JP2006525811A5 - - Google Patents
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- Publication number
- JP2006525811A5 JP2006525811A5 JP2006514886A JP2006514886A JP2006525811A5 JP 2006525811 A5 JP2006525811 A5 JP 2006525811A5 JP 2006514886 A JP2006514886 A JP 2006514886A JP 2006514886 A JP2006514886 A JP 2006514886A JP 2006525811 A5 JP2006525811 A5 JP 2006525811A5
- Authority
- JP
- Japan
- Prior art keywords
- sirna
- sequence
- nucleotides
- nucleotide sequence
- target gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims 53
- 239000002773 nucleotide Substances 0.000 claims 50
- 125000003729 nucleotide group Chemical group 0.000 claims 50
- 238000000034 method Methods 0.000 claims 42
- 108020004459 Small interfering RNA Proteins 0.000 claims 34
- 239000004055 small Interfering RNA Substances 0.000 claims 34
- 210000003527 eukaryotic cell Anatomy 0.000 claims 21
- 230000000692 anti-sense effect Effects 0.000 claims 17
- 108091081021 Sense strand Proteins 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108091035707 Consensus sequence Proteins 0.000 claims 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 230000003828 downregulation Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000030279 gene silencing Effects 0.000 claims 2
- 230000009368 gene silencing by RNA Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47139203P | 2003-05-16 | 2003-05-16 | |
| US51522303P | 2003-10-27 | 2003-10-27 | |
| PCT/US2004/015439 WO2005018534A2 (en) | 2003-05-16 | 2004-05-17 | Methods and compositions for rna interference |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010202235A Division JP2011004763A (ja) | 2003-05-16 | 2010-09-09 | Ｒｎａ干渉の方法と組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006525811A JP2006525811A (ja) | 2006-11-16 |
| JP2006525811A5 true JP2006525811A5 (enExample) | 2007-07-05 |
Family
ID=34221197
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006514886A Pending JP2006525811A (ja) | 2003-05-16 | 2004-05-17 | Ｒｎａ干渉の方法と組成物 |
| JP2010202235A Pending JP2011004763A (ja) | 2003-05-16 | 2010-09-09 | Ｒｎａ干渉の方法と組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010202235A Pending JP2011004763A (ja) | 2003-05-16 | 2010-09-09 | Ｒｎａ干渉の方法と組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8609830B2 (enExample) |
| EP (1) | EP1628993A4 (enExample) |
| JP (2) | JP2006525811A (enExample) |
| CA (1) | CA2525619A1 (enExample) |
| WO (1) | WO2005018534A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040219565A1 (en) | 2002-10-21 | 2004-11-04 | Sakari Kauppinen | Oligonucleotides useful for detecting and analyzing nucleic acids of interest |
| US8447526B2 (en) | 2005-05-23 | 2013-05-21 | Microsoft Corporation | Methods and computer systems for analyzing high-throughput assays |
| US8014957B2 (en) | 2005-12-15 | 2011-09-06 | Fred Hutchinson Cancer Research Center | Genes associated with progression and response in chronic myeloid leukemia and uses thereof |
| WO2008137862A2 (en) * | 2007-05-03 | 2008-11-13 | Rosetta Inpharmatics Llc | Methods of using mir34 as a biomarker for tp53 functional status |
| IN2009KN04568A (enExample) | 2007-06-01 | 2015-08-28 | Univ Princeton | |
| KR101840618B1 (ko) * | 2008-12-04 | 2018-03-20 | 큐알엔에이, 인크. | 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료 |
| US20130131148A1 (en) * | 2010-04-12 | 2013-05-23 | Noam Shomron | Micro-rna for cancer diagnosis, prognosis and therapy |
| DE102011009470A1 (de) * | 2011-01-21 | 2012-08-09 | Friedrich-Schiller-Universität Jena | Biologisch wirksame Nukleotid-Moleküle zur gezielten Abtötung von Zellen, Verwendung derselben sowie Applikationskit |
| WO2012143427A1 (en) * | 2011-04-19 | 2012-10-26 | Santaris Pharma A/S | Anti polyomavirus compounds |
| EP3554535A4 (en) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS |
| EP3554561B1 (en) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| CN110225770B (zh) | 2016-12-14 | 2022-04-26 | 杨森生物科技公司 | 结合cd8a的纤连蛋白iii型结构域 |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| JP2022551204A (ja) | 2019-10-14 | 2022-12-07 | アロ・バイオセラピューティクス・カンパニー | Ｃｄ７１結合フィブロネクチンｉｉｉ型ドメイン |
| MX2023012128A (es) | 2021-04-14 | 2024-01-11 | Aro Biotherapeutics Company | Dominios tipo iii de la fibronectina que se unen a cd71. |
| KR20240031947A (ko) | 2021-04-14 | 2024-03-08 | 에이알오 바이오테라퓨틱스 컴패니 | Fn3 도메인-시르나 접합체 및 이의 용도 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
| PT969102E (pt) | 1991-09-24 | 2008-03-25 | Keygene Nv | Iniciadores, grupos e conjuntos de fragmentos de restrição usados na amplificação selectiva de fragmentos de restrição |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
| US6165709A (en) | 1997-02-28 | 2000-12-26 | Fred Hutchinson Cancer Research Center | Methods for drug target screening |
| US6028189A (en) | 1997-03-20 | 2000-02-22 | University Of Washington | Solvent for oligonucleotide synthesis and methods of use |
| WO1998041531A2 (en) | 1997-03-20 | 1998-09-24 | University Of Washington | Solvent for biopolymer synthesis, solvent microdroplets and methods of use |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US6217002B1 (en) * | 1998-01-13 | 2001-04-17 | Terry C. Shafer | Valve assembly having floating retainer rings |
| US5965352A (en) | 1998-05-08 | 1999-10-12 | Rosetta Inpharmatics, Inc. | Methods for identifying pathways of drug action |
| US6324479B1 (en) | 1998-05-08 | 2001-11-27 | Rosetta Impharmatics, Inc. | Methods of determining protein activity levels using gene expression profiles |
| US6218122B1 (en) | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
| US6132969A (en) | 1998-06-19 | 2000-10-17 | Rosetta Inpharmatics, Inc. | Methods for testing biological network models |
| US6203987B1 (en) | 1998-10-27 | 2001-03-20 | Rosetta Inpharmatics, Inc. | Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns |
| US6950752B1 (en) | 1998-10-27 | 2005-09-27 | Rosetta Inpharmatics Llc | Methods for removing artifact from biological profiles |
| US6801859B1 (en) | 1998-12-23 | 2004-10-05 | Rosetta Inpharmatics Llc | Methods of characterizing drug activities using consensus profiles |
| US6351712B1 (en) | 1998-12-28 | 2002-02-26 | Rosetta Inpharmatics, Inc. | Statistical combining of cell expression profiles |
| US6132997A (en) | 1999-05-28 | 2000-10-17 | Agilent Technologies | Method for linear mRNA amplification |
| US20020016216A1 (en) | 1999-06-08 | 2002-02-07 | Kenji Kobayashi | Golf club |
| US7013221B1 (en) | 1999-07-16 | 2006-03-14 | Rosetta Inpharmatics Llc | Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays |
| US6271002B1 (en) | 1999-10-04 | 2001-08-07 | Rosetta Inpharmatics, Inc. | RNA amplification method |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| US7807447B1 (en) | 2000-08-25 | 2010-10-05 | Merck Sharp & Dohme Corp. | Compositions and methods for exon profiling |
| WO2002018464A2 (en) | 2000-08-29 | 2002-03-07 | Mallinckrodt Baker Inc. | Functionalized polymeric media for separation of analytes |
| WO2002044399A2 (en) | 2000-11-28 | 2002-06-06 | Rosetta Inpharmatics, Inc. | In vitro transcription method for rna amplification |
| CZ302719B6 (cs) * | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
| US20020182590A1 (en) * | 2001-05-25 | 2002-12-05 | Vanderbilt University | Determining protein function in cell culture using RNA interference |
| CA2921821A1 (en) | 2001-07-12 | 2003-01-23 | University Of Massachusetts | In vivo production of small interfering rnas that mediate gene silencing |
| US7418351B2 (en) | 2002-01-31 | 2008-08-26 | Rosetta Inpharmatics Llc | Methods for analysis of measurement errors in measured signals |
| US20040248299A1 (en) * | 2002-12-27 | 2004-12-09 | Sumedha Jayasena | RNA interference |
| US7996155B2 (en) | 2003-01-22 | 2011-08-09 | Microsoft Corporation | ANOVA method for data analysis |
| EP1692262B1 (en) | 2003-10-27 | 2018-08-15 | Merck Sharp & Dohme Corp. | Method of designing sirnas for gene silencing |
-
2004
- 2004-05-17 EP EP04776024A patent/EP1628993A4/en not_active Withdrawn
- 2004-05-17 WO PCT/US2004/015439 patent/WO2005018534A2/en not_active Ceased
- 2004-05-17 JP JP2006514886A patent/JP2006525811A/ja active Pending
- 2004-05-17 US US10/557,219 patent/US8609830B2/en active Active
- 2004-05-17 CA CA002525619A patent/CA2525619A1/en not_active Abandoned
-
2010
- 2010-09-09 JP JP2010202235A patent/JP2011004763A/ja active Pending
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