JP2006519858A5 - - Google Patents
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- JP2006519858A5 JP2006519858A5 JP2006508945A JP2006508945A JP2006519858A5 JP 2006519858 A5 JP2006519858 A5 JP 2006519858A5 JP 2006508945 A JP2006508945 A JP 2006508945A JP 2006508945 A JP2006508945 A JP 2006508945A JP 2006519858 A5 JP2006519858 A5 JP 2006519858A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
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- substituents
- unsubstituted
- Prior art date
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- Granted
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- 150000001875 compounds Chemical class 0.000 claims 49
- 239000008194 pharmaceutical composition Substances 0.000 claims 38
- 125000001424 substituent group Chemical group 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- 150000002431 hydrogen Chemical class 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 13
- 125000005724 cycloalkenylene group Chemical group 0.000 claims 12
- 125000001475 halogen functional group Chemical group 0.000 claims 12
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 12
- 102000003958 Glutamate Carboxypeptidase II Human genes 0.000 claims 11
- 108090000369 Glutamate Carboxypeptidase II Proteins 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 10
- -1 carboxy, hydroxy Chemical group 0.000 claims 9
- 230000003287 optical effect Effects 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 8
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 7
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 6
- 125000004406 C3-C8 cycloalkylene group Chemical group 0.000 claims 6
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 6
- 230000005856 abnormality Effects 0.000 claims 6
- 125000004450 alkenylene group Chemical group 0.000 claims 6
- 125000004419 alkynylene group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 6
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 206010012601 diabetes mellitus Diseases 0.000 claims 5
- 208000033808 peripheral neuropathy Diseases 0.000 claims 5
- 208000010412 Glaucoma Diseases 0.000 claims 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 208000017442 Retinal disease Diseases 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 229930195712 glutamate Natural products 0.000 claims 4
- 230000001537 neural effect Effects 0.000 claims 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 4
- 208000023105 Huntington disease Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 201000001119 neuropathy Diseases 0.000 claims 3
- 230000007823 neuropathy Effects 0.000 claims 3
- 208000017497 prostate disease Diseases 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000016192 Demyelinating disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 125000002529 biphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C12)* 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 125000004957 naphthylene group Chemical group 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- LXECNSMYNFWFCZ-UHFFFAOYSA-N 3-(1-oxo-3,4-dihydroisothiochromen-8-yl)benzoic acid Chemical compound OC(=O)C1=CC=CC(C=2C=3C(=O)SCCC=3C=CC=2)=C1 LXECNSMYNFWFCZ-UHFFFAOYSA-N 0.000 claims 1
- OPWFMUIGBAFGOP-UHFFFAOYSA-N 3-(1-oxo-3,4-dihydrothiopyrano[3,4-b]indol-9-yl)benzoic acid Chemical compound OC(=O)C1=CC=CC(N2C3=CC=CC=C3C3=C2C(SCC3)=O)=C1 OPWFMUIGBAFGOP-UHFFFAOYSA-N 0.000 claims 1
- YYXJMOQAESRPSE-UHFFFAOYSA-N 3-(2-oxothian-3-yl)propanoic acid Chemical compound OC(=O)CCC1CCCSC1=O YYXJMOQAESRPSE-UHFFFAOYSA-N 0.000 claims 1
- HNFONZNDOVCFPB-UHFFFAOYSA-N 3-[(1-oxo-3,4-dihydroisothiochromen-8-yl)oxymethyl]benzoic acid Chemical compound OC(=O)C1=CC=CC(COC=2C=3C(=O)SCCC=3C=CC=2)=C1 HNFONZNDOVCFPB-UHFFFAOYSA-N 0.000 claims 1
- SWZSGEFGQYYIGV-UHFFFAOYSA-N 3-[(2-oxothian-3-yl)methyl]benzoic acid Chemical compound OC(=O)C1=CC=CC(CC2C(SCCC2)=O)=C1 SWZSGEFGQYYIGV-UHFFFAOYSA-N 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- SVOTYRUYQODXTA-UHFFFAOYSA-N C(C1=CC=CC=C1)OC1=C(C=CC=C1)C1=CC=CC=2C3=CC=CC=C3C12 Chemical group C(C1=CC=CC=C1)OC1=C(C=CC=C1)C1=CC=CC=2C3=CC=CC=C3C12 SVOTYRUYQODXTA-UHFFFAOYSA-N 0.000 claims 1
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 208000027932 Collagen disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 208000026251 Opioid-Related disease Diseases 0.000 claims 1
- 208000007222 Physiological Sexual Dysfunction Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 201000006145 cocaine dependence Diseases 0.000 claims 1
- 208000018631 connective tissue disease Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 230000000893 fibroproliferative effect Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000007074 memory dysfunction Effects 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000000626 neurodegenerative effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 230000009689 neuronal regeneration Effects 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 201000005040 opiate dependence Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000037390 scarring Effects 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 0 OC(*IC(**S1)C1=O)=O Chemical compound OC(*IC(**S1)C1=O)=O 0.000 description 7
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45064803P | 2003-03-03 | 2003-03-03 | |
| US60/450,648 | 2003-03-03 | ||
| PCT/US2004/006178 WO2004078742A1 (en) | 2003-03-03 | 2004-03-03 | Thiolactones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006519858A JP2006519858A (ja) | 2006-08-31 |
| JP2006519858A5 true JP2006519858A5 (https=) | 2008-06-26 |
| JP4773951B2 JP4773951B2 (ja) | 2011-09-14 |
Family
ID=32962505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508945A Expired - Fee Related JP4773951B2 (ja) | 2003-03-03 | 2004-03-03 | チオラクトン |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7125907B2 (https=) |
| EP (2) | EP1599461B1 (https=) |
| JP (1) | JP4773951B2 (https=) |
| AT (1) | ATE433445T1 (https=) |
| AU (1) | AU2004217969B2 (https=) |
| CA (1) | CA2518234C (https=) |
| CY (1) | CY1109356T1 (https=) |
| DE (1) | DE602004021476D1 (https=) |
| DK (1) | DK1599461T3 (https=) |
| ES (1) | ES2326083T3 (https=) |
| MX (1) | MXPA05009492A (https=) |
| PL (1) | PL1599461T3 (https=) |
| PT (1) | PT1599461E (https=) |
| SI (1) | SI1599461T1 (https=) |
| WO (1) | WO2004078742A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4773951B2 (ja) | 2003-03-03 | 2011-09-14 | エーザイ インコーポレーテッド | チオラクトン |
| WO2008094663A2 (en) * | 2007-01-31 | 2008-08-07 | Adam Heller | Electrochemical management of pain |
| WO2017029399A1 (en) | 2015-08-20 | 2017-02-23 | Universität Zu Köln | Pain tracking by pet-imaging (pain-trap) |
| WO2021155167A1 (en) * | 2020-01-31 | 2021-08-05 | The Johns Hopkins University | Bile acid-gcpii inhibitor conjugates to treat inflammatory diseases |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4239636A (en) * | 1978-10-23 | 1980-12-16 | Exxon Research & Engineering Co. | Thio-bis-(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions |
| JPH0532659A (ja) * | 1991-08-01 | 1993-02-09 | Tsumura & Co | 糖尿病治療剤 |
| GB9218810D0 (en) | 1992-09-04 | 1992-10-21 | Univ Birmingham | Antiviral pyrimidine nucleosides |
| US6011021A (en) * | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
| GB9602721D0 (en) | 1996-02-09 | 1996-04-10 | Pharmacia Spa | Biologically active ureido derivatives useful in the treatment of multiple sclerosis |
| US5795877A (en) * | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US5804602A (en) * | 1996-06-17 | 1998-09-08 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
| US6054444A (en) * | 1997-04-24 | 2000-04-25 | Guilford Pharmaceuticals Inc. | Phosphonic acid derivatives |
| US6017903A (en) * | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
| US5902817A (en) * | 1997-04-09 | 1999-05-11 | Guilford Pharmaceuticals Inc. | Certain sulfoxide and sulfone derivatives |
| US6025345A (en) * | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| RU2218179C2 (ru) | 1996-06-17 | 2003-12-10 | Гилфорд Фармасьютикалз Инк. | СПОСОБЫ ЛЕЧЕНИЯ РАКА С ПРИМЕНЕНИЕМ ИНГИБИТОРОВ NAALADазы |
| US6046180A (en) * | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
| US5672592A (en) * | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
| US5863536A (en) | 1996-12-31 | 1999-01-26 | Guilford Pharmaceuticals Inc. | Phosphoramidate derivatives |
| US6071965A (en) * | 1996-06-17 | 2000-06-06 | Guilford Pharmaceuticals Inc. | Phosphinic alkanoic acid derivatives |
| US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
| US6025344A (en) * | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
| US5977090A (en) | 1996-09-27 | 1999-11-02 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors |
| US6384022B1 (en) * | 1996-06-17 | 2002-05-07 | Guilford Pharmaceuticals Inc. | Prodrugs of NAALAdase inhibitors |
| GB9615202D0 (en) | 1996-07-19 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
| PL332413A1 (en) * | 1996-09-27 | 1999-09-13 | Guilford Pharm Inc | Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals |
| US5962521A (en) * | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
| US5981209A (en) * | 1997-12-04 | 1999-11-09 | Guilford Pharmaceuticals Inc. | Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia |
| US6028216A (en) * | 1997-12-31 | 2000-02-22 | Guilford Pharmaceuticals Inc. | Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives |
| US6121252A (en) * | 1998-03-30 | 2000-09-19 | Guilford Pharmaceuticals Inc. | Phosphinic acid derivatives |
| ES2251204T3 (es) | 1998-07-06 | 2006-04-16 | Mgi Gp, Inc. | Inhibidores de naaladasa utiles como compuestos y composiciones farmaceuticas. |
| US6265609B1 (en) * | 1998-07-06 | 2001-07-24 | Guilford Pharmaceuticals Inc. | Thio-substituted pentanedioic acid derivatives |
| US6395718B1 (en) * | 1998-07-06 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors |
| US6444657B1 (en) * | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
| CA2367787C (en) * | 1999-04-28 | 2011-07-26 | Alan P. Kozikowski | Ligands for metabotropic glutamate receptors |
| US6228888B1 (en) * | 1999-07-01 | 2001-05-08 | Guilford Pharmaceuticals Inc. | Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors |
| US6313159B1 (en) * | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
| US6348464B1 (en) * | 1999-11-12 | 2002-02-19 | Guilford Pharmaceuticals, Inc. | Pyrrolecarbonylimino derivatives as naaladase inhibitors |
| WO2001092274A2 (en) * | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating retinal disorders and glaucoma |
| WO2001091738A2 (en) | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating amyotrophic lateral sclerosis |
| WO2001092273A2 (en) * | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Benzenedicarboxylic acid derivatives |
| AU2002219348B2 (en) * | 2001-01-08 | 2006-11-16 | Pathway Intermediates Ltd | Autoinducer compounds and their uses |
| FR2819253B1 (fr) * | 2001-01-11 | 2004-12-03 | Servier Lab | Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6586623B2 (en) * | 2001-01-17 | 2003-07-01 | Guilford Pharmaceuticals Inc. | Thiol-based NAALADase inhibitors |
| WO2002092553A1 (en) * | 2001-05-11 | 2002-11-21 | Guilford Pharmaceuticals Inc. | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors |
| AU2002310202B2 (en) * | 2001-05-30 | 2008-05-15 | Eisai Inc. | Thiolalkyl benzoic acid derivatives |
| WO2003057154A2 (en) | 2001-12-28 | 2003-07-17 | Guildford Pharmaceuticals Inc. | Naaladase inhibitors for treating huntington's disease |
| US20040186081A1 (en) * | 2003-03-03 | 2004-09-23 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating opioid tolerance |
| JP4773951B2 (ja) * | 2003-03-03 | 2011-09-14 | エーザイ インコーポレーテッド | チオラクトン |
-
2004
- 2004-03-03 JP JP2006508945A patent/JP4773951B2/ja not_active Expired - Fee Related
- 2004-03-03 WO PCT/US2004/006178 patent/WO2004078742A1/en not_active Ceased
- 2004-03-03 AT AT04716834T patent/ATE433445T1/de active
- 2004-03-03 AU AU2004217969A patent/AU2004217969B2/en not_active Ceased
- 2004-03-03 US US10/791,278 patent/US7125907B2/en not_active Expired - Fee Related
- 2004-03-03 CA CA2518234A patent/CA2518234C/en not_active Expired - Fee Related
- 2004-03-03 SI SI200431195T patent/SI1599461T1/sl unknown
- 2004-03-03 MX MXPA05009492A patent/MXPA05009492A/es active IP Right Grant
- 2004-03-03 PT PT04716834T patent/PT1599461E/pt unknown
- 2004-03-03 PL PL04716834T patent/PL1599461T3/pl unknown
- 2004-03-03 EP EP04716834A patent/EP1599461B1/en not_active Expired - Lifetime
- 2004-03-03 DK DK04716834T patent/DK1599461T3/da active
- 2004-03-03 ES ES04716834T patent/ES2326083T3/es not_active Expired - Lifetime
- 2004-03-03 DE DE602004021476T patent/DE602004021476D1/de not_active Expired - Lifetime
- 2004-03-03 EP EP08013761A patent/EP1988088A1/en not_active Withdrawn
-
2006
- 2006-10-02 US US11/537,979 patent/US20070037798A1/en not_active Abandoned
-
2007
- 2007-07-30 US US11/830,737 patent/US7553866B2/en not_active Expired - Fee Related
-
2009
- 2009-05-26 US US12/472,251 patent/US7968593B2/en not_active Expired - Fee Related
- 2009-08-28 CY CY20091100904T patent/CY1109356T1/el unknown
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