JP2006520896A5 - - Google Patents
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- JP2006520896A5 JP2006520896A5 JP2006505940A JP2006505940A JP2006520896A5 JP 2006520896 A5 JP2006520896 A5 JP 2006520896A5 JP 2006505940 A JP2006505940 A JP 2006505940A JP 2006505940 A JP2006505940 A JP 2006505940A JP 2006520896 A5 JP2006520896 A5 JP 2006520896A5
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- JP
- Japan
- Prior art keywords
- disease
- mixture
- individual
- peptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 29
- 238000000034 method Methods 0.000 claims 27
- 201000010099 disease Diseases 0.000 claims 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 24
- 108060003951 Immunoglobulin Proteins 0.000 claims 20
- 102000018358 immunoglobulin Human genes 0.000 claims 20
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 150000001413 amino acids Chemical group 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 235000001014 amino acid Nutrition 0.000 claims 16
- 229940024606 amino acid Drugs 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 14
- 229940072221 immunoglobulins Drugs 0.000 claims 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 230000027455 binding Effects 0.000 claims 6
- 239000013074 reference sample Substances 0.000 claims 5
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Substances 0.000 claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Substances 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- 229930182817 methionine Natural products 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
- 239000004474 valine Substances 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000000513 principal component analysis Methods 0.000 claims 2
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 238000004422 calculation algorithm Methods 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 238000012567 pattern recognition method Methods 0.000 claims 1
- 238000002823 phage display Methods 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000012706 support-vector machine Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0305448.3A GB0305448D0 (en) | 2003-03-10 | 2003-03-10 | Immunoassay |
| PCT/GB2004/001016 WO2004081025A2 (en) | 2003-03-10 | 2004-03-10 | Differential megaplex immunoassay |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006520896A JP2006520896A (ja) | 2006-09-14 |
| JP2006520896A5 true JP2006520896A5 (enExample) | 2007-04-26 |
Family
ID=9954472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505940A Pending JP2006520896A (ja) | 2003-03-10 | 2004-03-10 | イムノアッセイ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060073611A1 (enExample) |
| EP (1) | EP1601974A2 (enExample) |
| JP (1) | JP2006520896A (enExample) |
| GB (1) | GB0305448D0 (enExample) |
| WO (1) | WO2004081025A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1171813B1 (en) * | 1999-03-18 | 2003-06-04 | 602531 British Columbia Ltd. | Data entry for personal computing devices |
| US20050037515A1 (en) * | 2001-04-23 | 2005-02-17 | Nicholson Jeremy Kirk | Methods for analysis of spectral data and their applications osteoporosis |
| US7901873B2 (en) * | 2001-04-23 | 2011-03-08 | Tcp Innovations Limited | Methods for the diagnosis and treatment of bone disorders |
| US20070054345A1 (en) | 2004-05-19 | 2007-03-08 | Hunter Christie L | Expression quantification using mass spectrometry |
| US20080206737A1 (en) * | 2004-05-19 | 2008-08-28 | Hunter Christie L | Expression quantification using mass spectrometry |
| DE102004052729A1 (de) | 2004-10-30 | 2006-05-04 | Roche Diagnostics Gmbh | Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten |
| US8592136B2 (en) * | 2005-09-13 | 2013-11-26 | Affymetrix, Inc. | Methods for producing codes for microparticles |
| GB0819720D0 (en) * | 2008-10-28 | 2008-12-03 | Univ Birmingham | Methods and products |
| CA2816014A1 (en) | 2010-11-03 | 2012-05-10 | Reametrix Inc. | Method and device for fluorescent measurement of samples |
| US9823248B2 (en) * | 2011-11-15 | 2017-11-21 | Erasmus University Medical Center Rotterdam | Methods and kits for detecting IgE-expressing B cells |
| WO2022118947A1 (ja) * | 2020-12-04 | 2022-06-09 | 富士フイルム和光純薬株式会社 | 抗体を測定する方法およびキット |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| IL106106A0 (en) * | 1993-06-22 | 1993-10-20 | Interpharm Lab Ltd | Library of polymeric molecules and its preparation |
| US6449562B1 (en) * | 1996-10-10 | 2002-09-10 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and method |
| US6617114B1 (en) * | 1996-10-31 | 2003-09-09 | Karo Bio Ab | Identification of drug complementary combinatorial libraries |
| EP1051624A4 (en) * | 1998-01-29 | 2002-05-02 | Glaucus Proteomics B V | HIGH DENSITY MATERIALS FOR PROTEOM ANALYSIS AND METHOD AND COMPOSITIONS THEREFOR |
| US5962244A (en) * | 1998-05-07 | 1999-10-05 | Tularik Inc. | High-throughput in vitro assays for modulators of peptidyl transferase |
| GB9816514D0 (en) * | 1998-07-29 | 1998-09-30 | Smithkline Beecham Plc | Novel method |
| DE10127572A1 (de) * | 2001-05-30 | 2002-12-05 | Pathoarray Gmbh | Werkzeuge zur Diagnostik, molekularen Definition und Therapieentwicklung chronischer entzündlicher Gelenkerkrankungen |
| EP1319954A1 (en) * | 2001-12-12 | 2003-06-18 | Centre National de Genotypage | Methods for protein analysis using protein capture arrays |
| CA2482863A1 (en) * | 2002-04-17 | 2003-10-30 | Roberto Crea | Universal libraries for immunoglobulins |
-
2003
- 2003-03-10 GB GBGB0305448.3A patent/GB0305448D0/en not_active Ceased
-
2004
- 2004-03-10 US US10/547,995 patent/US20060073611A1/en not_active Abandoned
- 2004-03-10 JP JP2006505940A patent/JP2006520896A/ja active Pending
- 2004-03-10 EP EP04719010A patent/EP1601974A2/en not_active Withdrawn
- 2004-03-10 WO PCT/GB2004/001016 patent/WO2004081025A2/en not_active Ceased
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