JP2007140219A - Agent for contact lens - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an agent for contact lenses which can identify solutions, particularly, has high safety for eyes, has excellent conformity to lenses, and comprises a coloring agent which is not adsorbed on contact lenses, and to provide a method for treating contact lenses using the same. <P>SOLUTION: When riboflavin phosphate or the salt thereof is used as a coloration component effective for the identification of a liquid agent, the same dissolves in a liquid agent for contact lenses and exhibits yellow, and these components do not adsorb on lenses as well. These coloration components have high safety, and are useful as components particularly for identifying whether a disinfectant, enzyme, a surfactant or the like having an anxiety of damaging the health of eyes when being brought into eyes together with lenses are present or not. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a contact lens agent that can identify a solution, and in particular, for a contact lens containing a colorant that is highly safe for the eye, excellent in lens compatibility, and is not adsorbed by the contact lens. The present invention relates to an agent and a method for treating a contact lens using the agent.

  In order to wear the contact lens comfortably, it is necessary to clean and disinfect regularly. This is because a contact lens is worn on the cornea and used in direct contact with a living body, so that proteins or lipids in tears are adsorbed as dirt on the surface of the lens that is recognized as a foreign substance, or tears. This is because microorganisms present in the environment, such as liquids, may adhere to the eyes and may damage eye health if they are worn without any care.

  Cleaning contact lenses is usually performed by immersing them in a solution containing a surfactant and rubbing them. Since the solution remains attached to the lens, it is brought into the eye together with the lens. Unless it is a surfactant that does not cause any problems, it may still be necessary to rinse with a suitable preservative or tap water (to remove the soiling components). Since this type of liquid containing a surfactant is conventionally colorless and transparent, the lens user is required to determine whether further rinsing is necessary.

  In addition, there is a method in which an enzyme agent is used to remove protein stains adhering to the contact lens. In general, since an enzyme gradually loses its activity in a solution, it is stored in a non-aqueous solvent such as a tablet or glycerin, and dissolved or diluted in a solution when used. The solution containing this enzyme is also colorless and transparent in the past, but if it is brought into the eye together with the lens, it may cause adverse effects on the corneal cells, and the lens after the enzyme treatment should be rinsed with a preservation solution before use. Be instructed to do.

  On the other hand, methods for disinfecting contact lenses include boiling disinfection, chemical disinfection with chemicals, and hydrogen peroxide disinfection. Each of these methods has advantages and disadvantages. For example, although boil disinfection has a high disinfection effect, it has problems such as deterioration of lens materials and the necessity of a disinfection device. Chemical disinfection with chemicals is simple in operation (simply soaked) However, hydrogen peroxide disinfection is more effective than other chemical disinfections, but requires neutralization after treatment. To do. Of these, chemical disinfection and hydrogen peroxide disinfection, which are simple disinfection methods, are becoming mainstream. In hydrogen peroxide disinfection, it is preferable that the user can identify whether or not neutralization is complete.

  As described above, since the treatment liquid for contact lenses is generally clear and colorless, a method that can clearly indicate to the user at which stage the lens treatment is required and whether additional treatment is required is desired. . This type of conventionally proposed technology includes, for example, a cleaning solution (JP-A-3-284725) composed of an enzyme solution and a diluent containing a colorant, and a technology for coloring an enzyme solution (JP-A-2005-2005). No. 165044), or using a discoloration indicator that changes color upon neutralization in hydrogen peroxide disinfection (Japanese Patent Publication No. 62-502245), and a composition for neutralization added with vitamin B-12 (special table) Hei 6-501643). However, some of these colorants are likely to adhere to the lens, and these proposals do not describe any color components used in the present invention.

  In addition, although riboflavin sodium phosphate is described as an example of vitamin B in an ophthalmic composition containing a cooling agent (Japanese Patent Laid-Open No. 2004-315517), the contact lens agent used in the present invention There is no suggestion about its use as a coloring component.

JP-A-3-284725 Japanese Patent Laid-Open No. 2005-165044 JP-T 62-502245 JP-T 6-501463 JP 2004-315517 A

  An object of the present invention is to provide a contact lens agent capable of discriminating a solution, and in particular, a colorant that is highly safe for eyes, excellent in lens compatibility, and is not adsorbed on a contact lens. An object of the present invention is to provide a contact lens agent to be contained and a method for treating a contact lens using the same.

  In the present invention, as a result of diligent studies to solve the above-mentioned problems, when riboflavin phosphate or a salt thereof is used as a coloring component effective for identifying the liquid, it dissolves in the liquid for contact lenses. It turned out yellow, and it was found that these components do not adsorb to the lens. Riboflavin phosphate or a salt thereof is vitamin B2, and riboflavin sodium phosphate is a highly safe compound listed in the Japanese Pharmacopoeia.

  In the contact lens agent of the present invention, the contact lens agent further contains at least one selected from the group consisting of a disinfectant, a peroxide neutralizing component, a proteolytic enzyme, and a surfactant as an active ingredient. Can be used. These second additive components are arbitrarily selected depending on the purpose of the treatment of the contact lens. Even if the second component is colorless and transparent in the solution, the presence of the second additive component by the coloration of the solution by riboflavin phosphate or a salt thereof is present. Be recognized.

  Furthermore, the present invention provides a method of treating one of the two contact lens preparations by combining one of them with riboflavin phosphate or a salt thereof and making the other contact lens preparation visible. In this case, not only the action of preventing the liquid agent from being brought into the eye, but also the usage and dosage such as the blending ratio and order of use of the both can be clearly understood by the user.

  Another aspect of the present invention is a method of disinfecting a contact lens by bringing a contact lens into contact with a hydrogen peroxide-containing liquid agent and adding a hydrogen peroxide neutralizing agent to the liquid agent, A method is provided in which the agent contains riboflavin phosphate or a salt thereof to make it possible to visually identify whether the liquid agent that the contact lens contacts is in the process of disinfection or neutralization.

  Since the contact lens preparation according to the present invention is colored with riboflavin phosphate or a salt thereof, which is a vitamin B2, it can be visually distinguished from other contact lens preparations. These color components are highly safe, especially as components for identifying whether there are disinfectants, enzymes, surfactants, etc. that may harm eye health when brought into the eye with the lens. Useful. Further, in the method of treating a contact lens using two kinds of agents simultaneously or successively, it is possible to provide a method in which compliance can be easily obtained so that the user can observe the usage and dose. Furthermore, in the disinfection method using hydrogen peroxide, it is necessary to perform neutralization with certainty. If riboflavin phosphate or a salt thereof is contained in the neutralizing agent, as a result of coloration by this, colorlessness is obtained. The difference from a clear hydrogen peroxide solution can be clarified.

Hereinafter, the present invention will be described in more detail.
The above-mentioned riboflavin phosphate or its salts are applied as vitamin B2 for the prevention and treatment of vitamin B2 deficiency. Among the stomatitis, cheilitis, conjunctivitis and diffuse superficial keratitis, vitamin B2 deficiency or metabolic disorder is involved. Then, it is also used when estimated. After being absorbed, riboflavin phosphate is partially converted into flavin adenine dinucleotide, and is mostly converted into flavin adenine dinucleotide, which acts as a coenzyme for the flavin enzyme in the intracellular redox system and mitochondrial electron transport system. Widely involved in in vivo metabolism of proteins, lipids and proteins. No adverse side effects have been reported (from the Japanese Pharmacopoeia manual). As described above, riboflavin phosphate or a salt thereof used in the present invention has been proved to be highly safe, and even if it is brought into the eye together with the lens, it is considered that there is no action that harms eye health. . In the present invention, attention is paid to this safety, and it is used that it is colored yellow when it is made into a solution by containing it in a contact lens preparation.

  In the present invention, the above-mentioned riboflavin phosphate or a salt thereof is contained in the contact lens agent, but the concentration of use varies depending on the method of use and the form of use described later and cannot be determined unconditionally. This is because, for example, when the contact lens preparation is prepared as a tablet and when it is produced as a liquid, the concentration in the preparation is different. However, even if it is a tablet, it will be used after being dissolved in the solution at the stage of contact with the contact lens. Therefore, in setting the concentration, the concentration of the solution in contact with the contact lens may be specified. preferable. And the density | concentration in a solution is 0.00001-0.2% specifically, Preferably it is 0.0001-0.02%, More preferably, it is 0.0002-0.002%. When the density is low, there is no coloration to such an extent that it can be visually discriminated. When the density is high, the density is higher than necessary as a coloring component, and these components are uselessly present. Because it will do.

  The contact lens agent of the present invention further contains at least one selected from the group consisting of a disinfectant, a peroxide neutralizing component, a proteolytic enzyme, and a surfactant as an active ingredient as a second component. Can be used. These additive components are arbitrarily determined depending on the use of the contact lens agent. For example, hydrogen peroxide, succinic acid peroxide, urea peroxide, perboric acid, percarbonate, persulfuric acid, N-halogen organic compound, chlorous acid as disinfectants conventionally used for disinfecting contact lenses Salts, chlorine dioxide, sorbic acid, paraoxybenzoic acid esters, benzalkonium chloride, chlorhexicidine, polyhexamethylene biguanide, chlorobutanol and the like.

  These disinfectants only need to contain an effective amount of the disinfecting effect, and the disinfecting effect is basically not hindered by riboflavin phosphate or a salt thereof, but the concentration of addition varies depending on the type of disinfectant used. For example, in the case of hydrogen peroxide, a precursor such as durachlor, pulogin or the like is generally added in an aqueous solution of about 3%, and in the case of chlorine dioxide, 0.002 to 0.02% in the solution. As granules, 0.00005 to 0.2% by weight in the case of benzalkonium chloride, 0.00001 to 0.001% by weight in the case of chlorhexidine, 0.000001 in the case of polyhexamethylene biguanide. It can be appropriately set as an aqueous solution of ˜0.001% by weight. Further, the dosage form can be made liquid by a disinfectant or other additive components, or can be formulated as a solid. For example, hydrogen peroxide can be formulated as an aqueous solution, and chlorine dioxide can be formulated as a tablet or granule.

  The disinfectant is not necessarily prohibited from being brought into the eye together with the lens in all of the examples, but it is desirable to suppress chemical substances from entering the eye as much as possible, and together with these disinfectants By recommending the user to perform operations such as rinsing the lens until the coloration of the existing riboflavin phosphate disappears, the wearing of the lens with higher safety can be realized.

  For example, when a neutralizing agent is used for an oxidizer-based disinfectant such as hydrogen peroxide, riboflavin phosphate or a salt thereof can be included together with the neutralizing agent. By coloring the neutralizing agent, it is colorless and transparent at the time of disinfection, and at the time of neutralization, it is colored by the action of riboflavin phosphate, etc. to inform the user whether the lens is ready for wearing safely. Because you can. As the neutralizing agent, there can be used conventionally used reducing agents such as sodium thiosulfate, sodium sulfite, ascorbic acid, pyruvic acid, animal or microbial catalase, peroxidase, etc. It depends on the type of oxidant to be combined and the mixing ratio. The dosage form can also be formulated in a liquid or solid form as in the case of the disinfectant. Furthermore, since the riboflavin phosphate of the present invention does not inhibit the neutralizing effect, it does not affect the action of detoxifying the oxidizing agent-based disinfectant, and the conventional treatment time can be used as it is.

  As a preferable example in the application of the present invention, a method for disinfecting a contact lens with hydrogen peroxide will be described. To disinfect a contact lens with hydrogen peroxide, immerse the lens in a solution containing hydrogen peroxide, dispose of the disinfectant solution and transfer it to a solution containing a neutralizing agent, or immerse the lens in a disinfectant solution. Then, there is a method of charging a tablet containing a neutralizing agent. As a specific example of the former method, the lens after wearing is immersed in about 10 ml of a solution containing about 3% hydrogen peroxide and left for 10 minutes to overnight, and the disinfecting solution is discarded before wearing the next day, Leave in about 10 ml of a liquid containing a reducing agent such as sodium thiosulfate colored by riboflavin phosphate or a salt thereof for several minutes to several hours, take it out and wear it. As an example of the latter, when the neutralized tablet is directly put into the solution after disinfection instead of disinfecting the disinfectant, or when the neutralizer is introduced at the same time as the start of disinfection, the disinfection of the lens is completed. Around this time, a delayed release system is employed in which neutralizing components elute into the solution. In this delayed release system, the neutralizing agent is coated with a coating film, which is colorless and transparent at the beginning of disinfection. However, when the neutralizing agent elutes, riboflavin phosphate and the like are also eluted and the solution is colored. Can recognize whether neutralization has been completed.

  As described above, since both the liquid at the time of disinfection and neutralization were basically colorless and transparent, it was difficult to identify them. If the lens was worn with neutralization forgotten, an oxidizing agent was used. There was a risk of an accident that would cause a stronger stimulus. In the present invention, regardless of which method is used, it is possible to identify which stage the lens processing stage is currently in depending on whether it is colored at the time of disinfection or at the time of neutralization. The treatment time is 1 minute to 24 hours for disinfection, preferably 10 to 30 minutes, and treatment for immersing the lens for 10 minutes to 24 hours, preferably 30 to 6 hours for neutralization is employed. As the processing takes a longer time in this way, it becomes more difficult for the user to identify the stage during the processing, and the effect of providing visual discrimination power according to the present invention becomes remarkable.

  By the way, there are several proposals for the identification method by coloring in the hydrogen peroxide disinfection as described in the prior art. For example, when a color change indicator such as methylene blue, brilliant green, or crystal violet is used (Patent Document 3), there is a problem that these dyes are actually difficult to use because they adsorb to the lens. However, the riboflavin phosphate and salts thereof of the present invention are not adsorbed to most lenses, and even if they are brought into the eye together with a liquid agent that adheres to the lenses, they are vitamin B2s as described above. It has the advantage of high performance.

  Further, when a proteolytic enzyme is used as the second component, it is used in a treatment method for removing a protein derived from a tear fluid component adhered or fixed to a lens. Enzyme decomposes and removes proteinaceous dirt on the lens, but if it is brought into the eye as it is, there is a concern about the effect on corneal cells, so after enzyme treatment is completed, the enzyme is deactivated or the lens is rinsed, etc. Operation is required. As a method for supplying the enzyme agent, there are liquid enzyme agents dissolved in water-miscible organic liquids such as glycerin and propylene glycol in addition to tablets and granules, but the riboflavin phosphate of the present invention in any supply form Alternatively, when the salt is included in the preparation, the lens treatment solution is colored, so that it becomes obvious to the user that the lens is currently being enzymatically treated. Due to the nature of this enzyme treatment, the treatment is not completed in a short time of several minutes, and a certain amount of treatment time is required. Therefore, the user simply has to immerse the lens in the preservation solution. It is easy to misunderstand that there is, and by being immersed in the colored liquid agent as in the present invention, treatment such as rinsing can be promoted. In addition, since riboflavin phosphate and the like have no effect on the enzyme activity, the usage method, usage time, etc., at the enzyme concentration as in the prior art (for example, 0.001 to 5.0% by weight in the treatment solution) Is still applied as it is.

  Specific enzymes include Esperase CLC, Clear Lens Pro, Clear Lens Lipo (Novozymes Japan Co., Ltd.), Alkaline Protease GL440 (Genencore Kyowa Co., Ltd.), and the like. These are available on the market and are sold as enzymes that can be used specifically for contact lenses.

  Next, a case where a surfactant is used as the second additive component is used for a treatment for removing lipid stains such as eye fat and fingers adhering to the lens. Surfactants have the effect of dispersing and dissolving lipids in water. However, when they are brought into the eye, there are concerns about adverse effects such as eye irritation and tear layer structure being broken. In the present invention, since the liquid containing a surfactant is colored, the user is encouraged to rinse by instructing to avoid wearing it on the eye while it is attached to the lens. can do.

  Any surfactants known in the art such as anionic, cationic, amphoteric and nonionic surfactants can be added as long as they are highly safe for eyes and do not affect the lens material. . However, when the above-mentioned disinfectants are used in combination with cationic ones, the disinfectant will be ionized and sequestered, such as anionic surfactants and amphoteric surfactants. It should be noted that this is not preferable because it cannot be obtained. Suitable activators in such cases are nonionic surfactants such as polyoxyethylene polyoxypropylene block polymers, polyoxyethylene polyoxypropylene substituted ethylenediamines, polyoxyethylene glycerin fatty acid esters. , Polyglycerin fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbit fatty acid ester, polyoxyethylene alkylphenyl formaldehyde condensate, polyoxyethylene hydrogenated castor oil, polyoxyethylene sterols, Polyethylene glycol fatty acid esters, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxy Polyoxyethylene alkyl ethers, polyoxyethylene lanolin alcohols, and than can be exemplified polyoxyethylene fatty acid amides, among others, preferably those containing a polyoxyethylene chain structure is employed. These active agents can be appropriately selected or used in combination, and in particular, polyoxyethylene hydrogenated castor oil is suitable from the viewpoints of safety to the living body and actual use.

  Since riboflavin phosphate or a salt thereof does not usually affect the cleaning effect of the surfactant, the amount of these surfactants added may be a conventionally known amount, generally about 0.005 to 2.0 w / v%. And preferably 0.01 to 1.0 w / v%. This is because if the amount added is too small, the desired cleaning effect cannot be obtained, and if it is too large, there is concern about adsorption to the lens, which may cause eye irritation.

  In addition to the above, the isotonic agent, buffering agent, chelating agent, thickening agent and the like conventionally used in contact lens agents are added to the contact lens agent of the present invention as necessary. However, there is no problem, and when it is supplied as a tablet or granule, a lubricant, an excipient or the like may be used. One or more of these are appropriately selected and added and blended by a conventional method.

  Specifically, as the tonicity agent, in addition to inorganic salts such as sodium chloride and potassium chloride, nonionic tonicity agents such as glycerin and propylene glycol are used. In order to prevent deformation of the lens size and the like when processing, the physiological osmotic pressure is adjusted to 100 to 400 mOsm, preferably 200 to 320 mOsm. Buffers are used to stabilize components in contact lens preparations and lens size, and borate buffer, phosphate buffer, citrate buffer, carbonate buffer. , Amino acids such as Tris buffer, glycine buffer, epsilon aminocaproic acid and aspartic acid, and used in the range of 0.001 to 10% by weight.

  In addition, the chelating agent has the purpose of preventing Ca stains of tear components from being insolubilized and preventing inorganic dirt from adhering to the lens. Specifically, ethylenediaminetetraacetic acid and its sodium salt, citric acid and its salt, trishydroxymethylaminomethane, polyphosphoric acid, sodium hexametaphosphate, nitrilotriacetic acid, etc. can be used, and particularly commonly used ethylenediamine Tetraacetic acid and its sodium salt are suitable. In addition, these addition amounts may be appropriately set in consideration of other additive components, but are generally about 0.005 to 2.0 w / v%, preferably 0.05 to 1.0 w / v. Used in the range of v%.

  The thickener is generally intended to improve the slip of the lens during cleaning, to prevent damage to the lens, and to impart hydrophilicity to the lens surface. Specific examples include polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylamide, polyacrylic acid, polyethylene glycol, isobutylene-maleic anhydride copolymer, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, chondroitin sulfate, dextran, xanthan gum. , Guar gum, gum arabic, gelatin and the like. These addition amounts are also set as appropriate as in the case of the other components described above, but are generally used in the range of 0.001 to 10%.

  Further, when a tablet or granule dosage form is employed as a neutralizing agent for an oxidizer-based disinfectant such as hydrogen peroxide, a lubricant or an excipient is often used. Lubricants are used for the purpose of smoothing the surface state of tablets and improving the releasability during tableting, and examples thereof include polyvinyl alcohol, polyvinyl pyrrolidone, and polyalkylene glycol. The excipient is added as necessary to adjust the size of the tablet, and examples thereof include lactose, starch, dextrin, sucrose, and hydroxypropylmethylcellulose.

  Next, as another aspect of the present invention, a method for treating a contact lens by combining two types of contact lens agents will be described. At present, a liquid agent that can be cleaned, disinfected, and stored with a single liquid is mainly used for hydrous contact lenses, which is called a multi-purpose solution (hereinafter referred to as MPS). If such a solution is a normal treatment, it is not used in combination with other solutions. However, it is necessary to remove protein stains adhering to the lens as a regular (for example, once a week) cleaning treatment. In order to do this, a liquid enzyme agent or enzyme tablet is added to the MPS for processing. The daily treatment is a cycle of immersion and storage in MPS after wearing the lens, taking it out the next day and wearing it as it is, so it is easy to forget that the enzyme treatment is in progress. There was a risk of causing damage. Therefore, in the present invention, when two kinds of contact lens agents are combined and treated, one agent is colored with riboflavin phosphate or a salt thereof so that the other contact lens agent can be visually recognized. This provides a method for grasping the processing status of the lens. This treatment method is not limited to the case of enzyme treatment. When two types of contact lens agents are mixed and used at the same time, if both are colorless and transparent, the necessity of mixing, procedures, dosage, treatment status, etc. are used. When it is difficult for a person to understand, one of them is colored with riboflavin phosphate or a salt thereof to provide a method for preventing misuse.

  Hereinafter, in order to clarify the present invention more specifically, several examples of the contact lens preparation according to the present invention are illustrated.

About each preparation liquid agent of Table 1, the coloring to a lens was evaluated with the following procedures.
-Lens coloring test-
Sodium chloride 0.89w / v%, disodium hydrogenphosphate 0.125w / v%, sodium dihydrogenphosphate dihydrate 0.071w / v% and sodium riboflavin phosphate 0.001w / v% So as to dissolve in purified water. This solution was colored yellow, and it was visually recognized that it was easily colored.
To 4 ml of this solution, Menicon Month Wear (Distributor: Menicon Hydrous Soft Contact Lens), Menicon Focus (Distributor: Menicon Hydrous Soft Contact Lens), O2 Optics (Distributor: Ciba Vision Co., Ltd.) One silicon hydrogel lens) was immersed and left at room temperature for 16 hours or longer. This operation was defined as one cycle, and the soft contact lens was transferred to 4 ml of fresh solution each time, and the cycle was repeated five times. Thereafter, the lens was taken out, rinsed with physiological saline, and abnormalities such as coloring and deformation were visually observed using a non-treated contact lens as a control in a color dish.
Criteria for coloring evaluation −: No change +: Slightly colored ++: Clearly colored ++++: Remarkably colored

  Further, a solution in which the concentration of riboflavin sodium phosphate was 0.002 w / v% and 0.0002 w / v%, respectively, or riboflavin 0.002 w / v%, cyanocobalamin (vitamin B-12) instead of riboflavin sodium phosphate. ) Each containing solution of 0.002 w / v% and methylene blue 0.0002 w / v% was prepared, and the same cycle test was performed. The results are shown in Table 1 below.

  From the results in Table 1, the lens immersed in the solution containing riboflavin sodium phosphate was not colored, but the lens immersed in the solution containing other components (riboflavin, cyanocobalamin, methylene blue) was colored. confirmed. No abnormality such as deformation was observed in any of the lenses.

Example 4
-Hydrogen peroxide neutralizer-
Each tablet was weighed and mixed so as to contain the following components, and a small amount of water was added to knead and granulate.
(Prescription)
Catalase (from the genus Micrococcus) 4000 units Sodium chloride 85mg
Sodium monohydrogen phosphate 15mg
Polyethylene glycol (average molecular weight 2600-3800) 1mg
Riboflavin sodium phosphate 0.06mg

This was dried at 40 ° C. for 3 hours, granulated and granulated, and then tableted using a rotary tableting machine (RT-F-9-2, manufactured by Kikusui Seisakusho) and peroxidized. Hydrogen neutralized tablets were prepared.
The prepared tablets were then coated with a coating for delayed release. That is, using a tablet coating apparatus (manufactured by POWREC Co., Ltd., Doria Coater DRC-300), a coating solution containing 10% methacrylic acid copolymer LD and 2.5% polyethylene glycol 4000 is supplied at a supply temperature of 70 ° C. and a supply air flow rate. Spray coating was applied so that the coating amount was about 5 mg per tablet under the condition of 50 m ³ / h to prepare a delayed release hydrogen peroxide neutralized tablet.

(Example 5)
-Hydrogen peroxide neutralizer-
Each tablet was weighed and mixed so as to contain the following components, and a small amount of water was added to knead and granulate.
(Prescription)
Catalase (derived from the genus Aspergillus) 200 units Sodium chloride 85mg
Sodium monohydrogen phosphate 15mg
Dextrin 10mg
Polyethylene glycol (average molecular weight 2600-3800) 2mg
Riboflavin sodium phosphate 0.1mg
This was tableted and coated in the same manner as in Example 4 to prepare a delayed release hydrogen peroxide neutralized tablet.

Using the hydrogen peroxide neutralized tablets prepared in Examples 4 and 5, contact lenses were sterilized by the following procedure.

Contact lens processing cases were prepared, and 10 ml of contact lens disinfecting solution containing 3 w / v% of colorless and transparent hydrogen peroxide was put in each case, and one Menicon focus was immersed therein. Next, the neutralization tablets were put in one tablet to disinfect and neutralize the contact lenses. It was observed that foaming began and hydrogen peroxide began to decompose 10-20 minutes after adding the neutralized tablet. After about 1 hour, the foaming had subsided and the liquid was yellow due to sodium riboflavin phosphate, so that it could be clearly identified that the liquid was neutralized. The hydrogen peroxide concentration after neutralization was 1 ppm or less.
In addition, after neutralization, the lens was taken out, rinsed with physiological saline, and visually observed for any abnormalities such as coloring and deformation in the color dish using the untreated lens as a control. There were no abnormalities such as or deformation.

(Example 6)
-Enzyme solution-
An enzyme solution having the following composition was prepared.
(composition)
Proteolytic enzyme (derived from the genus Bacillus) 2 w / v%
Glycerin 60w / v%
Borax 3w / v%
Riboflavin sodium phosphate 0.03 w / v%
Purified water Appropriate amount 40 μl of this enzyme solution was dropped into a lens case filled with 3 ml of a colorless and transparent commercially available MPS for contact lenses (trade name: Ines distributor: Menicon, Inc.) This solution turned yellow and could easily be identified as containing proteolytic enzymes.

Next, one Menicon Soft MA (distributor: Menicon water-containing soft contact lens) was immersed in this solution and allowed to stand at room temperature for 16 hours. After the immersion, the lens was taken out, rinsed with physiological saline, and abnormalities such as coloring and deformation were visually observed with the untreated lens as a control in the color dish, but no abnormality was observed.

Claims (4)

A contact lens agent containing riboflavin phosphate or a salt thereof as a coloring component effective for identifying a liquid agent. The contact lens preparation according to claim 1, further comprising at least one selected from the group consisting of a disinfectant, a peroxide neutralizing component, a proteolytic enzyme, and a surfactant as an active ingredient. A method for treating a contact lens by combining two contact lens agents, wherein one contact lens agent is colored with riboflavin phosphate or a salt thereof, and the other contact lens agent is visible. A method for processing a contact lens. A method of disinfecting a contact lens by bringing a contact lens into contact with a hydrogen peroxide-containing liquid and adding a hydrogen peroxide neutralizing agent to the liquid, wherein the neutralizing agent contains riboflavin phosphate or a salt thereof. A method of making it possible to visually recognize whether the liquid agent contacted with the contact lens is being disinfected or neutralized.