JP2007210933A - Therapeutic agent for hay fever by chinese drug recipe - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a therapeutic agent for hay fever caused by INKYO constitution (physical constitution with lack of body fluid, e.g., emaciated constitution). <P>SOLUTION: In the therapeutic agent, a JIIN component (a component for treating symptoms caused by lack of body fluid) comprises at least one species of crude drugs selected from dried roots of Rehmannia glutinosa, Scrophularia ningpoensis Hwmsl., Paeonia lactiflora, Discireae rhizoma, Ophiopongonis tuber, Glehnia littoralis Fr. Schmidt. ex Miq., Cornus officinalis and Achyranthis Radix., a SENYO component (a component for treating head ache, vertigo and the like caused by abnormal rising of activity in the liver) comprises at least one species of crude drugs selected from Red hematite, Carina and oyster, a SEINETSU component (an antifebrile component) comprises at least one species of crude drugs selected from Anemarrhenae rhizoma and gypsum, a SOKUFU component (a component for treating symptoms caused by central nervous system disorders) comprises at least one species of crude drugs selected from peppermint, chrysanthemum flowers and cicada's shells, a KASHITSU component (a moisturizing component) comprises at least one species of crude drugs selected from talc and Plantago seeds, a KATAN, KAIN component (a component for treating a large amount of phlegm with fever and the like) comprises at least one species of crude drugs selected from seeds of Trichosanthes kirilowii, roots of Trichosanthes kirilowii, Fritillaria verticillata and Pinelliae tuber. The rate of the JIIN component is 5-85 pts.wt. and the rate of a sub-component is 5-80 pts.wt. in the whole components. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a therapeutic agent for hay fever by a Chinese medicine prescription.

JP-A-8-40922

  Living conditions in modern Japan have changed significantly compared to ancient times, such as abundant dietary habits, car society, lack of exercise, stressful days (stress), complete air conditioning, global warming, etc. ing. For this reason, people today are apt to have internal heat and tend to have a fever and “blood”. The constitution that has become such a state is called a negative constitution in Chinese medicine.

  Here, the above-mentioned “Qi” is a symptom such as melancholy, depression, and anxiety that appears when the balance of “Qi”, which is the energy of the body, is lost in Chinese medicine. In addition, “internal heat” is heat generated in the body due to a relative increase in “cheerfulness”, which is a force for warming the body, compared to the negative fluid. “Shade” means a body fluid present in the body, and “shade” means that the body fluid is insufficient and is in a dry state. In addition, “salmon” is a pathological product caused by stagnation and boiling of body fluids. Of these pathological products, the sticky one is called “mochi” and the thin one is called “drink”. In addition, when the moisture in the body can be a pathogenic factor in this way, this moisture is referred to as “humidity”. “Blood” refers to blood circulation disorder and old blood that deviates from the blood flow.

  Even if it becomes a negative body, it remains relatively healthy and active until it exceeds a certain limit. Most of the recent elderly are younger than their age (compared to the past) and are active as crisp. This is also thought to be due to the insidious nature. A person with a vulgarity is a boxer type.

  There are very many people who have a negative aspect in the clinic (inventor's impression is 50-60% of patients). On the other hand, the number of people who belong to the positive, which is the opposite of the negative, is overwhelmingly smaller than the negative. It should be recognized that in Japan today, there are a large number of patients with a negative aspect in the base.

  In the ancient Chinese medical book “Huang Emperor Kyodo Elementary Question”, “Four Spirits of God”, “Winter March, this so-called closed-this winter Kino-no-Michiya Michiya”, “Holy Saint It is said that you should live a life that feeds your nymphs during cold weather. In modern times, however, they live in the same way in summer and winter, so they can't be nourished. Therefore, it can be said that if you live too actively in winter, it is highly possible that you will not be able to cultivate the shade and become a shame.

  From the above, it can be said that modern life itself has created people who are truly impatient. However, people with certain negative aspects are more active and more agile, and paradoxically, it is easier to adapt to modern life until the level of yin and yang dysfunction exceeds the limit. It can be said.

  A person with a negative body has internal heat (virtual heat). In the spring, the sky of heaven becomes brighter and the temperature rises compared to winter (heat from outside). As a result, the internal heat of the human body and the heat of the outside world respond to each other, and when the internal heat of the genus responds, it is stimulated by a light “cold” (pollen), the internal heat becomes more and more intense, and finally the state of positively enhanced wind And hay fever develops.

  The above-mentioned “cold” is read as “Fuja” and does not refer to the common pathology of cold, but refers to the substance that causes illness in Chinese medicine. In addition, “superiority” means that “cheerfulness” in the body rises, and “formation” means that the above-mentioned “cold” causes changes in the body.

  Among the symptoms of hay fever, nasal congestion, sore throat, cough, redness of the eyes, etc. are caused by the above-mentioned high elevation. A runny nose like clear water is a drink in your heart or stomach that rises with the positive momentum and overflows from your nose.

  In addition, itching in the eyes, itching in the throat, itching in the mouth, itching in the nose, crushing, etc. are caused by the breeze.

  In hay fever, the presence of pollen, that is, “cold” is important as a trigger for the onset, but “cold” itself is minor. Rather, Yin and Yang imbalance on the human side is more important as a pathological mechanism. In other words, hay fever develops only when the state of the internal heat reaches a certain level.

  In Japan, hay fever is often given to patients by prescriptions such as Mao-bushi-shoshin-to and Shosei-ryu, regardless of yin, yang, fever and cold. . These have a certain effectiveness against any hay fever because they drink and have a palliative effect. Note that the “communication effect” means improving the passage of a hole opened in the body. However, most of them are just prescriptions, that is, symptomatic treatments, and in that respect they are no different from administration of antiallergic agents in Western medicine. Administration of a therapeutic drug for such valve disease (judgment based only on the pathological condition) is at least not Kampo.

  The total number of affected cases is hay fever, but it is not a life-threatening illness. However, it is a serious problem for people who have trouble with daily life. In general, most are controlled by oral administration and local administration of antiallergic agents and antihistamines, and further by local administration of steroids. However, some of these drugs are poorly controlled even when administered with Mao-bushi-kosho-to, Shoseiryu-to, Shokei-sei-lung-to, etc. in addition to treatment with these drugs. Again, this is because such treatment is only a rule.

  In view of the above, the present invention focuses on the fact that the vulgarity causes hay fever. Specifically, the present invention, after identifying the symptoms and the pulse, against what is proved to be a yin-hyeon fever-enhanced wind, It is an object of the present invention to provide a hay fever remedy based on a Kampo prescription for improving the genital constitution by treating vaginosis and chemical drinking, and effectively treating hay fever.

  In addition, the invention which concerns on patent document 1 is related with the therapeutic agent which suppresses the excessive response | compatibility of the human body which causes an allergic disease by using the Chinese medicine which has an active blood effect. However, the provision of a hay fever therapeutic agent in terms of improving the vulgarity has not been done so far, and this is the first time the inventor of the present application has made it.

  In order to solve the above-mentioned problem, the invention according to claim 1 of the present application provides a therapeutic agent for hay fever by Kampo prescription, a Shi-Yin component having the effect of supplementing “Yin” in the Kampo philosophy, and “Yang”. A latent component that has the effect of suppressing, a clean heat component that has the effect of cooling the heat in the body, a folding screen component that has the effect of ameliorating various symptoms of the body caused by `` collapse '', and `` humidity '' Among the moisturizing ingredients that have the effect of being discharged outside the body, and the above-mentioned moist / ingredient ingredients that are effective in improving various symptoms of the body caused by "salmon" and "drinking" And a sub-component composed of one or more components selected from the above-mentioned latent and positive components, fresh heat components, folding screen components, moisturizing components, and chemical components The above-mentioned ingredients are dry ground yellow, ginseng, glaze, It is composed of at least one herbal medicine selected from medicinal, barley winter, north ginseng, yam, cow knee, and the latent component is at least one selected from metaphorite, keel, oyster It is composed of a variety of herbal medicines, and the fresh heat component is composed of at least one herbal medicine selected from a mother, gypsum, and the folding screen component is a thin load, chrysanthemum, declining It is composed of at least one selected herbal medicine, and the moisturizing component is composed of at least one herbal medicine selected from talc, car anterior, Is composed of at least one kind of herbal medicine selected from karoujin, karou root, shell mother, half-summer, and the ratio of the ingredients in the whole therapeutic drug is Is 5 to 85 parts by weight, and the above-mentioned subcomponent is 5 to 80 parts by weight. And wherein, to provide a therapeutic agent of hay fever due to Chinese medicine prescription.

  The invention according to claim 2 of the present application is characterized in that the subcomponent is composed of two or more components selected from the latent component, the clean heat component, and the folding screen component. Item 2. A remedy for hay fever according to Kampo prescription according to Item 1.

  Further, in the invention according to claim 3 of the present application, the subcomponent is at least one component selected from the latent component, the clean heat component, and the folding screen component, and the moisturizing component and the chemical component. The remedy for hay fever according to the Kampo prescription according to claim 1, comprising at least one component selected from chemical ingredients.

  The invention of the present application is made up mainly of a soy-ingredient component made up of herbal medicines that supplements “shade”, that is, has the effect of moisturizing the body. It was possible to provide a medicine for treating hay fever according to Kampo prescription that can treat hay fever.

  Hereinafter, an example of an embodiment of the present invention will be described as an example. In this example, the therapeutic agent is taken by decocting herbal medicines of the following components and extracting the active ingredients. The extraction of this active ingredient shall be performed by the patient himself, the patient may prescribe herbal medicine as it is, the extraction shall have been made in advance, and the patient shall be prescribed the extracted extract. Various means can be employed as the means for extracting the active ingredient.

  In addition, although the therapeutic agent based on this invention is prescribed to the patient who was admitted as the pyloric hyperthermia wind, pulse diagnosis is used as one of the judgments. More specifically, in the case of the Yin-Yu-inspired wind, the Sekizen's pulse is “Float, String, Number” or “Float, String, Fine, Number”, and the Sekigo's pulse is “Sink, Thin, , “Number” (sometimes “floating”), and so on.

  This pulse diagnosis is performed in three parts, “size”, “seki”, and “scale”. As shown in FIG. 1, the portion of the radial styloid process is referred to as “Seki” (A), the hand side of this “Seki” (A) is “Dimension” (B), and the elbow side is “Scale”. Say (C). The above-mentioned “pulse before Seki” indicates a pulse at this “dimension” (B), and the “pulse after Seki” indicates a pulse at this “scale” (C).

  The above `` floating '' refers to the state of a pulse that can be understood by simply touching the finger, and the `` string '' refers to the state of a stretched pulse that feels like touching the bowstring, with little vertical movement, "Number" refers to the state of a pulse with a high number of beats, "Thin" refers to the state of a narrow pulse, and "Sink" refers to the extent to which the finger is touched against "Floating" First, it refers to the state of the pulse that can be understood with strong pressure.

  The therapeutic agent according to the present invention comprises a shiin-in component and at least one component selected from the above-mentioned latent component, fresh heat component, folding screen component, moisturizing component, and chemical and chemical component. The subcomponent occupies at least a part of the contained components. About said subcomponent, it is prescribed suitably according to a patient's symptom etc.

  Shiin-yin is composed of herbal medicines that supplement the shade, that is, have the effect of moisturizing the body. Specifically, it is composed of at least one herbal medicine selected from dryland yellow, ginseng, glaze, mountain medicine, barley winter, north ginseng, yam, and cow knee.

  A latent component is comprised from the crude drug which has the effect which suppresses the cheerfulness which causes internal heat. Specifically, it is composed of at least one herbal medicine selected from metazoites, keel, and oysters.

  The fresh heat component is composed of a herbal medicine that has the effect of cooling the internal heat. Specifically, it is composed of at least one herbal medicine selected from mothers and gypsum.

  The folding screen component is made up of herbal medicines that have the effect of improving various symptoms of the body caused by the shade. Specifically, it is composed of at least one herbal medicine selected from light load, chrysanthemum flower, and withdrawal.

  The moisturizing component is composed of a herbal medicine having an effect of discharging a cold out of the body. Specifically, it is composed of at least one herbal medicine selected from talc and a car anterior element.

  The fossilized / drinking ingredient is composed of herbal medicines that have the effect of improving various symptoms of the body caused by wrinkles and drinking occurring in the body. Specifically, it is composed of at least one herbal medicine selected from karojin, karoune, kamika, and semi-summer.

  The proportion of the above-mentioned components in the whole therapeutic agent according to the present invention is 5 to 85 parts by weight (more preferably 15 to 75 parts by weight) of the innocuous component, and 5 to 80 (more preferably 10 to 75 parts by weight) of the subcomponents. Parts by weight.

  In addition, herbal medicines that do not belong to the ingredients other than the above-mentioned ingredients and sub-components are also appropriately blended in order to facilitate patient's symptoms and administration. For example, raw licorice, Nansha ginseng, Dansang, acid jinjin, Yuzujin, longan, distant, continuation, Tochu, malt, Daihuang, yellow cocoon, Saiko, Sasa, ripening yellow, gyudon, silver flowers, ream, Although it is peony skin, various other crude drugs can be blended.

  Below, thirteen cases in which the inventor has actually examined and prescribed as examples of the therapeutic agent according to the present invention will be described. In addition, the numerical value in Table 1-Table 4 shows the weight (unit: g) of a crude drug.

(Case 1) 33-year-old male first hay fever: 2005.4.5
Main symptoms: Nasal obstruction, nasal discharge, eyelids, sore throat, sneezing, dry head, dry mouth, cold drink, fever, night sweats prescription: as shown in column 1-1 of Table 1

Second examination: 2005.4.8
Main symptom: Symptom disappearance except nasal congestion and dry mouth about 2 days after taking: As shown in column 1-2 in Table 1

Third examination: 2005.4.12
Main symptoms: Nasal obstruction and dry mouth prescription: As shown in columns 1-3 of Table 1 (same prescription as the first diagnosis)

Fourth examination: 2005.4.16
Main symptoms: Various symptoms disappearance prescription: As shown in columns 1-4 of Table 1

(Case 2) 71-year-old male first hay fever: April 22, 2005
Main symptoms: Nasal discharge, nasal congestion, cough, eyelids, muscular sensation in the throat, squeaky, wandering prescription: as per column 2-1 in Table 1

Second diagnosis: 2005.5.6
Main symptoms: About 7 days after taking the drug

(Case 3) 60-year-old female first hay fever: April 1, 2005
Main symptoms: nasal discharge, nasal congestion, eyelids, throat, dry mouth, cold, headache, malaise prescription: as shown in column 3-1 of Table 1, but with antiallergic agent

Second examination: 2005.4.18
Main symptoms: nasal congestion continued, nasal discharge, eyelids, throat disappeared, headache improved Prescription: As shown in column 3-2 of Table 1, but combined with antiallergic agents

Third examination: 2005.5.9
Main symptoms: Approximately 4 days after taking the drug, disappearance of various symptoms Prescription: As shown in column 3-3 of Table 1, but combined with antiallergic agents

(Case 4) 60-year-old female, first pollinosis: 2005.4.13
Main symptoms: nasal discharge, nasal congestion, eyelids, cough, throat muscular sensation, insomnia prescription: as shown in column 4-1 of Table 2

Second examination: 2005.4.27
Main symptoms: nasal discharge, throat sensation of throat, insomnia continued, other symptom improvement prescription: as per column 4-2 in Table 2

Third examination: 2005.5.16
Main symptoms: disappearance of hay fever, insomnia is improved prescription: as shown in column 4-3 in Table 2

(Case 5) 64-year-old female first hay fever: April 4.4
Main symptoms: Nasal discharge, nasal congestion, sneezing, eyelids, cough, throat sensation of mouth, dry mouth, cold drink, low back pain, coolness, skin water, decreased appetite prescription: as per column 5-1 in Table 2, but anti Combined with allergic agents

Second examination: 2005.4.25
Main symptoms: nasal congestion, nasal discharge, sneezing, dry mouth, cold drinking continued, eyelids, coughing, throat sensation of throat improved Formulation: as shown in column 5-2 of Table 2, but combined with antiallergic agent

Third examination: 2005.5.16
Main symptoms: Insomnia appears. From the end of April, the symptoms of hay fever have improved, and back pain has been improved.

(Case 6) 57-year-old male first hay fever: April 18, 2005
Main symptoms: Nasal congestion, nasal discharge, eyelids, throat, sneezing, night sky cough, body heat prescription: as shown in column 6-1 of Table 2

Second examination: 2005.5.30
The symptoms of hay fever disappeared 4 to 5 days after taking the medicine, and the fever continued. Prescription: as shown in column 6-2 in Table 2

(Case 7) 28-year-old male first pollinosis: 2005.4.28
Main symptoms: Nasal congestion, nasal discharge, eyelids, sneezing, fever, dry mouth, cold drink prescription: as shown in column 7-1 of Table 3, but with antiallergic agents

Second diagnosis: May 19, 2005
Main symptoms: Various symptoms disappeared at the beginning of May: As per column 7-2 in Table 3

(Case 8) 69-year-old woman, first diagnosis of hay fever: 2005.4.21
Main symptoms: Nasal discharge, nasal congestion, nasal mucus, eyelids, tears, sneezing, skin water prescription: as shown in column 8-1 of Table 3

Second examination: 2005.5.19
Main symptoms: Symptoms disappear in early May

(Case 9) 43-year-old woman, first pollinosis: 2005.4.15
Main symptoms: Nasal congestion, nasal discharge, eyelids, throat, cough, sneezing, chest discomfort, malaise, skin water prescription: As shown in column 9-1 of Table 3, but with antiallergic agent (nasal drops) Combined use

Second examination: 2005.5.10
Main symptoms: 4-5 days after taking the hay fever symptoms disappeared, fatigue was continued prescription: as shown in column 9-2 in Table 3

(Case 10) 35-year-old woman Pollen allergy, first asthma diagnosis: 2005.4.11
Main symptoms: Nasal discharge, nasal congestion, eyelids, throat, cough, sneezing, stomach sag, malaise, limb cold, cold drink, dry mouth prescription: as per column 10-1 in Table 3

Second examination: 2005.4.25
Main symptoms: Cough disappearance, other hay fever symptoms, slightly improved stomach sag, dry mouth, cold, evening body heat prescription: as shown in Table 3, column 10-2

Third examination: 2005.5.16
A few days after taking the hay fever symptom disappearance prescription: according to column 10-3 in Table 3

(Case 11) 40-year-old woman Pollen allergy, first asthma diagnosis: 2005.6.6
Main symptoms: Nasal discharge, nasal congestion, crushing, eyelids, fever, mouth-drying prescription: As shown in column 11-1 in Table 4

Second examination: 2005.6.20
Main symptoms: From June 12th, hay fever symptoms disappearance prescription: as per column 11-2 in Table 4

(Case 12) 39-year-old woman, first hay fever: April 27, 2005
Main symptoms: nasal discharge, nasal congestion, eyelids, throat, dry mouth, palm dermatitis prescription: as per column 12-1 in Table 4

Second examination: May 11, 2005
Main symptoms: Improvement of hay fever symptoms, palm dermatitis improvement prescription: As shown in column 12-2 of Table 4

Third examination: 2005.6.5
Main symptoms: Pollen allergy symptom disappearance prescription: As shown in column 4-3 of Table 4

(Case 13) 80-year-old male first hay fever: June.
Main symptoms: Kushami, nasal discharge, nasal congestion, eyelids, hot flashes Prescription: As per column 13-1 in Table 4

Second examination: 2005.6.24
Main symptoms: Symptoms of hay fever improved 2 to 3 days after taking, disappeared on June 10

  As described above, it has been clinically confirmed that the therapeutic agent according to the present invention has effectiveness against hay fever caused by the genital constitution.

It is explanatory drawing of the site | part which performs a pulse diagnosis.

Explanation of symbols

A “Seki”
B “Dimension”, Sekizen C “Scale”, Sekigo

Claims (3)

In the treatment of hay fever by Kampo prescription,
In the Kampo philosophy, the Shiin-in component that has the effect of supplementing the "yin",
A latent component that has the effect of suppressing "yang", and
A clean heat component that has the effect of cooling the heat in the body,
A folding screen component that has the effect of improving various symptoms of the body caused by "collapse";
A moisturizing component having the effect of discharging "humidness" outside the body,
Among the vaginal and chemical ingredients that have the effect of improving various symptoms of the body caused by `` pox '' and `` drinking '' generated in the body,
A subcomponent composed of one or more components selected from the above-mentioned Shiin and Yin components and the above-mentioned latent components, fresh heat components, folding screen components, moisturizing components, and chemical and chemical components Occupy at least a part of
The above-mentioned ingredients are composed of at least one herbal medicine selected from dryland yellow, ginseng, glaze, mountain medicine, barley winter, north sand ginseng, yam, cow knee,
The latent ingredient is composed of at least one herbal medicine selected from metazoites, keel, oysters,
The fresh heat component is composed of at least one herbal medicine selected from mothers, gypsum,
The folding screen component is composed of at least one herbal medicine selected from light load, chrysanthemum flower, and retreat,
The moisturizing component is composed of at least one herbal medicine selected from talc and car antec;
The chemical and chemical ingredient is composed of at least one herbal medicine selected from karoujin, karoune, kamika, and half-summer,
About the proportion of ingredients in the whole therapeutic drug,
A therapeutic agent for hay fever by Kampo prescription, characterized in that 5 to 85 parts by weight of the above-mentioned ingredients and 5 to 80 parts by weight of the above-mentioned accessory ingredients are used.   The said subcomponent consists of 2 or more types of components selected from said latent component, a fresh heat component, and a folding screen component, The treatment of hay fever by the Chinese medicine prescription of Claim 1 characterized by the above-mentioned. medicine.   The subcomponent is one or more selected from the above-mentioned latent component, clean heat component, folding screen component, and one or more components selected from the moisturizing component and the chemical and chemical component The remedy for hay fever according to the Kampo prescription according to claim 1, characterized by comprising the following components.

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