JP2007099699A - Sunscreen cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sunscreen cosmetic containing sufficiently dissolved 2,4-bis[[4-(2-ethylhexyloxy)-2-hydroxy]phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine having low solubility and high crystallinity, exhibiting excellent UV-A absorption and having extremely excellent stability. <P>SOLUTION: The sunscreen cosmetic contains 2,4-bis[[4-(2-ethylhexyloxy)-2-hydroxy]phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine and a benzotriazole derivative expressed by general formula (I) (R' is a 1-6C straight-chain alkyl; and R" is a 1-3C straight-chain alkyl). <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a sunscreen cosmetic. More specifically, the present invention relates to a sunscreen cosmetic that is excellent in the dissolving ability of a specific powder solid ultraviolet absorber and particularly excellent in the absorbing ability in the UV-A region.

  The important ultraviolet absorption wavelength regions by sunscreen cosmetics are the UV-A region (320 to 400 nm) and the UV-B region (290 to 320 nm). UV rays in the UV-A region (320 to 400 nm) invade the skin black, but it is considered that sunburn occurs like the ultraviolet rays in the UV-B region (290 to 320 nm) and does not promote skin aging. It was. However, in recent years, ultraviolet rays in the UV-B region stay relatively on the surface of the skin, whereas ultraviolet rays in the UV-A region reach the deep part of the skin, and induce skin cancer as well as skin aging. It has been found to be the cause.

  Cosmetic UV absorbers that have been used to date are classified according to the structure: (1) benzoic acid derivatives, (2) cinnamic acid derivatives, (3) benzophenone derivatives, (4) dibenzoylmethane derivatives, (5) Salicylic acid derivatives and the like. In recent years, the ultraviolet absorbers (2) and (4) are frequently used.

  However, the ultraviolet absorbers listed above have their respective problems from a practical standpoint. For example, in the benzoic acid derivative of (1), for example, p-dimethylaminobenzoic acid-2-ethylhexyl is liquid and transparent, and has advantages that it is easy to handle, but there is a suspicion of safety including these derivatives. It has not been used in recent years. Further, the maximum absorption wavelength is in the vicinity of 290 nm, and the ultraviolet ray only in the UV-B region is absorbed.

  In the cinnamic acid derivative (2), there is p-methoxycinnamic acid-2-ethylhexyl ester as an ultraviolet absorber most frequently used in sun care cosmetics currently on the market. The maximum absorption wavelength is around 310 nm, and the absorption region does not reach the UV-A region. In addition, the color changes due to sunlight and there is a problem in the sustainability of the coloring property and the UV protection effect.

  In the benzophenone derivative of (3), for example, 2-hydroxy-4-methoxybenzophenone has absorption over the UV-A and UV-B regions and has relatively good solubility in a skin external preparation base, but has a maximum absorption wavelength. Slightly close to the UV-B region and the absorbance is not very large. In recent years, a basic skeleton structure (benzophenone) has been pointed out as an environmental hormone and its use has been avoided.

  Of the dibenzoylmethane derivatives of (4), 4-tert-butoxy-4-methoxydibenzoylmethane is often used as a skin external preparation. The maximum absorption is in the vicinity of 360 nm, the absorbance is large, and it is excellent as an ultraviolet absorber in the UV-A region. However, there is a problem in light stability, the compatibility with the oil for skin external preparation is poor, and only a small amount can be mixed.

  In the salicylic acid derivative (5), octyl salicylate is used. It has a maximum absorption wavelength in the UV-B region, is oily, and is excellent in compatibility with paraffin oil or the like, but is not practically used because of its low absorbance.

  For this reason, 2-ethylhexyl p-methoxycinnamate (2) is used in the UV-B region, and 4-tert-butoxy-4-methoxydibenzoylmethane (4) is used in the UV-A region. Often done. Particularly in recent years, there has been an increasing demand for ultraviolet absorption in the UV-A region.

  On the other hand, the benzotriazole derivative represented by the general formula (I) is blended as an ultraviolet absorber, has excellent compatibility with oils of various skin external preparation bases, and has excellent ultraviolet absorption in the UV-A region. However, an external preparation for skin that is excellent in light stability of the ultraviolet absorber itself and has a sustainable ultraviolet absorption effect over a long period of time has been developed (Patent Document 1).

  On the other hand, 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine has UV-A absorption ability. It is an excellent known UV absorber and is traded under the trade name Tinosorb® S as Ciba Specialty Chemicals Holding Inc. Is commercially available.

  However, this ultraviolet absorber is a powder, has low solubility in oil, and is easily recrystallized even if dissolved. Therefore, when it mix | blends with cosmetics, sufficient ultraviolet absorption ability cannot be exhibited. In addition, crystals precipitate over time, making it very difficult to produce a stable cosmetic.

  In order to avoid this, dissolved oil components that can be blended in cosmetics have been studied, but are not sufficient. For example, Patent Document 2 describes that ethylhexyl 2-cyano-3,3-diphenylacrylate (octocrylene) is used to solubilize it, but it cannot always be said to be a sufficient dissolved oil content. Further, the oil itself does not necessarily contribute to the absorption of UV-A.

JP 2005-206473 A JP 2000-309520 A

  As a result of intensive studies from the above viewpoint, the present inventors have found that a benzotriazole derivative of the general formula (I) having excellent ultraviolet absorption in the UV-A region is 2,4-bis [[4- (2- [Ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine has been found to be used as an excellent dissolved oil, and is excellent in UV-A ultraviolet absorption ability and stability. The present invention has been completed by producing an excellent sunscreen cosmetic.

（式中、Ｒ’＝Ｃ１〜Ｃ６の直鎖のアルキル基、Ｒ”＝Ｃ１〜Ｃ３の直鎖のアルキル基である。） That is, the present invention relates to 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine and the following general formula: The present invention provides a sunscreen cosmetic comprising the benzotriazole derivative represented by (I).
Formula (I)

(In the formula, R ′ = C1-C6 linear alkyl group, R ″ = C1-C3 linear alkyl group.)

  In the present invention, the benzotriazole derivative may be 2- [4- (2-ethylhexyloxy) -2-hydroxyphenyl] -2H-benzotriazole, 2- (2-hydroxy-4-isobutoxyphenyl) -2H. -The above-mentioned sunscreen cosmetics characterized by being one or more selected from benzotriazole.

The sunscreen cosmetic of the present invention is 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl), which is an ultraviolet absorber excellent in UV-A. ) By mixing the benzotriazole derivative of the general formula (I) as a dissolved oil component of 1,3,5-triazine, the powdery ultraviolet absorber can be sufficiently dissolved.
As a result, it is possible to provide a sunscreen cosmetic that can exhibit sufficient UV-A UV-absorbing ability of the UV-absorbing agent, and does not precipitate crystals of the UV-absorbing agent, and has excellent product stability. Is possible.
Moreover, since the benzotriazole derivative itself of the general formula (I) of the dissolved oil component is also excellent in UV-A ultraviolet absorbing ability, it can collectively exhibit high ultraviolet absorbing ability. Thereby, in order to exhibit the same level of ultraviolet absorbing ability, there is also an advantage that the blending amount of the ultraviolet absorbent can be reduced as compared with other sunscreen cosmetics.

  Hereinafter, the present invention will be described in detail.

  2,4-Bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine is traded under the trade name Tinosorb® S , Ciba Specialty Chemicals Holding Inc. Is commercially available. It is a powdery UV-A ultraviolet absorber.

第２工程

第３工程

第４工程

（式中、２，３−ＤＣＮは２，３−ジクロロ−１，４−ナフトキノンを表す。）
第５工程

（式中、Ｒ＝ＨもしくはＣＨ３、Ｒ’＝Ｃ１〜Ｃ６の直鎖のアルキル基、Ｒ”＝Ｃ１〜Ｃ３の直鎖のアルキル基である。）

（Ｂ法）
第１工程

第２工程

第３工程

第４工程

第５工程

（式中、Ｒ’＝Ｃ１〜Ｃ６の直鎖のアルキル基、Ｒ”＝Ｃ１〜Ｃ３の直鎖のアルキル基である。なお、２，３−ＤＣＮは２，３−ジクロロ−１，４−ナフトキノンを表す。） “Benzotriazole derivatives represented by general formula (I)”
The benzotriazole derivatives of general formula (I) are known compounds and are synthesized as follows. That is, a method is generally used in which o-nitroaniline is converted to a diazonium salt with sodium nitrite or the like, coupled with phenol to synthesize a monoazo compound, and then reduced to benzotriazole.
(Method A)
First step

Second step

Third step

4th process

(In the formula, 2,3-DCN represents 2,3-dichloro-1,4-naphthoquinone.)
5th process

(In the formula, R = H or CH3, R ′ = C1-C6 linear alkyl group, R ″ = C1-C3 linear alkyl group.)

(Method B)
First step

Second step

Third step

4th process

5th process

(In the formula, R ′ = C1-C6 linear alkyl group, R ″ = C1-C3 linear alkyl group. In addition, 2,3-DCN is 2,3-dichloro-1,4- Represents naphthoquinone.)

When the corresponding benzotriazole and alkyl halide are refluxed in a mixed solvent of methyl isobutyl ketone and dimethylformamide, the compound of the general formula (I) can be produced with a particularly high yield.
More specifically, 6- (2H-benzotriazol-2-yl) resorcinol is placed in a four-necked flask equipped with a thermometer and a reflux condenser, and methyl isobutyl ketone and dimethylformamide are added and stirred. To do. Sodium carbonate and 2-ethylhexyl bromide are added to this, and it heats to reflux temperature, stirring. After stirring for a predetermined time while maintaining the reflux temperature, methyl isobutyl ketone was recovered at normal pressure, and the remaining oil was washed with water to remove excess sodium carbonate and the produced inorganic substance, and liquid 2- [4- (2 -Ethylhexyloxy) -2-hydroxyphenyl] -2H-benzotriazole is obtained in high yield.

  The amount of 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine depends on the target product. Although it determines suitably, 0.5-5 mass% is preferable with respect to the sunscreen cosmetics whole quantity, and 1-3 mass% is more preferable.

  The amount of the benzotriazole derivative represented by the general formula (I) is 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) to be dissolved. ) -1,3,5-triazine is appropriately determined depending on the blending amount. Usually, 2-10 mass% is preferable with respect to the total amount of sunscreen cosmetics, and 3-7 mass% is further more preferable.

  In addition to the above essential ingredients, the sunscreen cosmetics of the present invention are usually used in skin preparations such as cosmetics and pharmaceuticals, such as whitening agents, moisturizers, antioxidants, oily ingredients, and other ultraviolet absorbers. , Surfactants, thickeners, alcohols, powder components, colorants, aqueous components, water, various skin nutrients and the like can be appropriately blended as necessary to produce them by conventional methods. For example, the following are mentioned as a compounding component.

Avocado oil, macadamia nut oil, corn oil, olive oil, rapeseed oil, evening primrose oil, castor oil, sunflower oil, teaseed oil, rice bran oil, jojoba oil, cacao butter, palm oil, squalene, beef tallow, owl, beeswax, candelilla wax Oils such as carnauba wax, whale wax, lanolin, liquid paraffin, polyoxyethylene (8 mol) oleyl alcohol ether, glyceryl monooleate, cyclomethicone, dimethylpolysiloxane, diphenylpolysiloxane.
Higher alcohols such as capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, phytosterol.
Higher fatty acids such as capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid.
Moisturizers such as polyethylene glycol, glycerin, sorbitol, xylitol, maltitol, mucopolysaccharide, hyaluronic acid, chondroitin sulfate and chitosan.
Thickeners such as methylcellulose, ethylcellulose, gum arabic, and polyvinyl alcohol.
Organic solvents such as ethanol and 1,3-butylene glycol.
Antioxidants such as butylhydroxytoluene, tocopherol and phytic acid.
Antibacterial preservatives such as benzoic acid, salicylic acid, sorbic acid, paraoxybenzoic acid esters (such as ethylparaben and butylparaben), and hexachlorophene.
Amino acids and hydrochlorides such as glycine, alanine, valine, leucine, serine, threonine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, arginine, histidine.
Organic acids such as acyl sarcosine acid (eg, lauroyl sarcosine sodium), glutathione, citric acid, malic acid, tartaric acid, lactic acid.
Vitamin A and its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B such as vitamin B12, vitamin B15 and its derivatives, ascorbic acid, ascorbic acid phosphate ( Salt), vitamin C such as ascorbic acid dipalmitate, α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin E such as vitamin E nicotinate, vitamin D, vitamin H, pantothenic acid, pantethine, etc. Vitamins.
Nicotinamide, benzyl nicotinate, γ-oryzanol, allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, mucidin, bisabolol, eucalyptol, thymol, inositol, saponins (psychosaponin, carrot saponin, loofah) Various drugs such as saponin, muclodisaponin, etc.), pantothenyl ethyl ether, ethinyl estradiol, tranexamic acid, cephalanthin, placenta extract.
Bark, Clara, Kouhone, Orange, Sage, Thyme, Yarrow, Zeni-oyster, Senkyu, Assembly, Spruce, Spruce, Birch, Sugina, Loofah, Maronie, Yukinoshita, Arnica, Lily, Mugwort, Peonies, Aloe, Gardenia, Sawara Natural extract extracted with solvent, alcohol, polyhydric alcohol, water, aqueous alcohol.
Cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, and laurylamine oxide.
Metal sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate and gluconic acid.
Fragrance, scrub agent, purified water, etc.

  Particularly preferred bases for the sunscreen cosmetics of the present invention are decamethylcyclopentasiloxane, isononyl isononanoate, dimethylpolysiloxane, heptamethyloctyltrisiloxane, trimethylsiloxysilicic acid, liquid paraffin, squalane, cetyl isooctanoate, isooctanoic acid It is an oil component of triglyceride and di-2-ethylhexyl succinate. Especially this invention is preferably utilized for the sunscreen cosmetics which have decamethylcyclopentasiloxane as a main component base.

  The sunscreen cosmetics of the present invention may be in any product form, such as ointments, creams, emulsions, lotions, packs, and the like. The dosage form is not particularly limited.

  The present invention will be specifically described below with reference to examples. The present invention is not limited to these examples.

<Synthesis example of benzotriazole derivative represented by general formula (I)>
"Synthesis Example 1: Synthesis of 2- [4- (2-ethylhexyloxy) -2-hydroxyphenyl] -2H-benzotriazole"
65.4 g (0.20 mol) of 6- (2H-benzotriazol-2-yl) resorcinol synthesized by a conventional method was put into a 500 ml four-necked flask equipped with a thermometer and a reflux condenser, and 50 ml of methyl isobutyl ketone, 4.0 g of dimethylformamide was added and stirred. To this, 25.4 g (0.24 mol) of sodium carbonate and 77.2 g (0.40 mol) of 2-ethylhexyl bromide were added and heated to the reflux temperature with stirring. After stirring for 15 hours while maintaining the reflux temperature, methyl isobutyl ketone was recovered at normal pressure, and the remaining oil was washed with water to remove excess sodium carbonate and produced inorganic substances. This oil was distilled under reduced pressure to obtain 52.1 g of a yellow transparent fraction of 220 to 225 ° C./0.2 to 0.3 mmHg. This compound was liquid at normal temperature, and the yield was 76.7% and the HPLC purity was 99.0%.

"Synthesis Example 2: Synthesis of 2- (2-hydroxy-4-isobutoxyphenyl) -2H-benzotriazole"
The same procedure as in Synthesis Example 1 was carried out using the same molar amount of isobutyl bromide instead of 2-ethylhexyl bromide. A slightly yellowish white powdery crystal was obtained with a yield of 72.5%. m. p. They were 120.0 to 120.8 ° C., λmax = 345.6 nm, and ε = 21750.

For the oil components A to E below, the solubility of 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine was measured. Examined. The result is shown in FIG.
A: Isodecyl benzoate B: 2-ethylhexylbenzoate C: ethylhexyl 2-cyano-3,3-diphenylacrylate (octocrylene)
<Oil content of patent document 2>
D: 2- [4- (2-Ethylhexyloxy) -2-hydroxyphenyl] -2H-benzotriazole <Oil content of Synthesis Example 1>
E: 2- (2-hydroxy-4-isobutoxyphenyl) -2H-benzotriazole <Oil content of Synthesis Example 2>

"Solubility Measurement Methods and Conditions"
2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine is added to each of the oils A to E. Dissolve by heating at 80 ° C. After allowing to cool to room temperature, 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine as powder is obtained. Add a small amount and cool with stirring (stirrer) at 0 ° C. for 3 days. Thereafter, the supernatant solution is quickly collected so that the temperature does not rise, and 30 mg (measured value record) is diluted to 100 mL with ethyl acetate. The absorbance at 342.8 nm of the obtained diluted solution is determined. The solubility is obtained by plotting the obtained absorbance on a calibration curve prepared in advance.

1 to 5 show that the solubility of D and E in the benzotriazole derivative of the general formula (I) is remarkably excellent.
Thus, 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine and the benzotriazole of general formula (I) The sunscreen cosmetics containing the derivatives are 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine. Sunscreen makeup excellent in solubility, and as a result, can exhibit the sufficient UV-A UV-absorbing ability of the UV-absorbing agent, and further, the UV-absorbing agent crystal does not precipitate and has excellent product stability. It is possible to provide a fee.
Moreover, since the benzotriazole derivative itself of the general formula (I) of the dissolved oil component is also excellent in UV-A ultraviolet absorbing ability, it can collectively exhibit high ultraviolet absorbing ability. Thereby, in order to exhibit the ultraviolet-ray absorption ability of the same grade, it also has the advantage that the compounding quantity of a ultraviolet absorber can be decreased rather than other sunscreen cosmetics.

Below, the prescription example of the sunscreen cosmetics of this invention which has the said effect is given.
"Example 1: Sunscreen cosmetic W / O emulsion"
mass%
1. Dimethylpolysiloxane 1
2. Decamethylcyclopentasiloxane 25
3. Trimethylsiloxysilicic acid 5
4). Polyoxyethylene methylpolysiloxane copolymer 1
5. Lauryl PEG-9 polydimethylsiloxyethyl dimethicone 1
6). Isononyl isononanoate 5
7). Dipropylene glycol 5
8). Dipotassium glycyrrhizinate 0.02
9. Glutathione 1
10. Thiotaurine 0.05
11. Clara extract 1
12 Paraben appropriate amount13. Phenoxyethanol appropriate amount14. 2-Ethylhexyl paramethoxycinnamate 7.5
15. Dimethyl distearyl ammonium hectorite 0.5
16. Spherical polyalkyl acrylate powder 5
17. Butylethylpropanediol 0.5
18. 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine 2
19. 2- [4- (2-Ethylhexyloxy) -2-hydroxyphenyl] -2H-benzotriazole 8
20. Hydrophobized zinc oxide or hydrophobically treated titanium oxide 15
21. Purified water Residual production method The aqueous phase was gradually added to the oil phase, and after completion of the addition, the emulsified particles were prepared to be uniform using a stirrer.

"Example 2: Sunscreen cosmetic O / W emulsion"
mass%
1. Polyoxyethylene hydrogenated castor oil 1
2. Dimethicone copolyol 0.5
3. Decamethylcyclopentasiloxane 15
4). Isostearic acid 0.5
5. Phenyltrimethicone 1
6). Hydrophobized titanium oxide 5
7). 2-methoxyhexyl paramethoxycinnamate 3
8.2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine 2
9. 2- (2-Hydroxy-4-isobutoxyphenyl) -2H-benzotriazole
5
10. Silica 1
11. Citric acid 0.01
12 Sodium citrate 0.09
13. Paraben appropriate amount14. Phenoxyethanol appropriate amount15. Alcohol 5
16. Dynamite Glycerin 1
17. Succinoglucan 0.2
18. Cellulose gum 1
19. Ion-exchanged water Residual production method After preparing the aqueous phase of 9 to 18, it was gradually added to the oil phase of 1 to 8, and finally stirred using a homomixer.

"Example 3: Sunscreen cosmetic O / W / O emulsion"
mass%
1. Polyoxyethylene hydrogenated castor oil 0.5
2. Isostearic acid 0.2
3. 2-Ethylhexyl paramethoxycinnamate 7.5
4. 2- [4- (2-Ethylhexyloxy) -2-hydroxyphenyl] -2H-benzotriazole 3.0
5. 2,4-Bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine 3.0
6). Decamethylcyclopentasiloxane 35
7). Polyoxybutylene polyoxypropylene glycol 2.0
8). Dimethyl distearyl ammonium hectorite 0.5
9. Hydrophobized titanium oxide 12.0
10. Citric acid 0.04
11. Sodium citrate 0.06
12 Dipropylene glycol 2.0
13. Methyl glucose 1.0
14 Dynamite Glycerin 1.0
15. Salt 0.1
16. Methyl paraben appropriate amount 17. Phenoxyethanol appropriate amount 18. Ion-exchanged water Residual production method The oil phase of 1 to 5 was gradually added to the water phase of 10 to 18 to obtain an O / W preparation. This formulation was gradually added to the oil phase of 6-9, and then stirred with a homomixer to obtain the desired sample.

  The sunscreen cosmetic of the present invention is 2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl), which is an ultraviolet absorber excellent in UV-A. ) By mixing the benzotriazole derivative of the general formula (I) as a dissolved oil component of 1,3,5-triazine, the powdery ultraviolet absorber can be sufficiently dissolved. As a result, it is possible to provide a sunscreen cosmetic that is excellent in UV-A absorption ability and extremely stable.

It is a figure which shows the solubility of 2, 4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine to various oils. .

Claims (2)

2,4-bis [[4- (2-ethylhexyloxy) -2-hydroxy] phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine and the following general formula (I) A sunscreen cosmetic comprising a benzotriazole derivative.
Formula (I)

(In the formula, R ′ = C1-C6 linear alkyl group, R ″ = C1-C3 linear alkyl group.) The benzotriazole derivative is selected from 2- [4- (2-ethylhexyloxy) -2-hydroxyphenyl] -2H-benzotriazole and 2- (2-hydroxy-4-isobutoxyphenyl) -2H-benzotriazole. The sunscreen cosmetic according to claim 1, wherein the sunscreen cosmetic is one type or two or more types.

Images