time regardless of the capacity of the dissolution tank. Therefore, a small amount of additional dissolution is possible, and waste of the dialysis stock solution can be reduced.

  Further, for example, the liquid level in the dialysate storage tank 14 (see FIG. 3) disposed in the dialysate supply apparatus 2 is detected continuously and in real time, and the dialysate reduction rate in the dialysate storage tank 14 is used for dialysis. You may make it estimate indirectly the time until the stock solution for dialysis in a storage tank becomes empty by estimating the decreasing rate of stock solution. Even in this case, it can be determined whether or not the dialysis stock solution to be supplied is insufficient by the determination means.

  Furthermore, in the case where the notification means performs a predetermined notification that an additional dialysis solution is necessary in the dissolution tank, the notification may be missed. Therefore, when informing that an additional dialysis stock solution is necessary, a signal is sent to each dialysis machine or central monitoring device, and the dialysis stock volume in the storage tank is reduced by forcibly reducing the amount of dialysis fluid used in the dialysis machine. You can extend the time until it becomes empty. At that time, it is preferable to further notify by the notifying means.

  The remaining amount of the dialysis stock solution in the storage tank is detected continuously and in real time, and the reduction rate of the dialysis stock solution in the storage tank is calculated based on the detected remaining amount, and the dialysis in the storage tank is calculated from the reduction rate. As long as the lysing solution and the lysing method using the lysing device and the lysing method for determining whether or not the dialysis stock solution to be supplied is insufficient are estimated, the time until the lysing stock solution is emptied depends on the form. It can also be applied to things.

The schematic diagram which shows the connection state of the melt | dissolution apparatus and other component in embodiment (common to 1st-3rd embodiment) of this invention. The schematic diagram which shows the structure of the melt | dissolution apparatus in the 1st Embodiment of this invention. The schematic diagram which shows the structure of the dialysate supply apparatus in embodiment (common to 1st-3rd embodiment) of this invention. The schematic diagram which shows the structure of the melt | dissolution apparatus in the 2nd Embodiment of this invention. The schematic diagram which shows the structure of the melt | dissolution apparatus in the 3rd Embodiment of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Dissolution apparatus 2 Dialysate supply apparatus 3 Central monitoring apparatus 4 Dialysis apparatus (dialysis monitoring apparatus)
5 Quantitative powder feeder 6 Dissolution tank 7 Storage tank 8 Level sensor (stock volume detection means)
DESCRIPTION OF SYMBOLS 9 Float switch 10 Calculation means 11 Judgment means 12 Input means 13 Water metering means 14 Dialysate storage tank 15 Float type sensor 16 Notification means 17 Dissolution tank 18 Storage tank L1 (L1a, L1b) Stock solution supply line L2-L4 Dialysate supply line L5 Water Supply line L6 Transfer line L7 Circulation line L8 Transfer line L9 Ventilation line

Claims (12)

A dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis;
A storage tank for temporarily storing the dialysis stock solution obtained in the dissolution tank;
A stock solution supply line for supplying a stock solution for dialysis stored in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient;
In a melting apparatus comprising:
Stock solution amount detection means capable of continuously and in real time detecting the remaining amount of the dialysis stock solution in the storage tank;
Calculation means for calculating a reduction rate of the dialysis stock solution in the storage tank based on the residual amount detected continuously and in real time by the stock solution amount detection means;
Judgment means for estimating the time until the dialysis stock solution in the storage tank is emptied from the decrease rate of the dialysis stock solution computed by the computing means and determining whether or not the dialysis stock solution to be supplied is insufficient When,
A melting apparatus comprising:   The determination means compares the estimated time when the dialysis stock solution in the storage tank becomes empty and the time when all the dialysis treatments by the dialysis apparatus are completed, and determines whether or not the dialysis stock solution is insufficient. The melting apparatus according to claim 1.   The dissolution apparatus according to claim 1 or 2, wherein the stock solution amount detecting means comprises a sensor capable of continuously and in real time detecting the liquid level of the stock solution for dialysis in the storage tank.   On the condition that the dialysis stock solution to be supplied by the determination means is determined to be insufficient, a predetermined amount of powdered dialysis drug and water are automatically added to the dissolution tank to obtain an additional dialysis stock solution. The melting apparatus according to any one of claims 1 to 4, characterized in that:   Provided with a notification means for performing a predetermined notification that an additional dialysis solution is required in the dissolution tank, provided that the determination device determines that the dialysis solution to be supplied is insufficient. The melting apparatus according to any one of claims 1 to 4.   At a timing that takes into account the time required to obtain an additional dialysis stock solution in the dissolution tank, a predetermined amount of dialysis powder drug and water are automatically added to the dissolution tank, or a predetermined notification is provided by a notification means. The melting apparatus according to claim 4, wherein the melting apparatus is performed. A dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis;
A storage tank for temporarily storing the dialysis stock solution obtained in the dissolution tank;
A stock solution supply line for supplying a stock solution for dialysis stored in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient;
In a melting method using a melting apparatus comprising:
A stock solution amount detection step capable of continuously and in real time detecting the remaining amount of the stock solution for dialysis in the storage tank;
A calculation step of calculating a reduction rate of the dialysis stock solution in the storage tank based on the remaining amount detected continuously and in real time in the stock solution amount detection step;
A determination step of estimating the time until the dialysis stock solution in the storage tank becomes empty from the decrease rate of the dialysis stock solution calculated in the calculation step and determining whether or not the dialysis stock solution to be supplied is insufficient. When,
A melting method using a melting apparatus.   The determination step compares the estimated time when the dialysis stock solution in the storage tank becomes empty and the time when all dialysis treatments by the dialysis device are completed, and determines whether or not the dialysis stock solution is insufficient. A melting method using a melting apparatus according to claim 7.   9. The dissolution method using a dissolution apparatus according to claim 7, wherein a sensor capable of detecting the liquid level of the dialysis stock solution in the storage tank continuously and in real time is used in the stock solution amount detection step.   On the condition that it is determined that the dialysis stock solution to be supplied by the determination step is insufficient, a predetermined amount of powder drug for dialysis and water are automatically added to the dissolution tank to obtain an additional dialysis stock solution. A melting method using the melting apparatus according to claim 7, wherein the melting method is performed.   8. A predetermined notification that an additional dialysis solution is required in the dissolution tank is provided on the condition that it is determined that the dialysis solution to be supplied is insufficient in the determination step. A melting method using the melting apparatus according to claim 10.   At a timing that takes into account the time required to obtain an additional dialysis stock solution in the dissolution tank, a predetermined amount of dialysis powder drug and water are automatically added to the dissolution tank, or a predetermined notification is provided by a notification means. The melting method using the melting apparatus according to claim 10, wherein the melting method is performed.

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