JP2006518197A - ラス発現の改変のためのオリゴマー化合物 - Google Patents

ラス発現の改変のためのオリゴマー化合物 Download PDF

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JP2006518197A
JP2006518197A JP2006501525A JP2006501525A JP2006518197A JP 2006518197 A JP2006518197 A JP 2006518197A JP 2006501525 A JP2006501525 A JP 2006501525A JP 2006501525 A JP2006501525 A JP 2006501525A JP 2006518197 A JP2006518197 A JP 2006518197A
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cancer
compound
lna
compound according
seq
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JP2006518197A5 (https=
Inventor
ボー・ハンセン
シャルロッテ・アルベク・トゥルーエ
カミーレ・ドゥモング・ペーターセン
マイケン・ヴェスターゴー
マルギット・ヴィッセンバッハ
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Roche Innovation Center Copenhagen AS
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Santaris Pharma AS
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JP2006501525A 2003-02-10 2004-02-10 ラス発現の改変のためのオリゴマー化合物 Withdrawn JP2006518197A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200300184 2003-02-10
DKPA200301539 2003-10-20
PCT/DK2004/000097 WO2004069992A2 (en) 2003-02-10 2004-02-10 Oligomeric compounds for the modulation of ras expression

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JP2006518197A true JP2006518197A (ja) 2006-08-10
JP2006518197A5 JP2006518197A5 (https=) 2007-03-22

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US (2) US20040248840A1 (https=)
EP (1) EP1592795A2 (https=)
JP (1) JP2006518197A (https=)
AU (1) AU2004209599A1 (https=)
CA (1) CA2515644A1 (https=)
WO (1) WO2004069992A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013545450A (ja) * 2010-10-27 2013-12-26 カッパーアールエヌエー，インコーポレイテッド インターフェロン関連発生制御因子１（ｉｆｒｄ１）への天然アンチセンス転写物の阻害によるｉｆｒｄ１関連疾患の治療
JP2015511821A (ja) * 2012-03-12 2015-04-23 ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ Ａｔｘｎ３発現の調節のための組成物および方法
JP2015093853A (ja) * 2013-11-12 2015-05-18 学校法人東京理科大学 ボラノホスフェート化合物、及び核酸オリゴマー
JP2016105703A (ja) * 2007-11-26 2016-06-16 エンゾン ファーマシューティカルズ，インコーポレーテッド アンドロゲン受容体を標的化するｌｎａアンタゴニスト

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003085110A2 (en) 2002-04-05 2003-10-16 Santaris Pharma A/S Oligomeric compounds for the modulation hif-1alpha expression
US7713738B2 (en) * 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
US20040241717A1 (en) * 2003-02-10 2004-12-02 Santaris Pharma A/S Oligomeric compounds for the modulation of thioredoxin expression
US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
AU2005304112B2 (en) 2004-11-09 2009-06-04 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
KR20070095882A (ko) * 2004-11-09 2007-10-01 산타리스 팔마 에이/에스 Ｌｎａ 올리고뉴클레오티드 및 암의 치료
WO2006105487A1 (en) * 2005-03-31 2006-10-05 Amgen Inc. Method for selectively blocking hemoglobin rna amplification
US20090069263A1 (en) * 2005-12-16 2009-03-12 Damha Masad J 4'-thioarabinonucleotide-containing oligonucleotides, compounds and methods for their preparation and uses thereof
CA2648132C (en) * 2006-04-03 2019-05-28 Santaris Pharma A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
US20100021914A1 (en) * 2006-11-23 2010-01-28 Querdenker Aps Oligonucleotides for modulating target rna activity
EP2001188A1 (en) * 2007-06-08 2008-12-10 F.Hoffmann-La Roche Ag Method for authenticating a medical device and a remote device
AU2008270835A1 (en) * 2007-06-29 2009-01-08 F. Hoffmann-La Roche Ag Device and methods for optimizing communications between a medical device and a remote electronic device
EP2186035B1 (en) * 2007-06-29 2018-12-26 Roche Diabetes Care GmbH Apparatus and method for remotely controlling an ambulatory medical device
DK2548962T3 (en) 2007-09-19 2016-04-11 Applied Biosystems Llc Sirna sequence-independent modification formats to reduce off-target phenotype effects in RNAI and stabilized forms thereof
US7863437B2 (en) * 2007-12-03 2011-01-04 Enzon Pharmaceuticals, Inc. RNA antagonist compounds for the modulation of PIK3CA expression
EP2580228B1 (en) 2010-06-08 2016-03-23 Ionis Pharmaceuticals, Inc. Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
HK1200484A1 (zh) 2011-09-14 2015-08-07 Translate Bio Ma, Inc. 多聚寡核苷酸化合物
CA2873766A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating atp2a2 expression
JP2015523854A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
CA2873769A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating hemoglobin gene family expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
BR112014028634A2 (pt) 2012-05-16 2017-06-27 Rana Therapeutics Inc composições e métodos para modulação da expressão de utrn
AU2013262709A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating MECP2 expression
EP2895200B1 (en) 2012-09-14 2019-11-06 Translate Bio MA, Inc. Multimeric oligonucleotide compounds
US9029335B2 (en) 2012-10-16 2015-05-12 Isis Pharmaceuticals, Inc. Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
US10266828B2 (en) 2013-12-16 2019-04-23 Syddansk Universitet RAS exon 2 skipping for cancer treatment
WO2016127002A1 (en) * 2015-02-04 2016-08-11 Bristol-Myers Squibb Company Lna oligonucleotides with alternating flanks
EP3254104B1 (en) 2015-02-04 2021-08-25 Bristol-Myers Squibb Company Methods of selecting therapeutic molecules
AU2016215155A1 (en) 2015-02-04 2017-08-17 F. Hoffmann-La Roche Ag Tau antisense oligomers and uses thereof
WO2016130943A1 (en) * 2015-02-13 2016-08-18 Rana Therapeutics, Inc. Hybrid oligonucleotides and uses thereof
WO2019046698A1 (en) * 2017-09-01 2019-03-07 Thomas Jefferson University COMPOSITIONS AND METHODS FOR MYC GENE MESSENGER RNA INHIBITORS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541308A (en) * 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5962218A (en) * 1988-11-03 1999-10-05 Igen International Inc. Methods and apparatus for improved luminescence assays
AU672175B2 (en) * 1991-06-14 1996-09-26 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of the ras gene
US5872242A (en) * 1992-10-05 1999-02-16 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of ras
US6794499B2 (en) * 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US20020068709A1 (en) * 1999-12-23 2002-06-06 Henrik Orum Therapeutic uses of LNA-modified oligonucleotides
WO2002097114A2 (en) * 2001-05-29 2002-12-05 Sirna Therapeutics, Inc. Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv
US7713738B2 (en) * 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
US20040241717A1 (en) * 2003-02-10 2004-12-02 Santaris Pharma A/S Oligomeric compounds for the modulation of thioredoxin expression

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016105703A (ja) * 2007-11-26 2016-06-16 エンゾン ファーマシューティカルズ，インコーポレーテッド アンドロゲン受容体を標的化するｌｎａアンタゴニスト
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JP2015511821A (ja) * 2012-03-12 2015-04-23 ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ Ａｔｘｎ３発現の調節のための組成物および方法
JP2015093853A (ja) * 2013-11-12 2015-05-18 学校法人東京理科大学 ボラノホスフェート化合物、及び核酸オリゴマー

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