JP2006527990A5 - - Google Patents
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- Publication number
- JP2006527990A5 JP2006527990A5 JP2006520828A JP2006520828A JP2006527990A5 JP 2006527990 A5 JP2006527990 A5 JP 2006527990A5 JP 2006520828 A JP2006520828 A JP 2006520828A JP 2006520828 A JP2006520828 A JP 2006520828A JP 2006527990 A5 JP2006527990 A5 JP 2006527990A5
- Authority
- JP
- Japan
- Prior art keywords
- subunit
- expression
- nucleic acid
- hybrid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 description 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03077266 | 2003-07-21 | ||
| PCT/EP2004/051522 WO2005011733A1 (en) | 2003-07-21 | 2004-07-16 | Hybrid toxins comprising shiga-like toxin subunits fused to escherichia coli heat labile enterotoxin subunits and vaccines thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006527990A JP2006527990A (ja) | 2006-12-14 |
| JP2006527990A5 true JP2006527990A5 (enExample) | 2010-05-27 |
| JP4599354B2 JP4599354B2 (ja) | 2010-12-15 |
Family
ID=34112462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520828A Expired - Fee Related JP4599354B2 (ja) | 2003-07-21 | 2004-07-16 | 大腸菌熱不安定性エンテロトキシンサブユニットに融合した志賀毒素サブユニットまたは志賀毒素様毒素サブユニットを含むハイブリッド毒素およびそのワクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7807184B2 (enExample) |
| EP (1) | EP1648501B1 (enExample) |
| JP (1) | JP4599354B2 (enExample) |
| AT (1) | ATE504312T1 (enExample) |
| CA (1) | CA2531441C (enExample) |
| DE (1) | DE602004032143D1 (enExample) |
| ES (1) | ES2365035T3 (enExample) |
| WO (1) | WO2005011733A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| EP2420246A1 (en) * | 2006-04-20 | 2012-02-22 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 1 protein |
| US9023352B2 (en) | 2007-02-20 | 2015-05-05 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein |
| JP5392528B2 (ja) * | 2008-03-25 | 2014-01-22 | 独立行政法人産業技術総合研究所 | 毒素またはウィルス含有汚染液の固相抽出方法および無毒化方法、並びにそれに用いる固相抽出用捕集剤および除染剤 |
| EP2728004B1 (en) * | 2008-05-02 | 2018-08-08 | Idemitsu Kosan Co., Ltd. | Bacterial toxin vaccine |
| ES2614803T3 (es) * | 2009-01-23 | 2017-06-02 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Métodos y composiciones basadas en proteína tipo 2 de la toxina Shiga |
| US20120269842A1 (en) * | 2009-10-09 | 2012-10-25 | South Dakota State University | Enterotoxigenic e. coli fusion protein vaccines |
| JP6497679B2 (ja) * | 2013-11-26 | 2019-04-10 | 出光興産株式会社 | 大腸菌症用ワクチン |
| WO2015100409A2 (en) | 2013-12-26 | 2015-07-02 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein |
| US11001625B2 (en) | 2014-12-10 | 2021-05-11 | Tufts University | VHH based binding antibodies for anthrax and botulinum toxins and methods of making and using therefor |
| US11965216B2 (en) | 2015-04-07 | 2024-04-23 | Polyskope Labs | Detection of one or more pathogens |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12077576B2 (en) | 2020-07-02 | 2024-09-03 | Trustees Of Tufts College | VHH polypeptides that bind to Clostridium difficile toxin b and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9501682D0 (sv) * | 1995-05-05 | 1995-05-05 | Jan Holmgren | Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits |
| EP1057895A1 (de) | 1999-06-04 | 2000-12-06 | Lohmann Animal Health GmbH & Co. KG | Fusionsprotein das das Fragment B des Shigatoxins enthält, dieses enthaltende (Impf-)Stoffzusammensetzung und Verfahren zu dessen Herstellung |
| US20010031485A1 (en) * | 2000-03-22 | 2001-10-18 | Sibtech, Inc. | Recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor fragments |
| US7063852B2 (en) | 2000-05-19 | 2006-06-20 | The Administrators Of The Tulane Educational Fund | Hybrid LT-A/CT-B holotoxin for use as an adjuvant |
-
2004
- 2004-07-16 US US10/565,183 patent/US7807184B2/en not_active Expired - Fee Related
- 2004-07-16 EP EP04766245A patent/EP1648501B1/en not_active Expired - Lifetime
- 2004-07-16 ES ES04766245T patent/ES2365035T3/es not_active Expired - Lifetime
- 2004-07-16 AT AT04766245T patent/ATE504312T1/de not_active IP Right Cessation
- 2004-07-16 DE DE602004032143T patent/DE602004032143D1/de not_active Expired - Lifetime
- 2004-07-16 JP JP2006520828A patent/JP4599354B2/ja not_active Expired - Fee Related
- 2004-07-16 WO PCT/EP2004/051522 patent/WO2005011733A1/en not_active Ceased
- 2004-07-16 CA CA2531441A patent/CA2531441C/en not_active Expired - Fee Related
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