JP2006519223A5 - - Google Patents
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- Publication number
- JP2006519223A5 JP2006519223A5 JP2006502646A JP2006502646A JP2006519223A5 JP 2006519223 A5 JP2006519223 A5 JP 2006519223A5 JP 2006502646 A JP2006502646 A JP 2006502646A JP 2006502646 A JP2006502646 A JP 2006502646A JP 2006519223 A5 JP2006519223 A5 JP 2006519223A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- derivative compound
- compound according
- sulfonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- 125000004421 aryl sulphonamide group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- LBLZPOGZQOBQKC-UHFFFAOYSA-N thiadiazole-4-sulfonamide Chemical group NS(=O)(=O)C1=CSN=N1 LBLZPOGZQOBQKC-UHFFFAOYSA-N 0.000 claims 4
- 208000028017 Psychotic disease Diseases 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- -1 2,2,3,3-tetramethylcyclopropanecarboxamide derivative compound Chemical class 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical group NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 125000005421 aryl sulfonamido group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- FBEZSDVCNGSNSI-UHFFFAOYSA-N n-acetyl-n-carbamoyl-2,2,3,3-tetramethylcyclopropane-1-carboxamide Chemical compound CC(=O)N(C(N)=O)C(=O)C1C(C)(C)C1(C)C FBEZSDVCNGSNSI-UHFFFAOYSA-N 0.000 claims 1
- XAWKSSQDMAKSSP-UHFFFAOYSA-N n-methoxy-2,2,3,3-tetramethylcyclopropane-1-carboxamide Chemical compound CONC(=O)C1C(C)(C)C1(C)C XAWKSSQDMAKSSP-UHFFFAOYSA-N 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL15469403A IL154694A0 (en) | 2003-02-28 | 2003-02-28 | New amide derivatives of 2,2,3,3,-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them |
| IL15775103A IL157751A0 (en) | 2003-02-28 | 2003-09-04 | New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them |
| PCT/IL2004/000193 WO2004076432A1 (en) | 2003-02-28 | 2004-02-26 | New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006519223A JP2006519223A (ja) | 2006-08-24 |
| JP2006519223A5 true JP2006519223A5 (https=) | 2007-04-12 |
Family
ID=32715250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502646A Pending JP2006519223A (ja) | 2003-02-28 | 2004-02-26 | ２，２，３，３−テトラメチルシクロプロパンカルボン酸の新規アミド誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7232929B2 (https=) |
| EP (1) | EP1603891B1 (https=) |
| JP (1) | JP2006519223A (https=) |
| AT (1) | ATE396980T1 (https=) |
| DE (1) | DE602004014115D1 (https=) |
| IL (1) | IL157751A0 (https=) |
| WO (1) | WO2004076432A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004098A1 (en) * | 2003-07-28 | 2006-01-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds useful for treating neurological disorders |
| DE102004010194A1 (de) * | 2004-03-02 | 2005-10-13 | Aventis Pharma Deutschland Gmbh | 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate, ihre Herstellung und Verwendung in Arzneimitteln |
| DE102004010207A1 (de) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| JP2010519287A (ja) * | 2007-02-21 | 2010-06-03 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド | α−ハロシクロプロピルカルボキシ化合物およびα−アルキルシクロプロピルカルボキシ化合物ならびにそれらの使用 |
| RU2648474C2 (ru) * | 2011-08-05 | 2018-03-26 | Сукампо Аг | Способ лечения шизофрении |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA74202B (en) | 1973-01-11 | 1974-11-27 | Hexachimie | New amine derivatives of 2,2-diaryl cyclopropanes |
| US5585358A (en) * | 1993-07-06 | 1996-12-17 | Yissum Research Development Corporation Of The Hebrew University Of Jerusalem | Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents |
| SE9303274D0 (sv) | 1993-10-07 | 1993-10-07 | Astra Ab | Novel phenylethyl and phenylproplamines |
| IL108595A (en) * | 1994-02-08 | 1998-09-24 | Yissum Res Dev Co | History of Carboxylic Acid 2,2,3,3 Tetramethyl Cyclophen (ACMT) (Process for their Preparation and Pharmaceutical Preparations Containing Them) |
| IL120006A (en) * | 1997-01-14 | 2000-12-06 | Yissum Res Dev Co | Valnoctamide stereoisomers and a method for their synthesis and separation |
| US6090854A (en) | 1998-03-20 | 2000-07-18 | Bristol-Meyers Company | Aryloxyanilides and related compounds |
| IL124118A (en) | 1998-04-16 | 2007-09-20 | Yissum Res Dev Co | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, method for their synthesis and pharmaceutical compositions containing them |
| US6969732B2 (en) * | 1999-04-12 | 2005-11-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them |
| PL365588A1 (en) * | 2000-07-21 | 2005-01-10 | Teva Pharmaceutical Industries, Ltd. | Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder |
| US6323365B1 (en) * | 2000-07-28 | 2001-11-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation |
| DK1311256T3 (da) * | 2000-08-17 | 2005-11-28 | Teva Pharma | Anvendelse af derivater af valproinsyreamider og 2-valproinsyreamider til behandling eller forebyggelse af smerter og/eller hovedpinelidelser |
| US6610326B2 (en) * | 2001-02-16 | 2003-08-26 | Andrx Corporation | Divalproex sodium tablets |
| WO2003000654A1 (en) * | 2001-06-26 | 2003-01-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Valproyltaurinamide derivatives as anticonvulsant and cns active agents |
| IL147953A (en) | 2002-02-01 | 2008-04-13 | Meir Bialer | Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl- |
| IL156203A0 (en) | 2003-05-29 | 2003-12-23 | Yissum Res Dev Co | Use of 2,2,3,3, tetramethylcyclopropane carboxylic acid derivatives for treating psychiatric disorders |
| EP1653937B1 (en) | 2003-07-28 | 2010-01-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds useful for treating neuropathic pain and migraine |
-
2003
- 2003-09-04 IL IL15775103A patent/IL157751A0/xx unknown
-
2004
- 2004-02-15 US US10/547,299 patent/US7232929B2/en not_active Expired - Fee Related
- 2004-02-26 EP EP04737264A patent/EP1603891B1/en not_active Expired - Lifetime
- 2004-02-26 JP JP2006502646A patent/JP2006519223A/ja active Pending
- 2004-02-26 DE DE602004014115T patent/DE602004014115D1/de not_active Expired - Lifetime
- 2004-02-26 WO PCT/IL2004/000193 patent/WO2004076432A1/en not_active Ceased
- 2004-02-26 AT AT04737264T patent/ATE396980T1/de not_active IP Right Cessation