JP2006519223A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006519223A5 JP2006519223A5 JP2006502646A JP2006502646A JP2006519223A5 JP 2006519223 A5 JP2006519223 A5 JP 2006519223A5 JP 2006502646 A JP2006502646 A JP 2006502646A JP 2006502646 A JP2006502646 A JP 2006502646A JP 2006519223 A5 JP2006519223 A5 JP 2006519223A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- derivative compound
- compound according
- sulfonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- 125000004421 aryl sulphonamide group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- LBLZPOGZQOBQKC-UHFFFAOYSA-N thiadiazole-4-sulfonamide Chemical group NS(=O)(=O)C1=CSN=N1 LBLZPOGZQOBQKC-UHFFFAOYSA-N 0.000 claims 4
- 208000028017 Psychotic disease Diseases 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- -1 2,2,3,3-tetramethylcyclopropanecarboxamide derivative compound Chemical class 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical group NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 125000005421 aryl sulfonamido group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- FBEZSDVCNGSNSI-UHFFFAOYSA-N n-acetyl-n-carbamoyl-2,2,3,3-tetramethylcyclopropane-1-carboxamide Chemical compound CC(=O)N(C(N)=O)C(=O)C1C(C)(C)C1(C)C FBEZSDVCNGSNSI-UHFFFAOYSA-N 0.000 claims 1
- XAWKSSQDMAKSSP-UHFFFAOYSA-N n-methoxy-2,2,3,3-tetramethylcyclopropane-1-carboxamide Chemical compound CONC(=O)C1C(C)(C)C1(C)C XAWKSSQDMAKSSP-UHFFFAOYSA-N 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL15469403A IL154694A0 (en) | 2003-02-28 | 2003-02-28 | New amide derivatives of 2,2,3,3,-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them |
| IL15775103A IL157751A0 (en) | 2003-02-28 | 2003-09-04 | New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them |
| PCT/IL2004/000193 WO2004076432A1 (en) | 2003-02-28 | 2004-02-26 | New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006519223A JP2006519223A (ja) | 2006-08-24 |
| JP2006519223A5 true JP2006519223A5 (https=) | 2007-04-12 |
Family
ID=32715250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502646A Pending JP2006519223A (ja) | 2003-02-28 | 2004-02-26 | ２，２，３，３−テトラメチルシクロプロパンカルボン酸の新規アミド誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7232929B2 (https=) |
| EP (1) | EP1603891B1 (https=) |
| JP (1) | JP2006519223A (https=) |
| AT (1) | ATE396980T1 (https=) |
| DE (1) | DE602004014115D1 (https=) |
| IL (1) | IL157751A0 (https=) |
| WO (1) | WO2004076432A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004098A1 (en) * | 2003-07-28 | 2006-01-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds useful for treating neurological disorders |
| DE102004010194A1 (de) * | 2004-03-02 | 2005-10-13 | Aventis Pharma Deutschland Gmbh | 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate, ihre Herstellung und Verwendung in Arzneimitteln |
| DE102004010207A1 (de) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| WO2008102348A1 (en) * | 2007-02-21 | 2008-08-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Alpha-halo- and alpha-alkyl-cyclopropylcarboxy compounds and uses thereof |
| US8592483B2 (en) * | 2011-08-05 | 2013-11-26 | Sucampo Ag | Method for treating schizophrenia |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA74202B (en) | 1973-01-11 | 1974-11-27 | Hexachimie | New amine derivatives of 2,2-diaryl cyclopropanes |
| US5585358A (en) | 1993-07-06 | 1996-12-17 | Yissum Research Development Corporation Of The Hebrew University Of Jerusalem | Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents |
| SE9303274D0 (sv) | 1993-10-07 | 1993-10-07 | Astra Ab | Novel phenylethyl and phenylproplamines |
| IL108595A (en) | 1994-02-08 | 1998-09-24 | Yissum Res Dev Co | History of Carboxylic Acid 2,2,3,3 Tetramethyl Cyclophen (ACMT) (Process for their Preparation and Pharmaceutical Preparations Containing Them) |
| IL120006A (en) | 1997-01-14 | 2000-12-06 | Yissum Res Dev Co | Valnoctamide stereoisomers and a method for their synthesis and separation |
| US6090854A (en) | 1998-03-20 | 2000-07-18 | Bristol-Meyers Company | Aryloxyanilides and related compounds |
| IL124118A (en) | 1998-04-16 | 2007-09-20 | Yissum Res Dev Co | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, method for their synthesis and pharmaceutical compositions containing them |
| US6969732B2 (en) | 1999-04-12 | 2005-11-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them |
| CN1251758C (zh) | 2000-07-21 | 2006-04-19 | 特瓦制药工业有限公司 | 丙戊酸和2－丙基戊烯酸酰胺的衍生物在制备治疗双极情感障碍症躁狂病药物中的用途 |
| US6323365B1 (en) | 2000-07-28 | 2001-11-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation |
| IL154470A0 (en) | 2000-08-17 | 2003-09-17 | Teva Pharma | Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders |
| US6610326B2 (en) | 2001-02-16 | 2003-08-26 | Andrx Corporation | Divalproex sodium tablets |
| EP1401805A1 (en) | 2001-06-26 | 2004-03-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Valproyltaurinamide derivatives as anticonvulsant and cns active agents |
| IL147953A (en) | 2002-02-01 | 2008-04-13 | Meir Bialer | Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl- |
| IL156203A0 (en) | 2003-05-29 | 2003-12-23 | Yissum Res Dev Co | Use of 2,2,3,3, tetramethylcyclopropane carboxylic acid derivatives for treating psychiatric disorders |
| DE602004025001D1 (de) | 2003-07-28 | 2010-02-25 | Yissum Res Dev Co | Verbindungen zur behandlung von neuropathischen schmerzen und migräne |
-
2003
- 2003-09-04 IL IL15775103A patent/IL157751A0/xx unknown
-
2004
- 2004-02-15 US US10/547,299 patent/US7232929B2/en not_active Expired - Fee Related
- 2004-02-26 EP EP04737264A patent/EP1603891B1/en not_active Expired - Lifetime
- 2004-02-26 DE DE602004014115T patent/DE602004014115D1/de not_active Expired - Lifetime
- 2004-02-26 WO PCT/IL2004/000193 patent/WO2004076432A1/en not_active Ceased
- 2004-02-26 AT AT04737264T patent/ATE396980T1/de not_active IP Right Cessation
- 2004-02-26 JP JP2006502646A patent/JP2006519223A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2324687C2 (ru) | Производные бензотиазола, характеризующиеся агонистической активностью к бета-2-адренорецепторам | |
| JPWO2020123827A5 (https=) | ||
| JP2016506387A5 (https=) | ||
| WO2017040993A4 (en) | Small molecule inhibitors of dyrk1a and uses thereof | |
| AR064212A1 (es) | Uso de profarmacos de analogos de gaba para tratar enfermedades | |
| RU2010126063A (ru) | Производные 4-(2-амино-1-гидроксиэтил)фенола как агонисты в2 адренергического рецептора | |
| JP2021514001A5 (https=) | ||
| RU2008145971A (ru) | Производные 2-тиоксантина, действующие в качестве ингибиторов мро | |
| JP2021534106A5 (https=) | ||
| RU2009136592A (ru) | Терапевтические агенты | |
| JP2011507878A5 (https=) | ||
| JP2008526999A5 (https=) | ||
| JP2009526831A5 (https=) | ||
| JP2009519903A5 (https=) | ||
| JP2008536833A5 (https=) | ||
| JP2010535706A5 (https=) | ||
| JP2017522304A5 (https=) | ||
| JP2006519223A5 (https=) | ||
| JP2007517037A5 (https=) | ||
| JP2021527650A5 (https=) | ||
| JP2008508248A5 (https=) | ||
| JP2009501745A5 (https=) | ||
| CA2491612A1 (en) | 4-'7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents | |
| JP2013538218A5 (https=) | ||
| JP2008536844A5 (https=) |