JPH0532531A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having high utility, suppressing inflammation of skin caused by ultraviolet rays, preventing blackening of skin resulting from melanism and skin cancer, containing a specific tetraenedicarboxylic acid or a derivative thereof. CONSTITUTION:A cosmetic containing preferably 0.01-10wt.%, based on the whole amount of cosmetic, of a tetraenedicarboxylic acid shown by the formula (R is H, alkyl, alkenyl, aryl, alkali metal, alkaline earth metal or amine) or salt thereof. The compound shown by the formula has the maximum absorption wavelength at approximately 338nm, excellent UV-A screening effects and excellent utility. Having high water solubility, the tetraenedicarboxylic acid is preferably applied to a cosmetic of aqueous solution and an ester thereof to an oily cosmetic because solubility in an oily component is increased by the esterification.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having a high UV blocking effect.

[0002]

2. Description of the Related Art Generally, when the skin is exposed to excessive ultraviolet rays outdoors, sunburn occurs several hours after exposure to the sun, and when it becomes severe, it causes blisters. Furthermore, the melanin pigment is subsequently deposited and the skin is blackened. Thus, excessive UV exposure is extremely harmful from the aesthetic point of view and the health of the skin.

Until now, as the cause of the above-mentioned symptoms, mid-wavelength ultraviolet rays (hereinafter referred to as UV-B) of 290 to 320 nm have been regarded as important among the ultraviolet rays reaching the ground. , Many salicylic acid ester-based UV absorbers have been developed.

However, in recent years, studies on the effects of ultraviolet rays on skin darkening and skin cancer have progressed, and like UV-B, long-wavelength ultraviolet rays of 320 to 400 nm (hereinafter UV-
It is also clear that (A) causes the above symptoms. A benzophenone-based or dibenzoylmethane-based UV absorber is generally used as a UV absorber for cosmetics that is added to prevent UV-A.

However, the benzophenone type ultraviolet absorber has absorption in both UV-A and B regions, but its absorption capacity is small and its absorption capacity in the UV-A region is relatively low. Therefore, it is said that there is a safety problem because a considerably large amount must be added to obtain a sufficient effect. Further, the dibenzoylmethane-based ultraviolet absorber is UV-A.
It also has a relatively high absorption capacity in the region, but when it reacts with heavy metals and amines and adheres to clothes, the clothes are dyed yellow, which poses a serious problem in terms of usability as a cosmetic product.

On the other hand, in order to alleviate the above-mentioned problems, the actual cosmetic composition contains the above-mentioned ultraviolet absorber,
Inorganic powder such as titanium oxide that physically reflects and scatters ultraviolet rays is often used. However, there is a problem that the formulation that can be blended is limited, such that the usability during application is deteriorated, and that it is difficult to apply it particularly to lotion type and oil type products.

As mentioned above, at present, UV-A and U
There is a strong demand for cosmetics that have the UV blocking effect of V-B and are highly safe and easy to use.

[0008]

DISCLOSURE OF THE INVENTION The present invention has high usability, suppresses skin inflammation caused by ultraviolet rays, prevents skin blackening due to melanin production, and can prevent skin cancer. The purpose is to provide a variety of cosmetics.

[0009]

The first gist of the present invention is as follows.
The present invention provides a cosmetic characterized by containing a tetraene dicarboxylic acid represented by the following general formula (I) or a derivative thereof. ROOC-CH = CH-CH = CH-CH = CH-CH = CH-COOR (I) (In the formula, R represents hydrogen or a linear or branched alkyl group, alkenyl group, aryl group and alkali metal, alkali Represents earth metals and amines.) The second gist is the first
In the summary, the present invention is a cosmetic characterized in that the tetraene dicarboxylic acid derivative is contained in an amount of 0.01 to 10% by weight based on the total amount of the cosmetic.

[0010]

The function and structure of the present invention will be described in detail below.

In the process of earnestly researching and developing an ultraviolet absorber for cosmetics, the present inventors have found that a substance having an absorption maximum near 350 nm has a good UV-A blocking effect, and particularly a tetraenedicarboxylic acid derivative. Sufficient UV-A when blended
It was discovered that a cosmetic having a blocking effect and excellent usability can be obtained.

The tetraene dicarboxylic acids and derivatives applicable to the present invention are substances represented by the general formula (I),
J. Amer. Chem. Soc. , 92, 5480
As described in (1970), it is a compound having a maximum absorption wavelength (λ _max ) near 338 nm.

In the present invention, the tetraene dicarboxylic acid is used as an acid, salt or ester as shown by the formula (I).

The salt of tetraene dicarboxylic acid can be obtained by reacting tetraene dicarboxylic acid with a salt-forming substance. Here, examples of the salt-forming substance include inorganic bases such as lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, and magnesium hydroxide, basic amino acids such as arginine, lysine, and histidine, such as monoethanolamine. , Organic bases such as diethanolamine and triethanolamine are used. Further, these salts may be prepared in advance as described above and added to them, or they may be used by adding tetraenedicarboxylic acid and a salt-forming substance separately and reacting in the formulation. Good.

Since the tetraene dicarboxylic acid salt has a high solubility in water, it is particularly suitably applied to an aqueous solution type cosmetic such as a lotion.

The tetraene dicarboxylic acid ester can be produced, for example, by a condensation reaction of tetraene dicarboxylic acid and alcohol. Examples of alcohols include linear, branched, and cyclic alkyl, alkenyl, and aryl alcohols. Specific examples include methanol, ethanol, propanol, hexyl alcohol, cetyl alcohol, allyl alcohol, oleyl alcohol, phenyl alcohol and the like.

The use of an ester improves the solubility in oily components, and thus is particularly suitably applied to oily cosmetics such as cosmetic oils. Also, the maximum absorption wavelength (λ _max ) shifts to the long wavelength side due to esterification, and UV-A
The absorption capacity for is increased. In the case of an alkyl ester, an alkyl group having 2 or more carbon atoms is more preferable.

In the cosmetic of the present invention, any one kind or two or more kinds are selected from the group consisting of the above-mentioned tetraene dicarboxylic acid and its derivative. The blending amount thereof is preferably 0.01 to 10% by weight with respect to the entire cosmetic,
10% by weight is more preferred. When the content is 0.1% or more, the ultraviolet blocking effect of the cosmetic material is further improved. Further, even if the amount exceeds 10% by weight, almost no change is effectively seen, and it is not necessary to exceed 10% by weight.

As the cosmetic base used in the cosmetic of the present invention, any base can be used as long as it can be usually used in cosmetics, for example, cream, ointment, emulsion, lotion, oil, lipstick, aerosol. It is possible to take a dosage form such as. Further, the raw materials constituting these bases may be any raw materials commonly used in cosmetics, and are not particularly limited.

In addition to the above cosmetic base, if necessary, an ultraviolet absorber other than tetraenedicarboxylic acid and its derivative, an ultraviolet scattering agent typified by particulate titanium oxide,
Ingredients having medicinal effects such as moisturizing, antioxidation, activation, etc., other thickeners, pigments, chelating agents, fragrances, etc. may be added within a range not impairing the effects of the present invention.

As described above, by blending tetraenedicarboxylic acid and its derivative, UV-A and UV-B ultraviolet rays are blocked while keeping high usability and usability, and skin blackening and It becomes possible to prevent skin cancer.

[0022]

EXAMPLES Examples of the present invention will be shown below. (Example 1 and Comparative Example 1) Each lotion shown in Table 1 was prepared. Apply this to a panel and irradiate it with sunlight to obtain the minimum amount of erythema formation in the sample application area and the minimum amount of erythema formation in the non-application area. From these ratios, SPF (sun protection f
actor) was calculated. The results are also summarized in Table 1.

[0023]

[Table 1] As is clear from Table 1, the cosmetic lotion of Comparative Example 1 containing sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate had an SPF of 2.0, whereas decatetraenedicarboxylic acid diester The lotion of Example 1 containing sodium had an SPF of 5.0 and showed an excellent ultraviolet blocking effect. There was also no skin irritation.

(Examples 2 and 3) The creams shown in Table 2 were prepared, applied to a panel and exposed to sunlight for 5 hours, and then the state of sunburn was examined.

[0025]

[Table 2] The skin of the panelist to which the cream of Comparative Example 2 was applied had a thin tan, whereas the skin of the panelist to which the cream of Examples 2 and 3 was applied had no change even after irradiation with sunlight and was not exposed to sunlight. No difference was seen with the skin.
The skin to which the cream was not applied was red and sunburned. (Example 4) A foundation having the following composition was prepared, and the ultraviolet blocking effect was evaluated in the same manner as in Example 1.
The skin of the panelists to which the cream of this example was applied did not show the same change as the skin not exposed to sunlight.

Foundation Dicetyl tetraene dicarboxylate 5.0 Sulfuric acid fine particles titanium oxide 7.0 Triglyceride isostearic acid 2.0 2-Octylated decyl oleate 8.0 Liquid paraffin 3.0 Cetyl alcohol 5.0 Candelilla wax 2. 0 POE (25) monostearate 2.0 sorbitan monostearate 1.0 yellow iron oxide 1.3 red iron oxide 0.8 polyethylene glycol 4.0 perfume 0.1 purified water balance (Example 5) Example 1 and Similarly, a lotion having the following composition was obtained. The effect of blocking the ultraviolet rays of this lotion was evaluated in the same manner as in Example 1. The skin of the panelist to which the lotion of the present invention was applied did not show the same change as the skin not exposed to sunlight. There was no skin irritation. Decatetraene dicarboxylic acid 0.1 Propylene glycol 10 Ethyl alcohol 20 Liquid paraffin 2.0 POE (30) hydrogenated castor oil 1.0 Polyethylene glycol 5.0 Citrate Na 0.2 Phosphate Na 0.3 EDTA-2Na 0 .05 Fragrance 0.1 Purified water Residue

[0027]

EFFECTS OF THE INVENTION According to the present invention, that is, by adding tetraenedicarboxylic acid and its derivative to cosmetics, it has high usability, suppresses inflammation of the skin due to ultraviolet rays, and darkens skin caused by melanin formation. It is possible to provide a novel cosmetic that can prevent aging and further prevent skin cancer.

Continued front page    (72) Inventor Kazuo Komatsu             Stock at 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa             Shiseido Research Institute

Claims (2)

[Claims] 1. A tetraene dicarboxylic acid represented by the following general formula (I) or a derivative thereof ROOC-CH = CH-CH = CH-CH = CH-CH = CH-COOR (I) (wherein R is hydrogen. Or a linear or branched alkyl group, alkenyl group, aryl group or alkali metal, alkaline earth metal, amines). 2. The cosmetic material according to claim 1, wherein the compounding amount of the tetraene dicarboxylic acid derivative is 0.01 to 10% by weight based on the total amount of the cosmetic material.