JP2006521082A5 - - Google Patents
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- JP2006521082A5 JP2006521082A5 JP2004536419A JP2004536419A JP2006521082A5 JP 2006521082 A5 JP2006521082 A5 JP 2006521082A5 JP 2004536419 A JP2004536419 A JP 2004536419A JP 2004536419 A JP2004536419 A JP 2004536419A JP 2006521082 A5 JP2006521082 A5 JP 2006521082A5
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- Prior art keywords
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- polypeptide
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- 229920001184 polypeptide Polymers 0.000 claims 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims 32
- 210000004027 cell Anatomy 0.000 claims 20
- 238000000034 method Methods 0.000 claims 15
- 241000124008 Mammalia Species 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010036105 Polyneuropathy Diseases 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000007824 polyneuropathy Effects 0.000 claims 2
- 230000004043 responsiveness Effects 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims 1
- 208000016192 Demyelinating disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010015218 Erythema multiforme Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- 108010068370 Glutens Proteins 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 208000037319 Hepatitis infectious Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 208000012287 Prolapse Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000006045 Spondylarthropathies Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 208000004732 Systemic Vasculitis Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000027207 Whipple disease Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 208000019748 bullous skin disease Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 230000009918 complex formation Effects 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000009580 eosinophilic pneumonia Diseases 0.000 claims 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 1
- 235000021312 gluten Nutrition 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 201000007192 granulomatous hepatitis Diseases 0.000 claims 1
- 208000007475 hemolytic anemia Diseases 0.000 claims 1
- 208000005252 hepatitis A Diseases 0.000 claims 1
- 208000024557 hepatobiliary disease Diseases 0.000 claims 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 1
- 208000013643 idiopathic inflammatory myopathy Diseases 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 201000009732 pulmonary eosinophilia Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 208000010157 sclerosing cholangitis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 206010043778 thyroiditis Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41034002P | 2002-09-11 | 2002-09-11 | |
| PCT/US2003/028317 WO2004024072A2 (en) | 2002-09-11 | 2003-09-10 | Novel compositions and methods for the treatment of immune related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009254405A Division JP2010088434A (ja) | 2002-09-11 | 2009-11-05 | 免疫関連疾患の治療のための新規組成物と方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006521082A JP2006521082A (ja) | 2006-09-21 |
| JP2006521082A5 true JP2006521082A5 (cg-RX-API-DMAC7.html) | 2006-11-02 |
Family
ID=31994113
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004536419A Withdrawn JP2006521082A (ja) | 2002-09-11 | 2003-09-10 | 免疫関連疾患の治療のための新規組成物と方法 |
| JP2009254405A Withdrawn JP2010088434A (ja) | 2002-09-11 | 2009-11-05 | 免疫関連疾患の治療のための新規組成物と方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009254405A Withdrawn JP2010088434A (ja) | 2002-09-11 | 2009-11-05 | 免疫関連疾患の治療のための新規組成物と方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060199181A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1578373A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2006521082A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2003276874B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2497334A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004024072A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE493433T1 (de) | 2002-09-11 | 2011-01-15 | Genentech Inc | Neue zusammensetzung und verfahren zur behandlung von immunerkrankungen |
| CA2518101A1 (en) | 2003-03-03 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the treatment of systemic lupus erythematosis |
| EP1923400A1 (en) * | 2003-03-03 | 2008-05-21 | Genentech, Inc. | Compositions and methods for the treatment of systemic lupus erythematosis |
| US20050272067A1 (en) * | 2004-03-10 | 2005-12-08 | Macina Roberto A | Compositions, splice variants and methods relating to cancer specific genes and proteins |
| US20070054360A1 (en) | 2005-05-12 | 2007-03-08 | Zeren Gao | Compositions and methods for modulating immune responses |
| KR101855381B1 (ko) * | 2008-04-09 | 2018-05-09 | 제넨테크, 인크. | 면역 관련 질병의 치료를 위한 신규한 조성물 및 방법 |
| EP3789036A1 (en) | 2013-07-16 | 2021-03-10 | F. Hoffmann-La Roche AG | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
| CN108137691B (zh) | 2015-09-02 | 2021-10-19 | 耶路撒冷希伯来大学伊萨姆研究发展有限公司 | 特异性针对人类t-细胞免疫球蛋白和itim结构域(tigit)的抗体 |
| SMT202500003T1 (it) | 2015-09-25 | 2025-03-12 | Hoffmann La Roche | Anticorpi anti-tigit e procedimenti di utilizzo |
| US11401339B2 (en) | 2018-08-23 | 2022-08-02 | Seagen Inc. | Anti-TIGIT antibodies |
| JP2023531200A (ja) | 2020-06-18 | 2023-07-21 | ジェネンテック， インコーポレイテッド | 抗ｔｉｇｉｔ抗体及びｐｄ－１軸結合アンタゴニストを用いた治療 |
| TW202320848A (zh) | 2021-07-28 | 2023-06-01 | 美商建南德克公司 | 治療癌症之方法及組成物 |
| WO2023056403A1 (en) | 2021-09-30 | 2023-04-06 | Genentech, Inc. | Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists |
| KR20250022049A (ko) | 2022-06-07 | 2025-02-14 | 제넨테크, 인크. | 항-pd-l1 길항제 및 항-tigit 길항제 항체를 포함하는, 폐암 치료의 효율을 결정하는 방법 |
| CN120826478A (zh) | 2023-03-06 | 2025-10-21 | 基因泰克公司 | 用于非小细胞肺癌的预后和治疗方法 |
| WO2025174933A1 (en) | 2024-02-14 | 2025-08-21 | Genentech, Inc. | Methods for treatment of pancreatic cancer with anti-pd-l1 ab, anti-tigit ab, gemcitabine and nab-placlitaxel |
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-
2003
- 2003-09-10 WO PCT/US2003/028317 patent/WO2004024072A2/en not_active Ceased
- 2003-09-10 EP EP03795679A patent/EP1578373A4/en not_active Withdrawn
- 2003-09-10 EP EP09010033A patent/EP2116551A1/en not_active Withdrawn
- 2003-09-10 AU AU2003276874A patent/AU2003276874B2/en not_active Ceased
- 2003-09-10 JP JP2004536419A patent/JP2006521082A/ja not_active Withdrawn
- 2003-09-10 CA CA002497334A patent/CA2497334A1/en not_active Abandoned
- 2003-09-10 US US10/527,100 patent/US20060199181A1/en not_active Abandoned
-
2009
- 2009-11-05 JP JP2009254405A patent/JP2010088434A/ja not_active Withdrawn
- 2009-11-30 AU AU2009243417A patent/AU2009243417A1/en not_active Abandoned